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Protein

Eukaryotic translation initiation factor 1A, Y-chromosomal

Gene

EIF1AY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 1A, Y-chromosomal
Short name:
eIF-1A Y isoform
Alternative name(s):
Eukaryotic translation initiation factor 4C
Short name:
eIF-4C
Gene namesi
Name:EIF1AY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:3252. EIF1AY.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 144143Eukaryotic translation initiation factor 1A, Y-chromosomalPRO_0000145102Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki88 – 88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiO14602.
PaxDbiO14602.
PRIDEiO14602.

PTM databases

PhosphoSiteiO14602.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiO14602.
CleanExiHS_EIF1AY.
ExpressionAtlasiO14602. baseline and differential.
GenevisibleiO14602. HS.

Organism-specific databases

HPAiHPA002561.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF5BO608412EBI-286439,EBI-928530

Protein-protein interaction databases

BioGridi114542. 4 interactions.
IntActiO14602. 4 interactions.
MINTiMINT-2865737.
STRINGi9606.ENSP00000354722.

Structurei

3D structure databases

ProteinModelPortaliO14602.
SMRiO14602. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 9675S1-likeAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-1A family.Curated
Contains 1 S1-like domain.Curated

Phylogenomic databases

eggNOGiCOG0361.
GeneTreeiENSGT00390000008256.
HOGENOMiHOG000223675.
HOVERGENiHBG001131.
InParanoidiO14602.
KOiK03236.
OMAiCTFEFGE.
OrthoDBiEOG7VHT0G.
PhylomeDBiO14602.
TreeFamiTF350394.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00216. aIF_1A.
InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
[Graphical view]
PANTHERiPTHR21668. PTHR21668. 1 hit.
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
ProDomiPD005579. TIF_eIF-1A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00523. eIF-1A. 1 hit.
PROSITEiPS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL
60 70 80 90 100
CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA
110 120 130 140
RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI
Length:144
Mass (Da):16,442
Last modified:January 23, 2007 - v4
Checksum:i1DE91334F191BEC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081E → G in AAC51834 (PubMed:9381176).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000987 mRNA. Translation: AAC51834.1.
BT007201 mRNA. Translation: AAP35865.1.
BC005248 mRNA. Translation: AAH05248.1.
CCDSiCCDS14795.1.
PIRiC53045.
RefSeqiNP_001265541.1. NM_001278612.1.
NP_004672.2. NM_004681.3.
UniGeneiHs.461178.

Genome annotation databases

EnsembliENST00000361365; ENSP00000354722; ENSG00000198692.
GeneIDi9086.
KEGGihsa:9086.
UCSCiuc004fuk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000987 mRNA. Translation: AAC51834.1.
BT007201 mRNA. Translation: AAP35865.1.
BC005248 mRNA. Translation: AAH05248.1.
CCDSiCCDS14795.1.
PIRiC53045.
RefSeqiNP_001265541.1. NM_001278612.1.
NP_004672.2. NM_004681.3.
UniGeneiHs.461178.

3D structure databases

ProteinModelPortaliO14602.
SMRiO14602. Positions 2-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114542. 4 interactions.
IntActiO14602. 4 interactions.
MINTiMINT-2865737.
STRINGi9606.ENSP00000354722.

PTM databases

PhosphoSiteiO14602.

Proteomic databases

MaxQBiO14602.
PaxDbiO14602.
PRIDEiO14602.

Protocols and materials databases

DNASUi9086.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361365; ENSP00000354722; ENSG00000198692.
GeneIDi9086.
KEGGihsa:9086.
UCSCiuc004fuk.3. human.

Organism-specific databases

CTDi9086.
GeneCardsiGC0YP022737.
HGNCiHGNC:3252. EIF1AY.
HPAiHPA002561.
MIMi400014. gene.
neXtProtiNX_O14602.
PharmGKBiPA27686.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0361.
GeneTreeiENSGT00390000008256.
HOGENOMiHOG000223675.
HOVERGENiHBG001131.
InParanoidiO14602.
KOiK03236.
OMAiCTFEFGE.
OrthoDBiEOG7VHT0G.
PhylomeDBiO14602.
TreeFamiTF350394.

Miscellaneous databases

ChiTaRSiEIF1AY. human.
GeneWikiiEIF1AY.
GenomeRNAii9086.
NextBioi34047.
PROiO14602.
SOURCEiSearch...

Gene expression databases

BgeeiO14602.
CleanExiHS_EIF1AY.
ExpressionAtlasiO14602. baseline and differential.
GenevisibleiO14602. HS.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00216. aIF_1A.
InterProiIPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR001253. TIF_eIF-1A.
IPR018104. TIF_eIF-1A_CS.
[Graphical view]
PANTHERiPTHR21668. PTHR21668. 1 hit.
PfamiPF01176. eIF-1a. 1 hit.
[Graphical view]
ProDomiPD005579. TIF_eIF-1A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00652. eIF1a. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00523. eIF-1A. 1 hit.
PROSITEiPS01262. IF1A. 1 hit.
PS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional coherence of the human Y chromosome."
    Lahn B.T., Page D.C.
    Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiIF1AY_HUMAN
AccessioniPrimary (citable) accession number: O14602
Secondary accession number(s): Q9BS77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. Translation initiation factors
    List of translation initiation factor entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.