O14604 (TYB4Y_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymosin beta-4, Y-chromosomal

Gene names

Name:	TMSB4Y
Synonyms:	TB4Y

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	44 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the thymosin beta family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro sequestering of actin monomers Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Peptide	2 – 44	43	Thymosin beta-4, Y-chromosomal		PRO_0000045921
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O14604 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 7B336158483A9BE2	FASTA	44	5,013
	10 20 30 40 MSDKPGMAEI EKFDKSKLKK TETQEKNPLS SKETIEQERQ AGES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional coherence of the human Y chromosome." Lahn B.T., Page D.C. Science 278:675-680(1997) [PubMed: 9381176] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hypothalamus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF000989 mRNA. Translation: AAC51836.1. AC006371 Genomic DNA. Translation: AAD54509.1. BC022482 mRNA. No translation available. BC119763 mRNA. Translation: AAI19764.1. BC119764 mRNA. Translation: AAI19765.1.
IPI	IPI00219803.
RefSeq	NP_004193.1. NM_004202.2.
UniGene	Hs.159201.
3D structure databases
ProteinModelPortal	O14604.
SMR	O14604. Positions 2-42.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14604. 1 interaction.
MINT	MINT-1445425.
STRING	O14604.
Proteomic databases
PRIDE	O14604.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000284856; ENSP00000284856; ENSG00000154620.
GeneID	9087.
KEGG	hsa:9087.
UCSC	uc004ftb.1. human.
Organism-specific databases
CTD	9087.
GeneCards	GC0YP015815.
H-InvDB	HIX0017187.
HGNC	HGNC:11882. TMSB4Y.
MIM	400017. gene.
neXtProt	NX_O14604.
PharmGKB	PA36582.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG21457.
GeneTree	ENSGT00390000007040.
HOGENOM	HBG444190.
HOVERGEN	HBG012534.
InParanoid	O14604.
OrthoDB	EOG4NKBXT.
PhylomeDB	O14604.
Gene expression databases
ArrayExpress	O14604.
Bgee	O14604.
CleanEx	HS_TMSB4Y.
Genevestigator	O14604.
GermOnline	ENSG00000154620. Homo sapiens.
Family and domain databases
InterPro	IPR001152. Thymosin_b4. IPR016323. Thymosin_b4_chordata. [Graphical view]
Gene3D	G3DSA:1.20.5.520. Thymosin_b4. 1 hit.
KO	K05764.
PANTHER	PTHR12021. PTHR12021. 1 hit.
Pfam	PF01290. Thymosin. 1 hit. [Graphical view]
PIRSF	PIRSF001828. Thymosin_beta. 1 hit.
ProDom	PD005116. Thymosin_b4. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00152. THY. 1 hit. [Graphical view]
PROSITE	PS00500. THYMOSIN_B4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

TYB4Y_HUMAN

Accession

Primary (citable) accession number: O14604
Secondary accession number(s): Q0VDA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.