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O14640

- DVL1_HUMAN

UniProt

O14640 - DVL1_HUMAN

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Protein

Segment polarity protein dishevelled homolog DVL-1

Gene

DVL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. frizzled binding Source: UniProtKB
  3. identical protein binding Source: IntAct
  4. protein kinase binding Source: BHF-UCL
  5. Rac GTPase binding Source: RefGenome

GO - Biological processi

  1. axon extension Source: RefGenome
  2. axon guidance Source: RefGenome
  3. canonical Wnt signaling pathway Source: BHF-UCL
  4. cochlea morphogenesis Source: RefGenome
  5. collateral sprouting Source: RefGenome
  6. convergent extension Source: RefGenome
  7. convergent extension involved in neural plate elongation Source: Ensembl
  8. cytoplasmic microtubule organization Source: Ensembl
  9. dendrite morphogenesis Source: BHF-UCL
  10. intracellular signal transduction Source: InterPro
  11. negative regulation of protein binding Source: BHF-UCL
  12. negative regulation of protein kinase activity Source: BHF-UCL
  13. neural tube development Source: BHF-UCL
  14. neuromuscular junction development Source: BHF-UCL
  15. neurotransmitter secretion Source: BHF-UCL
  16. planar cell polarity pathway involved in neural tube closure Source: RefGenome
  17. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  18. positive regulation of neuron projection development Source: Ensembl
  19. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  20. positive regulation of transcription, DNA-templated Source: BHF-UCL
  21. positive regulation of Wnt signaling pathway Source: BHF-UCL
  22. prepulse inhibition Source: Ensembl
  23. protein localization to microtubule Source: Ensembl
  24. protein localization to nucleus Source: BHF-UCL
  25. receptor clustering Source: BHF-UCL
  26. regulation of neurotransmitter levels Source: BHF-UCL
  27. skeletal muscle acetylcholine-gated channel clustering Source: RefGenome
  28. social behavior Source: Ensembl
  29. synapse organization Source: BHF-UCL
  30. transcription from RNA polymerase II promoter Source: UniProtKB
  31. Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_172581. PCP/CE pathway.
REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_200668. WNT mediated activation of DVL.
REACT_200777. TCF dependent signaling in response to WNT.
REACT_200841. degradation of DVL.
SignaLinkiO14640.

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-1
Short name:
Dishevelled-1
Alternative name(s):
DSH homolog 1
Gene namesi
Name:DVL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3084. DVL1.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytosol By similarity. Cytoplasmic vesicle By similarity
Note: Localizes at the cell membrane upon interaction with frizzled family members.By similarity

GO - Cellular componenti

  1. axon Source: RefGenome
  2. cell cortex Source: RefGenome
  3. clathrin-coated vesicle Source: RefGenome
  4. cytoplasmic membrane-bounded vesicle Source: BHF-UCL
  5. cytoplasmic vesicle Source: BHF-UCL
  6. dendrite Source: RefGenome
  7. growth cone Source: RefGenome
  8. microtubule Source: RefGenome
  9. neuronal cell body Source: RefGenome
  10. plasma membrane Source: UniProtKB-KW
  11. synapse Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27540.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Segment polarity protein dishevelled homolog DVL-1PRO_0000145742Add
BLAST

Post-translational modificationi

Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiO14640.
PRIDEiO14640.

PTM databases

PhosphoSiteiO14640.

Expressioni

Gene expression databases

BgeeiO14640.
CleanExiHS_DVL1.
ExpressionAtlasiO14640. baseline and differential.
GenevestigatoriO14640.

Organism-specific databases

HPAiCAB011538.

Interactioni

Subunit structurei

Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD (By similarity). Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site (By similarity). Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering (By similarity). Interacts (via PDZ domain) with TMEM88.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-723489,EBI-723489
APCP250546EBI-723489,EBI-727707
Axin1O7023912EBI-723489,EBI-6857773From a different organism.
CSNK1EP496746EBI-723489,EBI-749343
Cxxc4Q9EQC95EBI-723489,EBI-9344960From a different organism.
DVL3Q929975EBI-723489,EBI-739789
LRRK2Q5S0077EBI-6504027,EBI-5323863
SCYL2Q6P3W74EBI-723489,EBI-1046810
TFDP1Q141863EBI-723489,EBI-749713
WWTR1Q9GZV52EBI-723489,EBI-747743

Protein-protein interaction databases

BioGridi108188. 36 interactions.
DIPiDIP-40773N.
IntActiO14640. 25 interactions.
MINTiMINT-100885.
STRINGi9606.ENSP00000368169.

Structurei

3D structure databases

ProteinModelPortaliO14640.
SMRiO14640. Positions 3-84, 251-345, 406-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8585DIXPROSITE-ProRule annotationAdd
BLAST
Domaini251 – 32373PDZPROSITE-ProRule annotationAdd
BLAST
Domaini425 – 49975DEPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi221 – 2244Poly-Arg

Domaini

The DIX domain promotes homooligomerization.By similarity
The DEP domain mediates interaction with the cell membrane.By similarity

Sequence similaritiesi

Belongs to the DSH family.Curated
Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000013552.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
InParanoidiO14640.
KOiK02353.
OMAiYPRYGMS.
OrthoDBiEOG7BP82N.
PhylomeDBiO14640.
TreeFamiTF318198.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008340. DVL-1.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF5. PTHR10878:SF5. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14640) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK
60 70 80 90 100
SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT
110 120 130 140 150
DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR
160 170 180 190 200
RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST
210 220 230 240 250
SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI TDSTMSLNIV
260 270 280 290 300
TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM
310 320 330 340 350
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP
360 370 380 390 400
RADPVRPIDP AAWLSHTAAL TGALPRYGTS PCSSAVTRTS SSSLTSSVPG
410 420 430 440 450
APQLEEAPLT VKSDMSAVVR VMQLPDSGLE IRDRMWLKIT IANAVIGADV
460 470 480 490 500
VDWLYTHVEG FKERREARKY ASSLLKHGFL RHTVNKITFS EQCYYVFGDL
510 520 530 540 550
CSNLATLNLN SGSSGTSDQD TLAPLPHPAA PWPLGQGYPY QYPGPPPCFP
560 570 580 590 600
PAYQDPGFSY GSGSTGSQQS EGSKSSGSTR SSRRAPGREK ERRAAGAGGS
610 620 630 640 650
GSESDHTAPS GVGSSWRERP AGQLSRGSSP RSQASATAPG LPPPHPTTKA
660 670 680 690
YTVVGGPPGG PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM
Length:695
Mass (Da):75,187
Last modified:April 17, 2007 - v2
Checksum:iB009BDBCC57BD562
GO
Isoform 2 (identifier: O14640-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-403: GTSPCSSAVTRTSSSSLTSSVPGAPQ → E

Show »
Length:670
Mass (Da):72,881
Checksum:iCF31534E784A80A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → G in AAB65242. (PubMed:9192851)Curated
Sequence conflicti157 – 1571A → P in AAB65242. (PubMed:9192851)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei378 – 40326GTSPC…PGAPQ → E in isoform 2. 1 PublicationVSP_024460Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006011 mRNA. Translation: AAB65242.1.
AL139287 Genomic DNA. Translation: CAI23185.1.
AL139287 Genomic DNA. Translation: CAI23187.1.
CCDSiCCDS22.1. [O14640-2]
RefSeqiNP_004412.2. NM_004421.2. [O14640-2]
XP_005244788.1. XM_005244731.1. [O14640-1]
UniGeneiHs.731450.

Genome annotation databases

EnsembliENST00000378888; ENSP00000368166; ENSG00000107404. [O14640-1]
ENST00000378891; ENSP00000368169; ENSG00000107404. [O14640-2]
GeneIDi1855.
KEGGihsa:1855.
UCSCiuc001aer.4. human. [O14640-2]
uc002quu.3. human. [O14640-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006011 mRNA. Translation: AAB65242.1 .
AL139287 Genomic DNA. Translation: CAI23185.1 .
AL139287 Genomic DNA. Translation: CAI23187.1 .
CCDSi CCDS22.1. [O14640-2 ]
RefSeqi NP_004412.2. NM_004421.2. [O14640-2 ]
XP_005244788.1. XM_005244731.1. [O14640-1 ]
UniGenei Hs.731450.

3D structure databases

ProteinModelPortali O14640.
SMRi O14640. Positions 3-84, 251-345, 406-499.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108188. 36 interactions.
DIPi DIP-40773N.
IntActi O14640. 25 interactions.
MINTi MINT-100885.
STRINGi 9606.ENSP00000368169.

Chemistry

ChEMBLi CHEMBL6027.

PTM databases

PhosphoSitei O14640.

Proteomic databases

MaxQBi O14640.
PRIDEi O14640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378888 ; ENSP00000368166 ; ENSG00000107404 . [O14640-1 ]
ENST00000378891 ; ENSP00000368169 ; ENSG00000107404 . [O14640-2 ]
GeneIDi 1855.
KEGGi hsa:1855.
UCSCi uc001aer.4. human. [O14640-2 ]
uc002quu.3. human. [O14640-1 ]

Organism-specific databases

CTDi 1855.
GeneCardsi GC01M001262.
HGNCi HGNC:3084. DVL1.
HPAi CAB011538.
MIMi 601365. gene.
neXtProti NX_O14640.
PharmGKBi PA27540.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000013552.
HOGENOMi HOG000017084.
HOVERGENi HBG005542.
InParanoidi O14640.
KOi K02353.
OMAi YPRYGMS.
OrthoDBi EOG7BP82N.
PhylomeDBi O14640.
TreeFami TF318198.

Enzyme and pathway databases

Reactomei REACT_172581. PCP/CE pathway.
REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_200668. WNT mediated activation of DVL.
REACT_200777. TCF dependent signaling in response to WNT.
REACT_200841. degradation of DVL.
SignaLinki O14640.

Miscellaneous databases

GeneWikii DVL1.
GenomeRNAii 1855.
NextBioi 7599.
PROi O14640.
SOURCEi Search...

Gene expression databases

Bgeei O14640.
CleanExi HS_DVL1.
ExpressionAtlasi O14640. baseline and differential.
Genevestigatori O14640.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008340. DVL-1.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10878. PTHR10878. 1 hit.
PTHR10878:SF5. PTHR10878:SF5. 1 hit.
Pfami PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR01760. DISHEVELLED.
SMARTi SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human dishevelled genes constitute a DHR-containing multigene family."
    Semenov M.V., Snyder M.
    Genomics 42:302-310(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins."
    Chen W., Hu L.A., Semenov M.V., Yanagawa S., Kikuchi A., Lefkowitz R.J., Miller W.E.
    Proc. Natl. Acad. Sci. U.S.A. 98:14889-14894(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB1.
  4. "Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway."
    Oshita A., Kishida S., Kobayashi H., Michiue T., Asahara T., Asashima M., Kikuchi A.
    Genes Cells 8:1005-1017(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CCDC88C.
  5. "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth."
    Lu W., Yamamoto V., Ortega B., Baltimore D.
    Cell 119:97-108(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RYK.
  6. "Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways."
    Simons M., Gloy J., Ganner A., Bullerkotte A., Bashkurov M., Kroenig C., Schermer B., Benzing T., Cabello O.A., Jenny A., Mlodzik M., Polok B., Driever W., Obara T., Walz G.
    Nat. Genet. 37:537-543(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INVS.
  7. "Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein."
    Lee H.J., Finkelstein D., Li X., Wu D., Shi D.L., Zheng J.J.
    J. Biol. Chem. 285:41549-41556(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TMEM88.

Entry informationi

Entry nameiDVL1_HUMAN
AccessioniPrimary (citable) accession number: O14640
Secondary accession number(s): Q5TA33, Q5TA35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3