Reviewed, UniProtKB/Swiss-Prot O14617 (AP3D1_HUMAN)

Names and origin

Protein names

Recommended name:
    AP-3 complex subunit delta-1
Alternative name(s):
    Adapter-related protein complex 3 subunit delta-1
    AP-3 complex subunit delta
    Delta-adaptin

Gene names

Name:	AP3D1
ORF Names:	PRO0039

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.
Subunit structure	Adaptor protein complex 3 (AP-3) is an heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2).
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Tissue specificity	Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis. Ref.2
Sequence similarities	Belongs to the adaptor complexes large subunit family.
Sequence caution	The sequence AAG35473.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Presence of an unrelated sequence found on chromosome 7. The sequence AAH10065.1 differs from that shown. Reason: Miscellaneous discrepancy. Lack of 8 exons and truncation of 2 other exons in the C- terminus. Alternative splicing seems doubtful, since exon-intron junctions are not the consensus ones.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	eye pigment biosynthetic process Ref.1 Traceable author statement. Source: ProtInc intracellular protein transport Ref.2 Traceable author statement. Source: ProtInc vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell membrane coat Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro protein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14617-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14617-2)

The sequence of this isoform differs from the canonical sequence as follows:
     168-258: Missing.
     866-866: K → KKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQD

Isoform 3 (identifier: O14617-3)

The sequence of this isoform differs from the canonical sequence as follows:
     117-285: Missing.

Isoform 4 (identifier: O14617-4)

The sequence of this isoform differs from the canonical sequence as follows:
     746-877: Missing.

Isoform 5 (identifier: O14617-5)

The sequence of this isoform differs from the canonical sequence as follows:
     866-866: K → KKAEDLDFWLSTTPPPAPAPAPAPVPSTGELSVNTVTTPKDECEDAKTEAQGEEDDAEGQDQD

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1153	1153	AP-3 complex subunit delta-1		PRO_0000193766
Amino acid modifications
	Modified residue	632	1	Phosphoserine Ref.7 Ref.9
	Modified residue	634	1	Phosphoserine Ref.7 Ref.9
	Modified residue	636	1	Phosphoserine Ref.7 Ref.9
	Modified residue	658	1	Phosphoserine Ref.7
	Modified residue	686	1	Phosphoserine Ref.9
	Modified residue	688	1	Phosphoserine Ref.9
	Modified residue	758	1	Phosphoserine Ref.9
	Modified residue	759	1	Phosphoserine Ref.9
	Modified residue	762	1	Phosphothreonine Ref.9
	Modified residue	764	1	Phosphoserine Ref.9
	Modified residue	788	1	Phosphoserine Ref.9
	Modified residue	829	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	117 – 285	169	Missing in isoform 3.		VSP_000167
	Alternative sequence	168 – 258	91	Missing in isoform 2.		VSP_000165
	Alternative sequence	746 – 877	132	Missing in isoform 4.		VSP_000168
	Alternative sequence	866	1	K → KKAEDLDFWLSTTPPPAPAP APAPVPSTDECEDAKTEAQG EEDDAEGQDQD in isoform 2.		VSP_000166
	Alternative sequence	866	1	K → KKAEDLDFWLSTTPPPAPAP APAPVPSTGELSVNTVTTPK DECEDAKTEAQGEEDDAEGQ DQD in isoform 5.		VSP_017106
	Natural variant	541	1	G → R: dbSNP rs34569645.		VAR_033517
	Natural variant	1072	1	I → V: dbSNP rs25673.		VAR_033518
Experimental info
	Sequence conflict	3	1	L → F in AAD03777. Ref.2
	Sequence conflict	167	1	Missing in AAC34214. Ref.4
	Sequence conflict	252	1	E → G in AAH10065. Ref.5
	Sequence conflict	595 – 603	9	EVSALFAGE → DFVHCCYEL Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 1B491DD64EAD5096	FASTA	1,153	130,158
	10 20 30 40 50 60 MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 70 80 90 100 110 120 KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 130 140 150 160 170 180 SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES 190 200 210 220 230 240 LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK 250 260 270 280 290 300 IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 310 320 330 340 350 360 IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA 370 380 390 400 410 420 LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS 430 440 450 460 470 480 ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE 490 500 510 520 530 540 VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA 550 560 570 580 590 600 GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF 610 620 630 640 650 660 AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA 670 680 690 700 710 720 DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM 730 740 750 760 770 780 SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE 790 800 810 820 830 840 MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK 850 860 870 880 890 900 SKKPKKKEKK HKEKERDKEK KKEKEKKKSP KPKKKKHRKE KEERTKGKKK SKKQPPGSEE 910 920 930 940 950 960 AAGEPVQNGA PEEEQLPPES SYSLLAENSY VKMTCDIRGS LQEDSQVTVA IVLENRSSSI 970 980 990 1000 1010 1020 LKGMELSVLD SLNARMARPQ GSSVHDGVPV PFQLPPGVSN EAQYVFTIQS IVMAQKLKGT 1030 1040 1050 1060 1070 1080 LSFIAKNDEG ATHEKLDFRL HFSCSSYLIT TPCYSDAFAK LLESGDLSMS SIKVDGIRMS 1090 1100 1110 1120 1130 1140 FQNLLAKICF HHHFSVVERV DSCASMYSRS IQGHHVCLLV KKGENSVSVD GKCSDSTLLS 1150 NLLEEMKATL AKC
	Isoform 2. Checksum: 33380E690D5AC35F	FASTA	1,112	125,040
	10 20 30 40 50 60 MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 70 80 90 100 110 120 KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 130 140 150 160 170 180 SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIE PLTNLIHSTS 190 200 210 220 230 240 AMSLLYECVN TVIAVLISLS SGMPNHSASI QLCVQKLRIL IEDSDQNLKY LGLLAMSKIL 250 260 270 280 290 300 KTHPKSVQSH KDLILQCLDD KDESIRLRAL DLLYGMVSKK NLMEIVKKLM THVDKAEGTT 310 320 330 340 350 360 YRDELLTKII DICSQSNYQY ITNFEWYISI LVELTRLEGT RHGHLIAAQM LDVAIRVKAI 370 380 390 400 410 420 RKFAVSQMSA LLDSAHLLAS STQRNGICEV LYAAAWICGE FSEHLQEPHH TLEAMLRPRV 430 440 450 460 470 480 TTLPGHIQAV YVQNVVKLYA SILQQKEQAG EAEGAQAVTQ LMVDRLPQFV QSADLEVQER 490 500 510 520 530 540 ASCILQLVKH IQKLQAKDVP VAEEVSALFA GELNPVAPKA QKKVPVPEGL DLDAWINEPL 550 560 570 580 590 600 SDSESEDERP RAVFHEEEQR RPKHRPSEAD EEELARRREA RKQEQANNPF YIKSSPSPQK 610 620 630 640 650 660 RYQDTPGVEH IPVVQIDLSV PLKVPGLPMS DQYVKLEEER RHRQKLEKDK RRKKRKEKEK 670 680 690 700 710 720 KGKRRHSSLP TESDEDIAPA QQVDIVTEEM PENALPSDED DKDPNDPYRA LDIDLDKPLA 730 740 750 760 770 780 DSEKLPIQKH RNTETSKSPE KDVPMVEKKS KKPKKKEKKH KEKERDKEKK KEKEKKAEDL 790 800 810 820 830 840 DFWLSTTPPP APAPAPAPVP STDECEDAKT EAQGEEDDAE GQDQDKKSPK PKKKKHRKEK 850 860 870 880 890 900 EERTKGKKKS KKQPPGSEEA AGEPVQNGAP EEEQLPPESS YSLLAENSYV KMTCDIRGSL 910 920 930 940 950 960 QEDSQVTVAI VLENRSSSIL KGMELSVLDS LNARMARPQG SSVHDGVPVP FQLPPGVSNE 970 980 990 1000 1010 1020 AQYVFTIQSI VMAQKLKGTL SFIAKNDEGA THEKLDFRLH FSCSSYLITT PCYSDAFAKL 1030 1040 1050 1060 1070 1080 LESGDLSMSS IKVDGIRMSF QNLLAKICFH HHFSVVERVD SCASMYSRSI QGHHVCLLVK 1090 1100 1110 KGENSVSVDG KCSDSTLLSN LLEEMKATLA KC
	Isoform 3. Checksum: 8FA5C9ED9EF57A83	FASTA	984	111,238
	10 20 30 40 50 60 MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 70 80 90 100 110 120 KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIVLIS 130 140 150 160 170 180 LSSGMPNHSA SIQLCVQKLR ILIEDSDQNL KYLGLLAMSK ILKTHPKSVQ SHKDLILQCL 190 200 210 220 230 240 DDKDESIRLR ALDLLYGMVS KKNLMEIVKK LMTHVDKAEG TTYRDELLTK IIDICSQSNY 250 260 270 280 290 300 QYITNFEWYI SILVELTRLE GTRHGHLIAA QMLDVAIRVK AIRKFAVSQM SALLDSAHLL 310 320 330 340 350 360 ASSTQRNGIC EVLYAAAWIC GEFSEHLQEP HHTLEAMLRP RVTTLPGHIQ AVYVQNVVKL 370 380 390 400 410 420 YASILQQKEQ AGEAEGAQAV TQLMVDRLPQ FVQSADLEVQ ERASCILQLV KHIQKLQAKD 430 440 450 460 470 480 VPVAEEVSAL FAGELNPVAP KAQKKVPVPE GLDLDAWINE PLSDSESEDE RPRAVFHEEE 490 500 510 520 530 540 QRRPKHRPSE ADEEELARRR EARKQEQANN PFYIKSSPSP QKRYQDTPGV EHIPVVQIDL 550 560 570 580 590 600 SVPLKVPGLP MSDQYVKLEE ERRHRQKLEK DKRRKKRKEK EKKGKRRHSS LPTESDEDIA 610 620 630 640 650 660 PAQQVDIVTE EMPENALPSD EDDKDPNDPY RALDIDLDKP LADSEKLPIQ KHRNTETSKS 670 680 690 700 710 720 PEKDVPMVEK KSKKPKKKEK KHKEKERDKE KKKEKEKKKS PKPKKKKHRK EKEERTKGKK 730 740 750 760 770 780 KSKKQPPGSE EAAGEPVQNG APEEEQLPPE SSYSLLAENS YVKMTCDIRG SLQEDSQVTV 790 800 810 820 830 840 AIVLENRSSS ILKGMELSVL DSLNARMARP QGSSVHDGVP VPFQLPPGVS NEAQYVFTIQ 850 860 870 880 890 900 SIVMAQKLKG TLSFIAKNDE GATHEKLDFR LHFSCSSYLI TTPCYSDAFA KLLESGDLSM 910 920 930 940 950 960 SSIKVDGIRM SFQNLLAKIC FHHHFSVVER VDSCASMYSR SIQGHHVCLL VKKGENSVSV 970 980 DGKCSDSTLL SNLLEEMKAT LAKC
	Isoform 4. Checksum: 730F9AD61CEF63DD	FASTA	1,021	114,707
	10 20 30 40 50 60 MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 70 80 90 100 110 120 KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 130 140 150 160 170 180 SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES 190 200 210 220 230 240 LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK 250 260 270 280 290 300 IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 310 320 330 340 350 360 IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA 370 380 390 400 410 420 LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS 430 440 450 460 470 480 ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE 490 500 510 520 530 540 VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA 550 560 570 580 590 600 GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF 610 620 630 640 650 660 AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA 670 680 690 700 710 720 DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM 730 740 750 760 770 780 SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE ERTKGKKKSK KQPPGSEEAA GEPVQNGAPE 790 800 810 820 830 840 EEQLPPESSY SLLAENSYVK MTCDIRGSLQ EDSQVTVAIV LENRSSSILK GMELSVLDSL 850 860 870 880 890 900 NARMARPQGS SVHDGVPVPF QLPPGVSNEA QYVFTIQSIV MAQKLKGTLS FIAKNDEGAT 910 920 930 940 950 960 HEKLDFRLHF SCSSYLITTP CYSDAFAKLL ESGDLSMSSI KVDGIRMSFQ NLLAKICFHH 970 980 990 1000 1010 1020 HFSVVERVDS CASMYSRSIQ GHHVCLLVKK GENSVSVDGK CSDSTLLSNL LEEMKATLAK C
	Isoform 5. Checksum: E77257F13AD4A67F	FASTA	1,215	136,651
	10 20 30 40 50 60 MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC 70 80 90 100 110 120 KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ SFHEGTDVIM LTTNQIRKDL 130 140 150 160 170 180 SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES 190 200 210 220 230 240 LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK 250 260 270 280 290 300 IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS 310 320 330 340 350 360 IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LKTHPKSVQS HKDLILQCLD DKDESIRLRA 370 380 390 400 410 420 LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ YITNFEWYIS 430 440 450 460 470 480 ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRKFAVSQMS ALLDSAHLLA SSTQRNGICE 490 500 510 520 530 540 VLYAAAWICG EFSEHLQEPH HTLEAMLRPR VTTLPGHIQA VYVQNVVKLY ASILQQKEQA 550 560 570 580 590 600 GEAEGAQAVT QLMVDRLPQF VQSADLEVQE RASCILQLVK HIQKLQAKDV PVAEEVSALF 610 620 630 640 650 660 AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDER PRAVFHEEEQ RRPKHRPSEA 670 680 690 700 710 720 DEEELARRRE ARKQEQANNP FYIKSSPSPQ KRYQDTPGVE HIPVVQIDLS VPLKVPGLPM 730 740 750 760 770 780 SDQYVKLEEE RRHRQKLEKD KRRKKRKEKE KKGKRRHSSL PTESDEDIAP AQQVDIVTEE 790 800 810 820 830 840 MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPIQK HRNTETSKSP EKDVPMVEKK 850 860 870 880 890 900 SKKPKKKEKK HKEKERDKEK KKEKEKKAED LDFWLSTTPP PAPAPAPAPV PSTGELSVNT 910 920 930 940 950 960 VTTPKDECED AKTEAQGEED DAEGQDQDKK SPKPKKKKHR KEKEERTKGK KKSKKQPPGS 970 980 990 1000 1010 1020 EEAAGEPVQN GAPEEEQLPP ESSYSLLAEN SYVKMTCDIR GSLQEDSQVT VAIVLENRSS 1030 1040 1050 1060 1070 1080 SILKGMELSV LDSLNARMAR PQGSSVHDGV PVPFQLPPGV SNEAQYVFTI QSIVMAQKLK 1090 1100 1110 1120 1130 1140 GTLSFIAKND EGATHEKLDF RLHFSCSSYL ITTPCYSDAF AKLLESGDLS MSSIKVDGIR 1150 1160 1170 1180 1190 1200 MSFQNLLAKI CFHHHFSVVE RVDSCASMYS RSIQGHHVCL LVKKGENSVS VDGKCSDSTL 1210 LSNLLEEMKA TLAKC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet." Ooi C.E., Moreira J.E., Dell'Angelica E.C., Poy G., Wassarman D.A., Bonifacino J.S. EMBO J. 16:4508-4518(1997) [PubMed: 9303295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4). Tissue: Fetal brain.
[2]	"Characterization of the adaptor-related protein complex, AP-3." Simpson F., Peden A.A., Christopoulou L., Robinson M.S. J. Cell Biol. 137:835-845(1997) [PubMed: 9151686] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Heart.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle.
[6]	"Functional prediction of the coding sequences of 75 new genes deduced by analysis of cDNA clones from human fetal liver." Zhang C., Yu Y., Zhang S., Wei H., Bi J., Zhou G., Dong C., Zai Y., Xu W., Gao F., Liu M., He F. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-603 (ISOFORM 1). Tissue: Fetal liver.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-634; SER-636 AND SER-658, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-829, MASS SPECTROMETRY. Tissue: Platelet.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632; SER-634; SER-636; SER-686; SER-688; SER-758; SER-759; THR-762; SER-764 AND SER-788, MASS SPECTROMETRY.
[10]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF002163 mRNA. Translation: AAC51761.1. U91930 mRNA. Translation: AAD03777.1. AB208804 mRNA. Translation: BAD92041.1. Different initiation. AC005545 Genomic DNA. Translation: AAC34212.1. AC005545 Genomic DNA. Translation: AAC34214.1. BC010065 mRNA. Translation: AAH10065.1. Sequence problems. AF130042 mRNA. Translation: AAG35473.1. Sequence problems.
IPI	IPI00289608. IPI00411453. IPI00411677. IPI00413686. IPI00719680.
RefSeq	NP_001070991.1. NP_003929.4.
UniGene	Hs.512815
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O14617. 4 interactions.
PTM databases
PhosphoSite	O14617.
Proteomic databases
PRIDE	O14617.
Genome annotation databases
Ensembl	ENSG00000065000. Homo sapiens. [Contig view]
GeneID	8943.
KEGG	hsa:8943.
Organism-specific databases
GeneCards	GC19M002051.
H-InvDB	HIX0014607.
HGNC	HGNC:568. AP3D1.
MIM	607246. gene.
PharmGKB	PA24859.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O14617.
HOVERGEN	O14617.
OMA	O14617. QCIDEIK.
Gene expression databases
ArrayExpress	O14617.
Bgee	O14617.
CleanEx	HS_AP3D1.
GermOnline	ENSG00000065000. Homo sapiens.
Family and domain databases
InterPro	IPR017105. AP3_complex_dsu. IPR011989. ARM-like. IPR010474. BLV_receptor. IPR002553. Clathrin/coatomer_adapt-like_N. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit.
Pfam	PF01602. Adaptin_N. 1 hit. PF06375. BLVR. 1 hit. [Graphical view]
PIRSF	PIRSF037092. AP3_complex_delta. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	33636.
SOURCE	Search...

Entry information

Entry name

AP3D1_HUMAN

Accession

Primary (citable) accession number: O14617
Secondary accession number(s): O00202 , O75262, Q59HF5, Q96G11, Q9H3C6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)