Reviewed,
UniProtKB/Swiss-Prot O14603 (PRY_HUMAN)
Last modified
November 24, 2009.
Version 55.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: PTPN13-like protein, Y-linked Alternative name(s): Testis-specific PTP-BL-related Y protein | |||||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | |||||||||
| Taxonomic identifier | 9606 [NCBI] | |||||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 147 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Tissue specificity | Testis. |
| Caution | PRY has multiple locations on chromosome Y. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: O14603-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: O14603-2) The sequence of this isoform differs from the canonical sequence as follows: 63-71: YGKVGCISL → DGVSPCLPC 72-147: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 147 | 147 | PTPN13-like protein, Y-linked | PRO_0000097056 | |||||
Natural variations | |||||||||
| Alternative sequence | 63 – 71 | 9 | YGKVGCISL → DGVSPCLPC in isoform 2. | VSP_004068 | |||||
| Alternative sequence | 72 – 147 | 76 | Missing in isoform 2. | VSP_004069 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Functional coherence of the human Y chromosome." Lahn B.T., Page D.C. Science 278:675-680(1997) [PubMed: 9381176] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis. |
| [2] | Lahn B.T., Page D.C. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. |
| [3] | "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. Page D.C.Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
Cross-references
Sequence databases | |
|---|---|
| AF000988 mRNA. Translation: AAC51835.2. AF517635 mRNA. Translation: AAN06674.1. BC113548 mRNA. Translation: AAI13549.1. BC113550 mRNA. Translation: AAI13551.1. | |
| IPI | IPI00005839. IPI00218478. |
| RefSeq | NP_001002758.1. NP_004667.2. |
| UniGene | Hs.158343 Hs.632847 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000303728; ENSP00000302319; ENSG00000169789; Homo sapiens. [Genome view] ENST00000303804; ENSP00000303300; ENSG00000169807; Homo sapiens. [Genome view] ENST00000306589; ENSP00000303736; ENSG00000172283; Homo sapiens. [Genome view] ENST00000343584; ENSP00000342409; ENSG00000169763; Homo sapiens. [Genome view] |
| GeneID | 442862. 9081. |
| KEGG | hsa:442862. hsa:9081. |
| UCSC | uc004fuy.1. human. |
Organism-specific databases | |
| CTD | 442862. 9081. |
| GeneCards | GC0YM022627. GC0YP022974. |
| H-InvDB | HIX0056660. HIX0056702. HIX0056705. |
| HGNC | HGNC:14024. PRY. HGNC:21504. PRY2. |
| MIM | 400019. gene. 400041. gene. |
| PharmGKB | PA134979106. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O14603. |
| OMA | EMTAWIN |
Gene expression databases | |
| CleanEx | HS_PRY. HS_PRY2. |
| Genevestigator | O14603. |
| GermOnline | ENSG00000169763. Homo sapiens. ENSG00000169789. Homo sapiens. ENSG00000169807. Homo sapiens. ENSG00000172283. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 111280. |
| SOURCE | Search... |
Entry information
| Entry name | PRY_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O14603 Secondary accession number(s): Q14D09 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome Y Human chromosome Y: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |

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