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O14625

- CXL11_HUMAN

UniProt

O14625 - CXL11_HUMAN

Protein

C-X-C motif chemokine 11

Gene

CXCL11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

    GO - Molecular functioni

    1. chemokine activity Source: UniProtKB
    2. CXCR3 chemokine receptor binding Source: UniProtKB
    3. heparin binding Source: UniProt
    4. protein binding Source: IntAct

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. chemokine-mediated signaling pathway Source: UniProt
    3. chemotaxis Source: UniProtKB
    4. immune response Source: Ensembl
    5. inflammatory response Source: ProtInc
    6. positive regulation of cAMP-mediated signaling Source: UniProtKB
    7. positive regulation of cAMP metabolic process Source: UniProtKB
    8. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
    9. regulation of cell proliferation Source: UniProtKB
    10. signal transduction Source: ProtInc
    11. T cell chemotaxis Source: UniProt

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 11
    Alternative name(s):
    Beta-R1
    H174
    Interferon gamma-inducible protein 9
    Short name:
    IP-9
    Interferon-inducible T-cell alpha chemoattractant
    Short name:
    I-TAC
    Small-inducible cytokine B11
    Gene namesi
    Name:CXCL11
    Synonyms:ITAC, SCYB11, SCYB9B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:10638. CXCL11.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35569.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 9473C-X-C motif chemokine 11PRO_0000005106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271Citrulline; by PAD21 Publication
    Disulfide bondi30 ↔ 571 Publication
    Disulfide bondi32 ↔ 741 Publication

    Keywords - PTMi

    Citrullination, Disulfide bond

    Proteomic databases

    PaxDbiO14625.
    PRIDEiO14625.

    PTM databases

    PhosphoSiteiO14625.

    Miscellaneous databases

    PMAP-CutDBO14625.

    Expressioni

    Tissue specificityi

    High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

    Inductioni

    By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.

    Gene expression databases

    ArrayExpressiO14625.
    BgeeiO14625.
    CleanExiHS_CXCL11.
    GenevestigatoriO14625.

    Organism-specific databases

    HPAiCAB009921.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DPP4P274872EBI-2871971,EBI-2871277

    Protein-protein interaction databases

    BioGridi112275. 1 interaction.
    DIPiDIP-5890N.
    IntActiO14625. 4 interactions.
    MINTiMINT-153105.
    STRINGi9606.ENSP00000306884.

    Structurei

    Secondary structure

    1
    94
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni54 – 563
    Beta strandi57 – 593
    Beta strandi67 – 693
    Helixi82 – 898

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RJTNMR-A22-94[»]
    ProteinModelPortaliO14625.
    SMRiO14625. Positions 22-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14625.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43433.
    HOVERGENiHBG107789.
    InParanoidiO14625.
    KOiK12672.
    OMAiVIFCATI.
    OrthoDBiEOG7HHWVH.
    PhylomeDBiO14625.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    IPR027221. CXCL11.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF41. PTHR10179:SF41. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14625-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVKGMAIAL AVILCATVVQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI   50
    MYPSNNCDKI EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF 94
    Length:94
    Mass (Da):10,365
    Last modified:January 1, 1998 - v1
    Checksum:i9D9D8585749EA4CE
    GO

    Sequence cautioni

    The sequence AAB17374.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 724NKGQ → IRK in AAB17374. (PubMed:8798467)Curated
    Sequence conflicti78 – 781K → NRA in AAB17374. (PubMed:8798467)Curated
    Sequence conflicti89 – 891V → A in AAB17374. (PubMed:8798467)Curated

    Mass spectrometryi

    Molecular mass is 8303 Da from positions 22 - 94. Determined by MALDI. 1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551N → S.
    Corresponds to variant rs4859596 [ dbSNP | Ensembl ].
    VAR_048700

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59286 mRNA. Translation: AAB17374.1. Different initiation.
    AF002985 mRNA. Translation: AAC51845.1.
    AF030514 mRNA. Translation: AAC39775.1.
    Y15220 mRNA. Translation: CAA75510.1.
    U66096 mRNA. Translation: AAD38867.1.
    AF077867 Genomic DNA. Translation: AAD38327.1.
    Y15221 Genomic DNA. Translation: CAB51859.1.
    BT006787 mRNA. Translation: AAP35433.1.
    BC005292 mRNA. Translation: AAH05292.1.
    BC012532 mRNA. Translation: AAH12532.1.
    BC110986 mRNA. Translation: AAI10987.1.
    AF053972 Genomic DNA. Translation: AAD10206.1.
    CCDSiCCDS3574.1.
    RefSeqiNP_005400.1. NM_005409.4.
    UniGeneiHs.632592.

    Genome annotation databases

    EnsembliENST00000306621; ENSP00000306884; ENSG00000169248.
    ENST00000503860; ENSP00000425819; ENSG00000169248.
    GeneIDi6373.
    KEGGihsa:6373.
    UCSCiuc003hjm.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXCL11 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59286 mRNA. Translation: AAB17374.1 . Different initiation.
    AF002985 mRNA. Translation: AAC51845.1 .
    AF030514 mRNA. Translation: AAC39775.1 .
    Y15220 mRNA. Translation: CAA75510.1 .
    U66096 mRNA. Translation: AAD38867.1 .
    AF077867 Genomic DNA. Translation: AAD38327.1 .
    Y15221 Genomic DNA. Translation: CAB51859.1 .
    BT006787 mRNA. Translation: AAP35433.1 .
    BC005292 mRNA. Translation: AAH05292.1 .
    BC012532 mRNA. Translation: AAH12532.1 .
    BC110986 mRNA. Translation: AAI10987.1 .
    AF053972 Genomic DNA. Translation: AAD10206.1 .
    CCDSi CCDS3574.1.
    RefSeqi NP_005400.1. NM_005409.4.
    UniGenei Hs.632592.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RJT NMR - A 22-94 [» ]
    ProteinModelPortali O14625.
    SMRi O14625. Positions 22-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112275. 1 interaction.
    DIPi DIP-5890N.
    IntActi O14625. 4 interactions.
    MINTi MINT-153105.
    STRINGi 9606.ENSP00000306884.

    PTM databases

    PhosphoSitei O14625.

    Proteomic databases

    PaxDbi O14625.
    PRIDEi O14625.

    Protocols and materials databases

    DNASUi 6373.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306621 ; ENSP00000306884 ; ENSG00000169248 .
    ENST00000503860 ; ENSP00000425819 ; ENSG00000169248 .
    GeneIDi 6373.
    KEGGi hsa:6373.
    UCSCi uc003hjm.3. human.

    Organism-specific databases

    CTDi 6373.
    GeneCardsi GC04M076954.
    HGNCi HGNC:10638. CXCL11.
    HPAi CAB009921.
    MIMi 604852. gene.
    neXtProti NX_O14625.
    PharmGKBi PA35569.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43433.
    HOVERGENi HBG107789.
    InParanoidi O14625.
    KOi K12672.
    OMAi VIFCATI.
    OrthoDBi EOG7HHWVH.
    PhylomeDBi O14625.
    TreeFami TF333433.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    EvolutionaryTracei O14625.
    GeneWikii CXCL11.
    GenomeRNAii 6373.
    NextBioi 24760.
    PMAP-CutDB O14625.
    PROi O14625.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14625.
    Bgeei O14625.
    CleanExi HS_CXCL11.
    Genevestigatori O14625.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    IPR027221. CXCL11.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF41. PTHR10179:SF41. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha."
      Rani M.R.S., Foster G.R., Leung S., Leaman D., Stark G.R., Ransohoff R.M.
      J. Biol. Chem. 271:22878-22884(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Astrocyte.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Peripheral blood monocyte.
    3. "Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3."
      Cole K.E., Strick C.A., Paradis T.J., Ogborne K.T., Loetscher M., Gladue R.P., Lin W., Boyd J.G., Moser B., Wood D.E., Sahagan B.G., Neote K.
      J. Exp. Med. 187:2009-2021(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal astrocyte.
    4. "Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)."
      Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R.
      J. Invest. Dermatol. 112:716-722(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-38, MASS SPECTROMETRY.
      Tissue: Keratinocyte.
    5. "Structure and expression of the human small cytokine B subfamily member 11 (SCYB11/formerly SCYB9B, alias I-TAC) gene cloned from IFN-gamma-treated human monocytes (THP-1)."
      Laich A.M., Meyer M., Werner E.R., Werner-Felmayer G.
      J. Interferon Cytokine Res. 19:505-513(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Myeloma.
    6. "Genomic organization, sequence and transcriptional regulation of the human CXCL 11 gene."
      Tensen C.P., Flier J., Rampersad S., Sampat-Sardjoepersad S., Scheper R.J., Boorsma D.M., Willemze R.
      Biochim. Biophys. Acta 1446:167-172(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Keratinocyte.
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow, Brain and Liver.
    9. "The human gene encoding SCYB9B, a putative novel CXC chemokine, maps to human chromosome 4q21 like the closely related genes for MIG (SCYB9) and INP10 (SCYB10)."
      Erdel M., Laich A., Utermann G., Werner E.R., Werner-Felmayer G.
      Cytogenet. Cell Genet. 81:271-272(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 28-84.
    10. "Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation."
      Loos T., Mortier A., Gouwy M., Ronsse I., Put W., Lenaerts J.P., Van Damme J., Proost P.
      Blood 112:2648-2656(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: CITRULLINATION AT ARG-27.
    11. "NMR structure of CXCR3 binding chemokine CXCL11 (ITAC)."
      Booth V., Clark-Lewis I., Sykes B.D.
      Protein Sci. 13:2022-2028(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 22-94, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCXL11_HUMAN
    AccessioniPrimary (citable) accession number: O14625
    Secondary accession number(s): Q53YA3, Q92840
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 147 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3