Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Axonemal dynein light intermediate polypeptide 1

Gene

DNALI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a dynamic role in flagellar motility.

GO - Molecular functioni

  • microtubule motor activity Source: ProtInc

GO - Biological processi

  • movement of cell or subcellular component Source: ProtInc
  • single fertilization Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Axonemal dynein light intermediate polypeptide 1
Alternative name(s):
Inner dynein arm light chain, axonemal
hp28
Gene namesi
Name:DNALI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14353. DNALI1.

Subcellular locationi

GO - Cellular componenti

  • axonemal dynein complex Source: ProtInc
  • axoneme Source: MGI
  • cytoplasm Source: BHF-UCL
  • filopodium Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Dynein

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38381.

Polymorphism and mutation databases

BioMutaiDNALI1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Axonemal dynein light intermediate polypeptide 1PRO_0000114675Add
BLAST

Proteomic databases

EPDiO14645.
PaxDbiO14645.
PRIDEiO14645.

PTM databases

iPTMnetiO14645.
PhosphoSiteiO14645.

Expressioni

Tissue specificityi

Expressed in many tissues. A smaller 0.9 kb and a larger 2.5 kb transcripts were detected at the highest level in the testis, at medium levels in the prostate, heart, liver, lung and pancreas, at low levels in the ovary, skeletal muscle and small intestine. Not detected in spleen, colon epithelium, thymus or peripheral blood leukocytes. The 0.9 kb transcript is expressed at a 20-fold higher level than the 2.5 kb transcript in the testis.

Gene expression databases

BgeeiO14645.
CleanExiHS_DNALI1.
GenevisibleiO14645. HS.

Organism-specific databases

HPAiHPA028305.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-395638,EBI-466029
PRMT6Q96LA82EBI-395638,EBI-912440
SIAH1Q8IUQ43EBI-395638,EBI-747107

Protein-protein interaction databases

BioGridi113577. 7 interactions.
IntActiO14645. 8 interactions.
MINTiMINT-1372011.
STRINGi9606.ENSP00000296218.

Structurei

3D structure databases

ProteinModelPortaliO14645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili176 – 25580Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4001. Eukaryota.
ENOG410XP66. LUCA.
HOGENOMiHOG000090301.
HOVERGENiHBG019035.
InParanoidiO14645.
KOiK10410.
OrthoDBiEOG7HTHHP.
PhylomeDBiO14645.
TreeFamiTF314891.

Family and domain databases

InterProiIPR019347. Axonemal_dynein_light_chain.
[Graphical view]
PfamiPF10211. Ax_dynein_light. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14645-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPPADSLLK YDTPVLVSRN TEKRSPKARL LKVSPQQPGP SGSAPQPPKT
60 70 80 90 100
KLPSTPCVPD PTKQAEEILN AILPPREWVE DTQLWIQQVS STPSTRMDVV
110 120 130 140 150
HLQEQLDLKL QQRQARETGI CPVRRELYSQ CFDELIREVT INCAERGLLL
160 170 180 190 200
LRVRDEIRMT IAAYQTLYES SVAFGMRKAL QAEQGKSDME RKIAELETEK
210 220 230 240 250
RDLERQVNEQ KAKCEATEKR ESERRQVEEK KHNEEIQFLK RTNQQLKAQL

EGIIAPKK
Length:258
Mass (Da):29,662
Last modified:September 27, 2005 - v2
Checksum:i5E95F15FE4476BF7
GO
Isoform 2 (identifier: O14645-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MIPPAD → MPYYPQ
     7-132: Missing.

Note: No experimental confirmation available.
Show »
Length:132
Mass (Da):15,583
Checksum:iD0AD5D94C2965156
GO

Sequence cautioni

The sequence AAB69193.1 differs from that shown. Reason: Frameshift at positions 7, 28, 94, 125, 139 and 153. Curated
The sequence CAI20553.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI46082.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541S → P in CAI46082 (PubMed:17974005).Curated
Sequence conflicti76 – 761R → K in BAF83191 (PubMed:14702039).Curated
Sequence conflicti152 – 1521R → Q in AAB69193 (PubMed:9284741).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651A → V.
Corresponds to variant rs11749 [ dbSNP | Ensembl ].
VAR_014473
Natural varianti120 – 1201I → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035701

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66MIPPAD → MPYYPQ in isoform 2. 1 PublicationVSP_056965
Alternative sequencei7 – 132126Missing in isoform 2. 1 PublicationVSP_056966Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006386 mRNA. Translation: AAB69193.1. Frameshift.
AK295199 mRNA. Translation: BAG58198.1.
AK290502 mRNA. Translation: BAF83191.1.
BX647913 mRNA. Translation: CAI46082.1. Different initiation.
AL034379 Genomic DNA. Translation: CAI20553.1. Different initiation.
BC039074 mRNA. Translation: AAH39074.1.
BC046117 mRNA. Translation: AAH46117.1.
RefSeqiNP_003453.2. NM_003462.3.
XP_005271229.1. XM_005271172.1. [O14645-2]
UniGeneiHs.406050.

Genome annotation databases

EnsembliENST00000296218; ENSP00000296218; ENSG00000163879.
GeneIDi7802.
KEGGihsa:7802.
UCSCiuc001cbj.3. human. [O14645-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006386 mRNA. Translation: AAB69193.1. Frameshift.
AK295199 mRNA. Translation: BAG58198.1.
AK290502 mRNA. Translation: BAF83191.1.
BX647913 mRNA. Translation: CAI46082.1. Different initiation.
AL034379 Genomic DNA. Translation: CAI20553.1. Different initiation.
BC039074 mRNA. Translation: AAH39074.1.
BC046117 mRNA. Translation: AAH46117.1.
RefSeqiNP_003453.2. NM_003462.3.
XP_005271229.1. XM_005271172.1. [O14645-2]
UniGeneiHs.406050.

3D structure databases

ProteinModelPortaliO14645.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113577. 7 interactions.
IntActiO14645. 8 interactions.
MINTiMINT-1372011.
STRINGi9606.ENSP00000296218.

PTM databases

iPTMnetiO14645.
PhosphoSiteiO14645.

Polymorphism and mutation databases

BioMutaiDNALI1.

Proteomic databases

EPDiO14645.
PaxDbiO14645.
PRIDEiO14645.

Protocols and materials databases

DNASUi7802.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296218; ENSP00000296218; ENSG00000163879.
GeneIDi7802.
KEGGihsa:7802.
UCSCiuc001cbj.3. human. [O14645-1]

Organism-specific databases

CTDi7802.
GeneCardsiDNALI1.
H-InvDBHIX0023523.
HGNCiHGNC:14353. DNALI1.
HPAiHPA028305.
MIMi602135. gene.
neXtProtiNX_O14645.
PharmGKBiPA38381.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4001. Eukaryota.
ENOG410XP66. LUCA.
HOGENOMiHOG000090301.
HOVERGENiHBG019035.
InParanoidiO14645.
KOiK10410.
OrthoDBiEOG7HTHHP.
PhylomeDBiO14645.
TreeFamiTF314891.

Miscellaneous databases

ChiTaRSiDNALI1. human.
GenomeRNAii7802.
PROiO14645.
SOURCEiSearch...

Gene expression databases

BgeeiO14645.
CleanExiHS_DNALI1.
GenevisibleiO14645. HS.

Family and domain databases

InterProiIPR019347. Axonemal_dynein_light_chain.
[Graphical view]
PfamiPF10211. Ax_dynein_light. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complementary deoxyribonucleic acid cloning and characterization of a putative human axonemal dynein light chain gene."
    Kastury K., Taylor W.E., Shen R., Arver S., Gutierrez M., Fisher C.E., Coucke P.J., Van Hauwe P., Van Camp G., Bhasin S.
    J. Clin. Endocrinol. Metab. 82:3047-3053(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal liver, Fetal lung and Spleen.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Caudate nucleus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and PNS.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-120.

Entry informationi

Entry nameiIDLC_HUMAN
AccessioniPrimary (citable) accession number: O14645
Secondary accession number(s): A8K387
, B4DHN6, Q05BL9, Q5HYE2, Q5TGH0, Q7L0I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: September 27, 2005
Last modified: June 8, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.