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Protein

PTPN13-like protein, Y-linked

Gene

PRY

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

PRY has multiple identical or highly similar copies on chromosome Y, some of which might be non functional pseudogenes.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
PTPN13-like protein, Y-linked
Alternative name(s):
Testis-specific PTP-BL-related Y protein
Gene namesi
Name:PRY
Synonyms:PRY1, PTPN13LY
AND
Name:PRY2
Synonyms:PTPN13LY2
AND
Name:PRYP3
AND
Name:PRYP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000169789.10
HostDB:ENSG00000169807.10
HGNCiHGNC:14024 PRY
HGNC:21504 PRY2
HGNC:34020 PRYP3
HGNC:34021 PRYP4
MIMi400019 gene
400041 gene
neXtProtiNX_O14603

Pathology & Biotechi

Organism-specific databases

DisGeNETi442862
9081
GeneReviewsiPRY
PRY2
MalaCardsiPRY
PRY2
PharmGKBiPA33844

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000970561 – 147PTPN13-like protein, Y-linkedAdd BLAST147

Proteomic databases

PaxDbiO14603
PRIDEiO14603

Expressioni

Tissue specificityi

Expressed in testis. Detected in spermatocytes, spermatids and spermatozoa (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000169789
CleanExiHS_PRY
HS_PRY2
GenevisibleiO14603 HS

Organism-specific databases

HPAiHPA046366

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342409

Structurei

3D structure databases

ProteinModelPortaliO14603
SMRiO14603
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410KC9T Eukaryota
ENOG4110P6R LUCA
GeneTreeiENSGT00390000001812
HOGENOMiHOG000082492
HOVERGENiHBG031855
InParanoidiO14603
OrthoDBiEOG091G0R1J
PhylomeDBiO14603
TreeFamiTF341581

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14603-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE LSLNRGLEAR
60 70 80 90 100
RKKDLKDSFL WRYGKVGCIS LPLREMTAWI NPPQISEIFQ GYHQRVHGAD
110 120 130 140
ALSLQTNSLR SRLSSQCLGQ SFLLRTLERG RGFRALGDIC GHVHEED
Length:147
Mass (Da):16,512
Last modified:October 1, 2002 - v2
Checksum:i87C861FC2BEDAE9B
GO
Isoform 2 (identifier: O14603-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-71: YGKVGCISL → DGVSPCLPC
     72-147: Missing.

Note: No experimental confirmation available.
Show »
Length:71
Mass (Da):7,878
Checksum:i7FF5A6B242DC0426
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00406863 – 71YGKVGCISL → DGVSPCLPC in isoform 2. 1 Publication9
Alternative sequenceiVSP_00406972 – 147Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000988 mRNA Translation: AAC51835.2
AF517635 mRNA Translation: AAN06674.1
CH878735 Genomic DNA Translation: EAW61212.1
BC113548 mRNA Translation: AAI13549.1
BC113550 mRNA Translation: AAI13551.1
BC143893 mRNA Translation: AAI43894.1
BC171757 mRNA Translation: AAI71757.1
CCDSiCCDS14799.1 [O14603-1]
CCDS35482.1 [O14603-1]
RefSeqiNP_001002758.1, NM_001002758.1 [O14603-1]
NP_004667.2, NM_004676.2 [O14603-1]
XP_016885577.1, XM_017030088.1 [O14603-1]
UniGeneiHs.158343
Hs.632847

Genome annotation databases

EnsembliENST00000303728; ENSP00000302319; ENSG00000169789 [O14603-1]
ENST00000303804; ENSP00000303300; ENSG00000169807 [O14603-1]
ENST00000472391; ENSP00000474545; ENSG00000169807 [O14603-2]
ENST00000477123; ENSP00000474674; ENSG00000169789 [O14603-2]
GeneIDi442862
9081
KEGGihsa:442862
hsa:9081
UCSCiuc004fuy.1 human [O14603-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPRY_HUMAN
AccessioniPrimary (citable) accession number: O14603
Secondary accession number(s): B7ZLM1, Q14D09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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