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O14625 (CXL11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C motif chemokine 11
Alternative name(s):
Beta-R1
H174
Interferon gamma-inducible protein 9
Short name=IP-9
Interferon-inducible T-cell alpha chemoattractant
Short name=I-TAC
Small-inducible cytokine B11
Gene names
Name:CXCL11
Synonyms:ITAC, SCYB11, SCYB9B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length94 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Subcellular location

Secreted.

Tissue specificity

High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Induction

By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Mass spectrometry

Molecular mass is 8303 Da from positions 22 - 94. Determined by MALDI. Ref.4

Sequence caution

The sequence AAB17374.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMCitrullination
Disulfide bond
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processT cell chemotaxis

Inferred from mutant phenotype Ref.10. Source: UniProt

cell-cell signaling

Traceable author statement Ref.4. Source: ProtInc

chemokine-mediated signaling pathway

Inferred from mutant phenotype Ref.10. Source: UniProt

chemotaxis

Inferred from direct assay PubMed 12782716. Source: UniProtKB

immune response

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Traceable author statement Ref.4. Source: ProtInc

positive regulation of cAMP metabolic process

Inferred from direct assay PubMed 12782716. Source: UniProtKB

positive regulation of cAMP-mediated signaling

Inferred from direct assay PubMed 12782716. Source: UniProtKB

positive regulation of cell proliferation

Inferred from electronic annotation. Source: InterPro

positive regulation of leukocyte chemotaxis

Inferred from electronic annotation. Source: InterPro

positive regulation of release of sequestered calcium ion into cytosol

Inferred from direct assay PubMed 12782716. Source: UniProtKB

regulation of cell proliferation

Inferred from mutant phenotype PubMed 12782716. Source: UniProtKB

signal transduction

Traceable author statement Ref.4. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionCXCR3 chemokine receptor binding

Inferred from direct assay PubMed 12782716. Source: UniProtKB

chemokine activity

Inferred from direct assay PubMed 12782716. Source: UniProtKB

heparin binding

Inferred from mutant phenotype Ref.10. Source: UniProt

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DPP4P274872EBI-2871971,EBI-2871277

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.4
Chain22 – 9473C-X-C motif chemokine 11
PRO_0000005106

Amino acid modifications

Modified residue271Citrulline; by PAD2
Disulfide bond30 ↔ 57 Ref.11
Disulfide bond32 ↔ 74 Ref.11

Natural variations

Natural variant551N → S.
Corresponds to variant rs4859596 [ dbSNP | Ensembl ].
VAR_048700

Experimental info

Sequence conflict69 – 724NKGQ → IRK in AAB17374. Ref.1
Sequence conflict781K → NRA in AAB17374. Ref.1
Sequence conflict891V → A in AAB17374. Ref.1

Secondary structure

........ 94
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O14625 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9D9D8585749EA4CE

FASTA9410,365
        10         20         30         40         50         60 
MSVKGMAIAL AVILCATVVQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI 

        70         80         90 
EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha."
Rani M.R.S., Foster G.R., Leung S., Leaman D., Stark G.R., Ransohoff R.M.
J. Biol. Chem. 271:22878-22884(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Astrocyte.
[2]"A genetic selection for isolating cDNAs encoding secreted proteins."
Jacobs K.A., Collins-Racie L.A., Colbert M., Duckett M., Golden-Fleet M., Kelleher K., Kriz R., LaVallie E.R., Merberg D., Spaulding V., Stover J., Williamson M.J., McCoy J.M.
Gene 198:289-296(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Peripheral blood monocyte.
[3]"Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3."
Cole K.E., Strick C.A., Paradis T.J., Ogborne K.T., Loetscher M., Gladue R.P., Lin W., Boyd J.G., Moser B., Wood D.E., Sahagan B.G., Neote K.
J. Exp. Med. 187:2009-2021(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal astrocyte.
[4]"Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)."
Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R.
J. Invest. Dermatol. 112:716-722(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-38, MASS SPECTROMETRY.
Tissue: Keratinocyte.
[5]"Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1)."
Laich A.M., Meyer M., Werner E.R., Werner-Felmayer G.
J. Interferon Cytokine Res. 19:505-513(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Myeloma.
[6]"Genomic organization, sequence and transcriptional regulation of the human CXCL 11 gene."
Tensen C.P., Flier J., Rampersad S., Sampat-Sardjoepersad S., Scheper R.J., Boorsma D.M., Willemze R.
Biochim. Biophys. Acta 1446:167-172(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Keratinocyte.
[7]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow, Brain and Liver.
[9]"The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)."
Erdel M., Laich A., Utermann G., Werner E.R., Werner-Felmayer G.
Cytogenet. Cell Genet. 81:271-272(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 28-84.
[10]"Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation."
Loos T., Mortier A., Gouwy M., Ronsse I., Put W., Lenaerts J.P., Van Damme J., Proost P.
Blood 112:2648-2656(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: CITRULLINATION AT ARG-27.
[11]"NMR structure of CXCR3 binding chemokine CXCL11 (ITAC)."
Booth V., Clark-Lewis I., Sykes B.D.
Protein Sci. 13:2022-2028(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 22-94, DISULFIDE BONDS.
+Additional computationally mapped references.

Web resources

Wikipedia

CXCL11 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59286 mRNA. Translation: AAB17374.1. Different initiation.
AF002985 mRNA. Translation: AAC51845.1.
AF030514 mRNA. Translation: AAC39775.1.
Y15220 mRNA. Translation: CAA75510.1.
U66096 mRNA. Translation: AAD38867.1.
AF077867 Genomic DNA. Translation: AAD38327.1.
Y15221 Genomic DNA. Translation: CAB51859.1.
BT006787 mRNA. Translation: AAP35433.1.
BC005292 mRNA. Translation: AAH05292.1.
BC012532 mRNA. Translation: AAH12532.1.
BC110986 mRNA. Translation: AAI10987.1.
AF053972 Genomic DNA. Translation: AAD10206.1.
RefSeqNP_005400.1. NM_005409.4.
UniGeneHs.632592.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1RJTNMR-A22-94[»]
ProteinModelPortalO14625.
SMRO14625. Positions 22-94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112275. 1 interaction.
DIPDIP-5890N.
IntActO14625. 3 interactions.
MINTMINT-153105.
STRING9606.ENSP00000306884.

PTM databases

PhosphoSiteO14625.

Proteomic databases

PaxDbO14625.
PRIDEO14625.

Protocols and materials databases

DNASU6373.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306621; ENSP00000306884; ENSG00000169248.
ENST00000503860; ENSP00000425819; ENSG00000169248.
GeneID6373.
KEGGhsa:6373.
UCSCuc003hjm.3. human.

Organism-specific databases

CTD6373.
GeneCardsGC04M076954.
HGNCHGNC:10638. CXCL11.
HPACAB009921.
MIM604852. gene.
neXtProtNX_O14625.
PharmGKBPA35569.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43433.
HOVERGENHBG107789.
InParanoidO14625.
KOK12672.
OMAGGRCLCI.
OrthoDBEOG7HHWVH.
PhylomeDBO14625.
TreeFamTF333433.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO14625.
BgeeO14625.
CleanExHS_CXCL11.
GenevestigatorO14625.

Family and domain databases

InterProIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR027220. Chemokine_CXCL10/11.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF5. PTHR10179:SF5. 1 hit.
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR00437. SMALLCYTKCXC.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO14625.
GeneWikiCXCL11.
GenomeRNAi6373.
NextBio24760.
PMAP-CutDBO14625.
PROO14625.
SOURCESearch...

Entry information

Entry nameCXL11_HUMAN
AccessionPrimary (citable) accession number: O14625
Secondary accession number(s): Q53YA3, Q92840
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM