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O14604

- TYB4Y_HUMAN

UniProt

O14604 - TYB4Y_HUMAN

Protein

Thymosin beta-4, Y-chromosomal

Gene

TMSB4Y

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization By similarity.By similarity

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro
    2. regulation of actin polymerization or depolymerization Source: ProtInc
    3. regulation of cell migration Source: Ensembl
    4. sequestering of actin monomers Source: ProtInc

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymosin beta-4, Y-chromosomal
    Gene namesi
    Name:TMSB4Y
    Synonyms:TB4Y
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome Y

    Organism-specific databases

    HGNCiHGNC:11882. TMSB4Y.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. cytosol Source: Ensembl
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36582.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4444Thymosin beta-4, Y-chromosomalPRO_0000045921Add
    BLAST

    Proteomic databases

    PaxDbiO14604.
    PRIDEiO14604.

    PTM databases

    PhosphoSiteiO14604.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    BgeeiO14604.
    CleanExiHS_TMSB4Y.
    GenevestigatoriO14604.

    Interactioni

    Protein-protein interaction databases

    BioGridi114543. 5 interactions.
    IntActiO14604. 1 interaction.
    MINTiMINT-1445425.
    STRINGi9606.ENSP00000284856.

    Structurei

    3D structure databases

    ProteinModelPortaliO14604.
    SMRiO14604. Positions 2-42.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymosin beta family.Curated

    Phylogenomic databases

    eggNOGiNOG126035.
    HOGENOMiHOG000231370.
    HOVERGENiHBG012534.
    InParanoidiO14604.
    KOiK05764.
    OrthoDBiEOG7TJ3MT.
    PhylomeDBiO14604.

    Family and domain databases

    Gene3Di1.20.5.520. 1 hit.
    InterProiIPR001152. Thymosin_b4.
    IPR016323. Thymosin_b4_metazoa.
    [Graphical view]
    PANTHERiPTHR12021. PTHR12021. 1 hit.
    PfamiPF01290. Thymosin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
    ProDomiPD005116. Thymosin_b4. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00152. THY. 1 hit.
    [Graphical view]
    PROSITEiPS00500. THYMOSIN_B4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14604-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES         44
    Length:44
    Mass (Da):5,013
    Last modified:January 23, 2007 - v3
    Checksum:i7B336158483A9BE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000989 mRNA. Translation: AAC51836.1.
    AC006371 Genomic DNA. Translation: AAD54509.1.
    BC022482 mRNA. No translation available.
    BC119763 mRNA. Translation: AAI19764.1.
    BC119764 mRNA. Translation: AAI19765.1.
    CCDSiCCDS14786.1.
    RefSeqiNP_004193.1. NM_004202.2.
    UniGeneiHs.159201.

    Genome annotation databases

    EnsembliENST00000284856; ENSP00000284856; ENSG00000154620.
    GeneIDi9087.
    KEGGihsa:9087.
    UCSCiuc004ftb.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000989 mRNA. Translation: AAC51836.1 .
    AC006371 Genomic DNA. Translation: AAD54509.1 .
    BC022482 mRNA. No translation available.
    BC119763 mRNA. Translation: AAI19764.1 .
    BC119764 mRNA. Translation: AAI19765.1 .
    CCDSi CCDS14786.1.
    RefSeqi NP_004193.1. NM_004202.2.
    UniGenei Hs.159201.

    3D structure databases

    ProteinModelPortali O14604.
    SMRi O14604. Positions 2-42.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114543. 5 interactions.
    IntActi O14604. 1 interaction.
    MINTi MINT-1445425.
    STRINGi 9606.ENSP00000284856.

    PTM databases

    PhosphoSitei O14604.

    Proteomic databases

    PaxDbi O14604.
    PRIDEi O14604.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000284856 ; ENSP00000284856 ; ENSG00000154620 .
    GeneIDi 9087.
    KEGGi hsa:9087.
    UCSCi uc004ftb.3. human.

    Organism-specific databases

    CTDi 9087.
    GeneCardsi GC0YP015815.
    HGNCi HGNC:11882. TMSB4Y.
    MIMi 400017. gene.
    neXtProti NX_O14604.
    PharmGKBi PA36582.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG126035.
    HOGENOMi HOG000231370.
    HOVERGENi HBG012534.
    InParanoidi O14604.
    KOi K05764.
    OrthoDBi EOG7TJ3MT.
    PhylomeDBi O14604.

    Miscellaneous databases

    GeneWikii Thymosin_beta-4,_Y-chromosomal.
    GenomeRNAii 9087.
    NextBioi 34051.
    PROi O14604.
    SOURCEi Search...

    Gene expression databases

    Bgeei O14604.
    CleanExi HS_TMSB4Y.
    Genevestigatori O14604.

    Family and domain databases

    Gene3Di 1.20.5.520. 1 hit.
    InterProi IPR001152. Thymosin_b4.
    IPR016323. Thymosin_b4_metazoa.
    [Graphical view ]
    PANTHERi PTHR12021. PTHR12021. 1 hit.
    Pfami PF01290. Thymosin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001828. Thymosin_beta. 1 hit.
    ProDomi PD005116. Thymosin_b4. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00152. THY. 1 hit.
    [Graphical view ]
    PROSITEi PS00500. THYMOSIN_B4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional coherence of the human Y chromosome."
      Lahn B.T., Page D.C.
      Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiTYB4Y_HUMAN
    AccessioniPrimary (citable) accession number: O14604
    Secondary accession number(s): Q0VDA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3