Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein CDX-4

Gene

CDX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi173 – 23260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. blood vessel development Source: Ensembl
  3. labyrinthine layer development Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein CDX-4
Alternative name(s):
Caudal-type homeobox protein 4
Gene namesi
Name:CDX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:1808. CDX4.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Homeobox protein CDX-4PRO_0000048852Add
BLAST

Proteomic databases

PaxDbiO14627.
PRIDEiO14627.

PTM databases

PhosphoSiteiO14627.

Expressioni

Gene expression databases

BgeeiO14627.
CleanExiHS_CDX4.
GenevestigatoriO14627.

Organism-specific databases

HPAiHPA056528.

Interactioni

Protein-protein interaction databases

BioGridi107476. 6 interactions.
STRINGi9606.ENSP00000362613.

Structurei

3D structure databases

ProteinModelPortaliO14627.
SMRiO14627. Positions 177-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Caudal homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG291290.
GeneTreeiENSGT00530000063388.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiO14627.
KOiK09312.
OMAiSPYAWMR.
OrthoDBiEOG71P2BK.
PhylomeDBiO14627.
TreeFamiTF351605.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGSCLLEKE AGMYPGTLMS PGGDGTAGTG GTGGGGSPMP ASNFAAAPAF
60 70 80 90 100
SHYMGYPHMP SMDPHWPSLG VWGSPYSPPR EDWSVYPGPS STMGTVPVND
110 120 130 140 150
VTSSPAAFCS TDYSNLGPVG GGTSGSSLPG QAGGSLVPTD AGAAKASSPS
160 170 180 190 200
RSRHSPYAWM RKTVQVTGKT RTKEKYRVVY TDHQRLELEK EFHCNRYITI
210 220 230 240 250
QRKSELAVNL GLSERQVKIW FQNRRAKERK MIKKKISQFE NSGGSVQSDS
260 270 280
DSISPGELPN TFFTTPSAVR GFQPIEIQQV IVSE
Length:284
Mass (Da):30,480
Last modified:December 31, 1997 - v1
Checksum:i96D365D9F5F6D6D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003530 Genomic DNA. Translation: AAB66319.1.
AF029879, AF029877, AF029878 Genomic DNA. Translation: AAD01894.1.
AL450108 Genomic DNA. Translation: CAI40795.1.
CH471104 Genomic DNA. Translation: EAW98667.1.
BC128233 mRNA. Translation: AAI28234.1.
CCDSiCCDS14424.1.
RefSeqiNP_005184.1. NM_005193.1.
UniGeneiHs.553488.

Genome annotation databases

EnsembliENST00000373514; ENSP00000362613; ENSG00000131264.
GeneIDi1046.
KEGGihsa:1046.
UCSCiuc011mqk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003530 Genomic DNA. Translation: AAB66319.1.
AF029879, AF029877, AF029878 Genomic DNA. Translation: AAD01894.1.
AL450108 Genomic DNA. Translation: CAI40795.1.
CH471104 Genomic DNA. Translation: EAW98667.1.
BC128233 mRNA. Translation: AAI28234.1.
CCDSiCCDS14424.1.
RefSeqiNP_005184.1. NM_005193.1.
UniGeneiHs.553488.

3D structure databases

ProteinModelPortaliO14627.
SMRiO14627. Positions 177-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107476. 6 interactions.
STRINGi9606.ENSP00000362613.

PTM databases

PhosphoSiteiO14627.

Proteomic databases

PaxDbiO14627.
PRIDEiO14627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373514; ENSP00000362613; ENSG00000131264.
GeneIDi1046.
KEGGihsa:1046.
UCSCiuc011mqk.2. human.

Organism-specific databases

CTDi1046.
GeneCardsiGC0XP072583.
HGNCiHGNC:1808. CDX4.
HPAiHPA056528.
MIMi300025. gene.
neXtProtiNX_O14627.
PharmGKBiPA26353.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG291290.
GeneTreeiENSGT00530000063388.
HOGENOMiHOG000115975.
HOVERGENiHBG005302.
InParanoidiO14627.
KOiK09312.
OMAiSPYAWMR.
OrthoDBiEOG71P2BK.
PhylomeDBiO14627.
TreeFamiTF351605.

Miscellaneous databases

GenomeRNAii1046.
NextBioi4385.
PROiO14627.
SOURCEiSearch...

Gene expression databases

BgeeiO14627.
CleanExiHS_CDX4.
GenevestigatoriO14627.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR006820. Caudal_activation_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF04731. Caudal_act. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Chen E.Y., States D.J., Mazzarella R.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Genomic structure of the human CDX4 gene: a potential candidate for the FG syndrome."
    Chiaroni P., Colleaux L., Briault S., Lossi A.M., Moraine C., Fontes M.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCDX4_HUMAN
AccessioniPrimary (citable) accession number: O14627
Secondary accession number(s): A1A513, Q5JS20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1998
Last sequence update: December 31, 1997
Last modified: February 3, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.