SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O14628

- ZN195_HUMAN

UniProt

O14628 - ZN195_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Zinc finger protein 195
Gene
ZNF195, ZNFP104
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri244 – 26623C2H2-type 1
Add
BLAST
Zinc fingeri272 – 29423C2H2-type 2; degenerate
Add
BLAST
Zinc fingeri410 – 43223C2H2-type 3
Add
BLAST
Zinc fingeri438 – 46023C2H2-type 4
Add
BLAST
Zinc fingeri466 – 48823C2H2-type 5
Add
BLAST
Zinc fingeri494 – 51623C2H2-type 6
Add
BLAST
Zinc fingeri522 – 54423C2H2-type 7
Add
BLAST
Zinc fingeri550 – 57223C2H2-type 8
Add
BLAST
Zinc fingeri578 – 60023C2H2-type 9
Add
BLAST
Zinc fingeri606 – 62823C2H2-type 10
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 195
Gene namesi
Name:ZNF195
Synonyms:ZNFP104
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:12986. ZNF195.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 629629Zinc finger protein 195
PRO_0000047447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei408 – 4081N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO14628.
PaxDbiO14628.
PRIDEiO14628.

2D gel databases

REPRODUCTION-2DPAGEO14628.

PTM databases

PhosphoSiteiO14628.

Expressioni

Tissue specificityi

Expressed in adult heart, brain, placenta, skeletal muscle and pancreas, and in fetal lung, kidney and brain. There is little expression in adult lung, liver and kidney.

Gene expression databases

ArrayExpressiO14628.
BgeeiO14628.
CleanExiHS_ZNF195.
GenevestigatoriO14628.

Organism-specific databases

HPAiHPA030605.

Interactioni

Protein-protein interaction databases

BioGridi113532. 3 interactions.
IntActiO14628. 2 interactions.
STRINGi9606.ENSP00000005082.

Structurei

3D structure databases

ProteinModelPortaliO14628.
SMRiO14628. Positions 1-52, 190-629.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRAB
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 243168Spacer
Add
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOVERGENiHBG018163.
InParanoidiO14628.
KOiK09228.
OMAiAYTQSSH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiO14628.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14628-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTLLTFRDVA IEFSLEEWKC LDLAQQNLYR DVMLENYRNL FSVGLTVCKP    50
GLITCLEQRK EPWNVKRQEA ADGHPEMGFH HATQACLELL GSSDLPASAS 100
QSAGITGVNH RAQPGLNVSV DKFTALCSPG VLQTVKWFLE FRCIFSLAMS 150
SHFTQDLLPE QGIQDAFPKR ILRGYGNCGL DNLYLRKDWE SLDECKLQKD 200
YNGLNQCSST THSKIFQYNK YVKIFDNFSN LHRRNISNTG EKPFKCQECG 250
KSFQMLSFLT EHQKIHTGKK FQKCGECGKT FIQCSHFTEP ENIDTGEKPY 300
KCQECNNVIK TCSVLTKNRI YAGGEHYRCE EFGKVFNQCS HLTEHEHGTE 350
EKPCKYEECS SVFISCSSLS NQQMILAGEK LSKCETWYKG FNHSPNPSKH 400
QRNEIGGKPF KCEECDSIFK WFSDLTKHKR IHTGEKPYKC DECGKAYTQS 450
SHLSEHRRIH TGEKPYQCEE CGKVFRTCSS LSNHKRTHSE EKPYTCEECG 500
NIFKQLSDLT KHKKTHTGEK PYKCDECGKN FTQSSNLIVH KRIHTGEKPY 550
KCEECGRVFM WFSDITKHKK THTGEKPYKC DECGKNFTQS SNLIVHKRIH 600
TGEKPYKCEK CGKAFTQFSH LTVHESIHT 629
Length:629
Mass (Da):72,332
Last modified:September 23, 2008 - v2
Checksum:iD048217DFC6BFDFB
GO
Isoform 2 (identifier: O14628-2)

Also known as: B

Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: O14628-3)

Also known as: C

Sequence is not available
Length:
Mass (Da):
Isoform 4 (identifier: O14628-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-147: Missing.

Show »
Length:557
Mass (Da):64,658
Checksum:i5E06D5041ACBAB0E
GO
Isoform 5 (identifier: O14628-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-147: Missing.

Show »
Length:606
Mass (Da):69,692
Checksum:i2D48AE52C8AE69F8
GO
Isoform 6 (identifier: O14628-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     125-147: Missing.

Show »
Length:610
Mass (Da):70,019
Checksum:iBE8A3DF20C7FF02C
GO
Isoform 7 (identifier: O14628-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     76-147: Missing.

Show »
Length:561
Mass (Da):64,986
Checksum:i2BDEFB89E8A73BA4
GO
Isoform 8 (identifier: O14628-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGAQ
     76-86: EMGFHHATQAC → GIFFVVTMEII
     87-629: Missing.

Note: No experimental confirmation available.

Show »
Length:90
Mass (Da):10,364
Checksum:i2190262F0173ED6D
GO

Sequence cautioni

The sequence BAG57121.1 differs from that shown. Reason: Frameshift at position 118.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MAGAQ in isoform 6, isoform 7 and isoform 8.
VSP_036879
Alternative sequencei76 – 14772Missing in isoform 4 and isoform 7.
VSP_036880Add
BLAST
Alternative sequencei76 – 8611EMGFHHATQAC → GIFFVVTMEII in isoform 8.
VSP_045071Add
BLAST
Alternative sequencei87 – 629543Missing in isoform 8.
VSP_045072Add
BLAST
Alternative sequencei125 – 14723Missing in isoform 5 and isoform 6.
VSP_036881Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901P → R in BAG53114. 1 Publication
Sequence conflicti352 – 40756Missing in BAD18466. 1 Publication
Add
BLAST
Sequence conflicti558 – 5581V → A in AAB86596. 1 Publication
Sequence conflicti570 – 5701K → Q in AAB86596. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003540 mRNA. Translation: AAB86596.1.
AK095720 mRNA. Translation: BAG53114.1.
AK131296 mRNA. Translation: BAD18466.1.
AK290099 mRNA. Translation: BAF82788.1.
AK293679 mRNA. Translation: BAG57121.1. Frameshift.
AL833722 mRNA. Translation: CAH56261.1.
AC123788 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02548.1.
CH471158 Genomic DNA. Translation: EAX02549.1.
BC121028 mRNA. Translation: AAI21029.1.
BC121029 mRNA. Translation: AAI21030.1.
BM462194 mRNA. No translation available.
CCDSiCCDS41604.1. [O14628-4]
CCDS44521.1. [O14628-5]
CCDS44522.1. [O14628-1]
CCDS55736.1. [O14628-7]
CCDS55737.1. [O14628-6]
CCDS58111.1. [O14628-8]
RefSeqiNP_001123991.1. NM_001130519.2. [O14628-5]
NP_001123992.1. NM_001130520.2. [O14628-1]
NP_001229770.1. NM_001242841.1. [O14628-6]
NP_001229771.1. NM_001242842.1.
NP_001229772.1. NM_001242843.1. [O14628-7]
NP_001243752.1. NM_001256823.1. [O14628-8]
NP_001243753.1. NM_001256824.1.
NP_001243754.1. NM_001256825.1. [O14628-7]
NP_009083.2. NM_007152.4. [O14628-4]
UniGeneiHs.386294.

Genome annotation databases

EnsembliENST00000005082; ENSP00000005082; ENSG00000005801. [O14628-5]
ENST00000343338; ENSP00000344483; ENSG00000005801. [O14628-7]
ENST00000354599; ENSP00000346613; ENSG00000005801. [O14628-4]
ENST00000399602; ENSP00000382511; ENSG00000005801. [O14628-1]
ENST00000429541; ENSP00000387998; ENSG00000005801. [O14628-7]
ENST00000438262; ENSP00000414353; ENSG00000005801. [O14628-8]
ENST00000526601; ENSP00000435828; ENSG00000005801. [O14628-6]
ENST00000528218; ENSP00000436384; ENSG00000005801. [O14628-8]
GeneIDi7748.
KEGGihsa:7748.
UCSCiuc001lxs.3. human. [O14628-4]
uc001lxt.3. human. [O14628-1]
uc001lxu.3. human. [O14628-7]
uc001lxv.3. human. [O14628-5]
uc010qxr.2. human. [O14628-6]
uc031pyi.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003540 mRNA. Translation: AAB86596.1 .
AK095720 mRNA. Translation: BAG53114.1 .
AK131296 mRNA. Translation: BAD18466.1 .
AK290099 mRNA. Translation: BAF82788.1 .
AK293679 mRNA. Translation: BAG57121.1 . Frameshift.
AL833722 mRNA. Translation: CAH56261.1 .
AC123788 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02548.1 .
CH471158 Genomic DNA. Translation: EAX02549.1 .
BC121028 mRNA. Translation: AAI21029.1 .
BC121029 mRNA. Translation: AAI21030.1 .
BM462194 mRNA. No translation available.
CCDSi CCDS41604.1. [O14628-4 ]
CCDS44521.1. [O14628-5 ]
CCDS44522.1. [O14628-1 ]
CCDS55736.1. [O14628-7 ]
CCDS55737.1. [O14628-6 ]
CCDS58111.1. [O14628-8 ]
RefSeqi NP_001123991.1. NM_001130519.2. [O14628-5 ]
NP_001123992.1. NM_001130520.2. [O14628-1 ]
NP_001229770.1. NM_001242841.1. [O14628-6 ]
NP_001229771.1. NM_001242842.1.
NP_001229772.1. NM_001242843.1. [O14628-7 ]
NP_001243752.1. NM_001256823.1. [O14628-8 ]
NP_001243753.1. NM_001256824.1.
NP_001243754.1. NM_001256825.1. [O14628-7 ]
NP_009083.2. NM_007152.4. [O14628-4 ]
UniGenei Hs.386294.

3D structure databases

ProteinModelPortali O14628.
SMRi O14628. Positions 1-52, 190-629.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113532. 3 interactions.
IntActi O14628. 2 interactions.
STRINGi 9606.ENSP00000005082.

PTM databases

PhosphoSitei O14628.

2D gel databases

REPRODUCTION-2DPAGE O14628.

Proteomic databases

MaxQBi O14628.
PaxDbi O14628.
PRIDEi O14628.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000005082 ; ENSP00000005082 ; ENSG00000005801 . [O14628-5 ]
ENST00000343338 ; ENSP00000344483 ; ENSG00000005801 . [O14628-7 ]
ENST00000354599 ; ENSP00000346613 ; ENSG00000005801 . [O14628-4 ]
ENST00000399602 ; ENSP00000382511 ; ENSG00000005801 . [O14628-1 ]
ENST00000429541 ; ENSP00000387998 ; ENSG00000005801 . [O14628-7 ]
ENST00000438262 ; ENSP00000414353 ; ENSG00000005801 . [O14628-8 ]
ENST00000526601 ; ENSP00000435828 ; ENSG00000005801 . [O14628-6 ]
ENST00000528218 ; ENSP00000436384 ; ENSG00000005801 . [O14628-8 ]
GeneIDi 7748.
KEGGi hsa:7748.
UCSCi uc001lxs.3. human. [O14628-4 ]
uc001lxt.3. human. [O14628-1 ]
uc001lxu.3. human. [O14628-7 ]
uc001lxv.3. human. [O14628-5 ]
uc010qxr.2. human. [O14628-6 ]
uc031pyi.1. human.

Organism-specific databases

CTDi 7748.
GeneCardsi GC11M003336.
HGNCi HGNC:12986. ZNF195.
HPAi HPA030605.
MIMi 602187. gene.
neXtProti NX_O14628.
PharmGKBi PA37566.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOVERGENi HBG018163.
InParanoidi O14628.
KOi K09228.
OMAi AYTQSSH.
OrthoDBi EOG7KSX7Q.
PhylomeDBi O14628.
TreeFami TF342117.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF195. human.
GenomeRNAii 7748.
NextBioi 29986.
PROi O14628.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14628.
Bgeei O14628.
CleanExi HS_ZNF195.
Genevestigatori O14628.

Family and domain databases

Gene3Di 3.30.160.60. 11 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5."
    Hussey D.J., Parker N.J., Hussey N.D., Little P.F.R., Dobrovic A.
    Genomics 45:451-455(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4; 6 AND 7).
    Tissue: Brain, Cerebellum and Subthalamic nucleus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Stomach.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 8).
    Tissue: Retinoblastoma.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN195_HUMAN
AccessioniPrimary (citable) accession number: O14628
Secondary accession number(s): A8K234
, B3KTK2, B4DEL0, C9JLY9, L7MNK2, Q0VAJ6, Q658N8, Q6ZNA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi