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O14603 (PRY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PTPN13-like protein, Y-linked
Alternative name(s):
Testis-specific PTP-BL-related Y protein
Gene names
Name:PRY
Synonyms:PRY1, PTPN13LY
AND
Name:PRY2
Synonyms:PTPN13LY2
AND
Name:PRYP3
AND
Name:PRYP4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Expressed in testis. Detected in spermatocytes, spermatids and spermatozoa (at protein level). Ref.6 Ref.7

Caution

PRY has multiple identical or highly similar copies on chromosome Y, some of which might be non functional pseudogenes.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O14603-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O14603-2)

The sequence of this isoform differs from the canonical sequence as follows:
     63-71: YGKVGCISL → DGVSPCLPC
     72-147: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 147147PTPN13-like protein, Y-linked
PRO_0000097056

Natural variations

Alternative sequence63 – 719YGKVGCISL → DGVSPCLPC in isoform 2.
VSP_004068
Alternative sequence72 – 14776Missing in isoform 2.
VSP_004069

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: 87C861FC2BEDAE9B

FASTA14716,512
        10         20         30         40         50         60 
MGATGLGFLL SWRQDNLNGT DCQGCNILYF SETTGSMCSE LSLNRGLEAR RKKDLKDSFL 

        70         80         90        100        110        120 
WRYGKVGCIS LPLREMTAWI NPPQISEIFQ GYHQRVHGAD ALSLQTNSLR SRLSSQCLGQ 

       130        140 
SFLLRTLERG RGFRALGDIC GHVHEED 

« Hide

Isoform 2 [UniParc].

Checksum: 7FF5A6B242DC0426
Show »

FASTA717,878

References

« Hide 'large scale' references
[1]"Functional coherence of the human Y chromosome."
Lahn B.T., Page D.C.
Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Testis.
[2]Lahn B.T., Page D.C.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes."
Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. expand/collapse author list , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C.
Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Characterization of the genomic organization, localization and expression of four PRY genes (PRY1, PRY2, PRY3 and PRY4)."
Stouffs K., Lissens W., Van Landuyt L., Tournaye H., Van Steirteghem A., Liebaers I.
Mol. Hum. Reprod. 7:603-610(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"Expression pattern of the Y-linked PRY gene suggests a function in apoptosis but not in spermatogenesis."
Stouffs K., Lissens W., Verheyen G., Van Landuyt L., Goossens A., Tournaye H., Van Steirteghem A., Liebaers I.
Mol. Hum. Reprod. 10:15-21(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF000988 mRNA. Translation: AAC51835.2.
AF517635 mRNA. Translation: AAN06674.1.
CH878735 Genomic DNA. Translation: EAW61212.1.
BC113548 mRNA. Translation: AAI13549.1.
BC113550 mRNA. Translation: AAI13551.1.
BC143893 mRNA. Translation: AAI43894.1.
BC171757 mRNA. Translation: AAI71757.1.
RefSeqNP_001002758.1. NM_001002758.1.
NP_004667.2. NM_004676.2.
XP_003120383.1. XM_003120335.3.
UniGeneHs.158343.
Hs.632847.

3D structure databases

ProteinModelPortalO14603.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO14603.

Protocols and materials databases

DNASU442862.
9081.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303593; ENSP00000306622; ENSG00000169763.
ENST00000303728; ENSP00000302319; ENSG00000169789. [O14603-1]
ENST00000303804; ENSP00000303300; ENSG00000169807. [O14603-1]
ENST00000306589; ENSP00000303736; ENSG00000172283.
ENST00000338673; ENSP00000340542; ENSG00000172283.
ENST00000338793; ENSP00000341561; ENSG00000169789. [O14603-2]
ENST00000341740; ENSP00000341879; ENSG00000169807. [O14603-2]
ENST00000343584; ENSP00000342409; ENSG00000169763.
ENST00000472391; ENSP00000474545; ENSG00000169807. [O14603-2]
ENST00000477123; ENSP00000474674; ENSG00000169789. [O14603-2]
GeneID100509646.
442862.
9081.
KEGGhsa:100509646.
hsa:442862.
hsa:9081.
UCSCuc004fuy.1. human. [O14603-1]

Organism-specific databases

CTD442862.
9081.
GeneCardsGC0YM024217.
GC0YM025827.
GC0YP024637.
GC0YP028121.
HGNCHGNC:14024. PRY.
HGNC:21504. PRY2.
HGNC:34020. PRYP3.
HGNC:34021. PRYP4.
HPAHPA046366.
MIM400019. gene.
400041. gene.
neXtProtNX_O14603.
PharmGKBPA33844.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000082492.
HOVERGENHBG031855.
InParanoidO14603.
OMAQRVHGAD.
OrthoDBEOG7BW0PP.
PhylomeDBO14603.
TreeFamTF341581.

Gene expression databases

BgeeO14603.
CleanExHS_PRY.
HS_PRY2.
GenevestigatorO14603.

Family and domain databases

ProtoNetSearch...

Other

NextBio111280.
PROO14603.
SOURCESearch...

Entry information

Entry namePRY_HUMAN
AccessionPrimary (citable) accession number: O14603
Secondary accession number(s): B7ZLM1, Q14D09
Entry history
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM