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O14641

- DVL2_HUMAN

UniProt

O14641 - DVL2_HUMAN

Protein

Segment polarity protein dishevelled homolog DVL-2

Gene

DVL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: UniProtKB
    2. identical protein binding Source: IntAct
    3. protein binding Source: UniProtKB
    4. signal transducer activity Source: InterPro

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: BHF-UCL
    2. canonical Wnt signaling pathway involved in regulation of cell proliferation Source: BHF-UCL
    3. cell migration in hindbrain Source: RefGenome
    4. cellular protein localization Source: Ensembl
    5. cochlea morphogenesis Source: RefGenome
    6. convergent extension Source: RefGenome
    7. convergent extension involved in neural plate elongation Source: Ensembl
    8. heart development Source: BHF-UCL
    9. heart morphogenesis Source: RefGenome
    10. hippo signaling Source: Reactome
    11. neural tube closure Source: BHF-UCL
    12. non-canonical Wnt signaling pathway Source: BHF-UCL
    13. outflow tract morphogenesis Source: BHF-UCL
    14. planar cell polarity pathway involved in neural tube closure Source: RefGenome
    15. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    16. positive regulation of JUN kinase activity Source: BHF-UCL
    17. positive regulation of protein phosphorylation Source: BHF-UCL
    18. positive regulation of protein tyrosine kinase activity Source: Ensembl
    19. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    20. positive regulation of transcription, DNA-templated Source: BHF-UCL
    21. segment specification Source: BHF-UCL
    22. transcription from RNA polymerase II promoter Source: UniProtKB
    23. Wnt signaling pathway Source: MGI
    24. Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_118607. Signaling by Hippo.
    REACT_172581. PCP/CE pathway.
    REACT_172599. WNT5A-dependent internalization of FZD4.
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_200668. WNT mediated activation of DVL.
    REACT_200777. TCF dependent signaling in response to WNT.
    REACT_200841. degradation of DVL.
    SignaLinkiO14641.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-2
    Short name:
    Dishevelled-2
    Alternative name(s):
    DSH homolog 2
    Gene namesi
    Name:DVL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:3086. DVL2.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytosol By similarity. Cytoplasmic vesicle By similarity
    Note: Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta By similarity.By similarity

    GO - Cellular componenti

    1. apical part of cell Source: RefGenome
    2. cell cortex Source: RefGenome
    3. clathrin-coated endocytic vesicle Source: Reactome
    4. clathrin-coated vesicle Source: RefGenome
    5. cytoplasm Source: BHF-UCL
    6. cytoplasmic vesicle Source: MGI
    7. cytosol Source: Reactome
    8. nucleus Source: UniProtKB
    9. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27542.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 736736Segment polarity protein dishevelled homolog DVL-2PRO_0000145746Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei211 – 2111Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated by CSNK1D.4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO14641.
    PaxDbiO14641.
    PRIDEiO14641.

    PTM databases

    PhosphoSiteiO14641.

    Expressioni

    Gene expression databases

    ArrayExpressiO14641.
    BgeeiO14641.
    CleanExiHS_DVL2.
    GenevestigatoriO14641.

    Organism-specific databases

    HPAiCAB009312.
    HPA022914.

    Interactioni

    Subunit structurei

    Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 By similarity. Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex By similarity. Interacts with DACT1 and FAM105B/otulin.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-740850,EBI-740850
    CK1EQ5R2U32EBI-740850,EBI-9106301
    DACT1Q9NYF06EBI-740850,EBI-3951744
    DIXDC1Q155Q32EBI-740850,EBI-1104700
    LRRK2Q5S0073EBI-740850,EBI-5323863
    Pard6aQ9Z1016EBI-740850,EBI-81732From a different organism.
    Smurf2A2A5Z68EBI-740850,EBI-2348309From a different organism.
    TRIM29Q141345EBI-740850,EBI-702370
    WWTR1Q9GZV54EBI-740850,EBI-747743
    ZNF165P499102EBI-740850,EBI-741694

    Protein-protein interaction databases

    BioGridi108189. 66 interactions.
    DIPiDIP-34433N.
    IntActiO14641. 83 interactions.
    MINTiMINT-1435227.
    STRINGi9606.ENSP00000005340.

    Structurei

    Secondary structure

    1
    736
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi265 – 2706
    Helixi272 – 2754
    Beta strandi280 – 2856
    Beta strandi293 – 2997
    Helixi304 – 3085
    Beta strandi316 – 3205
    Helixi330 – 34112
    Beta strandi343 – 3453
    Beta strandi347 – 3526

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2REYX-ray1.55A261-355[»]
    3CBXX-ray1.70A/B264-354[»]
    3CBYX-ray1.50A/B264-354[»]
    3CBZX-ray1.38A264-354[»]
    3CC0X-ray1.75A/B/C264-354[»]
    ProteinModelPortaliO14641.
    SMRiO14641. Positions 13-90, 263-353, 422-582.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14641.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 9383DIXPROSITE-ProRule annotationAdd
    BLAST
    Domaini267 – 33973PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini433 – 50775DEPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 126Poly-Gly
    Compositional biasi235 – 2406Poly-Arg
    Compositional biasi686 – 6949Poly-Pro

    Domaini

    The DIX domain mediates homooligomerization.By similarity

    Sequence similaritiesi

    Belongs to the DSH family.Curated
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322275.
    HOGENOMiHOG000017084.
    HOVERGENiHBG005542.
    InParanoidiO14641.
    KOiK02353.
    OMAiFHLAMGN.
    OrthoDBiEOG7BP82N.
    PhylomeDBiO14641.
    TreeFamiTF318198.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR008341. Dishevelled_2.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF8. PTHR10878:SF8. 1 hit.
    PfamiPF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PRINTSiPR01760. DISHEVELLED.
    PR01762. DISHEVELLED2.
    SMARTiSM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14641-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP    50
    AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA 100
    PPVHEPRAEL APPAPPLPPL PPERTSGIGD SRPPSFHPNV SSSHENLEPE 150
    TETESVVSLR RERPRRRDSS EHGAGGHRTG GPSRLERHLA GYESSSTLMT 200
    SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR KQRPPRLERT 250
    SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM 300
    KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT 350
    VAKCWDPSPQ AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS 400
    TITSGSSLPD GCEGRGLSVH TDMASVTKAM AAPESGLEVR DRMWLKITIP 450
    NAFLGSDVVD WLYHHVEGFP ERREARKYAS GLLKAGLIRH TVNKITFSEQ 500
    CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP GATPWPLLPT 550
    FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG 600
    AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG 650
    STGGAPNLRA HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG 700
    APPVRDLGSV PPELTASRQS FHMAMGNPSE FFVDVM 736
    Length:736
    Mass (Da):78,948
    Last modified:January 1, 1998 - v1
    Checksum:i4BAD95B6C3FE531B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti282 – 2821I → T Found in a renal cell carcinoma case; somatic mutation. 1 Publication
    VAR_064708

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006012 mRNA. Translation: AAB65243.1.
    BT009822 mRNA. Translation: AAP88824.1.
    CH471108 Genomic DNA. Translation: EAW90244.1.
    CH471108 Genomic DNA. Translation: EAW90245.1.
    BC014844 mRNA. Translation: AAH14844.1.
    CCDSiCCDS11091.1.
    RefSeqiNP_004413.1. NM_004422.2.
    UniGeneiHs.118640.

    Genome annotation databases

    EnsembliENST00000005340; ENSP00000005340; ENSG00000004975.
    GeneIDi1856.
    KEGGihsa:1856.
    UCSCiuc002gez.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006012 mRNA. Translation: AAB65243.1 .
    BT009822 mRNA. Translation: AAP88824.1 .
    CH471108 Genomic DNA. Translation: EAW90244.1 .
    CH471108 Genomic DNA. Translation: EAW90245.1 .
    BC014844 mRNA. Translation: AAH14844.1 .
    CCDSi CCDS11091.1.
    RefSeqi NP_004413.1. NM_004422.2.
    UniGenei Hs.118640.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2REY X-ray 1.55 A 261-355 [» ]
    3CBX X-ray 1.70 A/B 264-354 [» ]
    3CBY X-ray 1.50 A/B 264-354 [» ]
    3CBZ X-ray 1.38 A 264-354 [» ]
    3CC0 X-ray 1.75 A/B/C 264-354 [» ]
    ProteinModelPortali O14641.
    SMRi O14641. Positions 13-90, 263-353, 422-582.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108189. 66 interactions.
    DIPi DIP-34433N.
    IntActi O14641. 83 interactions.
    MINTi MINT-1435227.
    STRINGi 9606.ENSP00000005340.

    Chemistry

    ChEMBLi CHEMBL1255125.

    PTM databases

    PhosphoSitei O14641.

    Proteomic databases

    MaxQBi O14641.
    PaxDbi O14641.
    PRIDEi O14641.

    Protocols and materials databases

    DNASUi 1856.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000005340 ; ENSP00000005340 ; ENSG00000004975 .
    GeneIDi 1856.
    KEGGi hsa:1856.
    UCSCi uc002gez.1. human.

    Organism-specific databases

    CTDi 1856.
    GeneCardsi GC17M007128.
    HGNCi HGNC:3086. DVL2.
    HPAi CAB009312.
    HPA022914.
    MIMi 602151. gene.
    neXtProti NX_O14641.
    PharmGKBi PA27542.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322275.
    HOGENOMi HOG000017084.
    HOVERGENi HBG005542.
    InParanoidi O14641.
    KOi K02353.
    OMAi FHLAMGN.
    OrthoDBi EOG7BP82N.
    PhylomeDBi O14641.
    TreeFami TF318198.

    Enzyme and pathway databases

    Reactomei REACT_118607. Signaling by Hippo.
    REACT_172581. PCP/CE pathway.
    REACT_172599. WNT5A-dependent internalization of FZD4.
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_200668. WNT mediated activation of DVL.
    REACT_200777. TCF dependent signaling in response to WNT.
    REACT_200841. degradation of DVL.
    SignaLinki O14641.

    Miscellaneous databases

    ChiTaRSi DVL2. human.
    EvolutionaryTracei O14641.
    GeneWikii DVL2.
    GenomeRNAii 1856.
    NextBioi 7605.
    PROi O14641.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14641.
    Bgeei O14641.
    CleanExi HS_DVL2.
    Genevestigatori O14641.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR008341. Dishevelled_2.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF8. PTHR10878:SF8. 1 hit.
    Pfami PF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01760. DISHEVELLED.
    PR01762. DISHEVELLED2.
    SMARTi SM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human dishevelled genes constitute a DHR-containing multigene family."
      Semenov M.V., Snyder M.
      Genomics 42:302-310(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    5. "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins."
      Chen W., Hu L.A., Semenov M.V., Yanagawa S., Kikuchi A., Lefkowitz R.J., Miller W.E.
      Proc. Natl. Acad. Sci. U.S.A. 98:14889-14894(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB1.
    6. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
      Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.-C.
      J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DIXDC1 AND RAC.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth."
      Greer Y.E., Rubin J.S.
      J. Cell Biol. 192:993-1004(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY CSNK1D/CK1.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Identification of novel rare mutations of DACT1 in human neural tube defects."
      Shi Y., Ding Y., Lei Y.P., Yang X.Y., Xie G.M., Wen J., Cai C.Q., Li H., Chen Y., Zhang T., Wu B.L., Jin L., Chen Y.G., Wang H.Y.
      Hum. Mutat. 33:1450-1455(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DACT1.
    12. Cited for: INTERACTION WITH FAM105B.
    13. Cited for: X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS) OF 264-353, FUNCTION.
    14. "Crystal structure of the PDZ domains of human dishevelled 2 (homologous to Drosophila dsh)."
      Structural genomics consortium (SGC)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 261-354.
    15. Cited for: VARIANT THR-282.

    Entry informationi

    Entry nameiDVL2_HUMAN
    AccessioniPrimary (citable) accession number: O14641
    Secondary accession number(s): D3DTN3, Q53XM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 147 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3