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Reviewed, UniProtKB/Swiss-Prot O14607 (UTY_HUMAN)

Last modified November 24, 2009. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Histone demethylase UTY
    EC=1.14.11.-
Alternative name(s):
    Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein
    Ubiquitously transcribed TPR protein on the Y chromosome
Gene names
Name: UTY
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1347 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Histone demethylase By similarity.

Cofactor

Ascorbate By similarity.

Fe2+ By similarity.

Subunit structure

Interacts with TLE1 and TLE2 By similarity.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the UTX family.

Contains 1 JmjC domain.

Contains 8 TPR repeats.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: O14607-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O14607-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     996-1079: EENEKRTQHK...GHTILGMNTV → AGMQWCDLSS...GITGVSHHAR
     1080-1347: Missing.
Isoform 3 (identifier: O14607-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1347: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13471347Histone demethylase UTY
PRO_0000106411

Regions

Repeat90 – 12334TPR 1
Repeat127 – 16034TPR 2
Repeat167 – 19630TPR 3
Repeat202 – 23534TPR 4
Repeat247 – 28034TPR 5
Repeat281 – 31434TPR 6
Repeat315 – 34834TPR 7
Repeat349 – 38234TPR 8
Domain1042 – 1205164JmjC

Natural variations

Alternative sequence996 – 107984EENEK…GMNTV → AGMQWCDLSSLQPPPPGFKR FSHLSLPNSWNYRHLPSCPT NFCIFVETGFHHVGQACLEL LTSGGLLASASQSAGITGVS HHAR in isoform 2.
VSP_006556
Alternative sequence1080 – 1347268Missing in isoform 2.
VSP_036783
Alternative sequence1241 – 1347107Missing in isoform 3.
VSP_036784

Experimental info

Sequence conflict3011F → S in BAF85547. Ref.2
Sequence conflict6251I → T in BAF85547. Ref.2
Sequence conflict11771A → T in AAC51841. Ref.1
Sequence conflict11771A → T in AAC51842. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: D83B8CAB861BCE60

FASTA1,347149,548
        10         20         30         40         50         60 
MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH 

        70         80         90        100        110        120 
EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ 

       130        140        150        160        170        180 
ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY 

       190        200        210        220        230        240 
KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA 

       250        260        270        280        290        300 
TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA 

       310        320        330        340        350        360 
FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE 

       370        380        390        400        410        420 
SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQNGSDN WNGGQSLSHH PVQQVYSLCL 

       430        440        450        460        470        480 
TPQKLQHLEQ LRANRDNLNP AQKHQLEQLE SQFVLMQQMR HKEVAQVRTT GIHNGAITDS 

       490        500        510        520        530        540 
SLPTNSVSNR QPHGALTRVS SVSQPGVRPA CVEKLLSSGA FSAGCIPCGT SKILGSTDTI 

       550        560        570        580        590        600 
LLGSNCIAGS ESNGNVPYLQ QNTHTLPHNH TDLNSSTEEP WRKQLSNSAQ GLHKSQSSCL 

       610        620        630        640        650        660 
SGPNEEQPLF STGSAQYHQA TSTGIKKANE HLTLPSNSVP QGDADSHLSC HTATSGGQQG 

       670        680        690        700        710        720 
IMFTKESKPS KNRSLVPETS RHTGDTSNGC ADVKGLSNHV HQLIADAVSS PNHGDSPNLL 

       730        740        750        760        770        780 
IADNPQLSAL LIGKANGNVG TGTCDKVNNI HPAVHTKTDH SVASSPSSAI STATPSPKST 

       790        800        810        820        830        840 
EQRSINSVTS LNSPHSGLHT VNGEGLGKSQ SSTKVDLPLA SHRSTSQILP SMSVSICPSS 

       850        860        870        880        890        900 
TEVLKACRNP GKNGLSNSCI LLDKCPPPRP PTSPYPPLPK DKLNPPTPSI YLENKRDAFF 

       910        920        930        940        950        960 
PPLHQFCTNP KNPVTVIRGL AGALKLDLGL FSTKTLVEAN NEHMVEVRTQ LLQPADENWD 

       970        980        990       1000       1010       1020 
PTGTKKIWRC ESNRSHTTIA KYAQYQASSF QESLREENEK RTQHKDHSDN ESTSSENSGR 

      1030       1040       1050       1060       1070       1080 
RRKGPFKTIK FGTNIDLSDN KKWKLQLHEL TKLPAFARVV SAGNLLTHVG HTILGMNTVQ 

      1090       1100       1110       1120       1130       1140 
LYMKVPGSRT PGHQENNNFC SVNINIGPGD CEWFVVPEDY WGVLNDFCEK NNLNFLMSSW 

      1150       1160       1170       1180       1190       1200 
WPNLEDLYEA NVPVYRFIQR PGDLVWINAG TVHWVQAVGW CNNIAWNVGP LTACQYKLAV 

      1210       1220       1230       1240       1250       1260 
ERYEWNKLKS VKSPVPMVHL SWNMARNIKV SDPKLFEMIK YCLLKILKQY QTLREALVAA 

      1270       1280       1290       1300       1310       1320 
GKEVIWHGRT NDEPAHYCSI CEVEVFNLLF VTNESNTQKT YIVHCHDCAR KTSKSLENFV 

      1330       1340 
VLEQYKMEDL IQVYDQFTLA LSLSSSS 

« Hide

Isoform 2 (Short).

Checksum: B48FF0FAFFED5998
Show »

FASTA1,079118,074
Isoform 3.

Checksum: 38B414FFA5AC7C07
Show »

FASTA1,240137,213

References

« Hide 'large scale' references
[1]"Functional coherence of the human Y chromosome."
Lahn B.T., Page D.C.
Science 278:675-680(1997) [PubMed: 9381176] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Trachea.
[3]"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes."
Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. expand/collapse author list , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C.
Nature 423:825-837(2003) [PubMed: 12815422] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract]
Cited for: PROTEIN SEQUENCE OF 461-468.
Tissue: Platelet.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF000994 mRNA. Translation: AAC51841.1.
AF000995 mRNA. Translation: AAC51842.1.
AF000996 mRNA. Translation: AAC51843.1.
AK292858 mRNA. Translation: BAF85547.1.
AC005820 Genomic DNA. No translation available.
AC006376 Genomic DNA. No translation available.
AC010877 Genomic DNA. No translation available.
IPIIPI00023013.
IPI00218824.
IPI00377009.
PIRT02214.
RefSeqNP_009056.3.
NP_872600.1.
NP_872601.1.
UniGeneHs.115277

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO14607.

PTM databases

PhosphoSiteO14607.

Genome annotation databases

EnsemblENST00000331397; ENSP00000328939; ENSG00000183878; Homo sapiens. [Genome view]
GeneID7404.
KEGGhsa:7404.
UCSCuc004fsx.1. human.

Organism-specific databases

CTD7404.
GeneCardsGC0YM013798.
GC0YM013868.
H-InvDBHIX0027034.
HGNCHGNC:12638. UTY.
HPAHPA000568.
HPA001165.
MIM400009. gene.
PharmGKBPA37263.
GenAtlasSearch...

Phylogenomic databases

HOVERGENO14607.
OMACIAGSES
OrthoDBEOG9PVRJJ

Gene expression databases

ArrayExpressO14607.
BgeeO14607.
CleanExHS_UTY.
GenevestigatorO14607.
GermOnlineENSG00000183878. Homo sapiens.

Family and domain databases

InterProIPR013129. TF_JmjC.
IPR003347. TF_JmjC_AAH.
IPR001440. TPR-1.
IPR011990. TPR-like_helical.
IPR013026. TPR_region.
IPR019734. TPR_repeat.
[Graphical view]
Gene3DG3DSA:1.25.40.10. TPR-like_helical. 2 hits.
PfamPF02373. JmjC. 1 hit.
PF00515. TPR_1. 7 hits.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEPS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio28984.
SOURCESearch...

Entry information

Entry nameUTY_HUMAN
AccessionPrimary (citable) accession number: O14607
Secondary accession number(s): A8K9Z3, O14608
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 14, 2009
Last modified: November 24, 2009
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents