O14607 (UTY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone demethylase UTY
EC=1.14.11.-

Alternative name(s):
Ubiquitously-transcribed TPR protein on the Y chromosome
Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein

Gene names

Name:

UTY

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1347 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Histone demethylase By similarity.
Cofactor	Ascorbate By similarity. Fe2+ By similarity.
Subunit structure	Interacts with TLE1 and TLE2 By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the UTX family. Contains 1 JmjC domain. Contains 8 TPR repeats.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat TPR repeat
Ligand	Iron Metal-binding
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cardiac muscle cell contraction Inferred from electronic annotation. Source: Compara establishment of protein localization Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara regulation of chromatin silencing Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone demethylase activity (H3-K36 specific) Inferred from electronic annotation. Source: Compara metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O14607-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14607-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     996-1079: EENEKRTQHK...GHTILGMNTV → AGMQWCDLSS...GITGVSHHAR
     1080-1347: Missing.

Isoform 3 (identifier: O14607-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1347: Missing.

Isoform 4 (identifier: O14607-4)

The sequence of this isoform differs from the canonical sequence as follows:
     394-394: L → LQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQ

Isoform 5 (identifier: O14607-5)

The sequence of this isoform differs from the canonical sequence as follows:
     394-394: L → LQAQLCNLPQSSLQNKTKLLPSIEEAWSLPIPAELTSRQGAMNTAQ
     465-588: Missing.
     1283-1339: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1347	1347	Histone demethylase UTY		PRO_0000106411
Regions
	Repeat	90 – 123	34	TPR 1
	Repeat	127 – 160	34	TPR 2
	Repeat	167 – 196	30	TPR 3
	Repeat	202 – 235	34	TPR 4
	Repeat	247 – 280	34	TPR 5
	Repeat	281 – 314	34	TPR 6
	Repeat	315 – 348	34	TPR 7
	Repeat	349 – 382	34	TPR 8
	Domain	1042 – 1205	164	JmjC
Sites
	Metal binding	1093	1	Iron By similarity
	Metal binding	1095	1	Iron By similarity
Natural variations
	Alternative sequence	394	1	L → LQAQLCNLPQSSLQNKTKLL PSIEEAWSLPIPAELTSRQG AMNTAQ in isoform 4 and isoform 5.		VSP_045611
	Alternative sequence	465 – 588	124	Missing in isoform 5.		VSP_045612
	Alternative sequence	996 – 1079	84	EENEK…GMNTV → AGMQWCDLSSLQPPPPGFKR FSHLSLPNSWNYRHLPSCPT NFCIFVETGFHHVGQACLEL LTSGGLLASASQSAGITGVS HHAR in isoform 2.		VSP_006556
	Alternative sequence	1080 – 1347	268	Missing in isoform 2.		VSP_036783
	Alternative sequence	1241 – 1347	107	Missing in isoform 3.		VSP_036784
	Alternative sequence	1283 – 1339	57	Missing in isoform 5.		VSP_045613
Experimental info
	Sequence conflict	81	1	I → L in ABA25871. Ref.2
	Sequence conflict	86	1	G → R in ABA25870. Ref.2
	Sequence conflict	122	1	D → G in ABA25870. Ref.2
	Sequence conflict	218	1	Y → C in ABA25871. Ref.2
	Sequence conflict	297	1	V → A in ABA25870. Ref.2
	Sequence conflict	301	1	F → S in BAF85547. Ref.3
	Sequence conflict	302	1	I → V in ABA25870. Ref.2
	Sequence conflict	372	1	Y → H in ABA25870. Ref.2
	Sequence conflict	431	1	L → P in ABA25870. Ref.2
	Sequence conflict	625	1	I → T in BAF85547. Ref.3
	Sequence conflict	644	1	A → V in ABA25870. Ref.2
	Sequence conflict	793	1	S → R in ABA25871. Ref.2
	Sequence conflict	1177	1	A → T in AAC51841. Ref.1
	Sequence conflict	1177	1	A → T in AAC51842. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified April 14, 2009. Version 2. Checksum: D83B8CAB861BCE60	FASTA	1,347	149,548
	10 20 30 40 50 60 MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH 70 80 90 100 110 120 EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ 130 140 150 160 170 180 ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY 190 200 210 220 230 240 KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA 250 260 270 280 290 300 TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA 310 320 330 340 350 360 FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE 370 380 390 400 410 420 SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQNGSDN WNGGQSLSHH PVQQVYSLCL 430 440 450 460 470 480 TPQKLQHLEQ LRANRDNLNP AQKHQLEQLE SQFVLMQQMR HKEVAQVRTT GIHNGAITDS 490 500 510 520 530 540 SLPTNSVSNR QPHGALTRVS SVSQPGVRPA CVEKLLSSGA FSAGCIPCGT SKILGSTDTI 550 560 570 580 590 600 LLGSNCIAGS ESNGNVPYLQ QNTHTLPHNH TDLNSSTEEP WRKQLSNSAQ GLHKSQSSCL 610 620 630 640 650 660 SGPNEEQPLF STGSAQYHQA TSTGIKKANE HLTLPSNSVP QGDADSHLSC HTATSGGQQG 670 680 690 700 710 720 IMFTKESKPS KNRSLVPETS RHTGDTSNGC ADVKGLSNHV HQLIADAVSS PNHGDSPNLL 730 740 750 760 770 780 IADNPQLSAL LIGKANGNVG TGTCDKVNNI HPAVHTKTDH SVASSPSSAI STATPSPKST 790 800 810 820 830 840 EQRSINSVTS LNSPHSGLHT VNGEGLGKSQ SSTKVDLPLA SHRSTSQILP SMSVSICPSS 850 860 870 880 890 900 TEVLKACRNP GKNGLSNSCI LLDKCPPPRP PTSPYPPLPK DKLNPPTPSI YLENKRDAFF 910 920 930 940 950 960 PPLHQFCTNP KNPVTVIRGL AGALKLDLGL FSTKTLVEAN NEHMVEVRTQ LLQPADENWD 970 980 990 1000 1010 1020 PTGTKKIWRC ESNRSHTTIA KYAQYQASSF QESLREENEK RTQHKDHSDN ESTSSENSGR 1030 1040 1050 1060 1070 1080 RRKGPFKTIK FGTNIDLSDN KKWKLQLHEL TKLPAFARVV SAGNLLTHVG HTILGMNTVQ 1090 1100 1110 1120 1130 1140 LYMKVPGSRT PGHQENNNFC SVNINIGPGD CEWFVVPEDY WGVLNDFCEK NNLNFLMSSW 1150 1160 1170 1180 1190 1200 WPNLEDLYEA NVPVYRFIQR PGDLVWINAG TVHWVQAVGW CNNIAWNVGP LTACQYKLAV 1210 1220 1230 1240 1250 1260 ERYEWNKLKS VKSPVPMVHL SWNMARNIKV SDPKLFEMIK YCLLKILKQY QTLREALVAA 1270 1280 1290 1300 1310 1320 GKEVIWHGRT NDEPAHYCSI CEVEVFNLLF VTNESNTQKT YIVHCHDCAR KTSKSLENFV 1330 1340 VLEQYKMEDL IQVYDQFTLA LSLSSSS
	Isoform 2 (Short) [UniParc]. Checksum: B48FF0FAFFED5998	FASTA	1,079	118,074
	10 20 30 40 50 60 MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH 70 80 90 100 110 120 EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ 130 140 150 160 170 180 ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY 190 200 210 220 230 240 KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA 250 260 270 280 290 300 TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA 310 320 330 340 350 360 FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE 370 380 390 400 410 420 SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQNGSDN WNGGQSLSHH PVQQVYSLCL 430 440 450 460 470 480 TPQKLQHLEQ LRANRDNLNP AQKHQLEQLE SQFVLMQQMR HKEVAQVRTT GIHNGAITDS 490 500 510 520 530 540 SLPTNSVSNR QPHGALTRVS SVSQPGVRPA CVEKLLSSGA FSAGCIPCGT SKILGSTDTI 550 560 570 580 590 600 LLGSNCIAGS ESNGNVPYLQ QNTHTLPHNH TDLNSSTEEP WRKQLSNSAQ GLHKSQSSCL 610 620 630 640 650 660 SGPNEEQPLF STGSAQYHQA TSTGIKKANE HLTLPSNSVP QGDADSHLSC HTATSGGQQG 670 680 690 700 710 720 IMFTKESKPS KNRSLVPETS RHTGDTSNGC ADVKGLSNHV HQLIADAVSS PNHGDSPNLL 730 740 750 760 770 780 IADNPQLSAL LIGKANGNVG TGTCDKVNNI HPAVHTKTDH SVASSPSSAI STATPSPKST 790 800 810 820 830 840 EQRSINSVTS LNSPHSGLHT VNGEGLGKSQ SSTKVDLPLA SHRSTSQILP SMSVSICPSS 850 860 870 880 890 900 TEVLKACRNP GKNGLSNSCI LLDKCPPPRP PTSPYPPLPK DKLNPPTPSI YLENKRDAFF 910 920 930 940 950 960 PPLHQFCTNP KNPVTVIRGL AGALKLDLGL FSTKTLVEAN NEHMVEVRTQ LLQPADENWD 970 980 990 1000 1010 1020 PTGTKKIWRC ESNRSHTTIA KYAQYQASSF QESLRAGMQW CDLSSLQPPP PGFKRFSHLS 1030 1040 1050 1060 1070 LPNSWNYRHL PSCPTNFCIF VETGFHHVGQ ACLELLTSGG LLASASQSAG ITGVSHHAR
	Isoform 3 [UniParc]. Checksum: 38B414FFA5AC7C07	FASTA	1,240	137,213
	10 20 30 40 50 60 MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH 70 80 90 100 110 120 EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ 130 140 150 160 170 180 ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY 190 200 210 220 230 240 KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA 250 260 270 280 290 300 TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA 310 320 330 340 350 360 FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE 370 380 390 400 410 420 SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQNGSDN WNGGQSLSHH PVQQVYSLCL 430 440 450 460 470 480 TPQKLQHLEQ LRANRDNLNP AQKHQLEQLE SQFVLMQQMR HKEVAQVRTT GIHNGAITDS 490 500 510 520 530 540 SLPTNSVSNR QPHGALTRVS SVSQPGVRPA CVEKLLSSGA FSAGCIPCGT SKILGSTDTI 550 560 570 580 590 600 LLGSNCIAGS ESNGNVPYLQ QNTHTLPHNH TDLNSSTEEP WRKQLSNSAQ GLHKSQSSCL 610 620 630 640 650 660 SGPNEEQPLF STGSAQYHQA TSTGIKKANE HLTLPSNSVP QGDADSHLSC HTATSGGQQG 670 680 690 700 710 720 IMFTKESKPS KNRSLVPETS RHTGDTSNGC ADVKGLSNHV HQLIADAVSS PNHGDSPNLL 730 740 750 760 770 780 IADNPQLSAL LIGKANGNVG TGTCDKVNNI HPAVHTKTDH SVASSPSSAI STATPSPKST 790 800 810 820 830 840 EQRSINSVTS LNSPHSGLHT VNGEGLGKSQ SSTKVDLPLA SHRSTSQILP SMSVSICPSS 850 860 870 880 890 900 TEVLKACRNP GKNGLSNSCI LLDKCPPPRP PTSPYPPLPK DKLNPPTPSI YLENKRDAFF 910 920 930 940 950 960 PPLHQFCTNP KNPVTVIRGL AGALKLDLGL FSTKTLVEAN NEHMVEVRTQ LLQPADENWD 970 980 990 1000 1010 1020 PTGTKKIWRC ESNRSHTTIA KYAQYQASSF QESLREENEK RTQHKDHSDN ESTSSENSGR 1030 1040 1050 1060 1070 1080 RRKGPFKTIK FGTNIDLSDN KKWKLQLHEL TKLPAFARVV SAGNLLTHVG HTILGMNTVQ 1090 1100 1110 1120 1130 1140 LYMKVPGSRT PGHQENNNFC SVNINIGPGD CEWFVVPEDY WGVLNDFCEK NNLNFLMSSW 1150 1160 1170 1180 1190 1200 WPNLEDLYEA NVPVYRFIQR PGDLVWINAG TVHWVQAVGW CNNIAWNVGP LTACQYKLAV 1210 1220 1230 1240 ERYEWNKLKS VKSPVPMVHL SWNMARNIKV SDPKLFEMIK
	Isoform 4 [UniParc]. Checksum: F49723B217462AD0	FASTA	1,392	154,437
	10 20 30 40 50 60 MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH 70 80 90 100 110 120 EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ 130 140 150 160 170 180 ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY 190 200 210 220 230 240 KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA 250 260 270 280 290 300 TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA 310 320 330 340 350 360 FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE 370 380 390 400 410 420 SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQAQLCN LPQSSLQNKT KLLPSIEEAW 430 440 450 460 470 480 SLPIPAELTS RQGAMNTAQQ NGSDNWNGGQ SLSHHPVQQV YSLCLTPQKL QHLEQLRANR 490 500 510 520 530 540 DNLNPAQKHQ LEQLESQFVL MQQMRHKEVA QVRTTGIHNG AITDSSLPTN SVSNRQPHGA 550 560 570 580 590 600 LTRVSSVSQP GVRPACVEKL LSSGAFSAGC IPCGTSKILG STDTILLGSN CIAGSESNGN 610 620 630 640 650 660 VPYLQQNTHT LPHNHTDLNS STEEPWRKQL SNSAQGLHKS QSSCLSGPNE EQPLFSTGSA 670 680 690 700 710 720 QYHQATSTGI KKANEHLTLP SNSVPQGDAD SHLSCHTATS GGQQGIMFTK ESKPSKNRSL 730 740 750 760 770 780 VPETSRHTGD TSNGCADVKG LSNHVHQLIA DAVSSPNHGD SPNLLIADNP QLSALLIGKA 790 800 810 820 830 840 NGNVGTGTCD KVNNIHPAVH TKTDHSVASS PSSAISTATP SPKSTEQRSI NSVTSLNSPH 850 860 870 880 890 900 SGLHTVNGEG LGKSQSSTKV DLPLASHRST SQILPSMSVS ICPSSTEVLK ACRNPGKNGL 910 920 930 940 950 960 SNSCILLDKC PPPRPPTSPY PPLPKDKLNP PTPSIYLENK RDAFFPPLHQ FCTNPKNPVT 970 980 990 1000 1010 1020 VIRGLAGALK LDLGLFSTKT LVEANNEHMV EVRTQLLQPA DENWDPTGTK KIWRCESNRS 1030 1040 1050 1060 1070 1080 HTTIAKYAQY QASSFQESLR EENEKRTQHK DHSDNESTSS ENSGRRRKGP FKTIKFGTNI 1090 1100 1110 1120 1130 1140 DLSDNKKWKL QLHELTKLPA FARVVSAGNL LTHVGHTILG MNTVQLYMKV PGSRTPGHQE 1150 1160 1170 1180 1190 1200 NNNFCSVNIN IGPGDCEWFV VPEDYWGVLN DFCEKNNLNF LMSSWWPNLE DLYEANVPVY 1210 1220 1230 1240 1250 1260 RFIQRPGDLV WINAGTVHWV QAVGWCNNIA WNVGPLTACQ YKLAVERYEW NKLKSVKSPV 1270 1280 1290 1300 1310 1320 PMVHLSWNMA RNIKVSDPKL FEMIKYCLLK ILKQYQTLRE ALVAAGKEVI WHGRTNDEPA 1330 1340 1350 1360 1370 1380 HYCSICEVEV FNLLFVTNES NTQKTYIVHC HDCARKTSKS LENFVVLEQY KMEDLIQVYD 1390 QFTLALSLSS SS
	Isoform 5 [UniParc]. Checksum: C429C9E257FD074A	FASTA	1,211	134,762
	10 20 30 40 50 60 MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH 70 80 90 100 110 120 EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ 130 140 150 160 170 180 ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY 190 200 210 220 230 240 KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA 250 260 270 280 290 300 TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA 310 320 330 340 350 360 FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE 370 380 390 400 410 420 SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQAQLCN LPQSSLQNKT KLLPSIEEAW 430 440 450 460 470 480 SLPIPAELTS RQGAMNTAQQ NGSDNWNGGQ SLSHHPVQQV YSLCLTPQKL QHLEQLRANR 490 500 510 520 530 540 DNLNPAQKHQ LEQLESQFVL MQQMRHKEVA QGLHKSQSSC LSGPNEEQPL FSTGSAQYHQ 550 560 570 580 590 600 ATSTGIKKAN EHLTLPSNSV PQGDADSHLS CHTATSGGQQ GIMFTKESKP SKNRSLVPET 610 620 630 640 650 660 SRHTGDTSNG CADVKGLSNH VHQLIADAVS SPNHGDSPNL LIADNPQLSA LLIGKANGNV 670 680 690 700 710 720 GTGTCDKVNN IHPAVHTKTD HSVASSPSSA ISTATPSPKS TEQRSINSVT SLNSPHSGLH 730 740 750 760 770 780 TVNGEGLGKS QSSTKVDLPL ASHRSTSQIL PSMSVSICPS STEVLKACRN PGKNGLSNSC 790 800 810 820 830 840 ILLDKCPPPR PPTSPYPPLP KDKLNPPTPS IYLENKRDAF FPPLHQFCTN PKNPVTVIRG 850 860 870 880 890 900 LAGALKLDLG LFSTKTLVEA NNEHMVEVRT QLLQPADENW DPTGTKKIWR CESNRSHTTI 910 920 930 940 950 960 AKYAQYQASS FQESLREENE KRTQHKDHSD NESTSSENSG RRRKGPFKTI KFGTNIDLSD 970 980 990 1000 1010 1020 NKKWKLQLHE LTKLPAFARV VSAGNLLTHV GHTILGMNTV QLYMKVPGSR TPGHQENNNF 1030 1040 1050 1060 1070 1080 CSVNINIGPG DCEWFVVPED YWGVLNDFCE KNNLNFLMSS WWPNLEDLYE ANVPVYRFIQ 1090 1100 1110 1120 1130 1140 RPGDLVWINA GTVHWVQAVG WCNNIAWNVG PLTACQYKLA VERYEWNKLK SVKSPVPMVH 1150 1160 1170 1180 1190 1200 LSWNMARNIK VSDPKLFEMI KYCLLKILKQ YQTLREALVA AGKEVIWHGR TNDEPAHYCS 1210 ICEALSLSSS S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional coherence of the human Y chromosome." Lahn B.T., Page D.C. Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
[2]	"Characterization of the human UTY gene." Laaser I., Kolb H.J., Adamski J. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Trachea.
[4]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 461-468. Tissue: Platelet.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF000994 mRNA. Translation: AAC51841.1.
AF000995 mRNA. Translation: AAC51842.1.
AF000996 mRNA. Translation: AAC51843.1.
DQ140389 mRNA. Translation: ABA25870.1.
DQ140390 mRNA. Translation: ABA25871.1.
AK292858 mRNA. Translation: BAF85547.1.
AC005820 Genomic DNA. No translation available.
AC006376 Genomic DNA. No translation available.
AC010877 Genomic DNA. No translation available.

IPI

IPI00023013.
IPI00218824.
IPI00377009.
IPI00973001.
IPI00973329.

PIR

T02214.

RefSeq

NP_001245181.1. NM_001258252.1.
NP_001245183.1. NM_001258254.1.
NP_009056.3. NM_007125.4.
NP_872600.1. NM_182659.1.
NP_872601.1. NM_182660.1.

UniGene

Hs.115277.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3ZLI	X-ray	1.80	A/B	878-1347	[»]

ProteinModelPortal

O14607.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-48650N.

IntAct

O14607. 1 interaction.

STRING

9606.ENSP00000328939.

PTM databases

PhosphoSite

O14607.

Proteomic databases

PaxDb

O14607.

PRIDE

O14607.

Protocols and materials databases

DNASU

7404.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000329134; ENSP00000330446; ENSG00000183878.
ENST00000331397; ENSP00000328939; ENSG00000183878.
ENST00000362096; ENSP00000355420; ENSG00000183878.
ENST00000382896; ENSP00000372352; ENSG00000183878.
ENST00000537580; ENSP00000439922; ENSG00000183878.

GeneID

7404.

KEGG

hsa:7404.

UCSC

uc004fsw.1. human.
uc004fsz.3. human.

Organism-specific databases

CTD

7404.

GeneCards

GC0YM015360.

H-InvDB

HIX0056663.

HGNC

HGNC:12638. UTY.

HPA

HPA000568.
HPA001165.
HPA002111.

MIM

400009. gene.

neXtProt

NX_O14607.

PharmGKB

PA37263.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0457.

HOGENOM

HOG000220834.

HOVERGEN

HBG018063.

KO

K11447.

OrthoDB

EOG4M91QN.

Gene expression databases

ArrayExpress

O14607.

Bgee

O14607.

CleanEx

HS_UTY.

Genevestigator

O14607.

GermOnline

ENSG00000183878. Homo sapiens.

Family and domain databases

Gene3D

1.25.40.10. 1 hit.

InterPro

IPR003347. JmjC_dom.
IPR001440. TPR-1.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]

Pfam

PF02373. JmjC. 1 hit.
PF00515. TPR_1. 3 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]

SMART

SM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]

PROSITE

PS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

7404.

NextBio

28984.

SOURCE

Search...

Entry information

Entry name

UTY_HUMAN

Accession

Primary (citable) accession number: O14607
Secondary accession number(s): A8K9Z3 , E1U199, E1U1A0, F5H4V7, F8W8R7, O14608

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	April 14, 2009
Last modified:	May 1, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.