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O14641

- DVL2_HUMAN

UniProt

O14641 - DVL2_HUMAN

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Protein

Segment polarity protein dishevelled homolog DVL-2

Gene

DVL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes By similarity.By similarity

GO - Molecular functioni

  1. frizzled binding Source: UniProtKB
  2. identical protein binding Source: IntAct

GO - Biological processi

  1. canonical Wnt signaling pathway Source: BHF-UCL
  2. canonical Wnt signaling pathway involved in regulation of cell proliferation Source: BHF-UCL
  3. cell migration in hindbrain Source: RefGenome
  4. cellular protein localization Source: Ensembl
  5. cochlea morphogenesis Source: RefGenome
  6. convergent extension Source: RefGenome
  7. convergent extension involved in neural plate elongation Source: Ensembl
  8. heart development Source: BHF-UCL
  9. heart morphogenesis Source: RefGenome
  10. hippo signaling Source: Reactome
  11. neural tube closure Source: BHF-UCL
  12. non-canonical Wnt signaling pathway Source: BHF-UCL
  13. outflow tract morphogenesis Source: BHF-UCL
  14. planar cell polarity pathway involved in neural tube closure Source: RefGenome
  15. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  16. positive regulation of JUN kinase activity Source: BHF-UCL
  17. positive regulation of protein phosphorylation Source: BHF-UCL
  18. positive regulation of protein tyrosine kinase activity Source: Ensembl
  19. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  20. positive regulation of transcription, DNA-templated Source: BHF-UCL
  21. segment specification Source: BHF-UCL
  22. transcription from RNA polymerase II promoter Source: UniProtKB
  23. Wnt signaling pathway Source: MGI
  24. Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_118607. Signaling by Hippo.
REACT_172581. PCP/CE pathway.
REACT_172599. WNT5A-dependent internalization of FZD4.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_200668. WNT mediated activation of DVL.
REACT_200777. TCF dependent signaling in response to WNT.
REACT_200841. degradation of DVL.
SignaLinkiO14641.

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-2
Short name:
Dishevelled-2
Alternative name(s):
DSH homolog 2
Gene namesi
Name:DVL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:3086. DVL2.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytosol By similarity. Cytoplasmic vesicle By similarity
Note: Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta By similarity.By similarity

GO - Cellular componenti

  1. apical part of cell Source: RefGenome
  2. cell cortex Source: RefGenome
  3. clathrin-coated endocytic vesicle Source: Reactome
  4. clathrin-coated vesicle Source: RefGenome
  5. cytoplasm Source: BHF-UCL
  6. cytoplasmic vesicle Source: MGI
  7. cytosol Source: Reactome
  8. nucleus Source: UniProtKB
  9. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Segment polarity protein dishevelled homolog DVL-2PRO_0000145746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei211 – 2111Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated by CSNK1D.4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14641.
PaxDbiO14641.
PRIDEiO14641.

PTM databases

PhosphoSiteiO14641.

Expressioni

Gene expression databases

BgeeiO14641.
CleanExiHS_DVL2.
ExpressionAtlasiO14641. baseline and differential.
GenevestigatoriO14641.

Organism-specific databases

HPAiCAB009312.
HPA022914.

Interactioni

Subunit structurei

Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 By similarity. Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex By similarity. Interacts with DACT1 and FAM105B/otulin.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-740850,EBI-740850
CK1EQ5R2U32EBI-740850,EBI-9106301
DACT1Q9NYF06EBI-740850,EBI-3951744
DIXDC1Q155Q32EBI-740850,EBI-1104700
LRRK2Q5S0073EBI-740850,EBI-5323863
Pard6aQ9Z1016EBI-740850,EBI-81732From a different organism.
Smurf2A2A5Z68EBI-740850,EBI-2348309From a different organism.
TRIM29Q141345EBI-740850,EBI-702370
WWTR1Q9GZV54EBI-740850,EBI-747743
ZNF165P499102EBI-740850,EBI-741694

Protein-protein interaction databases

BioGridi108189. 69 interactions.
DIPiDIP-34433N.
IntActiO14641. 84 interactions.
MINTiMINT-1435227.
STRINGi9606.ENSP00000005340.

Structurei

Secondary structure

1
736
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi265 – 2706Combined sources
Helixi272 – 2754Combined sources
Beta strandi280 – 2856Combined sources
Beta strandi293 – 2997Combined sources
Helixi304 – 3085Combined sources
Beta strandi316 – 3205Combined sources
Helixi330 – 34112Combined sources
Beta strandi343 – 3453Combined sources
Beta strandi347 – 3526Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2REYX-ray1.55A261-355[»]
3CBXX-ray1.70A/B264-354[»]
3CBYX-ray1.50A/B264-354[»]
3CBZX-ray1.38A264-354[»]
3CC0X-ray1.75A/B/C264-354[»]
ProteinModelPortaliO14641.
SMRiO14641. Positions 13-90, 263-353, 422-582.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14641.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 9383DIXPROSITE-ProRule annotationAdd
BLAST
Domaini267 – 33973PDZPROSITE-ProRule annotationAdd
BLAST
Domaini433 – 50775DEPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 126Poly-Gly
Compositional biasi235 – 2406Poly-Arg
Compositional biasi686 – 6949Poly-Pro

Domaini

The DIX domain mediates homooligomerization.By similarity

Sequence similaritiesi

Belongs to the DSH family.Curated
Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG322275.
GeneTreeiENSGT00390000013552.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
InParanoidiO14641.
KOiK02353.
OMAiFHLAMGN.
OrthoDBiEOG7BP82N.
PhylomeDBiO14641.
TreeFamiTF318198.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008341. DVL2.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF8. PTHR10878:SF8. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
PR01762. DISHEVELLED2.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14641-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP
60 70 80 90 100
AGAKYFFKSM DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA
110 120 130 140 150
PPVHEPRAEL APPAPPLPPL PPERTSGIGD SRPPSFHPNV SSSHENLEPE
160 170 180 190 200
TETESVVSLR RERPRRRDSS EHGAGGHRTG GPSRLERHLA GYESSSTLMT
210 220 230 240 250
SELESTSLGD SDEEDTMSRF SSSTEQSSAS RLLKRHRRRR KQRPPRLERT
260 270 280 290 300
SSFSSVTDST MSLNIITVTL NMEKYNFLGI SIVGQSNERG DGGIYIGSIM
310 320 330 340 350
KGGAVAADGR IEPGDMLLQV NDMNFENMSN DDAVRVLRDI VHKPGPIVLT
360 370 380 390 400
VAKCWDPSPQ AYFTLPRNEP IQPIDPAAWV SHSAALTGTF PAYPGSSSMS
410 420 430 440 450
TITSGSSLPD GCEGRGLSVH TDMASVTKAM AAPESGLEVR DRMWLKITIP
460 470 480 490 500
NAFLGSDVVD WLYHHVEGFP ERREARKYAS GLLKAGLIRH TVNKITFSEQ
510 520 530 540 550
CYYVFGDLSG GCESYLVNLS LNDNDGSSGA SDQDTLAPLP GATPWPLLPT
560 570 580 590 600
FSYQYPAPHP YSPQPPPYHE LSSYTYGGGS ASSQHSEGSR SSGSTRSDGG
610 620 630 640 650
AGRTGRPEER APESKSGSGS ESEPSSRGGS LRRGGEASGT SDGGPPPSRG
660 670 680 690 700
STGGAPNLRA HPGLHPYGPP PGMALPYNPM MVVMMPPPPP PVPPAVQPPG
710 720 730
APPVRDLGSV PPELTASRQS FHMAMGNPSE FFVDVM
Length:736
Mass (Da):78,948
Last modified:January 1, 1998 - v1
Checksum:i4BAD95B6C3FE531B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti282 – 2821I → T Found in a renal cell carcinoma case; somatic mutation. 1 Publication
VAR_064708

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006012 mRNA. Translation: AAB65243.1.
BT009822 mRNA. Translation: AAP88824.1.
CH471108 Genomic DNA. Translation: EAW90244.1.
CH471108 Genomic DNA. Translation: EAW90245.1.
BC014844 mRNA. Translation: AAH14844.1.
CCDSiCCDS11091.1.
RefSeqiNP_004413.1. NM_004422.2.
UniGeneiHs.118640.

Genome annotation databases

EnsembliENST00000005340; ENSP00000005340; ENSG00000004975.
GeneIDi1856.
KEGGihsa:1856.
UCSCiuc002gez.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006012 mRNA. Translation: AAB65243.1 .
BT009822 mRNA. Translation: AAP88824.1 .
CH471108 Genomic DNA. Translation: EAW90244.1 .
CH471108 Genomic DNA. Translation: EAW90245.1 .
BC014844 mRNA. Translation: AAH14844.1 .
CCDSi CCDS11091.1.
RefSeqi NP_004413.1. NM_004422.2.
UniGenei Hs.118640.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2REY X-ray 1.55 A 261-355 [» ]
3CBX X-ray 1.70 A/B 264-354 [» ]
3CBY X-ray 1.50 A/B 264-354 [» ]
3CBZ X-ray 1.38 A 264-354 [» ]
3CC0 X-ray 1.75 A/B/C 264-354 [» ]
ProteinModelPortali O14641.
SMRi O14641. Positions 13-90, 263-353, 422-582.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108189. 69 interactions.
DIPi DIP-34433N.
IntActi O14641. 84 interactions.
MINTi MINT-1435227.
STRINGi 9606.ENSP00000005340.

Chemistry

ChEMBLi CHEMBL1255125.

PTM databases

PhosphoSitei O14641.

Proteomic databases

MaxQBi O14641.
PaxDbi O14641.
PRIDEi O14641.

Protocols and materials databases

DNASUi 1856.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000005340 ; ENSP00000005340 ; ENSG00000004975 .
GeneIDi 1856.
KEGGi hsa:1856.
UCSCi uc002gez.1. human.

Organism-specific databases

CTDi 1856.
GeneCardsi GC17M007128.
HGNCi HGNC:3086. DVL2.
HPAi CAB009312.
HPA022914.
MIMi 602151. gene.
neXtProti NX_O14641.
PharmGKBi PA27542.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322275.
GeneTreei ENSGT00390000013552.
HOGENOMi HOG000017084.
HOVERGENi HBG005542.
InParanoidi O14641.
KOi K02353.
OMAi FHLAMGN.
OrthoDBi EOG7BP82N.
PhylomeDBi O14641.
TreeFami TF318198.

Enzyme and pathway databases

Reactomei REACT_118607. Signaling by Hippo.
REACT_172581. PCP/CE pathway.
REACT_172599. WNT5A-dependent internalization of FZD4.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_200668. WNT mediated activation of DVL.
REACT_200777. TCF dependent signaling in response to WNT.
REACT_200841. degradation of DVL.
SignaLinki O14641.

Miscellaneous databases

ChiTaRSi DVL2. human.
EvolutionaryTracei O14641.
GeneWikii DVL2.
GenomeRNAii 1856.
NextBioi 7605.
PROi O14641.
SOURCEi Search...

Gene expression databases

Bgeei O14641.
CleanExi HS_DVL2.
ExpressionAtlasi O14641. baseline and differential.
Genevestigatori O14641.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008341. DVL2.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10878. PTHR10878. 1 hit.
PTHR10878:SF8. PTHR10878:SF8. 1 hit.
Pfami PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR01760. DISHEVELLED.
PR01762. DISHEVELLED2.
SMARTi SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human dishevelled genes constitute a DHR-containing multigene family."
    Semenov M.V., Snyder M.
    Genomics 42:302-310(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins."
    Chen W., Hu L.A., Semenov M.V., Yanagawa S., Kikuchi A., Lefkowitz R.J., Miller W.E.
    Proc. Natl. Acad. Sci. U.S.A. 98:14889-14894(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB1.
  6. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
    Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.-C.
    J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DIXDC1 AND RAC.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth."
    Greer Y.E., Rubin J.S.
    J. Cell Biol. 192:993-1004(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY CSNK1D/CK1.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Identification of novel rare mutations of DACT1 in human neural tube defects."
    Shi Y., Ding Y., Lei Y.P., Yang X.Y., Xie G.M., Wen J., Cai C.Q., Li H., Chen Y., Zhang T., Wu B.L., Jin L., Chen Y.G., Wang H.Y.
    Hum. Mutat. 33:1450-1455(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DACT1.
  12. Cited for: INTERACTION WITH FAM105B.
  13. Cited for: X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS) OF 264-353, FUNCTION.
  14. "Crystal structure of the PDZ domains of human dishevelled 2 (homologous to Drosophila dsh)."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 261-354.
  15. Cited for: VARIANT THR-282.

Entry informationi

Entry nameiDVL2_HUMAN
AccessioniPrimary (citable) accession number: O14641
Secondary accession number(s): D3DTN3, Q53XM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3