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O14602 (IF1AY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eukaryotic translation initiation factor 1A, Y-chromosomal

Short name=eIF-1A Y isoform
Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name=eIF-4C
Gene names
Name:EIF1AY
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits By similarity. HAMAP-Rule MF_00216

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the eIF-1A family.

Contains 1 S1-like domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

EIF5BO608412EBI-286439,EBI-928530

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 144143Eukaryotic translation initiation factor 1A, Y-chromosomal HAMAP-Rule MF_00216
PRO_0000145102

Regions

Domain22 – 9675S1-like

Amino acid modifications

Cross-link88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) HAMAP-Rule MF_00216

Experimental info

Sequence conflict1081E → G in AAC51834. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O14602 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 1DE91334F191BEC5

FASTA14416,442
        10         20         30         40         50         60 
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL CFDGVKRLCH 

        70         80         90        100        110        120 
IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT 

       130        140 
FGPGDDDEIQ FDDIGDDDED IDDI 

« Hide

References

« Hide 'large scale' references
[1]"Functional coherence of the human Y chromosome."
Lahn B.T., Page D.C.
Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF000987 mRNA. Translation: AAC51834.1.
BT007201 mRNA. Translation: AAP35865.1.
BC005248 mRNA. Translation: AAH05248.1.
CCDSCCDS14795.1.
PIRC53045.
RefSeqNP_001265541.1. NM_001278612.1.
NP_004672.2. NM_004681.3.
UniGeneHs.461178.

3D structure databases

ProteinModelPortalO14602.
SMRO14602. Positions 2-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114542. 4 interactions.
IntActO14602. 4 interactions.
MINTMINT-2865737.
STRING9606.ENSP00000354722.

PTM databases

PhosphoSiteO14602.

Proteomic databases

MaxQBO14602.
PaxDbO14602.
PRIDEO14602.

Protocols and materials databases

DNASU9086.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361365; ENSP00000354722; ENSG00000198692.
GeneID9086.
KEGGhsa:9086.
UCSCuc004fuk.3. human.

Organism-specific databases

CTD9086.
GeneCardsGC0YP022737.
HGNCHGNC:3252. EIF1AY.
HPAHPA002561.
MIM400014. gene.
neXtProtNX_O14602.
PharmGKBPA27686.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0361.
HOGENOMHOG000223675.
HOVERGENHBG001131.
InParanoidO14602.
KOK03236.
OMADTAKINE.
OrthoDBEOG7VHT0G.
PhylomeDBO14602.
TreeFamTF350394.

Gene expression databases

ArrayExpressO14602.
BgeeO14602.
CleanExHS_EIF1AY.
GenevestigatorO14602.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_00216. aIF_1A.
InterProIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
[Graphical view]
PANTHERPTHR21668. PTHR21668. 1 hit.
PfamPF01176. eIF-1a. 1 hit.
[Graphical view]
ProDomPD005579. TIF_eIF-1A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMSSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00523. eIF-1A. 1 hit.
PROSITEPS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEIF1AY.
GenomeRNAi9086.
NextBio34047.
PROO14602.
SOURCESearch...

Entry information

Entry nameIF1AY_HUMAN
AccessionPrimary (citable) accession number: O14602
Secondary accession number(s): Q9BS77
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Translation initiation factors

List of translation initiation factor entries

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM