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Protein

C-X-C motif chemokine 11

Gene

CXCL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR3 chemokine receptor binding Source: UniProtKB
  • heparin binding Source: UniProtKB

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • chemokine-mediated signaling pathway Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: ProtInc
  • positive regulation of cAMP-mediated signaling Source: UniProtKB
  • positive regulation of cAMP metabolic process Source: UniProtKB
  • positive regulation of leukocyte chemotaxis Source: GO_Central
  • positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  • regulation of cell proliferation Source: UniProtKB
  • response to lipopolysaccharide Source: GO_Central
  • signal transduction Source: ProtInc
  • T cell chemotaxis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 11
Alternative name(s):
Beta-R1
H174
Interferon gamma-inducible protein 9
Short name:
IP-9
Interferon-inducible T-cell alpha chemoattractant
Short name:
I-TAC
Small-inducible cytokine B11
Gene namesi
Name:CXCL11
Synonyms:ITAC, SCYB11, SCYB9B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:10638. CXCL11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35569.

Polymorphism and mutation databases

BioMutaiCXCL11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 9473C-X-C motif chemokine 11PRO_0000005106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271Citrulline; by PAD21 Publication
Disulfide bondi30 ↔ 571 Publication
Disulfide bondi32 ↔ 741 Publication

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiO14625.
PeptideAtlasiO14625.
PRIDEiO14625.

PTM databases

iPTMnetiO14625.
PhosphoSiteiO14625.

Miscellaneous databases

PMAP-CutDBO14625.

Expressioni

Tissue specificityi

High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Inductioni

By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.

Gene expression databases

BgeeiENSG00000169248.
CleanExiHS_CXCL11.
GenevisibleiO14625. HS.

Organism-specific databases

HPAiCAB009921.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DPP4P274872EBI-2871971,EBI-2871277
MTUS2Q5JR593EBI-2871971,EBI-742948

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • CXCR3 chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112275. 2 interactions.
DIPiDIP-5890N.
IntActiO14625. 6 interactions.
MINTiMINT-153105.
STRINGi9606.ENSP00000306884.

Structurei

Secondary structure

1
94
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni54 – 563Combined sources
Beta strandi57 – 593Combined sources
Beta strandi67 – 693Combined sources
Helixi82 – 898Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RJTNMR-A22-94[»]
ProteinModelPortaliO14625.
SMRiO14625. Positions 22-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14625.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JDG9. Eukaryota.
ENOG41117T8. LUCA.
GeneTreeiENSGT00530000064263.
HOVERGENiHBG107789.
InParanoidiO14625.
KOiK12672.
OMAiGGRCLCI.
OrthoDBiEOG091G0Z10.
PhylomeDBiO14625.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027221. CXCL11.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF28. PTHR10179:SF28. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKGMAIAL AVILCATVVQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI
60 70 80 90
MYPSNNCDKI EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF
Length:94
Mass (Da):10,365
Last modified:January 1, 1998 - v1
Checksum:i9D9D8585749EA4CE
GO

Sequence cautioni

The sequence AAB17374 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 724NKGQ → IRK in AAB17374 (PubMed:8798467).Curated
Sequence conflicti78 – 781K → NRA in AAB17374 (PubMed:8798467).Curated
Sequence conflicti89 – 891V → A in AAB17374 (PubMed:8798467).Curated

Mass spectrometryi

Molecular mass is 8303 Da from positions 22 - 94. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551N → S.
Corresponds to variant rs4859596 [ dbSNP | Ensembl ].
VAR_048700

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59286 mRNA. Translation: AAB17374.1. Different initiation.
AF002985 mRNA. Translation: AAC51845.1.
AF030514 mRNA. Translation: AAC39775.1.
Y15220 mRNA. Translation: CAA75510.1.
U66096 mRNA. Translation: AAD38867.1.
AF077867 Genomic DNA. Translation: AAD38327.1.
Y15221 Genomic DNA. Translation: CAB51859.1.
BT006787 mRNA. Translation: AAP35433.1.
BC005292 mRNA. Translation: AAH05292.1.
BC012532 mRNA. Translation: AAH12532.1.
BC110986 mRNA. Translation: AAI10987.1.
AF053972 Genomic DNA. Translation: AAD10206.1.
CCDSiCCDS3574.1.
RefSeqiNP_001289052.1. NM_001302123.1.
NP_005400.1. NM_005409.4.
UniGeneiHs.632592.

Genome annotation databases

EnsembliENST00000306621; ENSP00000306884; ENSG00000169248.
ENST00000503860; ENSP00000425819; ENSG00000169248.
GeneIDi6373.
KEGGihsa:6373.
UCSCiuc003hjm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXCL11 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59286 mRNA. Translation: AAB17374.1. Different initiation.
AF002985 mRNA. Translation: AAC51845.1.
AF030514 mRNA. Translation: AAC39775.1.
Y15220 mRNA. Translation: CAA75510.1.
U66096 mRNA. Translation: AAD38867.1.
AF077867 Genomic DNA. Translation: AAD38327.1.
Y15221 Genomic DNA. Translation: CAB51859.1.
BT006787 mRNA. Translation: AAP35433.1.
BC005292 mRNA. Translation: AAH05292.1.
BC012532 mRNA. Translation: AAH12532.1.
BC110986 mRNA. Translation: AAI10987.1.
AF053972 Genomic DNA. Translation: AAD10206.1.
CCDSiCCDS3574.1.
RefSeqiNP_001289052.1. NM_001302123.1.
NP_005400.1. NM_005409.4.
UniGeneiHs.632592.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RJTNMR-A22-94[»]
ProteinModelPortaliO14625.
SMRiO14625. Positions 22-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112275. 2 interactions.
DIPiDIP-5890N.
IntActiO14625. 6 interactions.
MINTiMINT-153105.
STRINGi9606.ENSP00000306884.

PTM databases

iPTMnetiO14625.
PhosphoSiteiO14625.

Polymorphism and mutation databases

BioMutaiCXCL11.

Proteomic databases

PaxDbiO14625.
PeptideAtlasiO14625.
PRIDEiO14625.

Protocols and materials databases

DNASUi6373.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306621; ENSP00000306884; ENSG00000169248.
ENST00000503860; ENSP00000425819; ENSG00000169248.
GeneIDi6373.
KEGGihsa:6373.
UCSCiuc003hjm.4. human.

Organism-specific databases

CTDi6373.
GeneCardsiCXCL11.
HGNCiHGNC:10638. CXCL11.
HPAiCAB009921.
MIMi604852. gene.
neXtProtiNX_O14625.
PharmGKBiPA35569.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDG9. Eukaryota.
ENOG41117T8. LUCA.
GeneTreeiENSGT00530000064263.
HOVERGENiHBG107789.
InParanoidiO14625.
KOiK12672.
OMAiGGRCLCI.
OrthoDBiEOG091G0Z10.
PhylomeDBiO14625.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTraceiO14625.
GeneWikiiCXCL11.
GenomeRNAii6373.
PMAP-CutDBO14625.
PROiO14625.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169248.
CleanExiHS_CXCL11.
GenevisibleiO14625. HS.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027221. CXCL11.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF28. PTHR10179:SF28. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXL11_HUMAN
AccessioniPrimary (citable) accession number: O14625
Secondary accession number(s): Q53YA3, Q92840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.