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O14599 (VCY2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testis-specific basic protein Y 2
Alternative name(s):
Basic charge, Y-linked 2
Variably charged protein Y 2
Gene names
Name:BPY2
Synonyms:BPY2A, VCY2, VCY2A
AND
Name:BPY2B
Synonyms:VCY2B
AND
Name:BPY2C
Synonyms:VCY2C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length106 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with MAP1S. Interacts with UBE3A (via HECT domain). Ref.3 Ref.5

Tissue specificity

Expressed exclusively in testis. Expressed in ejaculated spermatozoa of germ cell. Expressed in the nuclei of spermatogonia, spermatocytes, and round spermatids, except elongated spermatids (at protein level). Ref.3 Ref.4 Ref.5

Sequence similarities

Belongs to the VCX/VCY family.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MAP1SQ66K743EBI-2133713,EBI-2133734

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 106106Testis-specific basic protein Y 2
PRO_0000184664

Experimental info

Sequence conflict1011R → K in AAC51828. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O14599 [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: 2573EC02A2C99788

FASTA10612,063
        10         20         30         40         50         60 
MMTLVPRART RAGQDHYSHP CPRFSQVLLT EGIMTYCLTK NLSDVNILHR LLKNGNVRNT 

        70         80         90        100 
LLQSKVGLLT YYVKLYPGEV TLLTRPSIQM RLCCITGSVS RPRSQK 

« Hide

References

« Hide 'large scale' references
[1]"Functional coherence of the human Y chromosome."
Lahn B.T., Page D.C.
Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes."
Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. expand/collapse author list , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C.
Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A."
Wong E.Y., Tse J.Y., Yao K.M., Tam P.C., Yeung W.S.
Biochem. Biophys. Res. Commun. 296:1104-1111(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH UBE3A, TISSUE SPECIFICITY.
[4]"Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility."
Tse J.Y., Wong E.Y., Cheung A.N., O W.S., Tam P.C., Yeung W.S.
Biol. Reprod. 69:746-751(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"Identification and characterization of a VCY2 interacting protein-1; VCY2IP-1, a MAP-like protein."
Wong E.Y., Tse J.Y., Yao K.-M., Lui V.C., Tam P.-C., Yeung W.S.
Biol. Reprod. 70:775-784(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MAP1S, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF000980 mRNA. Translation: AAC51828.1.
AC016728 Genomic DNA. No translation available.
CCDSCCDS14800.1.
CCDS44029.1.
CCDS44030.1.
RefSeqNP_001002760.1. NM_001002760.1.
NP_001002761.1. NM_001002761.1.
NP_004669.2. NM_004678.2.
UniGeneHs.632848.
Hs.664724.

3D structure databases

ProteinModelPortalO14599.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114539. 2 interactions.
IntActO14599. 1 interaction.
STRING9606.ENSP00000329106.

Proteomic databases

PaxDbO14599.
PRIDEO14599.

Protocols and materials databases

DNASU442867.
442868.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331070; ENSP00000329106; ENSG00000183753.
ENST00000382287; ENSP00000371724; ENSG00000185894.
ENST00000382392; ENSP00000371829; ENSG00000183795.
ENST00000382585; ENSP00000372028; ENSG00000183753.
GeneID442867.
442868.
9083.
KEGGhsa:442867.
hsa:442868.
hsa:9083.
UCSCuc004fvj.3. human.

Organism-specific databases

CTD442867.
442868.
9083.
GeneCardsGC0YM027177.
GC0YP025130.
GC0YP026764.
GeneReviewsBPY2.
H-InvDBHIX0177613.
HIX0177614.
HIX0177615.
HGNCHGNC:13508. BPY2.
HGNC:25449. BPY2B.
HGNC:18225. BPY2C.
MIM400013. gene.
neXtProtNX_O14599.
PharmGKBPA37794.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000206609.
InParanoidO14599.
OMALTEGIMT.
OrthoDBEOG7M0NTQ.
PhylomeDBO14599.
TreeFamTF342588.

Gene expression databases

BgeeO14599.
CleanExHS_BPY2.
HS_BPY2B.
GenevestigatorO14599.

Family and domain databases

ProtoNetSearch...

Other

GeneWikiBPY2.
NextBio34033.
PROO14599.
SOURCESearch...

Entry information

Entry nameVCY2_HUMAN
AccessionPrimary (citable) accession number: O14599
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 14, 2009
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM