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O14628 (ZN195_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 195
Gene names
Name:ZNF195
Synonyms:ZNFP104
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length629 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in adult lung, liver and kidney.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence BAG57121.1 differs from that shown. Reason: Frameshift at position 118.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O14628-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O14628-2)

Also known as: B;

The sequence of this isoform is not available.
Isoform 3 (identifier: O14628-3)

Also known as: C;

The sequence of this isoform is not available.
Isoform 4 (identifier: O14628-4)

The sequence of this isoform differs from the canonical sequence as follows:
     76-147: Missing.
Isoform 5 (identifier: O14628-5)

The sequence of this isoform differs from the canonical sequence as follows:
     125-147: Missing.
Isoform 6 (identifier: O14628-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     125-147: Missing.
Isoform 7 (identifier: O14628-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     76-147: Missing.
Isoform 8 (identifier: O14628-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     76-86: EMGFHHATQAC → GIFFVVTMEII
     87-629: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 629629Zinc finger protein 195
PRO_0000047447

Regions

Domain4 – 7572KRAB
Zinc finger244 – 26623C2H2-type 1
Zinc finger272 – 29423C2H2-type 2; degenerate
Zinc finger410 – 43223C2H2-type 3
Zinc finger438 – 46023C2H2-type 4
Zinc finger466 – 48823C2H2-type 5
Zinc finger494 – 51623C2H2-type 6
Zinc finger522 – 54423C2H2-type 7
Zinc finger550 – 57223C2H2-type 8
Zinc finger578 – 60023C2H2-type 9
Zinc finger606 – 62823C2H2-type 10
Region76 – 243168Spacer

Amino acid modifications

Modified residue4081N6-acetyllysine Ref.7

Natural variations

Alternative sequence11M → MAGAQ in isoform 6, isoform 7 and isoform 8.
VSP_036879
Alternative sequence76 – 14772Missing in isoform 4 and isoform 7.
VSP_036880
Alternative sequence76 – 8611EMGFHHATQAC → GIFFVVTMEII in isoform 8.
VSP_045071
Alternative sequence87 – 629543Missing in isoform 8.
VSP_045072
Alternative sequence125 – 14723Missing in isoform 5 and isoform 6.
VSP_036881

Experimental info

Sequence conflict2901P → R in BAG53114. Ref.2
Sequence conflict352 – 40756Missing in BAD18466. Ref.2
Sequence conflict5581V → A in AAB86596. Ref.1
Sequence conflict5701K → Q in AAB86596. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (A) [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: D048217DFC6BFDFB

FASTA62972,332
        10         20         30         40         50         60 
MTLLTFRDVA IEFSLEEWKC LDLAQQNLYR DVMLENYRNL FSVGLTVCKP GLITCLEQRK 

        70         80         90        100        110        120 
EPWNVKRQEA ADGHPEMGFH HATQACLELL GSSDLPASAS QSAGITGVNH RAQPGLNVSV 

       130        140        150        160        170        180 
DKFTALCSPG VLQTVKWFLE FRCIFSLAMS SHFTQDLLPE QGIQDAFPKR ILRGYGNCGL 

       190        200        210        220        230        240 
DNLYLRKDWE SLDECKLQKD YNGLNQCSST THSKIFQYNK YVKIFDNFSN LHRRNISNTG 

       250        260        270        280        290        300 
EKPFKCQECG KSFQMLSFLT EHQKIHTGKK FQKCGECGKT FIQCSHFTEP ENIDTGEKPY 

       310        320        330        340        350        360 
KCQECNNVIK TCSVLTKNRI YAGGEHYRCE EFGKVFNQCS HLTEHEHGTE EKPCKYEECS 

       370        380        390        400        410        420 
SVFISCSSLS NQQMILAGEK LSKCETWYKG FNHSPNPSKH QRNEIGGKPF KCEECDSIFK 

       430        440        450        460        470        480 
WFSDLTKHKR IHTGEKPYKC DECGKAYTQS SHLSEHRRIH TGEKPYQCEE CGKVFRTCSS 

       490        500        510        520        530        540 
LSNHKRTHSE EKPYTCEECG NIFKQLSDLT KHKKTHTGEK PYKCDECGKN FTQSSNLIVH 

       550        560        570        580        590        600 
KRIHTGEKPY KCEECGRVFM WFSDITKHKK THTGEKPYKC DECGKNFTQS SNLIVHKRIH 

       610        620 
TGEKPYKCEK CGKAFTQFSH LTVHESIHT 

« Hide

Isoform 2 (B) (Sequence not available).
Isoform 3 (C) (Sequence not available).
Isoform 4 [UniParc].

Checksum: 5E06D5041ACBAB0E
Show »

FASTA55764,658
Isoform 5 [UniParc].

Checksum: 2D48AE52C8AE69F8
Show »

FASTA60669,692
Isoform 6 [UniParc].

Checksum: BE8A3DF20C7FF02C
Show »

FASTA61070,019
Isoform 7 [UniParc].

Checksum: 2BDEFB89E8A73BA4
Show »

FASTA56164,986
Isoform 8 [UniParc].

Checksum: 2190262F0173ED6D
Show »

FASTA9010,364

References

« Hide 'large scale' references
[1]"Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5."
Hussey D.J., Parker N.J., Hussey N.D., Little P.F.R., Dobrovic A.
Genomics 45:451-455(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4; 6 AND 7).
Tissue: Brain, Cerebellum and Subthalamic nucleus.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Stomach.
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 8).
Tissue: Retinoblastoma.
[7]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF003540 mRNA. Translation: AAB86596.1.
AK095720 mRNA. Translation: BAG53114.1.
AK131296 mRNA. Translation: BAD18466.1.
AK290099 mRNA. Translation: BAF82788.1.
AK293679 mRNA. Translation: BAG57121.1. Frameshift.
AL833722 mRNA. Translation: CAH56261.1.
AC123788 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02548.1.
CH471158 Genomic DNA. Translation: EAX02549.1.
BC121028 mRNA. Translation: AAI21029.1.
BC121029 mRNA. Translation: AAI21030.1.
BM462194 mRNA. No translation available.
RefSeqNP_001123991.1. NM_001130519.2.
NP_001123992.1. NM_001130520.2.
NP_001229770.1. NM_001242841.1.
NP_001229771.1. NM_001242842.1.
NP_001229772.1. NM_001242843.1.
NP_001243752.1. NM_001256823.1.
NP_001243753.1. NM_001256824.1.
NP_001243754.1. NM_001256825.1.
NP_009083.2. NM_007152.4.
UniGeneHs.386294.

3D structure databases

ProteinModelPortalO14628.
SMRO14628. Positions 1-52, 190-629.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113532. 3 interactions.
IntActO14628. 2 interactions.
STRING9606.ENSP00000005082.

PTM databases

PhosphoSiteO14628.

2D gel databases

REPRODUCTION-2DPAGEO14628.

Proteomic databases

PaxDbO14628.
PRIDEO14628.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000005082; ENSP00000005082; ENSG00000005801. [O14628-5]
ENST00000343338; ENSP00000344483; ENSG00000005801. [O14628-7]
ENST00000354599; ENSP00000346613; ENSG00000005801. [O14628-4]
ENST00000399602; ENSP00000382511; ENSG00000005801. [O14628-1]
ENST00000429541; ENSP00000387998; ENSG00000005801. [O14628-7]
ENST00000438262; ENSP00000414353; ENSG00000005801. [O14628-8]
ENST00000526601; ENSP00000435828; ENSG00000005801. [O14628-6]
ENST00000528218; ENSP00000436384; ENSG00000005801. [O14628-8]
GeneID7748.
KEGGhsa:7748.
UCSCuc001lxs.3. human. [O14628-4]
uc001lxt.3. human. [O14628-1]
uc001lxu.3. human. [O14628-7]
uc001lxv.3. human. [O14628-5]
uc010qxr.2. human. [O14628-6]
uc031pyi.1. human.

Organism-specific databases

CTD7748.
GeneCardsGC11M003336.
HGNCHGNC:12986. ZNF195.
HPAHPA030605.
MIM602187. gene.
neXtProtNX_O14628.
PharmGKBPA37566.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOVERGENHBG018163.
InParanoidO14628.
KOK09228.
OMAAYTQSSH.
OrthoDBEOG7KSX7Q.
PhylomeDBO14628.
TreeFamTF342117.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressO14628.
BgeeO14628.
CleanExHS_ZNF195.
GenevestigatorO14628.

Family and domain databases

Gene3D3.30.160.60. 11 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF195. human.
GenomeRNAi7748.
NextBio29986.
PROO14628.
SOURCESearch...

Entry information

Entry nameZN195_HUMAN
AccessionPrimary (citable) accession number: O14628
Secondary accession number(s): A8K234 expand/collapse secondary AC list , B3KTK2, B4DEL0, C9JLY9, L7MNK2, Q0VAJ6, Q658N8, Q6ZNA9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM