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Protein

Cdc42 effector protein 2

Gene

CDC42EP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • GTP-Rho binding Source: UniProtKB
  • opioid peptide activity Source: Ensembl

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • actin filament organization Source: UniProtKB
  • cellular response to interferon-gamma Source: Ensembl
  • positive regulation of actin filament polymerization Source: UniProtKB
  • positive regulation of protein complex assembly Source: UniProtKB
  • positive regulation of pseudopodium assembly Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • Rho protein signal transduction Source: GO_Central

Keywordsi

Biological processCell shape

Enzyme and pathway databases

ReactomeiR-HSA-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 2
Alternative name(s):
Binder of Rho GTPases 1
Gene namesi
Name:CDC42EP2
Synonyms:BORG1, CEP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149798.4
HGNCiHGNC:16263 CDC42EP2
MIMi606132 gene
neXtProtiNX_O14613

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39 – 42HTIH → ATIA: No binding with CDC42; no induced pseudopodia formation. 1 Publication4

Organism-specific databases

OpenTargetsiENSG00000149798
PharmGKBiPA38396

Polymorphism and mutation databases

BioMutaiCDC42EP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002126482 – 210Cdc42 effector protein 2Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei101PhosphoserineBy similarity1
Modified residuei141PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO14613
MaxQBiO14613
PaxDbiO14613
PeptideAtlasiO14613
PRIDEiO14613

PTM databases

iPTMnetiO14613
PhosphoSitePlusiO14613

Expressioni

Tissue specificityi

Highly expressed in the heart. Weakly expressed in the pancreas and liver.1 Publication

Gene expression databases

BgeeiENSG00000149798
CleanExiHS_CDC42EP2
GenevisibleiO14613 HS

Organism-specific databases

HPAiHPA038562

Interactioni

Subunit structurei

Interacts with RHOQ and CDC42 in a GTP-dependent manner, and with SEPT7.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • GTP-Rho binding Source: UniProtKB
  • opioid peptide activity Source: Ensembl

Protein-protein interaction databases

BioGridi115702, 7 interactors
IntActiO14613, 7 interactors
STRINGi9606.ENSP00000279249

Structurei

3D structure databases

ProteinModelPortaliO14613
SMRiO14613
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 44CRIBPROSITE-ProRule annotationAdd BLAST15

Domaini

The CRIB domain mediates interaction with CDC42.

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Phylogenomic databases

eggNOGiENOG410IZS0 Eukaryota
ENOG4111X3X LUCA
GeneTreeiENSGT00730000110928
HOGENOMiHOG000233908
HOVERGENiHBG052803
InParanoidiO14613
OMAiIMDQDLG
OrthoDBiEOG091G0GMP
PhylomeDBiO14613
TreeFamiTF331725

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR017363 Cdc42_effector_prot_2
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
PIRSFiPIRSF038036 Cdc42_effector_p2, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGSD
60 70 80 90 100
MFGDISFLQG KFHLLPGTMV EGPEEDGTFD LPFQFTRTAT VCGRELPDGP
110 120 130 140 150
SPLLKNAISL PVIGGPQALT LPTAQAPPKP PRLHLETPQP SPQEGGSVDI
160 170 180 190 200
WRIPETGSPN SGLTPESGAE EPFLSNASSL LSLHVDLGPS ILDDVLQIMD
210
QDLDSMQIPT
Length:210
Mass (Da):22,484
Last modified:January 1, 1998 - v1
Checksum:i7755100672FFB69C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92C → V in AAD16185 (PubMed:11035016).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023001176N → S1 PublicationCorresponds to variant dbSNP:rs4149839Ensembl.1
Natural variantiVAR_023002191I → F1 PublicationCorresponds to variant dbSNP:rs7120634Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001436 mRNA Translation: AAB81206.1
AF163840 mRNA Translation: AAD48784.1
AF098290 mRNA Translation: AAD16185.1
AK315444 mRNA Translation: BAG37832.1
BT020004 mRNA Translation: AAV38807.1
AF548903 Genomic DNA Translation: AAN39381.1
BC022337 mRNA Translation: AAH22337.1
BC075834 mRNA Translation: AAH75834.1
CCDSiCCDS8099.1
RefSeqiNP_006770.1, NM_006779.3
XP_016872583.1, XM_017017094.1
UniGeneiHs.343380

Genome annotation databases

EnsembliENST00000279249; ENSP00000279249; ENSG00000149798
ENST00000533419; ENSP00000431660; ENSG00000149798
GeneIDi10435
KEGGihsa:10435
UCSCiuc001odl.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBORG1_HUMAN
AccessioniPrimary (citable) accession number: O14613
Secondary accession number(s): B2RD85, Q9UNS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 1, 1998
Last modified: January 31, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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