O14602 (IF1AY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 1A, Y-chromosomal
Short name=eIF-1A Y isoform

Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name=eIF-4C

Gene names

Name:

EIF1AY

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits By similarity.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the eIF-1A family. Contains 1 S1-like domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Initiation factor
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: HPA
Molecular function	protein binding Inferred from physical interaction. Source: IntAct translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EIF5B	O60841	2	EBI-286439,EBI-928530

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 144	143	Eukaryotic translation initiation factor 1A, Y-chromosomal		PRO_0000145102
Regions
	Domain	22 – 96	75	S1-like
Amino acid modifications
	Cross-link	88		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.4
Experimental info
	Sequence conflict	108	1	E → G in AAC51834. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O14602 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 1DE91334F191BEC5	FASTA	144	16,442
	10 20 30 40 50 60 MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL CFDGVKRLCH 70 80 90 100 110 120 IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT 130 140 FGPGDDDEIQ FDDIGDDDED IDDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional coherence of the human Y chromosome." Lahn B.T., Page D.C. Science 278:675-680(1997) [PubMed: 9381176] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[4]	"Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry." Meierhofer D., Wang X., Huang L., Kaiser P. J. Proteome Res. 7:4566-4576(2008) [PubMed: 18781797] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-88, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF000987 mRNA. Translation: AAC51834.1. BT007201 mRNA. Translation: AAP35865.1. BC005248 mRNA. Translation: AAH05248.1.
IPI	IPI00023004.
PIR	C53045.
RefSeq	NP_004672.2. NM_004681.2.
UniGene	Hs.461178.
3D structure databases
ProteinModelPortal	O14602.
SMR	O14602. Positions 2-131.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14602. 2 interactions.
MINT	MINT-2865737.
STRING	O14602.
PTM databases
PhosphoSite	O14602.
Proteomic databases
PRIDE	O14602.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361365; ENSP00000354722; ENSG00000198692.
GeneID	9086.
KEGG	hsa:9086.
NMPDR	fig|9606.3.peg.33815.
UCSC	uc004fuk.1. human.
Organism-specific databases
CTD	9086.
GeneCards	GC0YP022737.
H-InvDB	HIX0017196.
HGNC	HGNC:3252. EIF1AY.
HPA	HPA002561.
MIM	400014. gene.
neXtProt	NX_O14602.
PharmGKB	PA27686.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20821.
GeneTree	ENSGT00390000008256.
HOGENOM	HBG521228.
HOVERGEN	HBG001131.
InParanoid	O14602.
OMA	QGDIILI.
OrthoDB	EOG418BPV.
PhylomeDB	O14602.
Gene expression databases
ArrayExpress	O14602.
Bgee	O14602.
CleanEx	HS_EIF1AY.
Genevestigator	O14602.
GermOnline	ENSG00000198692. Homo sapiens.
Family and domain databases
InterPro	IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR006196. RNA-binding_domain_S1_IF1. IPR001253. TIF_eIF-1A. IPR018104. TIF_eIF-1A_CS. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K03236.
PANTHER	PTHR21668. TIF_eIF-1A. 1 hit.
Pfam	PF01176. eIF-1a. 1 hit. [Graphical view]
ProDom	PD005579. TIF_eIF-1A. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00652. eIF1a. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00523. EIF-1A. 1 hit.
PROSITE	PS01262. IF1A. 1 hit. PS50832. S1_IF1_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	34047.
SOURCE	Search...

Entry information

Entry name

IF1AY_HUMAN

Accession

Primary (citable) accession number: O14602
Secondary accession number(s): Q9BS77

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 99 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.