AP-3 complex subunit delta-1 - Homo sapiens (Human)

Preferred order of sections

Names and origin

Protein names

Recommended name:
AP-3 complex subunit delta-1

Alternative name(s):
AP-3 complex subunit delta
Adapter-related protein complex 3 subunit delta-1
Delta-adaptin

Gene names

Name:	AP3D1
ORF Names:	PRO0039

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1153 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Subunit structure	AP-3 associates with the BLOC-1 complex By similarity. Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2).
Subcellular location	Cytoplasm By similarity. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Tissue specificity	Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis. Ref.2
Sequence similarities	Belongs to the adaptor complexes large subunit family. Contains 11 HEAT repeats.
Sequence caution	The sequence AAG35473.1 differs from that shown. Reason: Contaminating sequence. Presence of an unrelated sequence found on chromosome 7. The sequence AAH10065.1 differs from that shown. Reason: Lack of 8 exons and truncation of 2 other exons in the C- terminus. Alternative splicing seems doubtful, since exon-intron junctions are not the consensus ones. The sequence BAD92041.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterograde axon cargo transport Inferred from sequence or structural similarity. Source: UniProtKB anterograde synaptic vesicle transport Inferred from sequence or structural similarity. Source: UniProtKB antigen processing and presentation, exogenous lipid antigen via MHC class Ib Inferred from electronic annotation. Source: Compara eye pigment biosynthetic process Traceable author statement Ref.1. Source: ProtInc intracellular protein transport Traceable author statement Ref.2. Source: ProtInc positive regulation of NK T cell differentiation Inferred from electronic annotation. Source: Compara protein localization to organelle Inferred from electronic annotation. Source: Compara regulation of sequestering of zinc ion Inferred from mutant phenotype PubMed 17349999. Source: BHF-UCL synaptic vesicle membrane organization Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Traceable author statement Ref.2. Source: ProtInc Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endosome membrane Inferred from direct assay PubMed 16162817. Source: UniProtKB membrane coat Inferred from electronic annotation. Source: InterPro terminal bouton Inferred from electronic annotation. Source: Compara
Molecular_function	protein transporter activity Inferred from electronic annotation. Source: InterPro transporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14617-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14617-2) The sequence of this isoform differs from the canonical sequence as follows: 168-258: Missing. 866-866: K → KKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQD
Note: Contains a phosphoserine at position 828.

Isoform 3 (identifier: O14617-3) The sequence of this isoform differs from the canonical sequence as follows: 117-285: Missing.

Isoform 4 (identifier: O14617-4) The sequence of this isoform differs from the canonical sequence as follows: 746-877: Missing.

Isoform 5 (identifier: O14617-5) The sequence of this isoform differs from the canonical sequence as follows: 866-866: K → KKAEDLDFWLSTTPPPAPAPAPAPVPSTGELSVNTVTTPKDECEDAKTEAQGEEDDAEGQDQD
Note: Contains a phosphoserine at position 931.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1153

1153

AP-3 complex subunit delta-1

PRO_0000193766

Regions

Repeat

34 – 71

38

HEAT 1

Repeat

77 – 114

38

HEAT 2

Repeat

142 – 179

38

HEAT 3

Repeat

180 – 216

37

HEAT 4

Repeat

254 – 292

39

HEAT 5

Repeat

299 – 336

38

HEAT 6

Repeat

338 – 373

36

HEAT 7

Repeat

375 – 409

35

HEAT 8

Repeat

431 – 468

38

HEAT 9

Repeat

497 – 535

39

HEAT 10

Repeat

548 – 585

38

HEAT 11

Coiled coil

659 – 679

21

Potential

Coiled coil

725 – 756

32

Potential

Coiled coil

845 – 869

25

Potential

Compositional bias

828 – 893

66

Lys-rich

Amino acid modifications

Modified residue

632

1

Phosphoserine Ref.7 Ref.10 Ref.12

Modified residue

634

1

Phosphoserine Ref.7 Ref.10

Modified residue

636

1

Phosphoserine Ref.7 Ref.10

Modified residue

658

1

Phosphoserine Ref.7 Ref.12

Modified residue

688

1

Phosphoserine Ref.9

Modified residue

758

1

Phosphoserine Ref.9

Modified residue

759

1

Phosphoserine Ref.9

Modified residue

762

1

Phosphothreonine Ref.9

Modified residue

764

1

Phosphoserine Ref.9

Modified residue

788

1

Phosphoserine Ref.9 Ref.10

Modified residue

829

1

Phosphoserine Ref.10

Natural variations

Alternative sequence

117 – 285

169

Missing in isoform 3.

VSP_000167

Alternative sequence

168 – 258

91

Missing in isoform 2.

VSP_000165

Alternative sequence

746 – 877

132

Missing in isoform 4.

VSP_000168

Alternative sequence

866

1

K → KKAEDLDFWLSTTPPPAPAP APAPVPSTDECEDAKTEAQG EEDDAEGQDQD in isoform 2.

VSP_000166

Alternative sequence

866

1

K → KKAEDLDFWLSTTPPPAPAP APAPVPSTGELSVNTVTTPK DECEDAKTEAQGEEDDAEGQ DQD in isoform 5.

VSP_017106

Natural variant

541

1

G → R.
Corresponds to variant rs34569645 [ dbSNP | Ensembl ].

VAR_033517

Natural variant

1072

1

I → V.
Corresponds to variant rs25673 [ dbSNP | Ensembl ].

VAR_033518

Experimental info

Sequence conflict

3

1

L → F in AAD03777. Ref.2

Sequence conflict

167

1

Missing in AAC34214. Ref.4

Sequence conflict

252

1

E → G in AAH10065. Ref.5

Sequence conflict

595 – 603

9

EVSALFAGE → DFVHCCYEL in AAG35473. Ref.6

Secondary structure

1

.

1153

Helix Strand Turn

Details...

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 1B491DD64EAD5096 Show »	FASTA	1,153	130,158
10 20 30 40 50 60 MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 70 80 90 100 110 120 KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 130 140 150 160 170 180 SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES 190 200 210 220 230 240 LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK 250 260 270 280 290 300 IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 310 320 330 340 350 360 IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA 370 380 390 400 410 420 LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS 430 440 450 460 470 480 ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE 490 500 510 520 530 540 VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA 550 560 570 580 590 600 GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF 610 620 630 640 650 660 AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA 670 680 690 700 710 720 DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM 730 740 750 760 770 780 SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE 790 800 810 820 830 840 MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK 850 860 870 880 890 900 SKKPKKKEKK HKEKERDKEK KKEKEKKKSP KPKKKKHRKE KEERTKGKKK SKKQPPGSEE 910 920 930 940 950 960 AAGEPVQNGA PEEEQLPPES SYSLLAENSY VKMTCDIRGS LQEDSQVTVA IVLENRSSSI 970 980 990 1000 1010 1020 LKGMELSVLD SLNARMARPQ GSSVHDGVPV PFQLPPGVSN EAQYVFTIQS IVMAQKLKGT 1030 1040 1050 1060 1070 1080 LSFIAKNDEG ATHEKLDFRL HFSCSSYLIT TPCYSDAFAK LLESGDLSMS SIKVDGIRMS 1090 1100 1110 1120 1130 1140 FQNLLAKICF HHHFSVVERV DSCASMYSRS IQGHHVCLLV KKGENSVSVD GKCSDSTLLS 1150 NLLEEMKATL AKC « Hide
Isoform 2 [UniParc]. Checksum: 33380E690D5AC35F Show »	FASTA	1,112	125,040
10 20 30 40 50 60 MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 70 80 90 100 110 120 KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 130 140 150 160 170 180 SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIE PLTNLIHSTS 190 200 210 220 230 240 AMSLLYECVN TVIAVLISLS SGMPNHSASI QLCVQKLRIL IEDSDQNLKY LGLLAMSKIL 250 260 270 280 290 300 KTHPKSVQSH KDLILQCLDD KDESIRLRAL DLLYGMVSKK NLMEIVKKLM THVDKAEGTT 310 320 330 340 350 360 YRDELLTKII DICSQSNYQY ITNFEWYISI LVELTRLEGT RHGHLIAAQM LDVAIRVKAI 370 380 390 400 410 420 RKFAVSQMSA LLDSAHLLAS STQRNGICEV LYAAAWICGE FSEHLQEPHH TLEAMLRPRV 430 440 450 460 470 480 TTLPGHIQAV YVQNVVKLYA SILQQKEQAG EAEGAQAVTQ LMVDRLPQFV QSADLEVQER 490 500 510 520 530 540 ASCILQLVKH IQKLQAKDVP VAEEVSALFA GELNPVAPKA QKKVPVPEGL DLDAWINEPL 550 560 570 580 590 600 SDSESEDERP RAVFHEEEQR RPKHRPSEAD EEELARRREA RKQEQANNPF YIKSSPSPQK 610 620 630 640 650 660 RYQDTPGVEH IPVVQIDLSV PLKVPGLPMS DQYVKLEEER RHRQKLEKDK RRKKRKEKEK 670 680 690 700 710 720 KGKRRHSSLP TESDEDIAPA QQVDIVTEEM PENALPSDED DKDPNDPYRA LDIDLDKPLA 730 740 750 760 770 780 DSEKLPIQKH RNTETSKSPE KDVPMVEKKS KKPKKKEKKH KEKERDKEKK KEKEKKAEDL 790 800 810 820 830 840 DFWLSTTPPP APAPAPAPVP STDECEDAKT EAQGEEDDAE GQDQDKKSPK PKKKKHRKEK 850 860 870 880 890 900 EERTKGKKKS KKQPPGSEEA AGEPVQNGAP EEEQLPPESS YSLLAENSYV KMTCDIRGSL 910 920 930 940 950 960 QEDSQVTVAI VLENRSSSIL KGMELSVLDS LNARMARPQG SSVHDGVPVP FQLPPGVSNE 970 980 990 1000 1010 1020 AQYVFTIQSI VMAQKLKGTL SFIAKNDEGA THEKLDFRLH FSCSSYLITT PCYSDAFAKL 1030 1040 1050 1060 1070 1080 LESGDLSMSS IKVDGIRMSF QNLLAKICFH HHFSVVERVD SCASMYSRSI QGHHVCLLVK 1090 1100 1110 KGENSVSVDG KCSDSTLLSN LLEEMKATLA KC « Hide
Isoform 3 [UniParc]. Checksum: 8FA5C9ED9EF57A83 Show »	FASTA	984	111,238
10 20 30 40 50 60 MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 70 80 90 100 110 120 KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIVLIS 130 140 150 160 170 180 LSSGMPNHSA SIQLCVQKLR ILIEDSDQNL KYLGLLAMSK ILKTHPKSVQ SHKDLILQCL 190 200 210 220 230 240 DDKDESIRLR ALDLLYGMVS KKNLMEIVKK LMTHVDKAEG TTYRDELLTK IIDICSQSNY 250 260 270 280 290 300 QYITNFEWYI SILVELTRLE GTRHGHLIAA QMLDVAIRVK AIRKFAVSQM SALLDSAHLL 310 320 330 340 350 360 ASSTQRNGIC EVLYAAAWIC GEFSEHLQEP HHTLEAMLRP RVTTLPGHIQ AVYVQNVVKL 370 380 390 400 410 420 YASILQQKEQ AGEAEGAQAV TQLMVDRLPQ FVQSADLEVQ ERASCILQLV KHIQKLQAKD 430 440 450 460 470 480 VPVAEEVSAL FAGELNPVAP KAQKKVPVPE GLDLDAWINE PLSDSESEDE RPRAVFHEEE 490 500 510 520 530 540 QRRPKHRPSE ADEEELARRR EARKQEQANN PFYIKSSPSP QKRYQDTPGV EHIPVVQIDL 550 560 570 580 590 600 SVPLKVPGLP MSDQYVKLEE ERRHRQKLEK DKRRKKRKEK EKKGKRRHSS LPTESDEDIA 610 620 630 640 650 660 PAQQVDIVTE EMPENALPSD EDDKDPNDPY RALDIDLDKP LADSEKLPIQ KHRNTETSKS 670 680 690 700 710 720 PEKDVPMVEK KSKKPKKKEK KHKEKERDKE KKKEKEKKKS PKPKKKKHRK EKEERTKGKK 730 740 750 760 770 780 KSKKQPPGSE EAAGEPVQNG APEEEQLPPE SSYSLLAENS YVKMTCDIRG SLQEDSQVTV 790 800 810 820 830 840 AIVLENRSSS ILKGMELSVL DSLNARMARP QGSSVHDGVP VPFQLPPGVS NEAQYVFTIQ 850 860 870 880 890 900 SIVMAQKLKG TLSFIAKNDE GATHEKLDFR LHFSCSSYLI TTPCYSDAFA KLLESGDLSM 910 920 930 940 950 960 SSIKVDGIRM SFQNLLAKIC FHHHFSVVER VDSCASMYSR SIQGHHVCLL VKKGENSVSV 970 980 DGKCSDSTLL SNLLEEMKAT LAKC « Hide
Isoform 4 [UniParc]. Checksum: 730F9AD61CEF63DD Show »	FASTA	1,021	114,707
10 20 30 40 50 60 MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 70 80 90 100 110 120 KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 130 140 150 160 170 180 SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES 190 200 210 220 230 240 LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK 250 260 270 280 290 300 IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 310 320 330 340 350 360 IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA 370 380 390 400 410 420 LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS 430 440 450 460 470 480 ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE 490 500 510 520 530 540 VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA 550 560 570 580 590 600 GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF 610 620 630 640 650 660 AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA 670 680 690 700 710 720 DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM 730 740 750 760 770 780 SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE ERTKGKKKSK KQPPGSEEAA GEPVQNGAPE 790 800 810 820 830 840 EEQLPPESSY SLLAENSYVK MTCDIRGSLQ EDSQVTVAIV LENRSSSILK GMELSVLDSL 850 860 870 880 890 900 NARMARPQGS SVHDGVPVPF QLPPGVSNEA QYVFTIQSIV MAQKLKGTLS FIAKNDEGAT 910 920 930 940 950 960 HEKLDFRLHF SCSSYLITTP CYSDAFAKLL ESGDLSMSSI KVDGIRMSFQ NLLAKICFHH 970 980 990 1000 1010 1020 HFSVVERVDS CASMYSRSIQ GHHVCLLVKK GENSVSVDGK CSDSTLLSNL LEEMKATLAK C « Hide
Isoform 5 [UniParc]. Checksum: E77257F13AD4A67F Show »	FASTA	1,215	136,651
10 20 30 40 50 60 MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 70 80 90 100 110 120 KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 130 140 150 160 170 180 SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES 190 200 210 220 230 240 LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK 250 260 270 280 290 300 IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 310 320 330 340 350 360 IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA 370 380 390 400 410 420 LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS 430 440 450 460 470 480 ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE 490 500 510 520 530 540 VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA 550 560 570 580 590 600 GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF 610 620 630 640 650 660 AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA 670 680 690 700 710 720 DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM 730 740 750 760 770 780 SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE 790 800 810 820 830 840 MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK 850 860 870 880 890 900 SKKPKKKEKK HKEKERDKEK KKEKEKKAED LDFWLSTTPP PAPAPAPAPV PSTGELSVNT 910 920 930 940 950 960 VTTPKDECED AKTEAQGEED DAEGQDQDKK SPKPKKKKHR KEKEERTKGK KKSKKQPPGS 970 980 990 1000 1010 1020 EEAAGEPVQN GAPEEEQLPP ESSYSLLAEN SYVKMTCDIR GSLQEDSQVT VAIVLENRSS 1030 1040 1050 1060 1070 1080 SILKGMELSV LDSLNARMAR PQGSSVHDGV PVPFQLPPGV SNEAQYVFTI QSIVMAQKLK 1090 1100 1110 1120 1130 1140 GTLSFIAKND EGATHEKLDF RLHFSCSSYL ITTPCYSDAF AKLLESGDLS MSSIKVDGIR 1150 1160 1170 1180 1190 1200 MSFQNLLAKI CFHHHFSVVE RVDSCASMYS RSIQGHHVCL LVKKGENSVS VDGKCSDSTL 1210 LSNLLEEMKA TLAKC « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet." Ooi C.E., Moreira J.E., Dell'Angelica E.C., Poy G., Wassarman D.A., Bonifacino J.S. EMBO J. 16:4508-4518(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4). Tissue: Fetal brain.
[2]	"Characterization of the adaptor-related protein complex, AP-3." Simpson F., Peden A.A., Christopoulou L., Robinson M.S. J. Cell Biol. 137:835-845(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Heart.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle.
[6]	"Functional prediction of the coding sequences of 75 new genes deduced by analysis of cDNA clones from human fetal liver." Zhang C., Yu Y., Zhang S., Wei H., Bi J., Zhou G., Dong C., Zai Y., Xu W., Gao F., Liu M., He F. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-603 (ISOFORM 1). Tissue: Fetal liver.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-634; SER-636 AND SER-658, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-688; SER-758; SER-759; THR-762; SER-764 AND SER-788, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-828 (ISOFORM 2), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-931 (ISOFORM 5), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-634; SER-636; SER-788 AND SER-829, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632 AND SER-658, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF002163 mRNA. Translation: AAC51761.1.
U91930 mRNA. Translation: AAD03777.1.
AB208804 mRNA. Translation: BAD92041.1. Different initiation.
AC005545 Genomic DNA. Translation: AAC34212.1.
AC005545 Genomic DNA. Translation: AAC34214.1.
BC010065 mRNA. Translation: AAH10065.1. Sequence problems.
AF130042 mRNA. Translation: AAG35473.1. Sequence problems.

IPI

IPI00289608.
IPI00411453.
IPI00411677.
IPI00413686.
IPI00719680.

RefSeq

NP_001248755.1. NM_001261826.1.
NP_003929.4. NM_003938.6.

UniGene

Hs.512815.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4AFI	X-ray	2.80	A/B	680-729	[»]

ProteinModelPortal

O14617.

ModBase

Search...

Protein-protein interaction databases

IntAct

O14617. 5 interactions.

STRING

9606.ENSP00000344055.

PTM databases

PhosphoSite

O14617.

Proteomic databases

PaxDb

O14617.

PRIDE

O14617.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000345016; ENSP00000344055; ENSG00000065000.
ENST00000355272; ENSP00000347416; ENSG00000065000.

GeneID

8943.

KEGG

hsa:8943.

UCSC

uc002luy.3. human.
uc002luz.3. human.
uc002lva.3. human.

Organism-specific databases

CTD

8943.

GeneCards

GC19M002101.

H-InvDB

HIX0014607.

HGNC

HGNC:568. AP3D1.

MIM

607246. gene.

neXtProt

NX_O14617.

PharmGKB

PA24859.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5096.

HOGENOM

HOG000000981.

HOVERGEN

HBG050520.

KO

K12396.

OMA

VCKLTYL.

Gene expression databases

ArrayExpress

O14617.

Bgee

O14617.

CleanEx

HS_AP3D1.

Genevestigator

O14617.

GermOnline

ENSG00000065000. Homo sapiens.

Family and domain databases

Gene3D

1.25.10.10. 1 hit.

InterPro

IPR017105. AP3_complex_dsu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR010474. BLV_receptor.
IPR002553. Clathrin/coatomer_adapt-like_N.
[Graphical view]

Pfam

PF01602. Adaptin_N. 1 hit.
PF06375. BLVR. 2 hits.
[Graphical view]

PIRSF

PIRSF037092. AP3_complex_delta. 1 hit.

SUPFAM

SSF48371. ARM-type_fold. 1 hit.

PROSITE

PS50077. HEAT_REPEAT. False negative.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

AP3D1. human.

GenomeRNAi

8943.

NextBio

33636.

SOURCE

Search...

Entry information

Entry name

AP3D1_HUMAN

Accession

Primary (citable) accession number: O14617
Secondary accession number(s): O00202

Q9H3C6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families