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O14610

- GBGT2_HUMAN

UniProt

O14610 - GBGT2_HUMAN

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Gene

GNGT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB
    2. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: UniProtKB
    2. GTP catabolic process Source: GOC
    3. phototransduction Source: UniProtKB
    4. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15457. G-protein activation.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18283. G alpha (q) signalling events.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19231. G alpha (i) signalling events.
    REACT_19290. G beta:gamma signalling through PI3Kgamma.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    REACT_21254. Presynaptic function of Kainate receptors.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_23946. Prostacyclin signalling through prostacyclin receptor.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
    Alternative name(s):
    G gamma-C
    G-gamma-8
    G-gamma-9
    Guanine nucleotide binding protein gamma transducing activity polypeptide 2
    Gene namesi
    Name:GNGT2
    Synonyms:GNG8, GNG9, GNGT8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:4412. GNGT2.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28791.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6666Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2PRO_0000012645Add
    BLAST
    Propeptidei67 – 693Removed in mature formBy similarityPRO_0000012646

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei66 – 661Cysteine methyl esterSequence Analysis
    Lipidationi66 – 661S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiO14610.
    PaxDbiO14610.
    PRIDEiO14610.

    Expressioni

    Tissue specificityi

    Retinal cones.

    Gene expression databases

    ArrayExpressiO14610.
    BgeeiO14610.
    CleanExiHS_GNG8.
    HS_GNGT2.
    GenevestigatoriO14610.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    BioGridi109055. 5 interactions.
    STRINGi9606.ENSP00000300406.

    Structurei

    3D structure databases

    ProteinModelPortaliO14610.
    SMRiO14610. Positions 5-62.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG304504.
    HOGENOMiHOG000231034.
    HOVERGENiHBG014983.
    InParanoidiO14610.
    KOiK04549.
    PhylomeDBiO14610.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14610-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQDLSEKDL LKMEVEQLKK EVKNTRIPIS KAGKEIKEYV EAQAGNDPFL   50
    KGIPEDKNPF KEKGGCLIS 69
    Length:69
    Mass (Da):7,747
    Last modified:January 1, 1998 - v1
    Checksum:i7ABD417F097F719B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111L → F.
    Corresponds to variant rs9895097 [ dbSNP | Ensembl ].
    VAR_049271

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001160, AF001159 Genomic DNA. Translation: AAB70039.1.
    AF365870 mRNA. Translation: AAK53384.1.
    AF493876 mRNA. Translation: AAM12590.1.
    AK312839 mRNA. Translation: BAG35693.1.
    CH471109 Genomic DNA. Translation: EAW94688.1.
    CH471109 Genomic DNA. Translation: EAW94689.1.
    BC008663 mRNA. Translation: AAH08663.1.
    CCDSiCCDS11545.1.
    RefSeqiNP_001185683.1. NM_001198754.1.
    NP_001185684.1. NM_001198755.1.
    NP_001185685.1. NM_001198756.1.
    NP_113686.1. NM_031498.2.
    XP_006721882.1. XM_006721819.1.
    UniGeneiHs.181781.

    Genome annotation databases

    EnsembliENST00000300406; ENSP00000300406; ENSG00000167083.
    ENST00000507680; ENSP00000421710; ENSG00000167083.
    ENST00000511277; ENSP00000426022; ENSG00000167083.
    ENST00000511673; ENSP00000422879; ENSG00000167083.
    ENST00000515635; ENSP00000423924; ENSG00000167083.
    GeneIDi2793.
    KEGGihsa:2793.
    UCSCiuc002ioo.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001160 , AF001159 Genomic DNA. Translation: AAB70039.1 .
    AF365870 mRNA. Translation: AAK53384.1 .
    AF493876 mRNA. Translation: AAM12590.1 .
    AK312839 mRNA. Translation: BAG35693.1 .
    CH471109 Genomic DNA. Translation: EAW94688.1 .
    CH471109 Genomic DNA. Translation: EAW94689.1 .
    BC008663 mRNA. Translation: AAH08663.1 .
    CCDSi CCDS11545.1.
    RefSeqi NP_001185683.1. NM_001198754.1.
    NP_001185684.1. NM_001198755.1.
    NP_001185685.1. NM_001198756.1.
    NP_113686.1. NM_031498.2.
    XP_006721882.1. XM_006721819.1.
    UniGenei Hs.181781.

    3D structure databases

    ProteinModelPortali O14610.
    SMRi O14610. Positions 5-62.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109055. 5 interactions.
    STRINGi 9606.ENSP00000300406.

    Proteomic databases

    MaxQBi O14610.
    PaxDbi O14610.
    PRIDEi O14610.

    Protocols and materials databases

    DNASUi 2793.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300406 ; ENSP00000300406 ; ENSG00000167083 .
    ENST00000507680 ; ENSP00000421710 ; ENSG00000167083 .
    ENST00000511277 ; ENSP00000426022 ; ENSG00000167083 .
    ENST00000511673 ; ENSP00000422879 ; ENSG00000167083 .
    ENST00000515635 ; ENSP00000423924 ; ENSG00000167083 .
    GeneIDi 2793.
    KEGGi hsa:2793.
    UCSCi uc002ioo.2. human.

    Organism-specific databases

    CTDi 2793.
    GeneCardsi GC17M047283.
    HGNCi HGNC:4412. GNGT2.
    MIMi 139391. gene.
    neXtProti NX_O14610.
    PharmGKBi PA28791.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304504.
    HOGENOMi HOG000231034.
    HOVERGENi HBG014983.
    InParanoidi O14610.
    KOi K04549.
    PhylomeDBi O14610.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_15457. G-protein activation.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18283. G alpha (q) signalling events.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19231. G alpha (i) signalling events.
    REACT_19290. G beta:gamma signalling through PI3Kgamma.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    REACT_21254. Presynaptic function of Kainate receptors.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_23946. Prostacyclin signalling through prostacyclin receptor.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.

    Miscellaneous databases

    GeneWikii GNGT2.
    GenomeRNAii 2793.
    NextBioi 11005.
    PROi O14610.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14610.
    Bgeei O14610.
    CleanExi HS_GNG8.
    HS_GNGT2.
    Genevestigatori O14610.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2)."
      Ong O.C., Hu K., Rong H., Lee R.H., Fung B.K.-K.
      Genomics 44:101-109(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Retina.
    2. "Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms."
      Cook L.A., Schey K.L., Cleator J.H., Wilcox M.D., Dingus J., Hildebrandt J.D.
      Protein Sci. 10:2548-2555(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiGBGT2_HUMAN
    AccessioniPrimary (citable) accession number: O14610
    Secondary accession number(s): B2R746, D3DTW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3