Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium channel subfamily K member 3

Gene

KCNK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.2 Publications

Miscellaneous

Inhibited by external acidification. Activated by halothane and isoflurane.

GO - Molecular functioni

  • growth factor activity Source: InterPro
  • ion channel activity Source: UniProtKB
  • open rectifier potassium channel activity Source: Ensembl
  • potassium channel activity Source: Reactome
  • potassium ion leak channel activity Source: UniProtKB
  • protein C-terminus binding Source: Ensembl
  • protein heterodimerization activity Source: Ensembl
  • protein homodimerization activity Source: Ensembl
  • S100 protein binding Source: UniProtKB

GO - Biological processi

  • brain development Source: Ensembl
  • cardiac conduction Source: Reactome
  • cellular response to hypoxia Source: Ensembl
  • cellular response to zinc ion Source: Ensembl
  • chemical synaptic transmission Source: ProtInc
  • cochlea development Source: Ensembl
  • ion transmembrane transport Source: UniProtKB
  • negative regulation of cytosolic calcium ion concentration Source: Ensembl
  • potassium ion transport Source: ProtInc
  • response to drug Source: Ensembl
  • stabilization of membrane potential Source: GO_Central

Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1299316 TWIK-releated acid-sensitive K+ channel (TASK)
R-HSA-5576886 Phase 4 - resting membrane potential
SIGNORiO14649

Protein family/group databases

TCDBi1.A.1.9.2 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 3
Alternative name(s):
Acid-sensitive potassium channel protein TASK-1
TWIK-related acid-sensitive K(+) channel 1
Two pore potassium channel KT3.1
Short name:
Two pore K(+) channel KT3.1
Gene namesi
Name:KCNK3
Synonyms:TASK, TASK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000171303.6
HGNCiHGNC:6278 KCNK3
MIMi603220 gene
neXtProtiNX_O14649

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Intramembranei78 – 101Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST24
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Intramembranei184 – 207Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST24
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 394CytoplasmicSequence analysisAdd BLAST151

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Pulmonary hypertension, primary, 4 (PPH4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.
See also OMIM:615344
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0701268T → K in PPH4; loss of function; channel activity can be rescued with the use of the phospholipase A2 inhibitor ONO-RS-082. 1 Publication1
Natural variantiVAR_07012797G → R in PPH4; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398123040EnsemblClinVar.1
Natural variantiVAR_070128182E → K in PPH4; loss of function; channel activity can be rescued with the use of the phospholipase A2 inhibitor ONO-RS-082. 1 PublicationCorresponds to variant dbSNP:rs398123042EnsemblClinVar.1
Natural variantiVAR_070129192Y → C in PPH4; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398123043EnsemblClinVar.1
Natural variantiVAR_070130203G → D in PPH4; loss of function; channel activity cannot be rescued with the use of the phospholipase A2 inhibitor ONO-RS-082. 1 PublicationCorresponds to variant dbSNP:rs398123039EnsemblClinVar.1
Natural variantiVAR_070131221V → L in PPH4; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398123041EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi98H → N: Greatly reduces pH sensitivity. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3777
MalaCardsiKCNK3
MIMi615344 phenotype
OpenTargetsiENSG00000171303
Orphaneti275777 Heritable pulmonary arterial hypertension
275766 Idiopathic pulmonary arterial hypertension
PharmGKBiPA30060

Chemistry databases

ChEMBLiCHEMBL2321613
DrugBankiDB00561 Doxapram
DB01159 Halothane
GuidetoPHARMACOLOGYi515

Polymorphism and mutation databases

BioMutaiKCNK3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017441 – 394Potassium channel subfamily K member 3Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO14649
PeptideAtlasiO14649
PRIDEiO14649
ProteomicsDBi48147

PTM databases

iPTMnetiO14649
PhosphoSitePlusiO14649

Expressioni

Tissue specificityi

Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.

Gene expression databases

BgeeiENSG00000171303
CleanExiHS_KCNK3
ExpressionAtlasiO14649 baseline and differential
GenevisibleiO14649 HS

Interactioni

Subunit structurei

Homodimer (Probable). Heterodimer with KCNK1.Curated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109978, 3 interactors
IntActiO14649, 1 interactor
MINTiO14649
STRINGi9606.ENSP00000306275

Chemistry databases

BindingDBiO14649

Structurei

3D structure databases

ProteinModelPortaliO14649
SMRiO14649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000231463
HOVERGENiHBG052239
InParanoidiO14649
KOiK04914
OMAiCSGTQRS
OrthoDBiEOG091G08DH
PhylomeDBiO14649
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR022341 IGF-I
IPR013099 K_chnl_dom
IPR005406 KCNK3
PANTHERiPTHR11003:SF138 PTHR11003:SF138, 1 hit
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01584 TASK1CHANNEL
PR01095 TASKCHANNEL

Sequencei

Sequence statusi: Complete.

O14649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPELIERQR LELRQQELRA
60 70 80 90 100
RYNLSQGGYE ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PSTDGGKVFC MFYALLGIPL TLVMFQSLGE RINTLVRYLL HRAKKGLGMR
160 170 180 190 200
RADVSMANMV LIGFFSCIST LCIGAAAFSH YEHWTFFQAY YYCFITLTTI
210 220 230 240 250
GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN LVVLRFMTMN
260 270 280 290 300
AEDEKRDAEH RALLTRNGQA GGGGGGGSAH TTDTASSTAA AGGGGFRNVY
310 320 330 340 350
AEVLHFQSMC SCLWYKSREK LQYSIPMIIP RDLSTSDTCV EQSHSSPGGG
360 370 380 390
GRYSDTPSRR CLCSGAPRSA ISSVSTGLHS LSTFRGLMKR RSSV
Length:394
Mass (Da):43,518
Last modified:January 1, 1998 - v1
Checksum:i9FF4C8266F615FB7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0701268T → K in PPH4; loss of function; channel activity can be rescued with the use of the phospholipase A2 inhibitor ONO-RS-082. 1 Publication1
Natural variantiVAR_07012797G → R in PPH4; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398123040EnsemblClinVar.1
Natural variantiVAR_070128182E → K in PPH4; loss of function; channel activity can be rescued with the use of the phospholipase A2 inhibitor ONO-RS-082. 1 PublicationCorresponds to variant dbSNP:rs398123042EnsemblClinVar.1
Natural variantiVAR_070129192Y → C in PPH4; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398123043EnsemblClinVar.1
Natural variantiVAR_070130203G → D in PPH4; loss of function; channel activity cannot be rescued with the use of the phospholipase A2 inhibitor ONO-RS-082. 1 PublicationCorresponds to variant dbSNP:rs398123039EnsemblClinVar.1
Natural variantiVAR_070131221V → L in PPH4; loss of function. 1 PublicationCorresponds to variant dbSNP:rs398123041EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006823 mRNA Translation: AAC51777.1
AF065163 mRNA Translation: AAG29340.1
AC015977 Genomic DNA Translation: AAY24312.1
CH471053 Genomic DNA Translation: EAX00678.1
CH471053 Genomic DNA Translation: EAX00679.1
CCDSiCCDS1727.1
RefSeqiNP_002237.1, NM_002246.2
UniGeneiHs.24040
Hs.645288

Genome annotation databases

EnsembliENST00000302909; ENSP00000306275; ENSG00000171303
GeneIDi3777
KEGGihsa:3777
UCSCiuc002rhn.3 human

Similar proteinsi

Entry informationi

Entry nameiKCNK3_HUMAN
AccessioniPrimary (citable) accession number: O14649
Secondary accession number(s): Q53SU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health