SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O14627

- CDX4_HUMAN

UniProt

O14627 - CDX4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Homeobox protein CDX-4
Gene
CDX4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi173 – 23260Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
  2. transcription regulatory region sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. blood vessel development Source: Ensembl
  3. labyrinthine layer development Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-4
Alternative name(s):
Caudal-type homeobox protein 4
Gene namesi
Name:CDX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:1808. CDX4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Homeobox protein CDX-4
PRO_0000048852Add
BLAST

Proteomic databases

PaxDbiO14627.
PRIDEiO14627.

PTM databases

PhosphoSiteiO14627.

Expressioni

Gene expression databases

BgeeiO14627.
CleanExiHS_CDX4.
GenevestigatoriO14627.

Organism-specific databases

HPAiHPA056528.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362613.

Structurei

3D structure databases

ProteinModelPortaliO14627.
SMRiO14627. Positions 177-230.

Family & Domainsi

Sequence similaritiesi

Belongs to the Caudal homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG291290.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiO14627.
KOiK09312.
OMAiSPYAWMR.
OrthoDBiEOG71P2BK.
PhylomeDBiO14627.
TreeFamiTF351605.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14627-1 [UniParc]FASTAAdd to Basket

« Hide

MYGSCLLEKE AGMYPGTLMS PGGDGTAGTG GTGGGGSPMP ASNFAAAPAF    50
SHYMGYPHMP SMDPHWPSLG VWGSPYSPPR EDWSVYPGPS STMGTVPVND 100
VTSSPAAFCS TDYSNLGPVG GGTSGSSLPG QAGGSLVPTD AGAAKASSPS 150
RSRHSPYAWM RKTVQVTGKT RTKEKYRVVY TDHQRLELEK EFHCNRYITI 200
QRKSELAVNL GLSERQVKIW FQNRRAKERK MIKKKISQFE NSGGSVQSDS 250
DSISPGELPN TFFTTPSAVR GFQPIEIQQV IVSE 284
Length:284
Mass (Da):30,480
Last modified:January 1, 1998 - v1
Checksum:i96D365D9F5F6D6D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003530 Genomic DNA. Translation: AAB66319.1.
AF029879, AF029877, AF029878 Genomic DNA. Translation: AAD01894.1.
AL450108 Genomic DNA. Translation: CAI40795.1.
CH471104 Genomic DNA. Translation: EAW98667.1.
BC128233 mRNA. Translation: AAI28234.1.
CCDSiCCDS14424.1.
RefSeqiNP_005184.1. NM_005193.1.
UniGeneiHs.553488.

Genome annotation databases

EnsembliENST00000373514; ENSP00000362613; ENSG00000131264.
GeneIDi1046.
KEGGihsa:1046.
UCSCiuc011mqk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003530 Genomic DNA. Translation: AAB66319.1 .
AF029879 , AF029877 , AF029878 Genomic DNA. Translation: AAD01894.1 .
AL450108 Genomic DNA. Translation: CAI40795.1 .
CH471104 Genomic DNA. Translation: EAW98667.1 .
BC128233 mRNA. Translation: AAI28234.1 .
CCDSi CCDS14424.1.
RefSeqi NP_005184.1. NM_005193.1.
UniGenei Hs.553488.

3D structure databases

ProteinModelPortali O14627.
SMRi O14627. Positions 177-230.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000362613.

PTM databases

PhosphoSitei O14627.

Proteomic databases

PaxDbi O14627.
PRIDEi O14627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373514 ; ENSP00000362613 ; ENSG00000131264 .
GeneIDi 1046.
KEGGi hsa:1046.
UCSCi uc011mqk.2. human.

Organism-specific databases

CTDi 1046.
GeneCardsi GC0XP072583.
HGNCi HGNC:1808. CDX4.
HPAi HPA056528.
MIMi 300025. gene.
neXtProti NX_O14627.
PharmGKBi PA26353.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG291290.
HOGENOMi HOG000115975.
HOVERGENi HBG005302.
InParanoidi O14627.
KOi K09312.
OMAi SPYAWMR.
OrthoDBi EOG71P2BK.
PhylomeDBi O14627.
TreeFami TF351605.

Miscellaneous databases

GenomeRNAii 1046.
NextBioi 4385.
PROi O14627.
SOURCEi Search...

Gene expression databases

Bgeei O14627.
CleanExi HS_CDX4.
Genevestigatori O14627.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Chen E.Y., States D.J., Mazzarella R.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genomic structure of the human CDX4 gene: a potential candidate for the FG syndrome."
    Chiaroni P., Colleaux L., Briault S., Lossi A.M., Moraine C., Fontes M.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCDX4_HUMAN
AccessioniPrimary (citable) accession number: O14627
Secondary accession number(s): A1A513, Q5JS20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi