Reviewed, UniProtKB/Swiss-Prot O14603 (PRY_HUMAN)

Names and origin

Protein names

Recommended name:
    PTPN13-like protein, Y-linked
Alternative name(s):
    Testis-specific PTP-BL-related Y protein

Gene names

Name:	PRY
Synonyms:	PTPN13LY
AND
Name:	PRY2
Synonyms:	PTPN13LY2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Testis.
Caution	PRY has multiple locations on chromosome Y.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14603-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14603-2)

The sequence of this isoform differs from the canonical sequence as follows:
     63-71: YGKVGCISL → DGVSPCLPC
     72-147: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 147	147	PTPN13-like protein, Y-linked		PRO_0000097056
Natural variations
	Alternative sequence	63 – 71	9	YGKVGCISL → DGVSPCLPC in isoform 2.		VSP_004068
	Alternative sequence	72 – 147	76	Missing in isoform 2.		VSP_004069

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 87C861FC2BEDAE9B	FASTA	147	16,512
	10 20 30 40 50 60 MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE LSLNRGLEAR RKKDLKDSFL 70 80 90 100 110 120 WRYGKVGCIS LPLREMTAWI NPPQISEIFQ GYHQRVHGAD ALSLQTNSLR SRLSSQCLGQ 130 140 SFLLRTLERG RGFRALGDIC GHVHEED
	Isoform 2. Checksum: 7FF5A6B242DC0426	FASTA	71	7,878
	10 20 30 40 50 60 MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE LSLNRGLEAR RKKDLKDSFL 70 WRDGVSPCLP C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional coherence of the human Y chromosome." Lahn B.T., Page D.C. Science 278:675-680(1997) [PubMed: 9381176] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	Lahn B.T., Page D.C. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF000988 mRNA. Translation: AAC51835.2. AF517635 mRNA. Translation: AAN06674.1. BC113548 mRNA. Translation: AAI13549.1. BC113550 mRNA. Translation: AAI13551.1.
IPI	IPI00005839. IPI00218478.
RefSeq	NP_001002758.1. NP_004667.2.
UniGene	Hs.158343 Hs.632847
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENST00000303728; ENSP00000302319; ENSG00000169789; Homo sapiens. [Genome view] ENST00000303804; ENSP00000303300; ENSG00000169807; Homo sapiens. [Genome view] ENST00000306589; ENSP00000303736; ENSG00000172283; Homo sapiens. [Genome view] ENST00000343584; ENSP00000342409; ENSG00000169763; Homo sapiens. [Genome view]
GeneID	442862. 9081.
KEGG	hsa:442862. hsa:9081.
UCSC	uc004fuy.1. human.
Organism-specific databases
CTD	442862. 9081.
GeneCards	GC0YM022627. GC0YP022974.
H-InvDB	HIX0056660. HIX0056702. HIX0056705.
HGNC	HGNC:14024. PRY. HGNC:21504. PRY2.
MIM	400019. gene. 400041. gene.
PharmGKB	PA134979106.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O14603.
OMA	EMTAWIN
Gene expression databases
CleanEx	HS_PRY. HS_PRY2.
Genevestigator	O14603.
GermOnline	ENSG00000169763. Homo sapiens. ENSG00000169789. Homo sapiens. ENSG00000169807. Homo sapiens. ENSG00000172283. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	111280.
SOURCE	Search...

Entry information

Entry name

PRY_HUMAN

Accession

Primary (citable) accession number: O14603
Secondary accession number(s): Q14D09

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	October 1, 2002
Last modified:	November 24, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.