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Protein

Chromodomain-helicase-DNA-binding protein 1

Gene

CHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.By similarity1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi506 – 513ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent DNA helicase activity Source: ProtInc
  • DNA binding Source: UniProtKB-KW
  • methylated histone binding Source: UniProtKB

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • chromatin remodeling Source: Ensembl
  • positive regulation by host of viral transcription Source: CACAO
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153922-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 1 (EC:3.6.4.12)
Short name:
CHD-1
Alternative name(s):
ATP-dependent helicase CHD1
Gene namesi
Name:CHD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1915. CHD1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.By similarity

GO - Cellular componenti

  • cytoplasm Source: CACAO
  • nucleus Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1105.
OpenTargetsiENSG00000153922.
PharmGKBiPA26451.

Chemistry databases

DrugBankiDB00445. Epirubicin.

Polymorphism and mutation databases

BioMutaiCHD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802241 – 1710Chromodomain-helicase-DNA-binding protein 1Add BLAST1710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei237PhosphothreonineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei250PhosphothreonineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei1025PhosphoserineCombined sources1
Modified residuei1040PhosphoserineCombined sources1
Modified residuei1081PhosphoserineCombined sources1
Modified residuei1096PhosphoserineCombined sources1
Modified residuei1098PhosphoserineCombined sources1
Modified residuei1100PhosphoserineCombined sources1
Modified residuei1102PhosphoserineCombined sources1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1353PhosphoserineCombined sources1
Modified residuei1355PhosphoserineCombined sources1
Modified residuei1356PhosphoserineCombined sources1
Modified residuei1360PhosphoserineCombined sources1
Modified residuei1363PhosphoserineCombined sources1
Modified residuei1371PhosphoserineCombined sources1
Modified residuei1622PhosphoserineCombined sources1
Modified residuei1677PhosphoserineCombined sources1
Modified residuei1689PhosphoserineCombined sources1
Isoform 2 (identifier: O14646-2)
Modified residuei1688PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14646.
MaxQBiO14646.
PaxDbiO14646.
PeptideAtlasiO14646.
PRIDEiO14646.

PTM databases

iPTMnetiO14646.
PhosphoSitePlusiO14646.

Expressioni

Gene expression databases

BgeeiENSG00000153922.
CleanExiHS_CHD1.
ExpressionAtlasiO14646. baseline and differential.
GenevisibleiO14646. HS.

Organism-specific databases

HPAiHPA022236.

Interactioni

Subunit structurei

Component of the SAGA complex (By similarity). Interacts with BCLAF1, NCoR, SRP20 and SAFB (By similarity). Specifically interacts with methylated H3K4me2 and H3K4me3. Interacts with the FACT complex, the PAF complex and the U2 snRNP. Interacts directly with PAF1, SFA3A1, SFA3A2, SFA3A3, SNF2 and SSRP1.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NS1B2BUF13EBI-1560858,EBI-4291940From a different organism.

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107530. 32 interactors.
DIPiDIP-38922N.
IntActiO14646. 10 interactors.
STRINGi9606.ENSP00000284049.

Structurei

Secondary structure

11710
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi273 – 284Combined sources12
Helixi290 – 292Combined sources3
Helixi294 – 300Combined sources7
Turni303 – 306Combined sources4
Turni309 – 311Combined sources3
Beta strandi314 – 322Combined sources9
Helixi327 – 329Combined sources3
Beta strandi331 – 333Combined sources3
Helixi335 – 340Combined sources6
Helixi347 – 360Combined sources14
Turni363 – 365Combined sources3
Helixi375 – 387Combined sources13
Beta strandi390 – 401Combined sources12
Beta strandi407 – 413Combined sources7
Helixi418 – 420Combined sources3
Beta strandi422 – 425Combined sources4
Helixi426 – 442Combined sources17
Helixi1128 – 1138Combined sources11
Helixi1144 – 1146Combined sources3
Helixi1148 – 1154Combined sources7
Helixi1162 – 1180Combined sources19
Beta strandi1201 – 1204Combined sources4
Beta strandi1207 – 1210Combined sources4
Helixi1211 – 1227Combined sources17
Helixi1232 – 1236Combined sources5
Beta strandi1249 – 1251Combined sources3
Helixi1255 – 1268Combined sources14
Helixi1273 – 1278Combined sources6
Beta strandi1280 – 1283Combined sources4
Turni1285 – 1287Combined sources3
Helixi1299 – 1324Combined sources26
Helixi1411 – 1420Combined sources10
Helixi1425 – 1432Combined sources8
Helixi1440 – 1463Combined sources24
Helixi1468 – 1484Combined sources17
Beta strandi1486 – 1488Combined sources3
Helixi1490 – 1504Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B2TX-ray2.45A/B268-443[»]
C268-373[»]
2B2UX-ray2.95A/B268-443[»]
C268-373[»]
2B2VX-ray2.65A/B268-443[»]
C268-373[»]
2B2WX-ray2.40A/B268-443[»]
C268-373[»]
2B2YX-ray2.35A/B268-443[»]
C268-373[»]
2N39NMR-A1409-1511[»]
4B4CX-ray1.62A1119-1327[»]
4NW2X-ray1.90A/C268-443[»]
4O42X-ray1.87A268-443[»]
5AFWX-ray1.60A270-443[»]
ProteinModelPortaliO14646.
SMRiO14646.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14646.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini272 – 364Chromo 1PROSITE-ProRule annotationAdd BLAST93
Domaini389 – 452Chromo 2PROSITE-ProRule annotationAdd BLAST64
Domaini493 – 663Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST171
Domaini792 – 943Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152
Repeati1628 – 163215
Repeati1634 – 163825
Repeati1640 – 164435

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1628 – 16443 X 5 AA repeats of H-S-D-H-RAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi614 – 617DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 70Ser-richAdd BLAST70
Compositional biasi117 – 137Ser-richAdd BLAST21

Domaini

The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3).1 Publication

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 2 chromo domains.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0383. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00760000119067.
HOGENOMiHOG000207917.
HOVERGENiHBG005325.
InParanoidiO14646.
KOiK11367.
OMAiEITSVKH.
OrthoDBiEOG091G00HF.
PhylomeDBiO14646.
TreeFamiTF313461.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR025260. DUF4208.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00385. Chromo. 2 hits.
PF13907. DUF4208. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM01176. DUF4208. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS00598. CHROMO_1. 2 hits.
PS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14646-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGHSDEESV RNSSGESSQS DDDSGSASGS GSGSSSGSSS DGSSSQSGSS
60 70 80 90 100
DSDSGSESGS QSESESDTSR ENKVQAKPPK VDGAEFWKSS PSILAVQRSA
110 120 130 140 150
ILKKQQQQQQ QQQHQASSNS GSEEDSSSSE DSDDSSSEVK RKKHKDEDWQ
160 170 180 190 200
MSGSGSPSQS GSDSESEEER EKSSCDETES DYEPKNKVKS RKPQNRSKSK
210 220 230 240 250
NGKKILGQKK RQIDSSEEDD DEEDYDNDKR SSRRQATVNV SYKEDEEMKT
260 270 280 290 300
DSDDLLEVCG EDVPQPEEEE FETIERFMDC RIGRKGATGA TTTIYAVEAD
310 320 330 340 350
GDPNAGFEKN KEPGEIQYLI KWKGWSHIHN TWETEETLKQ QNVRGMKKLD
360 370 380 390 400
NYKKKDQETK RWLKNASPED VEYYNCQQEL TDDLHKQYQI VERIIAHSNQ
410 420 430 440 450
KSAAGYPDYY CKWQGLPYSE CSWEDGALIS KKFQACIDEY FSRNQSKTTP
460 470 480 490 500
FKDCKVLKQR PRFVALKKQP SYIGGHEGLE LRDYQLNGLN WLAHSWCKGN
510 520 530 540 550
SCILADEMGL GKTIQTISFL NYLFHEHQLY GPFLLVVPLS TLTSWQREIQ
560 570 580 590 600
TWASQMNAVV YLGDINSRNM IRTHEWTHHQ TKRLKFNILL TTYEILLKDK
610 620 630 640 650
AFLGGLNWAF IGVDEAHRLK NDDSLLYKTL IDFKSNHRLL ITGTPLQNSL
660 670 680 690 700
KELWSLLHFI MPEKFSSWED FEEEHGKGRE YGYASLHKEL EPFLLRRVKK
710 720 730 740 750
DVEKSLPAKV EQILRMEMSA LQKQYYKWIL TRNYKALSKG SKGSTSGFLN
760 770 780 790 800
IMMELKKCCN HCYLIKPPDN NEFYNKQEAL QHLIRSSGKL ILLDKLLIRL
810 820 830 840 850
RERGNRVLIF SQMVRMLDIL AEYLKYRQFP FQRLDGSIKG ELRKQALDHF
860 870 880 890 900
NAEGSEDFCF LLSTRAGGLG INLASADTVV IFDSDWNPQN DLQAQARAHR
910 920 930 940 950
IGQKKQVNIY RLVTKGSVEE DILERAKKKM VLDHLVIQRM DTTGKTVLHT
960 970 980 990 1000
GSAPSSSTPF NKEELSAILK FGAEELFKEP EGEEQEPQEM DIDEILKRAE
1010 1020 1030 1040 1050
THENEPGPLT VGDELLSQFK VANFSNMDED DIELEPERNS KNWEEIIPED
1060 1070 1080 1090 1100
QRRRLEEEER QKELEEIYML PRMRNCAKQI SFNGSEGRRS RSRRYSGSDS
1110 1120 1130 1140 1150
DSISEGKRPK KRGRPRTIPR ENIKGFSDAE IRRFIKSYKK FGGPLERLDA
1160 1170 1180 1190 1200
IARDAELVDK SETDLRRLGE LVHNGCIKAL KDSSSGTERT GGRLGKVKGP
1210 1220 1230 1240 1250
TFRISGVQVN AKLVISHEEE LIPLHKSIPS DPEERKQYTI PCHTKAAHFD
1260 1270 1280 1290 1300
IDWGKEDDSN LLIGIYEYGY GSWEMIKMDP DLSLTHKILP DDPDKKPQAK
1310 1320 1330 1340 1350
QLQTRADYLI KLLSRDLAKK EALSGAGSSK RRKARAKKNK AMKSIKVKEE
1360 1370 1380 1390 1400
IKSDSSPLPS EKSDEDDDKL SESKSDGRER SKKSSVSDAP VHITASGEPV
1410 1420 1430 1440 1450
PISEESEELD QKTFSICKER MRPVKAALKQ LDRPEKGLSE REQLEHTRQC
1460 1470 1480 1490 1500
LIKIGDHITE CLKEYTNPEQ IKQWRKNLWI FVSKFTEFDA RKLHKLYKHA
1510 1520 1530 1540 1550
IKKRQESQQN SDQNSNLNPH VIRNPDVERL KENTNHDDSS RDSYSSDRHL
1560 1570 1580 1590 1600
TQYHDHHKDR HQGDSYKKSD SRKRPYSSFS NGKDHRDWDH YKQDSRYYSD
1610 1620 1630 1640 1650
REKHRKLDDH RSRDHRSNLE GSLKDRSHSD HRSHSDHRLH SDHRSSSEYT
1660 1670 1680 1690 1700
HHKSSRDYRY HSDWQMDHRA SSSGPRSPLD QRSPYGSRSP FEHSVEHKST
1710
PEHTWSSRKT
Length:1,710
Mass (Da):196,688
Last modified:November 24, 2009 - v2
Checksum:iD888AAA46FDA31B1
GO
Isoform 2 (identifier: O14646-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1684-1684: Missing.

Show »
Length:1,709
Mass (Da):196,590
Checksum:i8B2C96C7597E55B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti392E → G in AAB87381 (PubMed:9326634).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055652264P → T.Corresponds to variant rs10062803dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0384321684Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006513 mRNA. Translation: AAB87381.1.
AC022121 Genomic DNA. No translation available.
BC117134 mRNA. Translation: AAI17135.1.
CCDSiCCDS34204.1. [O14646-1]
RefSeqiNP_001261.2. NM_001270.2. [O14646-1]
XP_005271924.1. XM_005271867.4. [O14646-1]
UniGeneiHs.643465.

Genome annotation databases

EnsembliENST00000284049; ENSP00000284049; ENSG00000153922. [O14646-1]
ENST00000614616; ENSP00000483667; ENSG00000153922. [O14646-1]
GeneIDi1105.
KEGGihsa:1105.
UCSCiuc003knf.3. human. [O14646-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006513 mRNA. Translation: AAB87381.1.
AC022121 Genomic DNA. No translation available.
BC117134 mRNA. Translation: AAI17135.1.
CCDSiCCDS34204.1. [O14646-1]
RefSeqiNP_001261.2. NM_001270.2. [O14646-1]
XP_005271924.1. XM_005271867.4. [O14646-1]
UniGeneiHs.643465.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B2TX-ray2.45A/B268-443[»]
C268-373[»]
2B2UX-ray2.95A/B268-443[»]
C268-373[»]
2B2VX-ray2.65A/B268-443[»]
C268-373[»]
2B2WX-ray2.40A/B268-443[»]
C268-373[»]
2B2YX-ray2.35A/B268-443[»]
C268-373[»]
2N39NMR-A1409-1511[»]
4B4CX-ray1.62A1119-1327[»]
4NW2X-ray1.90A/C268-443[»]
4O42X-ray1.87A268-443[»]
5AFWX-ray1.60A270-443[»]
ProteinModelPortaliO14646.
SMRiO14646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107530. 32 interactors.
DIPiDIP-38922N.
IntActiO14646. 10 interactors.
STRINGi9606.ENSP00000284049.

Chemistry databases

DrugBankiDB00445. Epirubicin.

PTM databases

iPTMnetiO14646.
PhosphoSitePlusiO14646.

Polymorphism and mutation databases

BioMutaiCHD1.

Proteomic databases

EPDiO14646.
MaxQBiO14646.
PaxDbiO14646.
PeptideAtlasiO14646.
PRIDEiO14646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284049; ENSP00000284049; ENSG00000153922. [O14646-1]
ENST00000614616; ENSP00000483667; ENSG00000153922. [O14646-1]
GeneIDi1105.
KEGGihsa:1105.
UCSCiuc003knf.3. human. [O14646-1]

Organism-specific databases

CTDi1105.
DisGeNETi1105.
GeneCardsiCHD1.
H-InvDBHIX0005061.
HGNCiHGNC:1915. CHD1.
HPAiHPA022236.
MIMi602118. gene.
neXtProtiNX_O14646.
OpenTargetsiENSG00000153922.
PharmGKBiPA26451.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0383. Eukaryota.
COG0553. LUCA.
GeneTreeiENSGT00760000119067.
HOGENOMiHOG000207917.
HOVERGENiHBG005325.
InParanoidiO14646.
KOiK11367.
OMAiEITSVKH.
OrthoDBiEOG091G00HF.
PhylomeDBiO14646.
TreeFamiTF313461.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000153922-MONOMER.

Miscellaneous databases

ChiTaRSiCHD1. human.
EvolutionaryTraceiO14646.
GeneWikiiCHD1.
GenomeRNAii1105.
PROiO14646.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153922.
CleanExiHS_CHD1.
ExpressionAtlasiO14646. baseline and differential.
GenevisibleiO14646. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR025260. DUF4208.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00385. Chromo. 2 hits.
PF13907. DUF4208. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM01176. DUF4208. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS00598. CHROMO_1. 2 hits.
PS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHD1_HUMAN
AccessioniPrimary (citable) accession number: O14646
Secondary accession number(s): Q17RZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 24, 2009
Last modified: November 2, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.