Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O14640

- DVL1_HUMAN

UniProt

O14640 - DVL1_HUMAN

Protein

Segment polarity protein dishevelled homolog DVL-1

Gene

DVL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

    GO - Molecular functioni

    1. enzyme binding Source: UniProtKB
    2. frizzled binding Source: UniProtKB
    3. identical protein binding Source: IntAct
    4. protein binding Source: UniProtKB
    5. protein kinase binding Source: BHF-UCL
    6. Rac GTPase binding Source: RefGenome
    7. signal transducer activity Source: InterPro

    GO - Biological processi

    1. axon extension Source: RefGenome
    2. axon guidance Source: RefGenome
    3. canonical Wnt signaling pathway Source: BHF-UCL
    4. cochlea morphogenesis Source: RefGenome
    5. collateral sprouting Source: RefGenome
    6. convergent extension Source: RefGenome
    7. convergent extension involved in neural plate elongation Source: Ensembl
    8. cytoplasmic microtubule organization Source: Ensembl
    9. dendrite morphogenesis Source: BHF-UCL
    10. intracellular signal transduction Source: InterPro
    11. negative regulation of protein binding Source: BHF-UCL
    12. negative regulation of protein kinase activity Source: BHF-UCL
    13. neural tube development Source: BHF-UCL
    14. neuromuscular junction development Source: BHF-UCL
    15. neurotransmitter secretion Source: BHF-UCL
    16. planar cell polarity pathway involved in neural tube closure Source: RefGenome
    17. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    18. positive regulation of neuron projection development Source: Ensembl
    19. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
    20. positive regulation of transcription, DNA-templated Source: BHF-UCL
    21. positive regulation of Wnt signaling pathway Source: BHF-UCL
    22. prepulse inhibition Source: Ensembl
    23. protein localization to microtubule Source: Ensembl
    24. protein localization to nucleus Source: BHF-UCL
    25. receptor clustering Source: BHF-UCL
    26. regulation of neurotransmitter levels Source: BHF-UCL
    27. skeletal muscle acetylcholine-gated channel clustering Source: RefGenome
    28. social behavior Source: Ensembl
    29. synapse organization Source: BHF-UCL
    30. transcription from RNA polymerase II promoter Source: UniProtKB
    31. Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_172581. PCP/CE pathway.
    REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_200668. WNT mediated activation of DVL.
    REACT_200777. TCF dependent signaling in response to WNT.
    REACT_200841. degradation of DVL.
    SignaLinkiO14640.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-1
    Short name:
    Dishevelled-1
    Alternative name(s):
    DSH homolog 1
    Gene namesi
    Name:DVL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3084. DVL1.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytosol By similarity. Cytoplasmic vesicle By similarity
    Note: Localizes at the cell membrane upon interaction with frizzled family members.By similarity

    GO - Cellular componenti

    1. axon Source: RefGenome
    2. cell cortex Source: RefGenome
    3. clathrin-coated vesicle Source: RefGenome
    4. cytoplasmic membrane-bounded vesicle Source: BHF-UCL
    5. cytoplasmic vesicle Source: BHF-UCL
    6. cytosol Source: UniProtKB-SubCell
    7. dendrite Source: RefGenome
    8. growth cone Source: RefGenome
    9. microtubule Source: RefGenome
    10. neuronal cell body Source: RefGenome
    11. plasma membrane Source: UniProtKB-SubCell
    12. synapse Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27540.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695Segment polarity protein dishevelled homolog DVL-1PRO_0000145742Add
    BLAST

    Post-translational modificationi

    Ubiquitinated; undergoes both 'Lys-48'-linked ubiquitination, leading to its subsequent degradation by the ubiquitin-proteasome pathway, and 'Lys-63'-linked ubiquitination. The interaction with INVS is required for ubiquitination. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiO14640.
    PRIDEiO14640.

    PTM databases

    PhosphoSiteiO14640.

    Expressioni

    Gene expression databases

    ArrayExpressiO14640.
    BgeeiO14640.
    CleanExiHS_DVL1.
    GenevestigatoriO14640.

    Organism-specific databases

    HPAiCAB011538.

    Interactioni

    Subunit structurei

    Interacts with CXXC4. Interacts (via PDZ domain) with NXN By similarity. Interacts with BRD7 and INVS. Interacts through its PDZ domain with the C-terminal regions of VANGL1, VANGL2 and CCDC88C/DAPLE. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1. Interacts with CYLD By similarity. Interacts (via PDZ domain) with RYK. Self-associates (via DIX domain) and forms higher homooligomers. Interacts (via PDZ domain) with DACT1 and FZD7, where DACT1 and FZD7 compete for the same binding site By similarity. Interacts (via DEP domain) with MUSK; the interaction is direct and mediates the formation a DVL1, MUSK and PAK1 ternary complex involved in AChR clustering By similarity. Interacts (via PDZ domain) with TMEM88.By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-723489,EBI-723489
    APCP250546EBI-723489,EBI-727707
    Axin1O7023912EBI-723489,EBI-6857773From a different organism.
    CSNK1EP496746EBI-723489,EBI-749343
    Cxxc4Q9EQC95EBI-723489,EBI-9344960From a different organism.
    DVL3Q929975EBI-723489,EBI-739789
    LRRK2Q5S0077EBI-6504027,EBI-5323863
    SCYL2Q6P3W74EBI-723489,EBI-1046810
    TFDP1Q141863EBI-723489,EBI-749713
    WWTR1Q9GZV52EBI-723489,EBI-747743

    Protein-protein interaction databases

    BioGridi108188. 34 interactions.
    DIPiDIP-40773N.
    IntActiO14640. 25 interactions.
    MINTiMINT-100885.
    STRINGi9606.ENSP00000368169.

    Structurei

    3D structure databases

    ProteinModelPortaliO14640.
    SMRiO14640. Positions 3-84, 251-345, 406-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8585DIXPROSITE-ProRule annotationAdd
    BLAST
    Domaini251 – 32373PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini425 – 49975DEPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi221 – 2244Poly-Arg

    Domaini

    The DIX domain promotes homooligomerization.By similarity
    The DEP domain mediates interaction with the cell membrane.By similarity

    Sequence similaritiesi

    Belongs to the DSH family.Curated
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000017084.
    HOVERGENiHBG005542.
    InParanoidiO14640.
    KOiK02353.
    OMAiYPRYGMS.
    OrthoDBiEOG7BP82N.
    PhylomeDBiO14640.
    TreeFamiTF318198.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR008340. Dishevelled_1.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF5. PTHR10878:SF5. 1 hit.
    PfamiPF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PRINTSiPR01760. DISHEVELLED.
    SMARTiSM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14640-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK    50
    SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT 100
    DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR 150
    RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST 200
    SRLSSSTEQS TSSRLIRKHK RRRRKQRLRQ ADRASSFSSI TDSTMSLNIV 250
    TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 300
    LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PTPRSYFTVP 350
    RADPVRPIDP AAWLSHTAAL TGALPRYGTS PCSSAVTRTS SSSLTSSVPG 400
    APQLEEAPLT VKSDMSAVVR VMQLPDSGLE IRDRMWLKIT IANAVIGADV 450
    VDWLYTHVEG FKERREARKY ASSLLKHGFL RHTVNKITFS EQCYYVFGDL 500
    CSNLATLNLN SGSSGTSDQD TLAPLPHPAA PWPLGQGYPY QYPGPPPCFP 550
    PAYQDPGFSY GSGSTGSQQS EGSKSSGSTR SSRRAPGREK ERRAAGAGGS 600
    GSESDHTAPS GVGSSWRERP AGQLSRGSSP RSQASATAPG LPPPHPTTKA 650
    YTVVGGPPGG PPVRELAAVP PELTGSRQSF QKAMGNPCEF FVDIM 695
    Length:695
    Mass (Da):75,187
    Last modified:April 17, 2007 - v2
    Checksum:iB009BDBCC57BD562
    GO
    Isoform 2 (identifier: O14640-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         378-403: GTSPCSSAVTRTSSSSLTSSVPGAPQ → E

    Show »
    Length:670
    Mass (Da):72,881
    Checksum:iCF31534E784A80A2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21A → G in AAB65242. (PubMed:9192851)Curated
    Sequence conflicti157 – 1571A → P in AAB65242. (PubMed:9192851)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei378 – 40326GTSPC…PGAPQ → E in isoform 2. 1 PublicationVSP_024460Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006011 mRNA. Translation: AAB65242.1.
    AL139287 Genomic DNA. Translation: CAI23185.1.
    AL139287 Genomic DNA. Translation: CAI23187.1.
    CCDSiCCDS22.1. [O14640-2]
    RefSeqiNP_004412.2. NM_004421.2. [O14640-2]
    XP_005244788.1. XM_005244731.1. [O14640-1]
    UniGeneiHs.731450.

    Genome annotation databases

    EnsembliENST00000378888; ENSP00000368166; ENSG00000107404. [O14640-1]
    ENST00000378891; ENSP00000368169; ENSG00000107404. [O14640-2]
    GeneIDi1855.
    KEGGihsa:1855.
    UCSCiuc001aer.4. human. [O14640-2]
    uc002quu.3. human. [O14640-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006011 mRNA. Translation: AAB65242.1 .
    AL139287 Genomic DNA. Translation: CAI23185.1 .
    AL139287 Genomic DNA. Translation: CAI23187.1 .
    CCDSi CCDS22.1. [O14640-2 ]
    RefSeqi NP_004412.2. NM_004421.2. [O14640-2 ]
    XP_005244788.1. XM_005244731.1. [O14640-1 ]
    UniGenei Hs.731450.

    3D structure databases

    ProteinModelPortali O14640.
    SMRi O14640. Positions 3-84, 251-345, 406-499.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108188. 34 interactions.
    DIPi DIP-40773N.
    IntActi O14640. 25 interactions.
    MINTi MINT-100885.
    STRINGi 9606.ENSP00000368169.

    Chemistry

    ChEMBLi CHEMBL6027.

    PTM databases

    PhosphoSitei O14640.

    Proteomic databases

    MaxQBi O14640.
    PRIDEi O14640.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378888 ; ENSP00000368166 ; ENSG00000107404 . [O14640-1 ]
    ENST00000378891 ; ENSP00000368169 ; ENSG00000107404 . [O14640-2 ]
    GeneIDi 1855.
    KEGGi hsa:1855.
    UCSCi uc001aer.4. human. [O14640-2 ]
    uc002quu.3. human. [O14640-1 ]

    Organism-specific databases

    CTDi 1855.
    GeneCardsi GC01M001262.
    HGNCi HGNC:3084. DVL1.
    HPAi CAB011538.
    MIMi 601365. gene.
    neXtProti NX_O14640.
    PharmGKBi PA27540.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000017084.
    HOVERGENi HBG005542.
    InParanoidi O14640.
    KOi K02353.
    OMAi YPRYGMS.
    OrthoDBi EOG7BP82N.
    PhylomeDBi O14640.
    TreeFami TF318198.

    Enzyme and pathway databases

    Reactomei REACT_172581. PCP/CE pathway.
    REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_200668. WNT mediated activation of DVL.
    REACT_200777. TCF dependent signaling in response to WNT.
    REACT_200841. degradation of DVL.
    SignaLinki O14640.

    Miscellaneous databases

    GeneWikii DVL1.
    GenomeRNAii 1855.
    NextBioi 7599.
    PROi O14640.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14640.
    Bgeei O14640.
    CleanExi HS_DVL1.
    Genevestigatori O14640.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR008340. Dishevelled_1.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF5. PTHR10878:SF5. 1 hit.
    Pfami PF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01760. DISHEVELLED.
    SMARTi SM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human dishevelled genes constitute a DHR-containing multigene family."
      Semenov M.V., Snyder M.
      Genomics 42:302-310(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins."
      Chen W., Hu L.A., Semenov M.V., Yanagawa S., Kikuchi A., Lefkowitz R.J., Miller W.E.
      Proc. Natl. Acad. Sci. U.S.A. 98:14889-14894(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB1.
    4. "Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway."
      Oshita A., Kishida S., Kobayashi H., Michiue T., Asahara T., Asashima M., Kikuchi A.
      Genes Cells 8:1005-1017(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CCDC88C.
    5. "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth."
      Lu W., Yamamoto V., Ortega B., Baltimore D.
      Cell 119:97-108(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RYK.
    6. "Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways."
      Simons M., Gloy J., Ganner A., Bullerkotte A., Bashkurov M., Kroenig C., Schermer B., Benzing T., Cabello O.A., Jenny A., Mlodzik M., Polok B., Driever W., Obara T., Walz G.
      Nat. Genet. 37:537-543(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INVS.
    7. "Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein."
      Lee H.J., Finkelstein D., Li X., Wu D., Shi D.L., Zheng J.J.
      J. Biol. Chem. 285:41549-41556(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TMEM88.

    Entry informationi

    Entry nameiDVL1_HUMAN
    AccessioniPrimary (citable) accession number: O14640
    Secondary accession number(s): Q5TA33, Q5TA35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 148 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3