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O14599

- VCY2_HUMAN

UniProt

O14599 - VCY2_HUMAN

Protein

Testis-specific basic protein Y 2

Gene

BPY2

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. HECT domain binding Source: HGNC
    2. protein binding Source: IntAct

    GO - Biological processi

    1. single fertilization Source: ProtInc
    2. spermatogenesis Source: HGNC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-specific basic protein Y 2
    Alternative name(s):
    Basic charge, Y-linked 2
    Variably charged protein Y 2
    Gene namesi
    Name:BPY2
    Synonyms:BPY2A, VCY2, VCY2A
    AND
    Name:BPY2B
    Synonyms:VCY2B
    AND
    Name:BPY2C
    Synonyms:VCY2C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome Y

    Organism-specific databases

    HGNCiHGNC:13508. BPY2.
    HGNC:25449. BPY2B.
    HGNC:18225. BPY2C.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HGNC

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37794.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 106106Testis-specific basic protein Y 2PRO_0000184664Add
    BLAST

    Proteomic databases

    PaxDbiO14599.
    PRIDEiO14599.

    Expressioni

    Tissue specificityi

    Expressed exclusively in testis. Expressed in ejaculated spermatozoa of germ cell. Expressed in the nuclei of spermatogonia, spermatocytes, and round spermatids, except elongated spermatids (at protein level).3 Publications

    Gene expression databases

    BgeeiO14599.
    CleanExiHS_BPY2.
    HS_BPY2B.
    GenevestigatoriO14599.

    Interactioni

    Subunit structurei

    Interacts with MAP1S. Interacts with UBE3A (via HECT domain).2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAP1SQ66K743EBI-2133713,EBI-2133734

    Protein-protein interaction databases

    BioGridi114539. 2 interactions.
    IntActiO14599. 1 interaction.
    STRINGi9606.ENSP00000329106.

    Structurei

    3D structure databases

    ProteinModelPortaliO14599.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the VCX/VCY family.Curated

    Phylogenomic databases

    HOGENOMiHOG000206609.
    InParanoidiO14599.
    OMAiLTEGIMT.
    OrthoDBiEOG7M0NTQ.
    PhylomeDBiO14599.
    TreeFamiTF342588.

    Sequencei

    Sequence statusi: Complete.

    O14599-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMTLVPRART RAGQDHYSHP CPRFSQVLLT EGIMTYCLTK NLSDVNILHR    50
    LLKNGNVRNT LLQSKVGLLT YYVKLYPGEV TLLTRPSIQM RLCCITGSVS 100
    RPRSQK 106
    Length:106
    Mass (Da):12,063
    Last modified:April 14, 2009 - v2
    Checksum:i2573EC02A2C99788
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti101 – 1011R → K in AAC51828. (PubMed:9381176)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000980 mRNA. Translation: AAC51828.1.
    AC016728 Genomic DNA. No translation available.
    CCDSiCCDS14800.1.
    CCDS44029.1.
    CCDS44030.1.
    RefSeqiNP_001002760.1. NM_001002760.1.
    NP_001002761.1. NM_001002761.1.
    NP_004669.2. NM_004678.2.
    UniGeneiHs.632848.
    Hs.664724.

    Genome annotation databases

    EnsembliENST00000331070; ENSP00000329106; ENSG00000183753.
    ENST00000382287; ENSP00000371724; ENSG00000185894.
    ENST00000382392; ENSP00000371829; ENSG00000183795.
    ENST00000382585; ENSP00000372028; ENSG00000183753.
    GeneIDi442867.
    442868.
    9083.
    KEGGihsa:442867.
    hsa:442868.
    hsa:9083.
    UCSCiuc004fvj.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000980 mRNA. Translation: AAC51828.1 .
    AC016728 Genomic DNA. No translation available.
    CCDSi CCDS14800.1.
    CCDS44029.1.
    CCDS44030.1.
    RefSeqi NP_001002760.1. NM_001002760.1.
    NP_001002761.1. NM_001002761.1.
    NP_004669.2. NM_004678.2.
    UniGenei Hs.632848.
    Hs.664724.

    3D structure databases

    ProteinModelPortali O14599.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114539. 2 interactions.
    IntActi O14599. 1 interaction.
    STRINGi 9606.ENSP00000329106.

    Proteomic databases

    PaxDbi O14599.
    PRIDEi O14599.

    Protocols and materials databases

    DNASUi 442867.
    442868.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331070 ; ENSP00000329106 ; ENSG00000183753 .
    ENST00000382287 ; ENSP00000371724 ; ENSG00000185894 .
    ENST00000382392 ; ENSP00000371829 ; ENSG00000183795 .
    ENST00000382585 ; ENSP00000372028 ; ENSG00000183753 .
    GeneIDi 442867.
    442868.
    9083.
    KEGGi hsa:442867.
    hsa:442868.
    hsa:9083.
    UCSCi uc004fvj.3. human.

    Organism-specific databases

    CTDi 442867.
    442868.
    9083.
    GeneCardsi GC0YM027177.
    GC0YP025130.
    GC0YP026764.
    GeneReviewsi BPY2.
    H-InvDB HIX0177613.
    HIX0177614.
    HIX0177615.
    HGNCi HGNC:13508. BPY2.
    HGNC:25449. BPY2B.
    HGNC:18225. BPY2C.
    MIMi 400013. gene.
    neXtProti NX_O14599.
    PharmGKBi PA37794.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000206609.
    InParanoidi O14599.
    OMAi LTEGIMT.
    OrthoDBi EOG7M0NTQ.
    PhylomeDBi O14599.
    TreeFami TF342588.

    Miscellaneous databases

    GeneWikii BPY2.
    NextBioi 34033.
    PROi O14599.
    SOURCEi Search...

    Gene expression databases

    Bgeei O14599.
    CleanExi HS_BPY2.
    HS_BPY2B.
    Genevestigatori O14599.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Functional coherence of the human Y chromosome."
      Lahn B.T., Page D.C.
      Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A."
      Wong E.Y., Tse J.Y., Yao K.M., Tam P.C., Yeung W.S.
      Biochem. Biophys. Res. Commun. 296:1104-1111(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UBE3A, TISSUE SPECIFICITY.
    4. "Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility."
      Tse J.Y., Wong E.Y., Cheung A.N., O W.S., Tam P.C., Yeung W.S.
      Biol. Reprod. 69:746-751(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Identification and characterization of a VCY2 interacting protein-1; VCY2IP-1, a MAP-like protein."
      Wong E.Y., Tse J.Y., Yao K.-M., Lui V.C., Tam P.-C., Yeung W.S.
      Biol. Reprod. 70:775-784(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAP1S, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiVCY2_HUMAN
    AccessioniPrimary (citable) accession number: O14599
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3