Reviewed, UniProtKB/Swiss-Prot O14599 (VCY2_HUMAN)

Names and origin

Protein names

Recommended name:
    Testis-specific basic protein Y 2
Alternative name(s):
    Variably charged protein Y 2
    Basic charge, Y-linked 2

Gene names

Name:	BPY2
Synonyms:	BPY2A, VCY2, VCY2A
AND
Name:	BPY2B
Synonyms:	VCY2B
AND
Name:	BPY2C
Synonyms:	VCY2C

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with MAP1S. Ref.3
Tissue specificity	Expressed exclusively in testis.
Sequence similarities	Belongs to the VCX/VCY family.

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	single fertilization Ref.1 Traceable author statement. Source: ProtInc spermatogenesis Inferred from mutant phenotype. Source: HGNC
Cellular component	nucleus Inferred from direct assay. Source: HGNC
Molecular function	HECT domain binding Inferred from physical interaction. Source: HGNC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MAP1S	Q66K74	1	EBI-2133713,EBI-2133734

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 106	106	Testis-specific basic protein Y 2		PRO_0000184664
Experimental info
	Sequence conflict	101	1	R → K in AAC51828. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O14599-1 [UniParc]. Last modified April 14, 2009. Version 2. Checksum: 2573EC02A2C99788	FASTA	106	12,063
	10 20 30 40 50 60 MMTLVPRART RAGQDHYSHP CPRFSQVLLT EGIMTYCLTK NLSDVNILHR LLKNGNVRNT 70 80 90 100 LLQSKVGLLT YYVKLYPGEV TLLTRPSIQM RLCCITGSVS RPRSQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional coherence of the human Y chromosome." Lahn B.T., Page D.C. Science 278:675-680(1997) [PubMed: 9381176] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed: 12815422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Identification and characterization of a VCY2 interacting protein-1; VCY2IP-1, a MAP-like protein." Wong E.Y., Tse J.Y., Yao K.-M., Lui V.C., Tam P.-C., Yeung W.S. Biol. Reprod. 70:775-784(2004) [PubMed: 14627543] [Abstract] Cited for: INTERACTION WITH MAP1S.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF000980 mRNA. Translation: AAC51828.1. AC016728 Genomic DNA. No translation available.
IPI	IPI00022529.
RefSeq	NP_001002760.1. NP_001002761.1. NP_004669.2.
UniGene	Hs.632848 Hs.664724
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O14599. 1 interaction.
STRING	O14599.
Proteomic databases
PRIDE	O14599.
Genome annotation databases
Ensembl	ENST00000331070; ENSP00000329106; ENSG00000183753; Homo sapiens. [Genome view] ENST00000382287; ENSP00000371724; ENSG00000185894; Homo sapiens. [Genome view] ENST00000382392; ENSP00000371829; ENSG00000183795; Homo sapiens. [Genome view] ENST00000382585; ENSP00000372028; ENSG00000183753; Homo sapiens. [Genome view]
GeneID	442867. 442868. 9083.
KEGG	hsa:442867. hsa:442868. hsa:9083.
UCSC	uc004fvj.1. human.
Organism-specific databases
CTD	442867. 442868. 9083.
GeneCards	GC0YM025586. GC0YP023468. GC0YP025173.
H-InvDB	HIX0056658. HIX0077342. HIX0077343.
HGNC	HGNC:13508. BPY2. HGNC:25449. BPY2B. HGNC:18225. BPY2C.
MIM	400013. gene.
PharmGKB	PA37794.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O14599.
OMA	LTEGIMT
Gene expression databases
CleanEx	HS_BPY2. HS_BPY2B.
Genevestigator	O14599.
GermOnline	ENSG00000183753. Homo sapiens. ENSG00000185894. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	34033.
SOURCE	Search...

Entry information

Entry name

VCY2_HUMAN

Accession

Primary (citable) accession number: O14599

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	April 14, 2009
Last modified:	November 3, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.