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Protein

Thymosin beta-4, Y-chromosomal

Gene

TMSB4Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
  2. regulation of actin polymerization or depolymerization Source: ProtInc
  3. sequestering of actin monomers Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-4, Y-chromosomal
Gene namesi
Name:TMSB4Y
Synonyms:TB4Y
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:11882. TMSB4Y.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36582.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4444Thymosin beta-4, Y-chromosomalPRO_0000045921Add
BLAST

Proteomic databases

PaxDbiO14604.
PRIDEiO14604.

PTM databases

PhosphoSiteiO14604.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiO14604.
CleanExiHS_TMSB4Y.
GenevestigatoriO14604.

Interactioni

Protein-protein interaction databases

BioGridi114543. 5 interactions.
IntActiO14604. 1 interaction.
MINTiMINT-1445425.
STRINGi9606.ENSP00000284856.

Structurei

3D structure databases

ProteinModelPortaliO14604.
SMRiO14604. Positions 2-42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiNOG126035.
GeneTreeiENSGT00390000007040.
HOGENOMiHOG000231370.
HOVERGENiHBG012534.
InParanoidiO14604.
KOiK05764.
OrthoDBiEOG7TJ3MT.
PhylomeDBiO14604.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Thymosin_b4.
IPR016323. Thymosin_b4_metazoa.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14604-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40 
MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES
Length:44
Mass (Da):5,013
Last modified:January 23, 2007 - v3
Checksum:i7B336158483A9BE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000989 mRNA. Translation: AAC51836.1.
AC006371 Genomic DNA. Translation: AAD54509.1.
BC022482 mRNA. No translation available.
BC119763 mRNA. Translation: AAI19764.1.
BC119764 mRNA. Translation: AAI19765.1.
CCDSiCCDS14786.1.
RefSeqiNP_004193.1. NM_004202.2.
UniGeneiHs.159201.

Genome annotation databases

EnsembliENST00000284856; ENSP00000284856; ENSG00000154620.
ENST00000622974; ENSP00000485416; ENSG00000279828.
GeneIDi9087.
KEGGihsa:9087.
UCSCiuc004ftb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000989 mRNA. Translation: AAC51836.1.
AC006371 Genomic DNA. Translation: AAD54509.1.
BC022482 mRNA. No translation available.
BC119763 mRNA. Translation: AAI19764.1.
BC119764 mRNA. Translation: AAI19765.1.
CCDSiCCDS14786.1.
RefSeqiNP_004193.1. NM_004202.2.
UniGeneiHs.159201.

3D structure databases

ProteinModelPortaliO14604.
SMRiO14604. Positions 2-42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114543. 5 interactions.
IntActiO14604. 1 interaction.
MINTiMINT-1445425.
STRINGi9606.ENSP00000284856.

PTM databases

PhosphoSiteiO14604.

Proteomic databases

PaxDbiO14604.
PRIDEiO14604.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284856; ENSP00000284856; ENSG00000154620.
ENST00000622974; ENSP00000485416; ENSG00000279828.
GeneIDi9087.
KEGGihsa:9087.
UCSCiuc004ftb.3. human.

Organism-specific databases

CTDi9087.
GeneCardsiGC0YP015815.
HGNCiHGNC:11882. TMSB4Y.
MIMi400017. gene.
neXtProtiNX_O14604.
PharmGKBiPA36582.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG126035.
GeneTreeiENSGT00390000007040.
HOGENOMiHOG000231370.
HOVERGENiHBG012534.
InParanoidiO14604.
KOiK05764.
OrthoDBiEOG7TJ3MT.
PhylomeDBiO14604.

Miscellaneous databases

GeneWikiiThymosin_beta-4,_Y-chromosomal.
GenomeRNAii9087.
NextBioi34051.
PROiO14604.
SOURCEiSearch...

Gene expression databases

BgeeiO14604.
CleanExiHS_TMSB4Y.
GenevestigatoriO14604.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Thymosin_b4.
IPR016323. Thymosin_b4_metazoa.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional coherence of the human Y chromosome."
    Lahn B.T., Page D.C.
    Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hypothalamus.

Entry informationi

Entry nameiTYB4Y_HUMAN
AccessioniPrimary (citable) accession number: O14604
Secondary accession number(s): Q0VDA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.