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O14603

- PRY_HUMAN

UniProt

O14603 - PRY_HUMAN

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Protein
PTPN13-like protein, Y-linked
Gene
PRY, PRY1, PTPN13LY
PRY2, PTPN13LY2
PRYP3
PRYP4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
PTPN13-like protein, Y-linked
Alternative name(s):
Testis-specific PTP-BL-related Y protein
Gene namesi
Name:PRY
Synonyms:PRY1, PTPN13LY
AND
Name:PRY2
Synonyms:PTPN13LY2
AND
Name:PRYP3
AND
Name:PRYP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y
HGNCiHGNC:14024. PRY.
HGNC:21504. PRY2.
HGNC:34020. PRYP3.
HGNC:34021. PRYP4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33844.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147PTPN13-like protein, Y-linked
PRO_0000097056Add
BLAST

Proteomic databases

PRIDEiO14603.

Expressioni

Tissue specificityi

Expressed in testis. Detected in spermatocytes, spermatids and spermatozoa (at protein level).2 Publications

Gene expression databases

BgeeiO14603.
CleanExiHS_PRY.
HS_PRY2.
GenevestigatoriO14603.

Organism-specific databases

HPAiHPA046366.

Structurei

3D structure databases

ProteinModelPortaliO14603.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000082492.
HOVERGENiHBG031855.
InParanoidiO14603.
OMAiQRVHGAD.
OrthoDBiEOG7BW0PP.
PhylomeDBiO14603.
TreeFamiTF341581.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14603-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE LSLNRGLEAR    50
RKKDLKDSFL WRYGKVGCIS LPLREMTAWI NPPQISEIFQ GYHQRVHGAD 100
ALSLQTNSLR SRLSSQCLGQ SFLLRTLERG RGFRALGDIC GHVHEED 147
Length:147
Mass (Da):16,512
Last modified:October 1, 2002 - v2
Checksum:i87C861FC2BEDAE9B
GO
Isoform 2 (identifier: O14603-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-71: YGKVGCISL → DGVSPCLPC
     72-147: Missing.

Note: No experimental confirmation available.

Show »
Length:71
Mass (Da):7,878
Checksum:i7FF5A6B242DC0426
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei63 – 719YGKVGCISL → DGVSPCLPC in isoform 2.
VSP_004068
Alternative sequencei72 – 14776Missing in isoform 2.
VSP_004069Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000988 mRNA. Translation: AAC51835.2.
AF517635 mRNA. Translation: AAN06674.1.
CH878735 Genomic DNA. Translation: EAW61212.1.
BC113548 mRNA. Translation: AAI13549.1.
BC113550 mRNA. Translation: AAI13551.1.
BC143893 mRNA. Translation: AAI43894.1.
BC171757 mRNA. Translation: AAI71757.1.
CCDSiCCDS14799.1. [O14603-1]
CCDS35482.1. [O14603-1]
RefSeqiNP_001002758.1. NM_001002758.1. [O14603-1]
NP_004667.2. NM_004676.2. [O14603-1]
XP_003120383.1. XM_003120335.3. [O14603-1]
UniGeneiHs.158343.
Hs.632847.

Genome annotation databases

EnsembliENST00000303593; ENSP00000306622; ENSG00000169763.
ENST00000303728; ENSP00000302319; ENSG00000169789. [O14603-1]
ENST00000303804; ENSP00000303300; ENSG00000169807. [O14603-1]
ENST00000306589; ENSP00000303736; ENSG00000172283.
ENST00000338673; ENSP00000340542; ENSG00000172283.
ENST00000338793; ENSP00000341561; ENSG00000169789. [O14603-2]
ENST00000341740; ENSP00000341879; ENSG00000169807. [O14603-2]
ENST00000343584; ENSP00000342409; ENSG00000169763.
ENST00000472391; ENSP00000474545; ENSG00000169807. [O14603-2]
ENST00000477123; ENSP00000474674; ENSG00000169789. [O14603-2]
GeneIDi100509646.
442862.
9081.
KEGGihsa:100509646.
hsa:442862.
hsa:9081.
UCSCiuc004fuy.1. human. [O14603-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000988 mRNA. Translation: AAC51835.2 .
AF517635 mRNA. Translation: AAN06674.1 .
CH878735 Genomic DNA. Translation: EAW61212.1 .
BC113548 mRNA. Translation: AAI13549.1 .
BC113550 mRNA. Translation: AAI13551.1 .
BC143893 mRNA. Translation: AAI43894.1 .
BC171757 mRNA. Translation: AAI71757.1 .
CCDSi CCDS14799.1. [O14603-1 ]
CCDS35482.1. [O14603-1 ]
RefSeqi NP_001002758.1. NM_001002758.1. [O14603-1 ]
NP_004667.2. NM_004676.2. [O14603-1 ]
XP_003120383.1. XM_003120335.3. [O14603-1 ]
UniGenei Hs.158343.
Hs.632847.

3D structure databases

ProteinModelPortali O14603.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O14603.

Protocols and materials databases

DNASUi 442862.
9081.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303593 ; ENSP00000306622 ; ENSG00000169763 .
ENST00000303728 ; ENSP00000302319 ; ENSG00000169789 . [O14603-1 ]
ENST00000303804 ; ENSP00000303300 ; ENSG00000169807 . [O14603-1 ]
ENST00000306589 ; ENSP00000303736 ; ENSG00000172283 .
ENST00000338673 ; ENSP00000340542 ; ENSG00000172283 .
ENST00000338793 ; ENSP00000341561 ; ENSG00000169789 . [O14603-2 ]
ENST00000341740 ; ENSP00000341879 ; ENSG00000169807 . [O14603-2 ]
ENST00000343584 ; ENSP00000342409 ; ENSG00000169763 .
ENST00000472391 ; ENSP00000474545 ; ENSG00000169807 . [O14603-2 ]
ENST00000477123 ; ENSP00000474674 ; ENSG00000169789 . [O14603-2 ]
GeneIDi 100509646.
442862.
9081.
KEGGi hsa:100509646.
hsa:442862.
hsa:9081.
UCSCi uc004fuy.1. human. [O14603-1 ]

Organism-specific databases

CTDi 442862.
9081.
GeneCardsi GC0YM024217.
GC0YM025827.
GC0YP024637.
GC0YP028121.
GeneReviewsi PRY.
PRY2.
HGNCi HGNC:14024. PRY.
HGNC:21504. PRY2.
HGNC:34020. PRYP3.
HGNC:34021. PRYP4.
HPAi HPA046366.
MIMi 400019. gene.
400041. gene.
neXtProti NX_O14603.
PharmGKBi PA33844.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000082492.
HOVERGENi HBG031855.
InParanoidi O14603.
OMAi QRVHGAD.
OrthoDBi EOG7BW0PP.
PhylomeDBi O14603.
TreeFami TF341581.

Miscellaneous databases

NextBioi 111280.
PROi O14603.
SOURCEi Search...

Gene expression databases

Bgeei O14603.
CleanExi HS_PRY.
HS_PRY2.
Genevestigatori O14603.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Functional coherence of the human Y chromosome."
    Lahn B.T., Page D.C.
    Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Lahn B.T., Page D.C.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Characterization of the genomic organization, localization and expression of four PRY genes (PRY1, PRY2, PRY3 and PRY4)."
    Stouffs K., Lissens W., Van Landuyt L., Tournaye H., Van Steirteghem A., Liebaers I.
    Mol. Hum. Reprod. 7:603-610(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Expression pattern of the Y-linked PRY gene suggests a function in apoptosis but not in spermatogenesis."
    Stouffs K., Lissens W., Verheyen G., Van Landuyt L., Goossens A., Tournaye H., Van Steirteghem A., Liebaers I.
    Mol. Hum. Reprod. 10:15-21(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPRY_HUMAN
AccessioniPrimary (citable) accession number: O14603
Secondary accession number(s): B7ZLM1, Q14D09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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