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O14626

- GP171_HUMAN

UniProt

O14626 - GP171_HUMAN

Protein

Probable G-protein coupled receptor 171

Gene

GPR171

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 171
    Alternative name(s):
    G-protein coupled receptor H963
    Gene namesi
    Name:GPR171
    Synonyms:H963
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30057. GPR171.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134948560.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Probable G-protein coupled receptor 171PRO_0000069649Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO14626.
    PRIDEiO14626.

    Expressioni

    Gene expression databases

    ArrayExpressiO14626.
    BgeeiO14626.
    CleanExiHS_GPR171.
    GenevestigatoriO14626.

    Organism-specific databases

    HPAiHPA062429.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308479.

    Structurei

    3D structure databases

    ProteinModelPortaliO14626.
    SMRiO14626. Positions 17-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini43 – 486CytoplasmicSequence Analysis
    Topological domaini70 – 8920ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini111 – 13222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini154 – 18128ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini203 – 22422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini246 – 26823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 31930CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146192.
    HOGENOMiHOG000273884.
    HOVERGENiHBG095159.
    InParanoidiO14626.
    KOiK08441.
    OMAiAFRLKVT.
    OrthoDBiEOG725DJ1.
    PhylomeDBiO14626.
    TreeFamiTF330969.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14626-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS    50
    IYLINLLTAD FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL 100
    SIIFLAFVSI DRCLQLTHSC KIYRIQEPGF AKMISTVVWL MVLLIMVPNM 150
    MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT NFICVAIFLN FSAIILISNC 200
    LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH IVRIPYTLSQ 250
    TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF 300
    ASPKETKAQK EKLRCENNA 319
    Length:319
    Mass (Da):36,754
    Last modified:January 1, 1998 - v1
    Checksum:i79B9821C10841114
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti283 – 2831I → V.1 Publication
    Corresponds to variant rs3732756 [ dbSNP | Ensembl ].
    VAR_049408

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF002986 mRNA. Translation: AAC51846.1.
    AF411849 Genomic DNA. Translation: AAL47763.1.
    CH471052 Genomic DNA. Translation: EAW78811.1.
    CH471052 Genomic DNA. Translation: EAW78812.1.
    BC036815 mRNA. Translation: AAH36815.1.
    CCDSiCCDS3155.1.
    RefSeqiNP_037440.3. NM_013308.3.
    XP_005247459.1. XM_005247402.1.
    XP_005247460.1. XM_005247403.1.
    UniGeneiHs.549152.

    Genome annotation databases

    EnsembliENST00000309180; ENSP00000308479; ENSG00000174946.
    GeneIDi29909.
    KEGGihsa:29909.
    UCSCiuc003eyq.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF002986 mRNA. Translation: AAC51846.1 .
    AF411849 Genomic DNA. Translation: AAL47763.1 .
    CH471052 Genomic DNA. Translation: EAW78811.1 .
    CH471052 Genomic DNA. Translation: EAW78812.1 .
    BC036815 mRNA. Translation: AAH36815.1 .
    CCDSi CCDS3155.1.
    RefSeqi NP_037440.3. NM_013308.3.
    XP_005247459.1. XM_005247402.1.
    XP_005247460.1. XM_005247403.1.
    UniGenei Hs.549152.

    3D structure databases

    ProteinModelPortali O14626.
    SMRi O14626. Positions 17-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308479.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O14626.
    PRIDEi O14626.

    Protocols and materials databases

    DNASUi 29909.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309180 ; ENSP00000308479 ; ENSG00000174946 .
    GeneIDi 29909.
    KEGGi hsa:29909.
    UCSCi uc003eyq.4. human.

    Organism-specific databases

    CTDi 29909.
    GeneCardsi GC03M150915.
    HGNCi HGNC:30057. GPR171.
    HPAi HPA062429.
    neXtProti NX_O14626.
    PharmGKBi PA134948560.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146192.
    HOGENOMi HOG000273884.
    HOVERGENi HBG095159.
    InParanoidi O14626.
    KOi K08441.
    OMAi AFRLKVT.
    OrthoDBi EOG725DJ1.
    PhylomeDBi O14626.
    TreeFami TF330969.

    Miscellaneous databases

    GeneWikii GPR171.
    GenomeRNAii 29909.
    NextBioi 52492.
    PROi O14626.

    Gene expression databases

    ArrayExpressi O14626.
    Bgeei O14626.
    CleanExi HS_GPR171.
    Genevestigatori O14626.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Peripheral blood monocyte.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-283.
      Tissue: Pancreas.

    Entry informationi

    Entry nameiGP171_HUMAN
    AccessioniPrimary (citable) accession number: O14626
    Secondary accession number(s): D3DNJ4, Q8IV06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3