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Protein

Chromodomain-helicase-DNA-binding protein 2

Gene

CHD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi509 – 5168ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent DNA helicase activity Source: ProtInc
  • core promoter sequence-specific DNA binding Source: UniProtKB
  • DNA binding Source: ProtInc
  • histone binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

Myogenesis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 2 (EC:3.6.4.12)
Short name:
CHD-2
Alternative name(s):
ATP-dependent helicase CHD2
Gene namesi
Name:CHD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:1917. CHD2.

Subcellular locationi

  • Nucleus By similarity

  • Note: Binds to myogenic gene promoters.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Epileptic encephalopathy, childhood-onset (EEOC)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA severe form of epilepsy characterized by onset of multiple seizure types in the first few years of life and associated with poor prognosis. Affected individuals have cognitive regression and intellectual disability.

See also OMIM:615369
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti548 – 5481W → R in EEOC. 1 Publication
VAR_070209
Natural varianti823 – 8231L → P in EEOC. 1 Publication
VAR_070210

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

MIMi615369. phenotype.
Orphaneti2382. Lennox-Gastaut syndrome.
1942. Myoclonic-astastic epilepsy.
PharmGKBiPA26453.

Polymorphism and mutation databases

BioMutaiCHD2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18281828Chromodomain-helicase-DNA-binding protein 2PRO_0000080226Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei207 – 2071Phosphoserine3 Publications
Modified residuei208 – 2081Phosphoserine3 Publications
Modified residuei240 – 2401Phosphothreonine2 Publications
Modified residuei242 – 2421Phosphoserine2 Publications
Modified residuei1085 – 10851Phosphoserine1 Publication
Modified residuei1087 – 10871Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14647.
PaxDbiO14647.
PRIDEiO14647.

PTM databases

PhosphoSiteiO14647.

Expressioni

Gene expression databases

BgeeiO14647.
CleanExiHS_CHD2.
ExpressionAtlasiO14647. baseline and differential.
GenevisibleiO14647. HS.

Organism-specific databases

HPAiHPA060744.
HPA060960.

Interactioni

Subunit structurei

Interacts with MYOD1. Interacts with histone H3.3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BEND7Q8N7W2-23EBI-1210503,EBI-10181188
MID2Q9UJV3-23EBI-1210503,EBI-10172526
TEKT1Q969V43EBI-1210503,EBI-10180409
THAP1Q9NVV93EBI-1210503,EBI-741515
TRIM41Q8WV444EBI-1210503,EBI-725997

Protein-protein interaction databases

BioGridi107531. 8 interactions.
IntActiO14647. 10 interactions.
STRINGi9606.ENSP00000377747.

Structurei

3D structure databases

ProteinModelPortaliO14647.
SMRiO14647. Positions 261-446, 1129-1334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini261 – 35393Chromo 1PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 45679Chromo 2PROSITE-ProRule annotationAdd
BLAST
Domaini496 – 666171Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini795 – 946152Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi617 – 6204DEAH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 7462Ser-richAdd
BLAST
Compositional biasi121 – 13919Ser-richAdd
BLAST
Compositional biasi966 – 1066101Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 2 chromo domains.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00760000119067.
HOGENOMiHOG000207917.
HOVERGENiHBG005325.
InParanoidiO14647.
KOiK11367.
OMAiKRPYEQY.
OrthoDBiEOG7NPFSB.
PhylomeDBiO14647.
TreeFamiTF313461.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030485. CHD2.
IPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR025260. DUF4208.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PANTHERiPTHR10799:SF538. PTHR10799:SF538. 1 hit.
PfamiPF00385. Chromo. 2 hits.
PF13907. DUF4208. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS00598. CHROMO_1. 2 hits.
PS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14647-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMRNKDKSQE EDSSLHSNAS SHSASEEASG SDSGSQSESE QGSDPGSGHG
60 70 80 90 100
SESNSSSESS ESQSESESES AGSKSQPVLP EAKEKPASKK ERIADVKKMW
110 120 130 140 150
EEYPDVYGVR RSNRSRQEPS RFNIKEEASS GSESGSPKRR GQRQLKKQEK
160 170 180 190 200
WKQEPSEDEQ EQGTSAESEP EQKKVKARRP VPRRTVPKPR VKKQPKTQRG
210 220 230 240 250
KRKKQDSSDE DDDDDEAPKR QTRRRAAKNV SYKEDDDFET DSDDLIEMTG
260 270 280 290 300
EGVDEQQDNS ETIEKVLDSR LGKKGATGAS TTVYAIEANG DPSGDFDTEK
310 320 330 340 350
DEGEIQYLIK WKGWSYIHST WESEESLQQQ KVKGLKKLEN FKKKEDEIKQ
360 370 380 390 400
WLGKVSPEDV EYFNCQQELA SELNKQYQIV ERVIAVKTSK STLGQTDFPA
410 420 430 440 450
HSRKPAPSNE PEYLCKWMGL PYSECSWEDE ALIGKKFQNC IDSFHSRNNS
460 470 480 490 500
KTIPTRECKA LKQRPRFVAL KKQPAYLGGE NLELRDYQLE GLNWLAHSWC
510 520 530 540 550
KNNSVILADE MGLGKTIQTI SFLSYLFHQH QLYGPFLIVV PLSTLTSWQR
560 570 580 590 600
EFEIWAPEIN VVVYIGDLMS RNTIREYEWI HSQTKRLKFN ALITTYEILL
610 620 630 640 650
KDKTVLGSIN WAFLGVDEAH RLKNDDSLLY KTLIDFKSNH RLLITGTPLQ
660 670 680 690 700
NSLKELWSLL HFIMPEKFEF WEDFEEDHGK GRENGYQSLH KVLEPFLLRR
710 720 730 740 750
VKKDVEKSLP AKVEQILRVE MSALQKQYYK WILTRNYKAL AKGTRGSTSG
760 770 780 790 800
FLNIVMELKK CCNHCYLIKP PEENERENGQ EILLSLIRSS GKLILLDKLL
810 820 830 840 850
TRLRERGNRV LIFSQMVRML DILAEYLTIK HYPFQRLDGS IKGEIRKQAL
860 870 880 890 900
DHFNADGSED FCFLLSTRAG GLGINLASAD TVVIFDSDWN PQNDLQAQAR
910 920 930 940 950
AHRIGQKKQV NIYRLVTKGT VEEEIIERAK KKMVLDHLVI QRMDTTGRTI
960 970 980 990 1000
LENNSGRSNS NPFNKEELTA ILKFGAEDLF KELEGEESEP QEMDIDEILR
1010 1020 1030 1040 1050
LAETRENEVS TSATDELLSQ FKVANFATME DEEELEERPH KDWDEIIPEE
1060 1070 1080 1090 1100
QRKKVEEEER QKELEEIYML PRIRSSTKKA QTNDSDSDTE SKRQAQRSSA
1110 1120 1130 1140 1150
SESETEDSDD DKKPKRRGRP RSVRKDLVEG FTDAEIRRFI KAYKKFGLPL
1160 1170 1180 1190 1200
ERLECIARDA ELVDKSVADL KRLGELIHNS CVSAMQEYEE QLKENASEGK
1210 1220 1230 1240 1250
GPGKRRGPTI KISGVQVNVK SIIQHEEEFE MLHKSIPVDP EEKKKYCLTC
1260 1270 1280 1290 1300
RVKAAHFDVE WGVEDDSRLL LGIYEHGYGN WELIKTDPEL KLTDKILPVE
1310 1320 1330 1340 1350
TDKKPQGKQL QTRADYLLKL LRKGLEKKGA VTGGEEAKLK KRKPRVKKEN
1360 1370 1380 1390 1400
KVPRLKEEHG IELSSPRHSD NPSEEGEVKD DGLEKSPMKK KQKKKENKEN
1410 1420 1430 1440 1450
KEKQMSSRKD KEGDKERKKS KDKKEKPKSG DAKSSSKSKR SQGPVHITAG
1460 1470 1480 1490 1500
SEPVPIGEDE DDDLDQETFS ICKERMRPVK KALKQLDKPD KGLNVQEQLE
1510 1520 1530 1540 1550
HTRNCLLKIG DRIAECLKAY SDQEHIKLWR RNLWIFVSKF TEFDARKLHK
1560 1570 1580 1590 1600
LYKMAHKKRS QEEEEQKKKD DVTGGKKPFR PEASGSSRDS LISQSHTSHN
1610 1620 1630 1640 1650
LHPQKPHLPA SHGPQMHGHP RDNYNHPNKR HFSNADRGDW QRERKFNYGG
1660 1670 1680 1690 1700
GNNNPPWGSD RHHQYEQHWY KDHHYGDRRH MDAHRSGSYR PNNMSRKRPY
1710 1720 1730 1740 1750
DQYSSDRDHR GHRDYYDRHH HDSKRRRSDE FRPQNYHQQD FRRMSDHRPA
1760 1770 1780 1790 1800
MGYHGQGPSD HYRSFHTDKL GEYKQPLPPL HPAVSDPRSP PSQKSPHDSK
1810 1820
SPLDHRSPLE RSLEQKNNPD YNWNVRKT
Length:1,828
Mass (Da):211,344
Last modified:December 12, 2006 - v2
Checksum:i13139D6059210F00
GO
Isoform 2 (identifier: O14647-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1719-1739: HHHDSKRRRSDEFRPQNYHQQ → YAKGCETPGANLCQELFLGRK
     1740-1828: Missing.

Note: No experimental confirmation available.
Show »
Length:1,739
Mass (Da):200,562
Checksum:i934528063B1A950E
GO
Isoform 3 (identifier: O14647-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     502-1828: Missing.

Show »
Length:501
Mass (Da):56,826
Checksum:i14320F994CE72BF1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1156 – 11561I → L in AAB87382 (PubMed:9326634).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti548 – 5481W → R in EEOC. 1 Publication
VAR_070209
Natural varianti823 – 8231L → P in EEOC. 1 Publication
VAR_070210
Natural varianti1574 – 15741G → A.
Corresponds to variant rs56227200 [ dbSNP | Ensembl ].
VAR_061099

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei502 – 18281327Missing in isoform 3. 2 PublicationsVSP_042791Add
BLAST
Alternative sequencei1719 – 173921HHHDS…NYHQQ → YAKGCETPGANLCQELFLGR K in isoform 2. 1 PublicationVSP_021918Add
BLAST
Alternative sequencei1740 – 182889Missing in isoform 2. 1 PublicationVSP_021919Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006514 mRNA. Translation: AAB87382.1.
BT007050 mRNA. Translation: AAP35699.1.
FJ515838 Genomic DNA. Translation: ACS13730.1.
AC013394 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02160.1.
BC007347 mRNA. Translation: AAH07347.1.
CR978407 mRNA. No translation available.
CCDSiCCDS10374.2. [O14647-1]
CCDS45356.1. [O14647-3]
RefSeqiNP_001036037.1. NM_001042572.2. [O14647-3]
NP_001262.3. NM_001271.3. [O14647-1]
UniGeneiHs.220864.

Genome annotation databases

EnsembliENST00000394196; ENSP00000377747; ENSG00000173575.
ENST00000420239; ENSP00000406581; ENSG00000173575. [O14647-3]
GeneIDi1106.
KEGGihsa:1106.
UCSCiuc002bsn.3. human. [O14647-3]
uc002bso.1. human. [O14647-2]
uc002bsp.3. human. [O14647-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006514 mRNA. Translation: AAB87382.1.
BT007050 mRNA. Translation: AAP35699.1.
FJ515838 Genomic DNA. Translation: ACS13730.1.
AC013394 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02160.1.
BC007347 mRNA. Translation: AAH07347.1.
CR978407 mRNA. No translation available.
CCDSiCCDS10374.2. [O14647-1]
CCDS45356.1. [O14647-3]
RefSeqiNP_001036037.1. NM_001042572.2. [O14647-3]
NP_001262.3. NM_001271.3. [O14647-1]
UniGeneiHs.220864.

3D structure databases

ProteinModelPortaliO14647.
SMRiO14647. Positions 261-446, 1129-1334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107531. 8 interactions.
IntActiO14647. 10 interactions.
STRINGi9606.ENSP00000377747.

PTM databases

PhosphoSiteiO14647.

Polymorphism and mutation databases

BioMutaiCHD2.

Proteomic databases

MaxQBiO14647.
PaxDbiO14647.
PRIDEiO14647.

Protocols and materials databases

DNASUi1106.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394196; ENSP00000377747; ENSG00000173575.
ENST00000420239; ENSP00000406581; ENSG00000173575. [O14647-3]
GeneIDi1106.
KEGGihsa:1106.
UCSCiuc002bsn.3. human. [O14647-3]
uc002bso.1. human. [O14647-2]
uc002bsp.3. human. [O14647-1]

Organism-specific databases

CTDi1106.
GeneCardsiGC15P094584.
HGNCiHGNC:1917. CHD2.
HPAiHPA060744.
HPA060960.
MIMi602119. gene.
615369. phenotype.
neXtProtiNX_O14647.
Orphaneti2382. Lennox-Gastaut syndrome.
1942. Myoclonic-astastic epilepsy.
PharmGKBiPA26453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00760000119067.
HOGENOMiHOG000207917.
HOVERGENiHBG005325.
InParanoidiO14647.
KOiK11367.
OMAiKRPYEQY.
OrthoDBiEOG7NPFSB.
PhylomeDBiO14647.
TreeFamiTF313461.

Miscellaneous databases

ChiTaRSiCHD2. human.
GeneWikiiCHD2.
GenomeRNAii1106.
NextBioi4584.
PROiO14647.
SOURCEiSearch...

Gene expression databases

BgeeiO14647.
CleanExiHS_CHD2.
ExpressionAtlasiO14647. baseline and differential.
GenevisibleiO14647. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030485. CHD2.
IPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR025260. DUF4208.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PANTHERiPTHR10799:SF538. PTHR10799:SF538. 1 hit.
PfamiPF00385. Chromo. 2 hits.
PF13907. DUF4208. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS00598. CHROMO_1. 2 hits.
PS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  3. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Skin.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1635-1828 (ISOFORM 1).
    Tissue: T-cell.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-240 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207 AND SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207; SER-208; THR-240 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207; SER-208; SER-1085 AND SER-1087, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  13. Cited for: VARIANTS EEOC ARG-548 AND PRO-823.

Entry informationi

Entry nameiCHD2_HUMAN
AccessioniPrimary (citable) accession number: O14647
Secondary accession number(s): C6G482, Q96IP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 12, 2006
Last modified: July 22, 2015
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.