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Protein

Zinc finger protein 195

Gene

ZNF195

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 266C2H2-type 1Add BLAST23
Zinc fingeri272 – 294C2H2-type 2; degenerateAdd BLAST23
Zinc fingeri410 – 432C2H2-type 3Add BLAST23
Zinc fingeri438 – 460C2H2-type 4Add BLAST23
Zinc fingeri466 – 488C2H2-type 5Add BLAST23
Zinc fingeri494 – 516C2H2-type 6Add BLAST23
Zinc fingeri522 – 544C2H2-type 7Add BLAST23
Zinc fingeri550 – 572C2H2-type 8Add BLAST23
Zinc fingeri578 – 600C2H2-type 9Add BLAST23
Zinc fingeri606 – 628C2H2-type 10Add BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 195
Gene namesi
Name:ZNF195
Synonyms:ZNFP104
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000005801.16.
HGNCiHGNC:12986. ZNF195.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7748.
OpenTargetsiENSG00000005801.
PharmGKBiPA37566.

Polymorphism and mutation databases

BioMutaiZNF195.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474471 – 629Zinc finger protein 195Add BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki383Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei408N6-acetyllysineCombined sources1
Cross-linki492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiO14628.
PaxDbiO14628.
PeptideAtlasiO14628.
PRIDEiO14628.

2D gel databases

REPRODUCTION-2DPAGEiO14628.

PTM databases

iPTMnetiO14628.
PhosphoSitePlusiO14628.

Expressioni

Tissue specificityi

Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in adult lung, liver and kidney.

Gene expression databases

BgeeiENSG00000005801.
CleanExiHS_ZNF195.
ExpressionAtlasiO14628. baseline and differential.
GenevisibleiO14628. HS.

Organism-specific databases

HPAiHPA030605.

Interactioni

Protein-protein interaction databases

BioGridi113532. 16 interactors.
IntActiO14628. 2 interactors.
STRINGi9606.ENSP00000382511.

Structurei

3D structure databases

ProteinModelPortaliO14628.
SMRiO14628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 243SpacerAdd BLAST168

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 266C2H2-type 1Add BLAST23
Zinc fingeri272 – 294C2H2-type 2; degenerateAdd BLAST23
Zinc fingeri410 – 432C2H2-type 3Add BLAST23
Zinc fingeri438 – 460C2H2-type 4Add BLAST23
Zinc fingeri466 – 488C2H2-type 5Add BLAST23
Zinc fingeri494 – 516C2H2-type 6Add BLAST23
Zinc fingeri522 – 544C2H2-type 7Add BLAST23
Zinc fingeri550 – 572C2H2-type 8Add BLAST23
Zinc fingeri578 – 600C2H2-type 9Add BLAST23
Zinc fingeri606 – 628C2H2-type 10Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139354.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiO14628.
KOiK09228.
PhylomeDBiO14628.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 3 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14628-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLLTFRDVA IEFSLEEWKC LDLAQQNLYR DVMLENYRNL FSVGLTVCKP
60 70 80 90 100
GLITCLEQRK EPWNVKRQEA ADGHPEMGFH HATQACLELL GSSDLPASAS
110 120 130 140 150
QSAGITGVNH RAQPGLNVSV DKFTALCSPG VLQTVKWFLE FRCIFSLAMS
160 170 180 190 200
SHFTQDLLPE QGIQDAFPKR ILRGYGNCGL DNLYLRKDWE SLDECKLQKD
210 220 230 240 250
YNGLNQCSST THSKIFQYNK YVKIFDNFSN LHRRNISNTG EKPFKCQECG
260 270 280 290 300
KSFQMLSFLT EHQKIHTGKK FQKCGECGKT FIQCSHFTEP ENIDTGEKPY
310 320 330 340 350
KCQECNNVIK TCSVLTKNRI YAGGEHYRCE EFGKVFNQCS HLTEHEHGTE
360 370 380 390 400
EKPCKYEECS SVFISCSSLS NQQMILAGEK LSKCETWYKG FNHSPNPSKH
410 420 430 440 450
QRNEIGGKPF KCEECDSIFK WFSDLTKHKR IHTGEKPYKC DECGKAYTQS
460 470 480 490 500
SHLSEHRRIH TGEKPYQCEE CGKVFRTCSS LSNHKRTHSE EKPYTCEECG
510 520 530 540 550
NIFKQLSDLT KHKKTHTGEK PYKCDECGKN FTQSSNLIVH KRIHTGEKPY
560 570 580 590 600
KCEECGRVFM WFSDITKHKK THTGEKPYKC DECGKNFTQS SNLIVHKRIH
610 620
TGEKPYKCEK CGKAFTQFSH LTVHESIHT
Length:629
Mass (Da):72,332
Last modified:September 23, 2008 - v2
Checksum:iD048217DFC6BFDFB
GO
Isoform 2 (identifier: O14628-2)
Also known as: B
Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: O14628-3)
Also known as: C
Sequence is not available
Length:
Mass (Da):
Isoform 4 (identifier: O14628-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-147: Missing.

Show »
Length:557
Mass (Da):64,658
Checksum:i5E06D5041ACBAB0E
GO
Isoform 5 (identifier: O14628-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-147: Missing.

Show »
Length:606
Mass (Da):69,692
Checksum:i2D48AE52C8AE69F8
GO
Isoform 6 (identifier: O14628-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     125-147: Missing.

Show »
Length:610
Mass (Da):70,019
Checksum:iBE8A3DF20C7FF02C
GO
Isoform 7 (identifier: O14628-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     76-147: Missing.

Show »
Length:561
Mass (Da):64,986
Checksum:i2BDEFB89E8A73BA4
GO
Isoform 8 (identifier: O14628-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     76-86: EMGFHHATQAC → GIFFVVTMEII
     87-629: Missing.

Note: No experimental confirmation available.
Show »
Length:90
Mass (Da):10,364
Checksum:i2190262F0173ED6D
GO

Sequence cautioni

The sequence BAG57121 differs from that shown. Reason: Frameshift at position 118.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290P → R in BAG53114 (PubMed:14702039).Curated1
Sequence conflicti352 – 407Missing in BAD18466 (PubMed:14702039).CuratedAdd BLAST56
Sequence conflicti558V → A in AAB86596 (PubMed:9344677).Curated1
Sequence conflicti570K → Q in AAB86596 (PubMed:9344677).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0368791M → MAGAQ in isoform 6, isoform 7 and isoform 8. 2 Publications1
Alternative sequenceiVSP_03688076 – 147Missing in isoform 4 and isoform 7. 3 PublicationsAdd BLAST72
Alternative sequenceiVSP_04507176 – 86EMGFHHATQAC → GIFFVVTMEII in isoform 8. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_04507287 – 629Missing in isoform 8. 1 PublicationAdd BLAST543
Alternative sequenceiVSP_036881125 – 147Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003540 mRNA. Translation: AAB86596.1.
AK095720 mRNA. Translation: BAG53114.1.
AK131296 mRNA. Translation: BAD18466.1.
AK290099 mRNA. Translation: BAF82788.1.
AK293679 mRNA. Translation: BAG57121.1. Frameshift.
AL833722 mRNA. Translation: CAH56261.1.
AC123788 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02548.1.
CH471158 Genomic DNA. Translation: EAX02549.1.
BC121028 mRNA. Translation: AAI21029.1.
BC121029 mRNA. Translation: AAI21030.1.
BM462194 mRNA. No translation available.
CCDSiCCDS41604.1. [O14628-4]
CCDS44521.1. [O14628-5]
CCDS44522.1. [O14628-1]
CCDS55736.1. [O14628-7]
CCDS55737.1. [O14628-6]
CCDS58111.1. [O14628-8]
RefSeqiNP_001123991.1. NM_001130519.2. [O14628-5]
NP_001123992.1. NM_001130520.2. [O14628-1]
NP_001229770.1. NM_001242841.1. [O14628-6]
NP_001229771.1. NM_001242842.1.
NP_001229772.1. NM_001242843.1. [O14628-7]
NP_001243752.1. NM_001256823.1. [O14628-8]
NP_001243753.1. NM_001256824.1.
NP_001243754.1. NM_001256825.1. [O14628-7]
NP_009083.2. NM_007152.4. [O14628-4]
XP_016873752.1. XM_017018263.1. [O14628-6]
UniGeneiHs.386294.

Genome annotation databases

EnsembliENST00000005082; ENSP00000005082; ENSG00000005801. [O14628-5]
ENST00000343338; ENSP00000344483; ENSG00000005801. [O14628-7]
ENST00000354599; ENSP00000346613; ENSG00000005801. [O14628-4]
ENST00000399602; ENSP00000382511; ENSG00000005801. [O14628-1]
ENST00000429541; ENSP00000387998; ENSG00000005801. [O14628-7]
ENST00000438262; ENSP00000414353; ENSG00000005801. [O14628-8]
ENST00000526601; ENSP00000435828; ENSG00000005801. [O14628-6]
ENST00000528218; ENSP00000436384; ENSG00000005801. [O14628-8]
ENST00000618467; ENSP00000482411; ENSG00000005801. [O14628-8]
GeneIDi7748.
KEGGihsa:7748.
UCSCiuc001lxs.4. human. [O14628-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN195_HUMAN
AccessioniPrimary (citable) accession number: O14628
Secondary accession number(s): A8K234
, B3KTK2, B4DEL0, C9JLY9, L7MNK2, Q0VAJ6, Q658N8, Q6ZNA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: October 25, 2017
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families