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O14647

- CHD2_HUMAN

UniProt

O14647 - CHD2_HUMAN

Protein

Chromodomain-helicase-DNA-binding protein 2

Gene

CHD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi509 – 5168ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent DNA helicase activity Source: ProtInc
    3. core promoter sequence-specific DNA binding Source: UniProtKB
    4. DNA binding Source: ProtInc
    5. histone binding Source: UniProtKB
    6. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: Ensembl
    2. chromatin modification Source: UniProtKB-KW
    3. DNA duplex unwinding Source: GOC
    4. hematopoietic stem cell differentiation Source: Ensembl
    5. muscle organ development Source: UniProtKB
    6. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Helicase, Hydrolase

    Keywords - Biological processi

    Myogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 2 (EC:3.6.4.12)
    Short name:
    CHD-2
    Alternative name(s):
    ATP-dependent helicase CHD2
    Gene namesi
    Name:CHD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:1917. CHD2.

    Subcellular locationi

    Nucleus By similarity
    Note: Binds to myogenic gene promoters.By similarity

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Epileptic encephalopathy, childhood-onset (EEOC) [MIM:615369]: A severe form of epilepsy characterized by onset of multiple seizure types in the first few years of life and associated with poor prognosis. Affected individuals have cognitive regression and intellectual disability.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti548 – 5481W → R in EEOC. 1 Publication
    VAR_070209
    Natural varianti823 – 8231L → P in EEOC. 1 Publication
    VAR_070210

    Keywords - Diseasei

    Disease mutation, Epilepsy

    Organism-specific databases

    MIMi615369. phenotype.
    Orphaneti1942. Epilepsy with myoclonic-astatic seizures.
    2382. Lennox-Gastaut syndrome.
    PharmGKBiPA26453.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18281828Chromodomain-helicase-DNA-binding protein 2PRO_0000080226Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei207 – 2071Phosphoserine2 Publications
    Modified residuei208 – 2081Phosphoserine2 Publications
    Modified residuei240 – 2401Phosphothreonine2 Publications
    Modified residuei242 – 2421Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO14647.
    PaxDbiO14647.
    PRIDEiO14647.

    PTM databases

    PhosphoSiteiO14647.

    Expressioni

    Gene expression databases

    ArrayExpressiO14647.
    BgeeiO14647.
    CleanExiHS_CHD2.
    GenevestigatoriO14647.

    Organism-specific databases

    HPAiHPA053875.
    HPA060744.
    HPA060960.

    Interactioni

    Subunit structurei

    Interacts with MYOD1. Interacts with histone H3.3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi107531. 7 interactions.
    IntActiO14647. 6 interactions.
    STRINGi9606.ENSP00000377747.

    Structurei

    3D structure databases

    ProteinModelPortaliO14647.
    SMRiO14647. Positions 261-446, 1129-1334.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini261 – 35393Chromo 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini378 – 45679Chromo 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini496 – 666171Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini795 – 946152Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi617 – 6204DEAH box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi13 – 7462Ser-richAdd
    BLAST
    Compositional biasi121 – 13919Ser-richAdd
    BLAST
    Compositional biasi966 – 1066101Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SNF2/RAD54 helicase family.Curated
    Contains 2 chromo domains.PROSITE-ProRule annotation
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0553.
    HOGENOMiHOG000207917.
    HOVERGENiHBG005325.
    InParanoidiO14647.
    KOiK11367.
    OMAiKRPYEQY.
    OrthoDBiEOG7NPFSB.
    PhylomeDBiO14647.
    TreeFamiTF313461.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR025260. DUF4208.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000330. SNF2_N.
    [Graphical view]
    PfamiPF00385. Chromo. 2 hits.
    PF13907. DUF4208. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view]
    SMARTiSM00298. CHROMO. 2 hits.
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF54160. SSF54160. 2 hits.
    PROSITEiPS00598. CHROMO_1. 2 hits.
    PS50013. CHROMO_2. 2 hits.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14647-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMRNKDKSQE EDSSLHSNAS SHSASEEASG SDSGSQSESE QGSDPGSGHG     50
    SESNSSSESS ESQSESESES AGSKSQPVLP EAKEKPASKK ERIADVKKMW 100
    EEYPDVYGVR RSNRSRQEPS RFNIKEEASS GSESGSPKRR GQRQLKKQEK 150
    WKQEPSEDEQ EQGTSAESEP EQKKVKARRP VPRRTVPKPR VKKQPKTQRG 200
    KRKKQDSSDE DDDDDEAPKR QTRRRAAKNV SYKEDDDFET DSDDLIEMTG 250
    EGVDEQQDNS ETIEKVLDSR LGKKGATGAS TTVYAIEANG DPSGDFDTEK 300
    DEGEIQYLIK WKGWSYIHST WESEESLQQQ KVKGLKKLEN FKKKEDEIKQ 350
    WLGKVSPEDV EYFNCQQELA SELNKQYQIV ERVIAVKTSK STLGQTDFPA 400
    HSRKPAPSNE PEYLCKWMGL PYSECSWEDE ALIGKKFQNC IDSFHSRNNS 450
    KTIPTRECKA LKQRPRFVAL KKQPAYLGGE NLELRDYQLE GLNWLAHSWC 500
    KNNSVILADE MGLGKTIQTI SFLSYLFHQH QLYGPFLIVV PLSTLTSWQR 550
    EFEIWAPEIN VVVYIGDLMS RNTIREYEWI HSQTKRLKFN ALITTYEILL 600
    KDKTVLGSIN WAFLGVDEAH RLKNDDSLLY KTLIDFKSNH RLLITGTPLQ 650
    NSLKELWSLL HFIMPEKFEF WEDFEEDHGK GRENGYQSLH KVLEPFLLRR 700
    VKKDVEKSLP AKVEQILRVE MSALQKQYYK WILTRNYKAL AKGTRGSTSG 750
    FLNIVMELKK CCNHCYLIKP PEENERENGQ EILLSLIRSS GKLILLDKLL 800
    TRLRERGNRV LIFSQMVRML DILAEYLTIK HYPFQRLDGS IKGEIRKQAL 850
    DHFNADGSED FCFLLSTRAG GLGINLASAD TVVIFDSDWN PQNDLQAQAR 900
    AHRIGQKKQV NIYRLVTKGT VEEEIIERAK KKMVLDHLVI QRMDTTGRTI 950
    LENNSGRSNS NPFNKEELTA ILKFGAEDLF KELEGEESEP QEMDIDEILR 1000
    LAETRENEVS TSATDELLSQ FKVANFATME DEEELEERPH KDWDEIIPEE 1050
    QRKKVEEEER QKELEEIYML PRIRSSTKKA QTNDSDSDTE SKRQAQRSSA 1100
    SESETEDSDD DKKPKRRGRP RSVRKDLVEG FTDAEIRRFI KAYKKFGLPL 1150
    ERLECIARDA ELVDKSVADL KRLGELIHNS CVSAMQEYEE QLKENASEGK 1200
    GPGKRRGPTI KISGVQVNVK SIIQHEEEFE MLHKSIPVDP EEKKKYCLTC 1250
    RVKAAHFDVE WGVEDDSRLL LGIYEHGYGN WELIKTDPEL KLTDKILPVE 1300
    TDKKPQGKQL QTRADYLLKL LRKGLEKKGA VTGGEEAKLK KRKPRVKKEN 1350
    KVPRLKEEHG IELSSPRHSD NPSEEGEVKD DGLEKSPMKK KQKKKENKEN 1400
    KEKQMSSRKD KEGDKERKKS KDKKEKPKSG DAKSSSKSKR SQGPVHITAG 1450
    SEPVPIGEDE DDDLDQETFS ICKERMRPVK KALKQLDKPD KGLNVQEQLE 1500
    HTRNCLLKIG DRIAECLKAY SDQEHIKLWR RNLWIFVSKF TEFDARKLHK 1550
    LYKMAHKKRS QEEEEQKKKD DVTGGKKPFR PEASGSSRDS LISQSHTSHN 1600
    LHPQKPHLPA SHGPQMHGHP RDNYNHPNKR HFSNADRGDW QRERKFNYGG 1650
    GNNNPPWGSD RHHQYEQHWY KDHHYGDRRH MDAHRSGSYR PNNMSRKRPY 1700
    DQYSSDRDHR GHRDYYDRHH HDSKRRRSDE FRPQNYHQQD FRRMSDHRPA 1750
    MGYHGQGPSD HYRSFHTDKL GEYKQPLPPL HPAVSDPRSP PSQKSPHDSK 1800
    SPLDHRSPLE RSLEQKNNPD YNWNVRKT 1828
    Length:1,828
    Mass (Da):211,344
    Last modified:December 12, 2006 - v2
    Checksum:i13139D6059210F00
    GO
    Isoform 2 (identifier: O14647-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1719-1739: HHHDSKRRRSDEFRPQNYHQQ → YAKGCETPGANLCQELFLGRK
         1740-1828: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,739
    Mass (Da):200,562
    Checksum:i934528063B1A950E
    GO
    Isoform 3 (identifier: O14647-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         502-1828: Missing.

    Show »
    Length:501
    Mass (Da):56,826
    Checksum:i14320F994CE72BF1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1156 – 11561I → L in AAB87382. (PubMed:9326634)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti548 – 5481W → R in EEOC. 1 Publication
    VAR_070209
    Natural varianti823 – 8231L → P in EEOC. 1 Publication
    VAR_070210
    Natural varianti1574 – 15741G → A.
    Corresponds to variant rs56227200 [ dbSNP | Ensembl ].
    VAR_061099

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei502 – 18281327Missing in isoform 3. 2 PublicationsVSP_042791Add
    BLAST
    Alternative sequencei1719 – 173921HHHDS…NYHQQ → YAKGCETPGANLCQELFLGR K in isoform 2. 1 PublicationVSP_021918Add
    BLAST
    Alternative sequencei1740 – 182889Missing in isoform 2. 1 PublicationVSP_021919Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006514 mRNA. Translation: AAB87382.1.
    BT007050 mRNA. Translation: AAP35699.1.
    FJ515838 Genomic DNA. Translation: ACS13730.1.
    AC013394 Genomic DNA. No translation available.
    CH471101 Genomic DNA. Translation: EAX02160.1.
    BC007347 mRNA. Translation: AAH07347.1.
    CR978407 mRNA. No translation available.
    CCDSiCCDS10374.2. [O14647-1]
    CCDS45356.1. [O14647-3]
    RefSeqiNP_001036037.1. NM_001042572.2. [O14647-3]
    NP_001262.3. NM_001271.3. [O14647-1]
    UniGeneiHs.220864.

    Genome annotation databases

    EnsembliENST00000394196; ENSP00000377747; ENSG00000173575. [O14647-1]
    ENST00000420239; ENSP00000406581; ENSG00000173575. [O14647-3]
    ENST00000557381; ENSP00000451366; ENSG00000173575. [O14647-2]
    GeneIDi1106.
    KEGGihsa:1106.
    UCSCiuc002bsn.3. human. [O14647-3]
    uc002bso.1. human. [O14647-2]
    uc002bsp.3. human. [O14647-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006514 mRNA. Translation: AAB87382.1 .
    BT007050 mRNA. Translation: AAP35699.1 .
    FJ515838 Genomic DNA. Translation: ACS13730.1 .
    AC013394 Genomic DNA. No translation available.
    CH471101 Genomic DNA. Translation: EAX02160.1 .
    BC007347 mRNA. Translation: AAH07347.1 .
    CR978407 mRNA. No translation available.
    CCDSi CCDS10374.2. [O14647-1 ]
    CCDS45356.1. [O14647-3 ]
    RefSeqi NP_001036037.1. NM_001042572.2. [O14647-3 ]
    NP_001262.3. NM_001271.3. [O14647-1 ]
    UniGenei Hs.220864.

    3D structure databases

    ProteinModelPortali O14647.
    SMRi O14647. Positions 261-446, 1129-1334.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107531. 7 interactions.
    IntActi O14647. 6 interactions.
    STRINGi 9606.ENSP00000377747.

    PTM databases

    PhosphoSitei O14647.

    Proteomic databases

    MaxQBi O14647.
    PaxDbi O14647.
    PRIDEi O14647.

    Protocols and materials databases

    DNASUi 1106.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394196 ; ENSP00000377747 ; ENSG00000173575 . [O14647-1 ]
    ENST00000420239 ; ENSP00000406581 ; ENSG00000173575 . [O14647-3 ]
    ENST00000557381 ; ENSP00000451366 ; ENSG00000173575 . [O14647-2 ]
    GeneIDi 1106.
    KEGGi hsa:1106.
    UCSCi uc002bsn.3. human. [O14647-3 ]
    uc002bso.1. human. [O14647-2 ]
    uc002bsp.3. human. [O14647-1 ]

    Organism-specific databases

    CTDi 1106.
    GeneCardsi GC15P094240.
    HGNCi HGNC:1917. CHD2.
    HPAi HPA053875.
    HPA060744.
    HPA060960.
    MIMi 602119. gene.
    615369. phenotype.
    neXtProti NX_O14647.
    Orphaneti 1942. Epilepsy with myoclonic-astatic seizures.
    2382. Lennox-Gastaut syndrome.
    PharmGKBi PA26453.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0553.
    HOGENOMi HOG000207917.
    HOVERGENi HBG005325.
    InParanoidi O14647.
    KOi K11367.
    OMAi KRPYEQY.
    OrthoDBi EOG7NPFSB.
    PhylomeDBi O14647.
    TreeFami TF313461.

    Miscellaneous databases

    ChiTaRSi CHD2. human.
    GeneWikii CHD2.
    GenomeRNAii 1106.
    NextBioi 4584.
    PROi O14647.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14647.
    Bgeei O14647.
    CleanExi HS_CHD2.
    Genevestigatori O14647.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR025260. DUF4208.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000330. SNF2_N.
    [Graphical view ]
    Pfami PF00385. Chromo. 2 hits.
    PF13907. DUF4208. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view ]
    SMARTi SM00298. CHROMO. 2 hits.
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF54160. SSF54160. 2 hits.
    PROSITEi PS00598. CHROMO_1. 2 hits.
    PS50013. CHROMO_2. 2 hits.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    3. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Skin.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1635-1828 (ISOFORM 1).
      Tissue: T-cell.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-240 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207 AND SER-208, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207; SER-208; THR-240 AND SER-242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: VARIANTS EEOC ARG-548 AND PRO-823.

    Entry informationi

    Entry nameiCHD2_HUMAN
    AccessioniPrimary (citable) accession number: O14647
    Secondary accession number(s): C6G482, Q96IP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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