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O14626 (GP171_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 171
Alternative name(s):
G-protein coupled receptor H963
Gene names
Name:GPR171
Synonyms:H963
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentintegral component of membrane

Non-traceable author statement Ref.1. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionG-protein coupled receptor activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Probable G-protein coupled receptor 171
PRO_0000069649

Regions

Topological domain1 – 2121Extracellular Potential
Transmembrane22 – 4221Helical; Name=1; Potential
Topological domain43 – 486Cytoplasmic Potential
Transmembrane49 – 6921Helical; Name=2; Potential
Topological domain70 – 8920Extracellular Potential
Transmembrane90 – 11021Helical; Name=3; Potential
Topological domain111 – 13222Cytoplasmic Potential
Transmembrane133 – 15321Helical; Name=4; Potential
Topological domain154 – 18128Extracellular Potential
Transmembrane182 – 20221Helical; Name=5; Potential
Topological domain203 – 22422Cytoplasmic Potential
Transmembrane225 – 24521Helical; Name=6; Potential
Topological domain246 – 26823Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 31930Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential

Natural variations

Natural variant2831I → V. Ref.4
Corresponds to variant rs3732756 [ dbSNP | Ensembl ].
VAR_049408

Sequences

Sequence LengthMass (Da)Tools
O14626 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 79B9821C10841114

FASTA31936,754
        10         20         30         40         50         60 
MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS IYLINLLTAD 

        70         80         90        100        110        120 
FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL SIIFLAFVSI DRCLQLTHSC 

       130        140        150        160        170        180 
KIYRIQEPGF AKMISTVVWL MVLLIMVPNM MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT 

       190        200        210        220        230        240 
NFICVAIFLN FSAIILISNC LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH 

       250        260        270        280        290        300 
IVRIPYTLSQ TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF 

       310 
ASPKETKAQK EKLRCENNA 

« Hide

References

« Hide 'large scale' references
[1]"A genetic selection for isolating cDNAs encoding secreted proteins."
Jacobs K.A., Collins-Racie L.A., Colbert M., Duckett M., Golden-Fleet M., Kelleher K., Kriz R., LaVallie E.R., Merberg D., Spaulding V., Stover J., Williamson M.J., McCoy J.M.
Gene 198:289-296(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Peripheral blood monocyte.
[2]"Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3."
Joensuu T., Haemaelaeinen R., Yuan B., Johnson C., Tegelberg S., Gasparini P., Zelante L., Pirvola U., Pakarinen L., Lehesjoki A.-E., de la Chapelle A., Sankila E.-M.
Am. J. Hum. Genet. 69:673-684(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-283.
Tissue: Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF002986 mRNA. Translation: AAC51846.1.
AF411849 Genomic DNA. Translation: AAL47763.1.
CH471052 Genomic DNA. Translation: EAW78811.1.
CH471052 Genomic DNA. Translation: EAW78812.1.
BC036815 mRNA. Translation: AAH36815.1.
CCDSCCDS3155.1.
RefSeqNP_037440.3. NM_013308.3.
XP_005247459.1. XM_005247402.1.
XP_005247460.1. XM_005247403.1.
UniGeneHs.549152.

3D structure databases

ProteinModelPortalO14626.
SMRO14626. Positions 17-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308479.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbO14626.
PRIDEO14626.

Protocols and materials databases

DNASU29909.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309180; ENSP00000308479; ENSG00000174946.
GeneID29909.
KEGGhsa:29909.
UCSCuc003eyq.4. human.

Organism-specific databases

CTD29909.
GeneCardsGC03M150915.
HGNCHGNC:30057. GPR171.
HPAHPA062429.
neXtProtNX_O14626.
PharmGKBPA134948560.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146192.
HOGENOMHOG000273884.
HOVERGENHBG095159.
InParanoidO14626.
KOK08441.
OMAAFRLKVT.
OrthoDBEOG725DJ1.
PhylomeDBO14626.
TreeFamTF330969.

Gene expression databases

ArrayExpressO14626.
BgeeO14626.
CleanExHS_GPR171.
GenevestigatorO14626.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR171.
GenomeRNAi29909.
NextBio52492.
PROO14626.

Entry information

Entry nameGP171_HUMAN
AccessionPrimary (citable) accession number: O14626
Secondary accession number(s): D3DNJ4, Q8IV06
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries