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Protein

C-X-C motif chemokine 11

Gene

CXCL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

GO - Molecular functioni

  1. chemokine activity Source: UniProtKB
  2. CXCR3 chemokine receptor binding Source: UniProtKB
  3. heparin binding Source: UniProtKB

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. chemokine-mediated signaling pathway Source: UniProtKB
  3. chemotaxis Source: UniProtKB
  4. G-protein coupled receptor signaling pathway Source: GO_Central
  5. immune response Source: GO_Central
  6. inflammatory response Source: ProtInc
  7. positive regulation of cAMP-mediated signaling Source: UniProtKB
  8. positive regulation of cAMP metabolic process Source: UniProtKB
  9. positive regulation of leukocyte chemotaxis Source: GO_Central
  10. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  11. regulation of cell proliferation Source: UniProtKB
  12. response to lipopolysaccharide Source: GO_Central
  13. signal transduction Source: ProtInc
  14. T cell chemotaxis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 11
Alternative name(s):
Beta-R1
H174
Interferon gamma-inducible protein 9
Short name:
IP-9
Interferon-inducible T-cell alpha chemoattractant
Short name:
I-TAC
Small-inducible cytokine B11
Gene namesi
Name:CXCL11
Synonyms:ITAC, SCYB11, SCYB9B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:10638. CXCL11.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 9473C-X-C motif chemokine 11PRO_0000005106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271Citrulline; by PAD21 Publication
Disulfide bondi30 ↔ 571 Publication
Disulfide bondi32 ↔ 741 Publication

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiO14625.
PRIDEiO14625.

PTM databases

PhosphoSiteiO14625.

Miscellaneous databases

PMAP-CutDBO14625.

Expressioni

Tissue specificityi

High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Inductioni

By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.

Gene expression databases

BgeeiO14625.
CleanExiHS_CXCL11.
ExpressionAtlasiO14625. baseline and differential.
GenevestigatoriO14625.

Organism-specific databases

HPAiCAB009921.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DPP4P274872EBI-2871971,EBI-2871277

Protein-protein interaction databases

BioGridi112275. 2 interactions.
DIPiDIP-5890N.
IntActiO14625. 4 interactions.
MINTiMINT-153105.
STRINGi9606.ENSP00000306884.

Structurei

Secondary structure

1
94
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni54 – 563Combined sources
Beta strandi57 – 593Combined sources
Beta strandi67 – 693Combined sources
Helixi82 – 898Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RJTNMR-A22-94[»]
ProteinModelPortaliO14625.
SMRiO14625. Positions 22-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14625.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43433.
GeneTreeiENSGT00530000064263.
HOVERGENiHBG107789.
InParanoidiO14625.
KOiK12672.
OMAiGGRCLCI.
OrthoDBiEOG7HHWVH.
PhylomeDBiO14625.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027221. CXCL11.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF41. PTHR10179:SF41. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14625-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVKGMAIAL AVILCATVVQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI
60 70 80 90
MYPSNNCDKI EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF
Length:94
Mass (Da):10,365
Last modified:January 1, 1998 - v1
Checksum:i9D9D8585749EA4CE
GO

Sequence cautioni

The sequence AAB17374.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 724NKGQ → IRK in AAB17374. (PubMed:8798467)Curated
Sequence conflicti78 – 781K → NRA in AAB17374. (PubMed:8798467)Curated
Sequence conflicti89 – 891V → A in AAB17374. (PubMed:8798467)Curated

Mass spectrometryi

Molecular mass is 8303 Da from positions 22 - 94. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551N → S.
Corresponds to variant rs4859596 [ dbSNP | Ensembl ].
VAR_048700

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59286 mRNA. Translation: AAB17374.1. Different initiation.
AF002985 mRNA. Translation: AAC51845.1.
AF030514 mRNA. Translation: AAC39775.1.
Y15220 mRNA. Translation: CAA75510.1.
U66096 mRNA. Translation: AAD38867.1.
AF077867 Genomic DNA. Translation: AAD38327.1.
Y15221 Genomic DNA. Translation: CAB51859.1.
BT006787 mRNA. Translation: AAP35433.1.
BC005292 mRNA. Translation: AAH05292.1.
BC012532 mRNA. Translation: AAH12532.1.
BC110986 mRNA. Translation: AAI10987.1.
AF053972 Genomic DNA. Translation: AAD10206.1.
CCDSiCCDS3574.1.
RefSeqiNP_001289052.1. NM_001302123.1.
NP_005400.1. NM_005409.4.
UniGeneiHs.632592.

Genome annotation databases

EnsembliENST00000306621; ENSP00000306884; ENSG00000169248.
ENST00000503860; ENSP00000425819; ENSG00000169248.
GeneIDi6373.
KEGGihsa:6373.
UCSCiuc003hjm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXCL11 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59286 mRNA. Translation: AAB17374.1. Different initiation.
AF002985 mRNA. Translation: AAC51845.1.
AF030514 mRNA. Translation: AAC39775.1.
Y15220 mRNA. Translation: CAA75510.1.
U66096 mRNA. Translation: AAD38867.1.
AF077867 Genomic DNA. Translation: AAD38327.1.
Y15221 Genomic DNA. Translation: CAB51859.1.
BT006787 mRNA. Translation: AAP35433.1.
BC005292 mRNA. Translation: AAH05292.1.
BC012532 mRNA. Translation: AAH12532.1.
BC110986 mRNA. Translation: AAI10987.1.
AF053972 Genomic DNA. Translation: AAD10206.1.
CCDSiCCDS3574.1.
RefSeqiNP_001289052.1. NM_001302123.1.
NP_005400.1. NM_005409.4.
UniGeneiHs.632592.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RJTNMR-A22-94[»]
ProteinModelPortaliO14625.
SMRiO14625. Positions 22-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112275. 2 interactions.
DIPiDIP-5890N.
IntActiO14625. 4 interactions.
MINTiMINT-153105.
STRINGi9606.ENSP00000306884.

PTM databases

PhosphoSiteiO14625.

Proteomic databases

PaxDbiO14625.
PRIDEiO14625.

Protocols and materials databases

DNASUi6373.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306621; ENSP00000306884; ENSG00000169248.
ENST00000503860; ENSP00000425819; ENSG00000169248.
GeneIDi6373.
KEGGihsa:6373.
UCSCiuc003hjm.3. human.

Organism-specific databases

CTDi6373.
GeneCardsiGC04M076954.
HGNCiHGNC:10638. CXCL11.
HPAiCAB009921.
MIMi604852. gene.
neXtProtiNX_O14625.
PharmGKBiPA35569.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43433.
GeneTreeiENSGT00530000064263.
HOVERGENiHBG107789.
InParanoidiO14625.
KOiK12672.
OMAiGGRCLCI.
OrthoDBiEOG7HHWVH.
PhylomeDBiO14625.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTraceiO14625.
GeneWikiiCXCL11.
GenomeRNAii6373.
NextBioi24760.
PMAP-CutDBO14625.
PROiO14625.
SOURCEiSearch...

Gene expression databases

BgeeiO14625.
CleanExiHS_CXCL11.
ExpressionAtlasiO14625. baseline and differential.
GenevestigatoriO14625.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027221. CXCL11.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF41. PTHR10179:SF41. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha."
    Rani M.R.S., Foster G.R., Leung S., Leaman D., Stark G.R., Ransohoff R.M.
    J. Biol. Chem. 271:22878-22884(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Astrocyte.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Peripheral blood monocyte.
  3. "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3."
    Cole K.E., Strick C.A., Paradis T.J., Ogborne K.T., Loetscher M., Gladue R.P., Lin W., Boyd J.G., Moser B., Wood D.E., Sahagan B.G., Neote K.
    J. Exp. Med. 187:2009-2021(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal astrocyte.
  4. "Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)."
    Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R.
    J. Invest. Dermatol. 112:716-722(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-38, MASS SPECTROMETRY.
    Tissue: Keratinocyte.
  5. "Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1)."
    Laich A.M., Meyer M., Werner E.R., Werner-Felmayer G.
    J. Interferon Cytokine Res. 19:505-513(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Myeloma.
  6. "Genomic organization, sequence and transcriptional regulation of the human CXCL 11 gene."
    Tensen C.P., Flier J., Rampersad S., Sampat-Sardjoepersad S., Scheper R.J., Boorsma D.M., Willemze R.
    Biochim. Biophys. Acta 1446:167-172(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Keratinocyte.
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow, Brain and Liver.
  9. "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)."
    Erdel M., Laich A., Utermann G., Werner E.R., Werner-Felmayer G.
    Cytogenet. Cell Genet. 81:271-272(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 28-84.
  10. "Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation."
    Loos T., Mortier A., Gouwy M., Ronsse I., Put W., Lenaerts J.P., Van Damme J., Proost P.
    Blood 112:2648-2656(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: CITRULLINATION AT ARG-27.
  11. "NMR structure of CXCR3 binding chemokine CXCL11 (ITAC)."
    Booth V., Clark-Lewis I., Sykes B.D.
    Protein Sci. 13:2022-2028(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 22-94, DISULFIDE BONDS.

Entry informationi

Entry nameiCXL11_HUMAN
AccessioniPrimary (citable) accession number: O14625
Secondary accession number(s): Q53YA3, Q92840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.