ID   VCY2_HUMAN              Reviewed;         106 AA.
AC   O14599;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   24-JAN-2024, entry version 146.
DE   RecName: Full=Testis-specific basic protein Y 2;
DE   AltName: Full=Basic charge, Y-linked 2;
DE   AltName: Full=Variably charged protein Y 2;
GN   Name=BPY2; Synonyms=BPY2A, VCY2, VCY2A;
GN   and
GN   Name=BPY2B; Synonyms=VCY2B;
GN   and
GN   Name=BPY2C; Synonyms=VCY2C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9381176; DOI=10.1126/science.278.5338.675;
RA   Lahn B.T., Page D.C.;
RT   "Functional coherence of the human Y chromosome.";
RL   Science 278:675-680(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA   Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA   Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA   Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA   McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA   Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA   Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of discrete
RT   sequence classes.";
RL   Nature 423:825-837(2003).
RN   [3]
RP   INTERACTION WITH UBE3A, AND TISSUE SPECIFICITY.
RX   PubMed=12207887; DOI=10.1016/s0006-291x(02)02040-5;
RA   Wong E.Y., Tse J.Y., Yao K.M., Tam P.C., Yeung W.S.;
RT   "VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase
RT   E3A.";
RL   Biochem. Biophys. Res. Commun. 296:1104-1111(2002).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=12724276; DOI=10.1095/biolreprod.103.015792;
RA   Tse J.Y., Wong E.Y., Cheung A.N., O W.S., Tam P.C., Yeung W.S.;
RT   "Specific expression of VCY2 in human male germ cells and its involvement
RT   in the pathogenesis of male infertility.";
RL   Biol. Reprod. 69:746-751(2003).
RN   [5]
RP   INTERACTION WITH MAP1S, AND TISSUE SPECIFICITY.
RX   PubMed=14627543; DOI=10.1095/biolreprod.103.018531;
RA   Wong E.Y., Tse J.Y., Yao K.-M., Lui V.C., Tam P.-C., Yeung W.S.;
RT   "Identification and characterization of a VCY2 interacting protein-1;
RT   VCY2IP-1, a MAP-like protein.";
RL   Biol. Reprod. 70:775-784(2004).
CC   -!- SUBUNIT: Interacts with MAP1S. Interacts with UBE3A (via HECT domain).
CC       {ECO:0000269|PubMed:12207887, ECO:0000269|PubMed:14627543}.
CC   -!- INTERACTION:
CC       O14599; Q66K74: MAP1S; NbExp=3; IntAct=EBI-2133713, EBI-2133734;
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in testis. Expressed in
CC       ejaculated spermatozoa of germ cell. Expressed in the nuclei of
CC       spermatogonia, spermatocytes, and round spermatids, except elongated
CC       spermatids (at protein level). {ECO:0000269|PubMed:12207887,
CC       ECO:0000269|PubMed:12724276, ECO:0000269|PubMed:14627543}.
CC   -!- SIMILARITY: Belongs to the VCX/VCY family. {ECO:0000305}.
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DR   EMBL; AF000980; AAC51828.1; -; mRNA.
DR   EMBL; AC016728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS14800.1; -.
DR   CCDS; CCDS44029.1; -.
DR   CCDS; CCDS44030.1; -.
DR   RefSeq; NP_001002760.1; NM_001002760.1.
DR   RefSeq; NP_001002761.1; NM_001002761.1.
DR   RefSeq; NP_004669.2; NM_004678.2.
DR   AlphaFoldDB; O14599; -.
DR   BioGRID; 114539; 3.
DR   BioGRID; 138582; 1.
DR   IntAct; O14599; 2.
DR   STRING; 9606.ENSP00000329106; -.
DR   BioMuta; BPY2; -.
DR   Antibodypedia; 58341; 19 antibodies from 7 providers.
DR   Antibodypedia; 65754; 2 antibodies from 2 providers.
DR   Antibodypedia; 70562; 31 antibodies from 3 providers.
DR   DNASU; 442867; -.
DR   Ensembl; ENST00000331070.8; ENSP00000329106.3; ENSG00000183753.10.
DR   Ensembl; ENST00000382287.5; ENSP00000371724.1; ENSG00000185894.8.
DR   Ensembl; ENST00000382392.5; ENSP00000371829.1; ENSG00000183795.8.
DR   Ensembl; ENST00000382585.2; ENSP00000372028.1; ENSG00000183753.10.
DR   Ensembl; ENST00000615850.1; ENSP00000480184.1; ENSG00000183795.8.
DR   Ensembl; ENST00000618574.1; ENSP00000480751.1; ENSG00000185894.8.
DR   GeneID; 442867; -.
DR   GeneID; 442868; -.
DR   GeneID; 9083; -.
DR   KEGG; hsa:442867; -.
DR   KEGG; hsa:442868; -.
DR   KEGG; hsa:9083; -.
DR   MANE-Select; ENST00000331070.8; ENSP00000329106.3; NM_004678.3; NP_004669.2.
DR   MANE-Select; ENST00000382287.5; ENSP00000371724.1; NM_001002761.1; NP_001002761.1.
DR   MANE-Select; ENST00000382392.5; ENSP00000371829.1; NM_001002760.1; NP_001002760.1.
DR   UCSC; uc004fwi.4; human.
DR   AGR; HGNC:13508; -.
DR   AGR; HGNC:18225; -.
DR   AGR; HGNC:25449; -.
DR   CTD; 442867; -.
DR   CTD; 442868; -.
DR   CTD; 9083; -.
DR   DisGeNET; 442867; -.
DR   DisGeNET; 442868; -.
DR   DisGeNET; 9083; -.
DR   GeneCards; BPY2; -.
DR   GeneCards; BPY2B; -.
DR   GeneCards; BPY2C; -.
DR   GeneReviews; BPY2; -.
DR   HGNC; HGNC:13508; BPY2.
DR   HGNC; HGNC:25449; BPY2B.
DR   HGNC; HGNC:18225; BPY2C.
DR   HPA; ENSG00000183753; Tissue enriched (testis).
DR   HPA; ENSG00000183795; Tissue enriched (testis).
DR   HPA; ENSG00000185894; Tissue enriched (testis).
DR   MalaCards; BPY2; -.
DR   MIM; 400013; gene.
DR   neXtProt; NX_O14599; -.
DR   OpenTargets; ENSG00000183753; -.
DR   PharmGKB; PA37794; -.
DR   VEuPathDB; HostDB:ENSG00000183753; -.
DR   VEuPathDB; HostDB:ENSG00000183795; -.
DR   VEuPathDB; HostDB:ENSG00000185894; -.
DR   GeneTree; ENSGT00390000015738; -.
DR   HOGENOM; CLU_2283759_0_0_1; -.
DR   InParanoid; O14599; -.
DR   PhylomeDB; O14599; -.
DR   TreeFam; TF342588; -.
DR   PathwayCommons; O14599; -.
DR   SignaLink; O14599; -.
DR   BioGRID-ORCS; 442867; 8 hits in 186 CRISPR screens.
DR   BioGRID-ORCS; 442868; 13 hits in 600 CRISPR screens.
DR   BioGRID-ORCS; 9083; 17 hits in 260 CRISPR screens.
DR   GeneWiki; BPY2; -.
DR   Pharos; O14599; Tbio.
DR   PRO; PR:O14599; -.
DR   Proteomes; UP000005640; Chromosome Y.
DR   RNAct; O14599; Protein.
DR   Bgee; ENSG00000183753; Expressed in left testis and 13 other cell types or tissues.
DR   ExpressionAtlas; O14599; baseline.
DR   GO; GO:0005634; C:nucleus; IDA:HGNC-UCL.
DR   GO; GO:0032399; F:HECT domain binding; IPI:HGNC-UCL.
DR   GO; GO:0007338; P:single fertilization; TAS:ProtInc.
DR   GO; GO:0007283; P:spermatogenesis; IMP:HGNC-UCL.
DR   Genevisible; O14599; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..106
FT                   /note="Testis-specific basic protein Y 2"
FT                   /id="PRO_0000184664"
FT   CONFLICT        101
FT                   /note="R -> K (in Ref. 1; AAC51828)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   106 AA;  12063 MW;  2573EC02A2C99788 CRC64;
     MMTLVPRART RAGQDHYSHP CPRFSQVLLT EGIMTYCLTK NLSDVNILHR LLKNGNVRNT
     LLQSKVGLLT YYVKLYPGEV TLLTRPSIQM RLCCITGSVS RPRSQK
//