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Protein

Actin-binding LIM protein 1

Gene

ABLIM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.By similarity1 Publication

GO - Molecular functioni

  • actin binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • animal organ morphogenesis Source: ProtInc
  • cilium assembly Source: MGI
  • cytoskeleton organization Source: InterPro
  • lamellipodium assembly Source: MGI
  • visual perception Source: ProtInc

Keywordsi

Molecular functionActin-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-418885. DCC mediated attractive signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding LIM protein 1
Short name:
abLIM-1
Alternative name(s):
Actin-binding LIM protein family member 1
Actin-binding double zinc finger protein
LIMAB1
Limatin
Gene namesi
Name:ABLIM1
Synonyms:ABLIM, KIAA0059, LIMAB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:78. ABLIM1.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: ProtInc
  • cytoplasm Source: UniProtKB-SubCell
  • lamellipodium Source: MGI
  • stress fiber Source: MGI

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi3983.
OpenTargetsiENSG00000099204.
PharmGKBiPA35023.

Polymorphism and mutation databases

BioMutaiABLIM1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000756971 – 778Actin-binding LIM protein 1Add BLAST778

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216PhosphoserineBy similarity1
Modified residuei367PhosphoserineCombined sources1
Modified residuei373PhosphotyrosineCombined sources1
Modified residuei396PhosphotyrosineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei426PhosphoserineCombined sources1
Modified residuei431PhosphoserineCombined sources1
Modified residuei433PhosphothreonineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei439PhosphotyrosineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Modified residuei458PhosphoserineCombined sources1
Modified residuei498PhosphoserineBy similarity1
Modified residuei587PhosphoserineCombined sources1
Cross-linki620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei640PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei677PhosphoserineBy similarity1
Modified residuei706PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO14639.
MaxQBiO14639.
PaxDbiO14639.
PeptideAtlasiO14639.
PRIDEiO14639.

PTM databases

iPTMnetiO14639.
PhosphoSitePlusiO14639.

Expressioni

Tissue specificityi

Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.1 Publication

Gene expression databases

BgeeiENSG00000099204.
CleanExiHS_ABLIM1.
ExpressionAtlasiO14639. baseline and differential.
GenevisibleiO14639. HS.

Organism-specific databases

HPAiHPA038951.
HPA038952.

Interactioni

Subunit structurei

Binds F-actin. Interacts with ABRA.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: ProtInc

Protein-protein interaction databases

BioGridi110171. 79 interactors.
IntActiO14639. 63 interactors.
MINTiMINT-1447354.
STRINGi9606.ENSP00000338190.

Structurei

3D structure databases

ProteinModelPortaliO14639.
SMRiO14639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 156LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini156 – 216LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini224 – 283LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini283 – 343LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61
Domaini710 – 778HPPROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili590 – 614Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coil, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1044. Eukaryota.
ENOG410XRPY. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000285997.
HOVERGENiHBG031499.
InParanoidiO14639.
KOiK07520.
OMAiQCARSEF.
OrthoDBiEOG091G025W.
PhylomeDBiO14639.
TreeFamiTF318042.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
InterProiView protein in InterPro
IPR028448. ABLIM1.
IPR032402. AbLIM_anchor.
IPR003128. Villin_headpiece.
IPR001781. Znf_LIM.
PANTHERiPTHR24213:SF23. PTHR24213:SF23. 1 hit.
PfamiView protein in Pfam
PF16182. AbLIM_anchor. 1 hit.
PF00412. LIM. 4 hits.
PF02209. VHP. 1 hit.
SMARTiView protein in SMART
SM00132. LIM. 4 hits.
SM00153. VHP. 1 hit.
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiView protein in PROSITE
PS51089. HP. 1 hit.
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14639-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAFLGLKCL GKLCSSEKSK VTSSERTSAR GSNRKRLIVE DRRVSGTSFT
60 70 80 90 100
AHRRATITHL LYLCPKDYCP RGRVCNSVDP FVAHPQDPHH PSEKPVIHCH
110 120 130 140 150
KCGEPCKGEV LRVQTKHFHI KCFTCKVCGC DLAQGGFFIK NGEYLCTLDY
160 170 180 190 200
QRMYGTRCHG CGEFVEGEVV TALGKTYHPN CFACTICKRP FPPGDRVTFN
210 220 230 240 250
GRDCLCQLCA QPMSSSPKET TFSSNCAGCG RDIKNGQALL ALDKQWHLGC
260 270 280 290 300
FKCKSCGKVL TGEYISKDGA PYCEKDYQGL FGVKCEACHQ FITGKVLEAG
310 320 330 340 350
DKHYHPSCAR CSRCNQMFTE GEEMYLQGST VWHPDCKQST KTEEKLRPTR
360 370 380 390 400
TSSESIYSRP GSSIPGSPGH TIYAKVDNEI LDYKDLAAIP KVKAIYDIER
410 420 430 440 450
PDLITYEPFY TSGYDDKQER QSLGESPRTL SPTPSAEGYQ DVRDRMIHRS
460 470 480 490 500
TSQGSINSPV YSRHSYTPTT SRSPQHFHRP GNEPSSGRNS PLPYRPDSRP
510 520 530 540 550
LTPTYAQAPK HFHVPDQGIN IYRKPPIYKQ HAALAAQSKS SEDIIKFSKF
560 570 580 590 600
PAAQAPDPSE TPKIETDHWP GPPSFAVVGP DMKRRSSGRE EDDEELLRRR
610 620 630 640 650
QLQEEQLMKL NSGLGQLILK EEMEKESRER SSLLASRYDS PINSASHIPS
660 670 680 690 700
SKTASLPGYG RNGLHRPVST DFAQYNSYGD VSGGVRDYQT LPDGHMPAMR
710 720 730 740 750
MDRGVSMPNM LEPKIFPYEM LMVTNRGRNK ILREVDRTRL ERHLAPEVFR
760 770
EIFGMSIQEF DRLPLWRRND MKKKAKLF
Length:778
Mass (Da):87,688
Last modified:September 23, 2008 - v3
Checksum:iEBC2F14BE558752B
GO
Isoform 2 (identifier: O14639-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MPAFLGLKCL...GRVCNSVDPF → MLMTLEMTELTDPHHTMGDYK

Show »
Length:718
Mass (Da):81,121
Checksum:iA9CAEEBA95BDF15E
GO
Isoform 3 (identifier: O14639-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     480-514: Missing.

Show »
Length:427
Mass (Da):48,804
Checksum:i1721FB3EC1D99994
GO
Isoform 4 (identifier: O14639-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     348-373: Missing.
     480-514: Missing.

Show »
Length:401
Mass (Da):46,087
Checksum:i0B2AC94C24A5D72F
GO
Isoform 5 (identifier: O14639-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.
     347-347: R → RLPNIRRSSSDFFYSKSLIRRTGRSPSLQ
     480-514: Missing.

Show »
Length:455
Mass (Da):52,056
Checksum:iCA7E610D14878674
GO
Isoform 6 (identifier: O14639-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MPAFLGLKCL...GRVCNSVDPF → MLMTLEMTELTDPHHTMGDYK
     347-347: R → RLPNIRRSSSDFFYSKSLIRRTGRSPSLQ
     531-531: H → HDA

Note: No experimental confirmation available.
Show »
Length:748
Mass (Da):84,559
Checksum:i363E71622011A691
GO

Sequence cautioni

The sequence BAA06681 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti499R → L in AAC51676 (PubMed:9245787).Curated1
Sequence conflicti532A → R in AAC51676 (PubMed:9245787).Curated1
Sequence conflicti563K → E in BAA06681 (PubMed:7584044).Curated1
Sequence conflicti578V → I in BAA06681 (PubMed:7584044).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050141434P → T. Corresponds to variant dbSNP:rs11593544Ensembl.1
Natural variantiVAR_050142637R → G. Corresponds to variant dbSNP:rs7091419Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0120991 – 316Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST316
Alternative sequenceiVSP_0121001 – 81MPAFL…SVDPF → MLMTLEMTELTDPHHTMGDY K in isoform 2 and isoform 6. 2 PublicationsAdd BLAST81
Alternative sequenceiVSP_041185347R → RLPNIRRSSSDFFYSKSLIR RTGRSPSLQ in isoform 5 and isoform 6. 1 Publication1
Alternative sequenceiVSP_012101348 – 373Missing in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_012102480 – 514Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST35
Alternative sequenceiVSP_057209531H → HDA in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005654 mRNA. Translation: AAC51676.1.
D31883 mRNA. Translation: BAA06681.2. Different initiation.
AK098277 mRNA. Translation: BAG53605.1.
AK122891 mRNA. Translation: BAG53784.1.
CR749819 mRNA. Translation: CAH18679.1.
AL133384 Genomic DNA. Translation: CAI40135.1.
AL133384 Genomic DNA. Translation: CAI40136.1.
AL133384, AL354873 Genomic DNA. Translation: CAI40140.1.
AL133384, AL354873 Genomic DNA. Translation: CAI40141.1.
AL354873, AL133384 Genomic DNA. Translation: CAI10908.1.
AL354873, AL133384 Genomic DNA. Translation: CAI10910.1.
AL590109 Genomic DNA. No translation available.
BC002448 mRNA. Translation: AAH02448.1.
CCDSiCCDS31288.1. [O14639-2]
CCDS31289.1. [O14639-5]
CCDS7590.1. [O14639-1]
CCDS81508.1. [O14639-4]
CCDS81509.1. [O14639-6]
RefSeqiNP_001003407.1. NM_001003407.1. [O14639-2]
NP_001003408.1. NM_001003408.1.
NP_001309811.1. NM_001322882.1. [O14639-6]
NP_001309821.1. NM_001322892.1. [O14639-3]
NP_001309822.1. NM_001322893.1. [O14639-3]
NP_001309825.1. NM_001322896.1. [O14639-4]
NP_002304.3. NM_002313.5. [O14639-1]
NP_006711.3. NM_006720.3. [O14639-5]
UniGeneiHs.438236.
Hs.538331.
Hs.593868.

Genome annotation databases

EnsembliENST00000277895; ENSP00000277895; ENSG00000099204. [O14639-1]
ENST00000369253; ENSP00000358257; ENSG00000099204. [O14639-4]
ENST00000369256; ENSP00000358260; ENSG00000099204. [O14639-6]
ENST00000392952; ENSP00000376679; ENSG00000099204. [O14639-5]
ENST00000392955; ENSP00000376682; ENSG00000099204. [O14639-2]
GeneIDi3983.
KEGGihsa:3983.
UCSCiuc057wcr.1. human. [O14639-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABLM1_HUMAN
AccessioniPrimary (citable) accession number: O14639
Secondary accession number(s): A6NI16
, A6NJ06, A8MXA9, B3KVH2, Q15039, Q5JVV1, Q5JVV2, Q5T6N2, Q5T6N3, Q5T6N5, Q68CQ9, Q9BUP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: September 23, 2008
Last modified: August 30, 2017
This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot