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O14602

- IF1AY_HUMAN

UniProt

O14602 - IF1AY_HUMAN

Protein

Eukaryotic translation initiation factor 1A, Y-chromosomal

Gene

EIF1AY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. translation initiation factor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eukaryotic translation initiation factor 1A, Y-chromosomal
    Short name:
    eIF-1A Y isoform
    Alternative name(s):
    Eukaryotic translation initiation factor 4C
    Short name:
    eIF-4C
    Gene namesi
    Name:EIF1AY
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome Y

    Organism-specific databases

    HGNCiHGNC:3252. EIF1AY.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27686.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 144143Eukaryotic translation initiation factor 1A, Y-chromosomalPRO_0000145102Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki88 – 88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiO14602.
    PaxDbiO14602.
    PRIDEiO14602.

    PTM databases

    PhosphoSiteiO14602.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiO14602.
    BgeeiO14602.
    CleanExiHS_EIF1AY.
    GenevestigatoriO14602.

    Organism-specific databases

    HPAiHPA002561.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EIF5BO608412EBI-286439,EBI-928530

    Protein-protein interaction databases

    BioGridi114542. 4 interactions.
    IntActiO14602. 4 interactions.
    MINTiMINT-2865737.
    STRINGi9606.ENSP00000354722.

    Structurei

    3D structure databases

    ProteinModelPortaliO14602.
    SMRiO14602. Positions 2-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 9675S1-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eIF-1A family.Curated
    Contains 1 S1-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0361.
    HOGENOMiHOG000223675.
    HOVERGENiHBG001131.
    InParanoidiO14602.
    KOiK03236.
    OMAiDTAKINE.
    OrthoDBiEOG7VHT0G.
    PhylomeDBiO14602.
    TreeFamiTF350394.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00216. aIF_1A.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR006196. RNA-binding_domain_S1_IF1.
    IPR001253. TIF_eIF-1A.
    IPR018104. TIF_eIF-1A_CS.
    [Graphical view]
    PANTHERiPTHR21668. PTHR21668. 1 hit.
    PfamiPF01176. eIF-1a. 1 hit.
    [Graphical view]
    ProDomiPD005579. TIF_eIF-1A. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00652. eIF1a. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00523. eIF-1A. 1 hit.
    PROSITEiPS01262. IF1A. 1 hit.
    PS50832. S1_IF1_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14602-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL    50
    CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA 100
    RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI 144
    Length:144
    Mass (Da):16,442
    Last modified:January 23, 2007 - v4
    Checksum:i1DE91334F191BEC5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti108 – 1081E → G in AAC51834. (PubMed:9381176)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000987 mRNA. Translation: AAC51834.1.
    BT007201 mRNA. Translation: AAP35865.1.
    BC005248 mRNA. Translation: AAH05248.1.
    CCDSiCCDS14795.1.
    PIRiC53045.
    RefSeqiNP_001265541.1. NM_001278612.1.
    NP_004672.2. NM_004681.3.
    UniGeneiHs.461178.

    Genome annotation databases

    EnsembliENST00000361365; ENSP00000354722; ENSG00000198692.
    GeneIDi9086.
    KEGGihsa:9086.
    UCSCiuc004fuk.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000987 mRNA. Translation: AAC51834.1 .
    BT007201 mRNA. Translation: AAP35865.1 .
    BC005248 mRNA. Translation: AAH05248.1 .
    CCDSi CCDS14795.1.
    PIRi C53045.
    RefSeqi NP_001265541.1. NM_001278612.1.
    NP_004672.2. NM_004681.3.
    UniGenei Hs.461178.

    3D structure databases

    ProteinModelPortali O14602.
    SMRi O14602. Positions 2-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114542. 4 interactions.
    IntActi O14602. 4 interactions.
    MINTi MINT-2865737.
    STRINGi 9606.ENSP00000354722.

    PTM databases

    PhosphoSitei O14602.

    Proteomic databases

    MaxQBi O14602.
    PaxDbi O14602.
    PRIDEi O14602.

    Protocols and materials databases

    DNASUi 9086.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361365 ; ENSP00000354722 ; ENSG00000198692 .
    GeneIDi 9086.
    KEGGi hsa:9086.
    UCSCi uc004fuk.3. human.

    Organism-specific databases

    CTDi 9086.
    GeneCardsi GC0YP022737.
    HGNCi HGNC:3252. EIF1AY.
    HPAi HPA002561.
    MIMi 400014. gene.
    neXtProti NX_O14602.
    PharmGKBi PA27686.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0361.
    HOGENOMi HOG000223675.
    HOVERGENi HBG001131.
    InParanoidi O14602.
    KOi K03236.
    OMAi DTAKINE.
    OrthoDBi EOG7VHT0G.
    PhylomeDBi O14602.
    TreeFami TF350394.

    Miscellaneous databases

    GeneWikii EIF1AY.
    GenomeRNAii 9086.
    NextBioi 34047.
    PROi O14602.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14602.
    Bgeei O14602.
    CleanExi HS_EIF1AY.
    Genevestigatori O14602.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00216. aIF_1A.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR006196. RNA-binding_domain_S1_IF1.
    IPR001253. TIF_eIF-1A.
    IPR018104. TIF_eIF-1A_CS.
    [Graphical view ]
    PANTHERi PTHR21668. PTHR21668. 1 hit.
    Pfami PF01176. eIF-1a. 1 hit.
    [Graphical view ]
    ProDomi PD005579. TIF_eIF-1A. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00652. eIF1a. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00523. eIF-1A. 1 hit.
    PROSITEi PS01262. IF1A. 1 hit.
    PS50832. S1_IF1_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional coherence of the human Y chromosome."
      Lahn B.T., Page D.C.
      Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiIF1AY_HUMAN
    AccessioniPrimary (citable) accession number: O14602
    Secondary accession number(s): Q9BS77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. Translation initiation factors
      List of translation initiation factor entries
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3