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O14626

- GP171_HUMAN

UniProt

O14626 - GP171_HUMAN

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Protein

Probable G-protein coupled receptor 171

Gene

GPR171

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 171
Alternative name(s):
G-protein coupled receptor H963
Gene namesi
Name:GPR171
Synonyms:H963
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:30057. GPR171.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei22 – 4221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini43 – 486CytoplasmicSequence Analysis
Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini70 – 8920ExtracellularSequence AnalysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini111 – 13222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei133 – 15321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini154 – 18128ExtracellularSequence AnalysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini203 – 22422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei225 – 24521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini246 – 26823ExtracellularSequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 31930CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Probable G-protein coupled receptor 171PRO_0000069649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO14626.
PRIDEiO14626.

Expressioni

Gene expression databases

BgeeiO14626.
CleanExiHS_GPR171.
ExpressionAtlasiO14626. baseline and differential.
GenevestigatoriO14626.

Organism-specific databases

HPAiHPA062429.

Interactioni

Protein-protein interaction databases

BioGridi118956. 1 interaction.
STRINGi9606.ENSP00000308479.

Structurei

3D structure databases

ProteinModelPortaliO14626.
SMRiO14626. Positions 17-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146192.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG095159.
InParanoidiO14626.
KOiK08441.
OMAiAFRLKVT.
OrthoDBiEOG725DJ1.
PhylomeDBiO14626.
TreeFamiTF330969.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14626-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS
60 70 80 90 100
IYLINLLTAD FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL
110 120 130 140 150
SIIFLAFVSI DRCLQLTHSC KIYRIQEPGF AKMISTVVWL MVLLIMVPNM
160 170 180 190 200
MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT NFICVAIFLN FSAIILISNC
210 220 230 240 250
LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH IVRIPYTLSQ
260 270 280 290 300
TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF
310
ASPKETKAQK EKLRCENNA
Length:319
Mass (Da):36,754
Last modified:January 1, 1998 - v1
Checksum:i79B9821C10841114
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti283 – 2831I → V.1 Publication
Corresponds to variant rs3732756 [ dbSNP | Ensembl ].
VAR_049408

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002986 mRNA. Translation: AAC51846.1.
AF411849 Genomic DNA. Translation: AAL47763.1.
CH471052 Genomic DNA. Translation: EAW78811.1.
CH471052 Genomic DNA. Translation: EAW78812.1.
BC036815 mRNA. Translation: AAH36815.1.
CCDSiCCDS3155.1.
RefSeqiNP_037440.3. NM_013308.3.
XP_005247459.1. XM_005247402.1.
XP_005247460.1. XM_005247403.1.
UniGeneiHs.549152.

Genome annotation databases

EnsembliENST00000309180; ENSP00000308479; ENSG00000174946.
ENST00000617554; ENSP00000482588; ENSG00000174946.
GeneIDi29909.
KEGGihsa:29909.
UCSCiuc003eyq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002986 mRNA. Translation: AAC51846.1 .
AF411849 Genomic DNA. Translation: AAL47763.1 .
CH471052 Genomic DNA. Translation: EAW78811.1 .
CH471052 Genomic DNA. Translation: EAW78812.1 .
BC036815 mRNA. Translation: AAH36815.1 .
CCDSi CCDS3155.1.
RefSeqi NP_037440.3. NM_013308.3.
XP_005247459.1. XM_005247402.1.
XP_005247460.1. XM_005247403.1.
UniGenei Hs.549152.

3D structure databases

ProteinModelPortali O14626.
SMRi O14626. Positions 17-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118956. 1 interaction.
STRINGi 9606.ENSP00000308479.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O14626.
PRIDEi O14626.

Protocols and materials databases

DNASUi 29909.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309180 ; ENSP00000308479 ; ENSG00000174946 .
ENST00000617554 ; ENSP00000482588 ; ENSG00000174946 .
GeneIDi 29909.
KEGGi hsa:29909.
UCSCi uc003eyq.4. human.

Organism-specific databases

CTDi 29909.
GeneCardsi GC03M150915.
HGNCi HGNC:30057. GPR171.
HPAi HPA062429.
neXtProti NX_O14626.
PharmGKBi PA134948560.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146192.
GeneTreei ENSGT00640000091213.
HOGENOMi HOG000273884.
HOVERGENi HBG095159.
InParanoidi O14626.
KOi K08441.
OMAi AFRLKVT.
OrthoDBi EOG725DJ1.
PhylomeDBi O14626.
TreeFami TF330969.

Miscellaneous databases

GeneWikii GPR171.
GenomeRNAii 29909.
NextBioi 52492.
PROi O14626.

Gene expression databases

Bgeei O14626.
CleanExi HS_GPR171.
ExpressionAtlasi O14626. baseline and differential.
Genevestigatori O14626.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood monocyte.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-283.
    Tissue: Pancreas.

Entry informationi

Entry nameiGP171_HUMAN
AccessioniPrimary (citable) accession number: O14626
Secondary accession number(s): D3DNJ4, Q8IV06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3