O14603 (PRY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PTPN13-like protein, Y-linked

Alternative name(s):
Testis-specific PTP-BL-related Y protein

Gene names

Name:	PRY
Synonyms:	PRY1, PTPN13LY
AND
Name:	PRY2
Synonyms:	PTPN13LY2
AND
Name:	PRYP3
AND
Name:	PRYP4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in testis. Detected in spermatocytes, spermatids and spermatozoa (at protein level). Ref.6 Ref.7
Caution	PRY has multiple identical or highly similar copies on chromosome Y, some of which might be non functional pseudogenes.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14603-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14603-2)

The sequence of this isoform differs from the canonical sequence as follows:
     63-71: YGKVGCISL → DGVSPCLPC
     72-147: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 147	147	PTPN13-like protein, Y-linked		PRO_0000097056
Natural variations
	Alternative sequence	63 – 71	9	YGKVGCISL → DGVSPCLPC in isoform 2.		VSP_004068
	Alternative sequence	72 – 147	76	Missing in isoform 2.		VSP_004069

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 87C861FC2BEDAE9B	FASTA	147	16,512
	10 20 30 40 50 60 MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE LSLNRGLEAR RKKDLKDSFL 70 80 90 100 110 120 WRYGKVGCIS LPLREMTAWI NPPQISEIFQ GYHQRVHGAD ALSLQTNSLR SRLSSQCLGQ 130 140 SFLLRTLERG RGFRALGDIC GHVHEED
	Isoform 2 [UniParc]. Checksum: 7FF5A6B242DC0426	FASTA	71	7,878
	10 20 30 40 50 60 MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE LSLNRGLEAR RKKDLKDSFL 70 WRDGVSPCLP C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional coherence of the human Y chromosome." Lahn B.T., Page D.C. Science 278:675-680(1997) [PubMed: 9381176] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	Lahn B.T., Page D.C. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"Characterization of the genomic organization, localization and expression of four PRY genes (PRY1, PRY2, PRY3 and PRY4)." Stouffs K., Lissens W., Van Landuyt L., Tournaye H., Van Steirteghem A., Liebaers I. Mol. Hum. Reprod. 7:603-610(2001) [PubMed: 11420382] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Expression pattern of the Y-linked PRY gene suggests a function in apoptosis but not in spermatogenesis." Stouffs K., Lissens W., Verheyen G., Van Landuyt L., Goossens A., Tournaye H., Van Steirteghem A., Liebaers I. Mol. Hum. Reprod. 10:15-21(2004) [PubMed: 14665702] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF000988 mRNA. Translation: AAC51835.2. AF517635 mRNA. Translation: AAN06674.1. CH878735 Genomic DNA. Translation: EAW61212.1. BC113548 mRNA. Translation: AAI13549.1. BC113550 mRNA. Translation: AAI13551.1. BC143893 mRNA. Translation: AAI43894.1. BC171757 mRNA. Translation: AAI71757.1.
IPI	IPI00005839. IPI00218478.
RefSeq	NP_001002758.1. NM_001002758.1. NP_004667.2. NM_004676.2. XP_003120383.1. XM_003120335.1.
UniGene	Hs.158343. Hs.632847.
3D structure databases
ProteinModelPortal	O14603.
ModBase	Search...
Protein-protein interaction databases
STRING	O14603.
Proteomic databases
PRIDE	O14603.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000303728; ENSP00000302319; ENSG00000169789. ENST00000303804; ENSP00000303300; ENSG00000169807. ENST00000306589; ENSP00000303736; ENSG00000172283. ENST00000343584; ENSP00000342409; ENSG00000169763.
GeneID	100509646. 442862. 9081.
KEGG	hsa:100509646. hsa:442862. hsa:9081.
UCSC	uc004fuy.1. human.
Organism-specific databases
CTD	442862. 9081.
GeneCards	GC0YM024217. GC0YM025827. GC0YP024637. GC0YP028121.
H-InvDB	HIX0056660.
HGNC	HGNC:14024. PRY. HGNC:21504. PRY2. HGNC:34020. PRYP3. HGNC:34021. PRYP4.
MIM	400019. gene. 400041. gene.
neXtProt	NX_O14603.
PharmGKB	PA33844.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000001812.
HOVERGEN	HBG031855.
InParanoid	O14603.
OMA	EMTAWIN.
OrthoDB	EOG4868FG.
Gene expression databases
CleanEx	HS_PRY. HS_PRY2.
Genevestigator	O14603.
GermOnline	ENSG00000169763. Homo sapiens. ENSG00000169789. Homo sapiens. ENSG00000169807. Homo sapiens. ENSG00000172283. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	111280.
SOURCE	Search...

Entry information

Entry name

PRY_HUMAN

Accession

Primary (citable) accession number: O14603
Secondary accession number(s): B7ZLM1, Q14D09

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.