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Protein

Probable G-protein coupled receptor 171

Gene

GPR171

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174946-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 171
Alternative name(s):
G-protein coupled receptor H963
Gene namesi
Name:GPR171
Synonyms:H963
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30057. GPR171.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 48CytoplasmicSequence analysis6
Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini70 – 89ExtracellularSequence analysisAdd BLAST20
Transmembranei90 – 110Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini111 – 132CytoplasmicSequence analysisAdd BLAST22
Transmembranei133 – 153Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini154 – 181ExtracellularSequence analysisAdd BLAST28
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini203 – 224CytoplasmicSequence analysisAdd BLAST22
Transmembranei225 – 245Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini246 – 268ExtracellularSequence analysisAdd BLAST23
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 319CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29909.
OpenTargetsiENSG00000174946.
PharmGKBiPA134948560.

Polymorphism and mutation databases

BioMutaiGPR171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696491 – 319Probable G-protein coupled receptor 171Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO14626.
PeptideAtlasiO14626.
PRIDEiO14626.

PTM databases

PhosphoSitePlusiO14626.

Expressioni

Gene expression databases

BgeeiENSG00000174946.
CleanExiHS_GPR171.
ExpressionAtlasiO14626. baseline and differential.
GenevisibleiO14626. HS.

Organism-specific databases

HPAiHPA062429.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308479.

Structurei

3D structure databases

ProteinModelPortaliO14626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IICW. Eukaryota.
ENOG410YCG6. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG095159.
InParanoidiO14626.
KOiK08441.
OMAiIMVPNMV.
OrthoDBiEOG091G0B1Z.
PhylomeDBiO14626.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS
60 70 80 90 100
IYLINLLTAD FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL
110 120 130 140 150
SIIFLAFVSI DRCLQLTHSC KIYRIQEPGF AKMISTVVWL MVLLIMVPNM
160 170 180 190 200
MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT NFICVAIFLN FSAIILISNC
210 220 230 240 250
LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH IVRIPYTLSQ
260 270 280 290 300
TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF
310
ASPKETKAQK EKLRCENNA
Length:319
Mass (Da):36,754
Last modified:January 1, 1998 - v1
Checksum:i79B9821C10841114
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049408283I → V.1 PublicationCorresponds to variant rs3732756dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002986 mRNA. Translation: AAC51846.1.
AF411849 Genomic DNA. Translation: AAL47763.1.
CH471052 Genomic DNA. Translation: EAW78811.1.
CH471052 Genomic DNA. Translation: EAW78812.1.
BC036815 mRNA. Translation: AAH36815.1.
CCDSiCCDS3155.1.
RefSeqiNP_037440.3. NM_013308.3.
XP_005247459.1. XM_005247402.3.
XP_005247460.1. XM_005247403.3.
XP_016861763.1. XM_017006274.1.
UniGeneiHs.549152.

Genome annotation databases

EnsembliENST00000309180; ENSP00000308479; ENSG00000174946.
ENST00000617554; ENSP00000482588; ENSG00000174946.
GeneIDi29909.
KEGGihsa:29909.
UCSCiuc003eyq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002986 mRNA. Translation: AAC51846.1.
AF411849 Genomic DNA. Translation: AAL47763.1.
CH471052 Genomic DNA. Translation: EAW78811.1.
CH471052 Genomic DNA. Translation: EAW78812.1.
BC036815 mRNA. Translation: AAH36815.1.
CCDSiCCDS3155.1.
RefSeqiNP_037440.3. NM_013308.3.
XP_005247459.1. XM_005247402.3.
XP_005247460.1. XM_005247403.3.
XP_016861763.1. XM_017006274.1.
UniGeneiHs.549152.

3D structure databases

ProteinModelPortaliO14626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308479.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO14626.

Polymorphism and mutation databases

BioMutaiGPR171.

Proteomic databases

PaxDbiO14626.
PeptideAtlasiO14626.
PRIDEiO14626.

Protocols and materials databases

DNASUi29909.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309180; ENSP00000308479; ENSG00000174946.
ENST00000617554; ENSP00000482588; ENSG00000174946.
GeneIDi29909.
KEGGihsa:29909.
UCSCiuc003eyq.5. human.

Organism-specific databases

CTDi29909.
DisGeNETi29909.
GeneCardsiGPR171.
HGNCiHGNC:30057. GPR171.
HPAiHPA062429.
neXtProtiNX_O14626.
OpenTargetsiENSG00000174946.
PharmGKBiPA134948560.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IICW. Eukaryota.
ENOG410YCG6. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG095159.
InParanoidiO14626.
KOiK08441.
OMAiIMVPNMV.
OrthoDBiEOG091G0B1Z.
PhylomeDBiO14626.
TreeFamiTF330969.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174946-MONOMER.

Miscellaneous databases

GeneWikiiGPR171.
GenomeRNAii29909.
PROiO14626.

Gene expression databases

BgeeiENSG00000174946.
CleanExiHS_GPR171.
ExpressionAtlasiO14626. baseline and differential.
GenevisibleiO14626. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP171_HUMAN
AccessioniPrimary (citable) accession number: O14626
Secondary accession number(s): D3DNJ4, Q8IV06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.