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O14610 (GBGT2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Alternative name(s):
G gamma-C
G-gamma-8
G-gamma-9
Guanine nucleotide binding protein gamma transducing activity polypeptide 2
Gene names
Name:GNGT2
Synonyms:GNG8, GNG9, GNGT8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length69 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Retinal cones.

Sequence similarities

Belongs to the G protein gamma family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6666Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
PRO_0000012645
Propeptide67 – 693Removed in mature form By similarity
PRO_0000012646

Amino acid modifications

Modified residue661Cysteine methyl ester Potential
Lipidation661S-farnesyl cysteine By similarity

Natural variations

Natural variant111L → F.
Corresponds to variant rs9895097 [ dbSNP | Ensembl ].
VAR_049271

Sequences

Sequence LengthMass (Da)Tools
O14610 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 7ABD417F097F719B

FASTA697,747
        10         20         30         40         50         60 
MAQDLSEKDL LKMEVEQLKK EVKNTRIPIS KAGKEIKEYV EAQAGNDPFL KGIPEDKNPF 


KEKGGCLIS 

« Hide

References

« Hide 'large scale' references
[1]"Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2)."
Ong O.C., Hu K., Rong H., Lee R.H., Fung B.K.-K.
Genomics 44:101-109(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Retina.
[2]"Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms."
Cook L.A., Schey K.L., Cleator J.H., Wilcox M.D., Dingus J., Hildebrandt J.D.
Protein Sci. 10:2548-2555(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF001160, AF001159 Genomic DNA. Translation: AAB70039.1.
AF365870 mRNA. Translation: AAK53384.1.
AF493876 mRNA. Translation: AAM12590.1.
AK312839 mRNA. Translation: BAG35693.1.
CH471109 Genomic DNA. Translation: EAW94688.1.
CH471109 Genomic DNA. Translation: EAW94689.1.
BC008663 mRNA. Translation: AAH08663.1.
CCDSCCDS11545.1.
RefSeqNP_001185683.1. NM_001198754.1.
NP_001185684.1. NM_001198755.1.
NP_001185685.1. NM_001198756.1.
NP_113686.1. NM_031498.2.
XP_006721882.1. XM_006721819.1.
UniGeneHs.181781.

3D structure databases

ProteinModelPortalO14610.
SMRO14610. Positions 5-62.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109055. 5 interactions.
STRING9606.ENSP00000300406.

Proteomic databases

MaxQBO14610.
PaxDbO14610.
PRIDEO14610.

Protocols and materials databases

DNASU2793.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300406; ENSP00000300406; ENSG00000167083.
ENST00000507680; ENSP00000421710; ENSG00000167083.
ENST00000511277; ENSP00000426022; ENSG00000167083.
ENST00000511673; ENSP00000422879; ENSG00000167083.
ENST00000515635; ENSP00000423924; ENSG00000167083.
GeneID2793.
KEGGhsa:2793.
UCSCuc002ioo.2. human.

Organism-specific databases

CTD2793.
GeneCardsGC17M047283.
HGNCHGNC:4412. GNGT2.
MIM139391. gene.
neXtProtNX_O14610.
PharmGKBPA28791.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304504.
HOGENOMHOG000231034.
HOVERGENHBG014983.
InParanoidO14610.
KOK04549.
PhylomeDBO14610.
TreeFamTF319909.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_13685. Neuronal System.
REACT_15518. Transmembrane transport of small molecules.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpressO14610.
BgeeO14610.
CleanExHS_GNG8.
HS_GNGT2.
GenevestigatorO14610.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGNGT2.
GenomeRNAi2793.
NextBio11005.
PROO14610.
SOURCESearch...

Entry information

Entry nameGBGT2_HUMAN
AccessionPrimary (citable) accession number: O14610
Secondary accession number(s): B2R746, D3DTW5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM