Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein CDX-4

Gene

CDX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi173 – 232HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-4
Alternative name(s):
Caudal-type homeobox protein 4
Gene namesi
Name:CDX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000131264.3.
HGNCiHGNC:1808. CDX4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1046.
OpenTargetsiENSG00000131264.
PharmGKBiPA26353.

Polymorphism and mutation databases

BioMutaiCDX4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488521 – 284Homeobox protein CDX-4Add BLAST284

Proteomic databases

EPDiO14627.
MaxQBiO14627.
PaxDbiO14627.
PeptideAtlasiO14627.
PRIDEiO14627.

PTM databases

PhosphoSitePlusiO14627.

Expressioni

Gene expression databases

BgeeiENSG00000131264.
CleanExiHS_CDX4.
GenevisibleiO14627. HS.

Organism-specific databases

HPAiHPA056528.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107476. 6 interactors.
IntActiO14627. 6 interactors.
STRINGi9606.ENSP00000362613.

Structurei

3D structure databases

ProteinModelPortaliO14627.
SMRiO14627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0848. Eukaryota.
ENOG4111W2J. LUCA.
GeneTreeiENSGT00530000063388.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiO14627.
KOiK09312.
OMAiHCNRYIT.
OrthoDBiEOG091G0LXJ.
PhylomeDBiO14627.
TreeFamiTF351605.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR006820. Caudal_activation_dom.
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O14627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGSCLLEKE AGMYPGTLMS PGGDGTAGTG GTGGGGSPMP ASNFAAAPAF
60 70 80 90 100
SHYMGYPHMP SMDPHWPSLG VWGSPYSPPR EDWSVYPGPS STMGTVPVND
110 120 130 140 150
VTSSPAAFCS TDYSNLGPVG GGTSGSSLPG QAGGSLVPTD AGAAKASSPS
160 170 180 190 200
RSRHSPYAWM RKTVQVTGKT RTKEKYRVVY TDHQRLELEK EFHCNRYITI
210 220 230 240 250
QRKSELAVNL GLSERQVKIW FQNRRAKERK MIKKKISQFE NSGGSVQSDS
260 270 280
DSISPGELPN TFFTTPSAVR GFQPIEIQQV IVSE
Length:284
Mass (Da):30,480
Last modified:January 1, 1998 - v1
Checksum:i96D365D9F5F6D6D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003530 Genomic DNA. Translation: AAB66319.1.
AF029879, AF029877, AF029878 Genomic DNA. Translation: AAD01894.1.
AL450108 Genomic DNA. No translation available.
CH471104 Genomic DNA. Translation: EAW98667.1.
BC128233 mRNA. Translation: AAI28234.1.
CCDSiCCDS14424.1.
RefSeqiNP_005184.1. NM_005193.1.
UniGeneiHs.553488.

Genome annotation databases

EnsembliENST00000373514; ENSP00000362613; ENSG00000131264.
GeneIDi1046.
KEGGihsa:1046.
UCSCiuc011mqk.3. human.

Similar proteinsi

Entry informationi

Entry nameiCDX4_HUMAN
AccessioniPrimary (citable) accession number: O14627
Secondary accession number(s): A1A513, Q5JS20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families