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O14599

- VCY2_HUMAN

UniProt

O14599 - VCY2_HUMAN

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Protein

Testis-specific basic protein Y 2

Gene

BPY2

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. HECT domain binding Source: HGNC

GO - Biological processi

  1. single fertilization Source: ProtInc
  2. spermatogenesis Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific basic protein Y 2
Alternative name(s):
Basic charge, Y-linked 2
Variably charged protein Y 2
Gene namesi
Name:BPY2
Synonyms:BPY2A, VCY2, VCY2A
AND
Name:BPY2B
Synonyms:VCY2B
AND
Name:BPY2C
Synonyms:VCY2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:13508. BPY2.
HGNC:25449. BPY2B.
HGNC:18225. BPY2C.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: HGNC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37794.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Testis-specific basic protein Y 2PRO_0000184664Add
BLAST

Proteomic databases

PaxDbiO14599.
PRIDEiO14599.

Expressioni

Tissue specificityi

Expressed exclusively in testis. Expressed in ejaculated spermatozoa of germ cell. Expressed in the nuclei of spermatogonia, spermatocytes, and round spermatids, except elongated spermatids (at protein level).3 Publications

Gene expression databases

BgeeiO14599.
CleanExiHS_BPY2.
HS_BPY2B.
GenevestigatoriO14599.

Interactioni

Subunit structurei

Interacts with MAP1S. Interacts with UBE3A (via HECT domain).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAP1SQ66K743EBI-2133713,EBI-2133734

Protein-protein interaction databases

BioGridi114539. 2 interactions.
IntActiO14599. 1 interaction.
STRINGi9606.ENSP00000329106.

Structurei

3D structure databases

ProteinModelPortaliO14599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VCX/VCY family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000015738.
HOGENOMiHOG000206609.
InParanoidiO14599.
OMAiLTEGIMT.
OrthoDBiEOG7M0NTQ.
PhylomeDBiO14599.
TreeFamiTF342588.

Sequencei

Sequence statusi: Complete.

O14599-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMTLVPRART RAGQDHYSHP CPRFSQVLLT EGIMTYCLTK NLSDVNILHR
60 70 80 90 100
LLKNGNVRNT LLQSKVGLLT YYVKLYPGEV TLLTRPSIQM RLCCITGSVS

RPRSQK
Length:106
Mass (Da):12,063
Last modified:April 14, 2009 - v2
Checksum:i2573EC02A2C99788
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011R → K in AAC51828. (PubMed:9381176)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000980 mRNA. Translation: AAC51828.1.
AC016728 Genomic DNA. No translation available.
CCDSiCCDS14800.1.
CCDS44029.1.
CCDS44030.1.
RefSeqiNP_001002760.1. NM_001002760.1.
NP_001002761.1. NM_001002761.1.
NP_004669.2. NM_004678.2.
UniGeneiHs.632848.
Hs.664724.

Genome annotation databases

EnsembliENST00000331070; ENSP00000329106; ENSG00000183753.
ENST00000382287; ENSP00000371724; ENSG00000185894.
ENST00000382392; ENSP00000371829; ENSG00000183795.
ENST00000382585; ENSP00000372028; ENSG00000183753.
ENST00000615850; ENSP00000480184; ENSG00000183795.
ENST00000618574; ENSP00000480751; ENSG00000185894.
ENST00000624671; ENSP00000485508; ENSG00000280052.
ENST00000624972; ENSP00000485496; ENSG00000279258.
ENST00000625021; ENSP00000485116; ENSG00000279564.
GeneIDi442867.
442868.
9083.
KEGGihsa:442867.
hsa:442868.
hsa:9083.
UCSCiuc004fvj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000980 mRNA. Translation: AAC51828.1 .
AC016728 Genomic DNA. No translation available.
CCDSi CCDS14800.1.
CCDS44029.1.
CCDS44030.1.
RefSeqi NP_001002760.1. NM_001002760.1.
NP_001002761.1. NM_001002761.1.
NP_004669.2. NM_004678.2.
UniGenei Hs.632848.
Hs.664724.

3D structure databases

ProteinModelPortali O14599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114539. 2 interactions.
IntActi O14599. 1 interaction.
STRINGi 9606.ENSP00000329106.

Proteomic databases

PaxDbi O14599.
PRIDEi O14599.

Protocols and materials databases

DNASUi 442867.
442868.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331070 ; ENSP00000329106 ; ENSG00000183753 .
ENST00000382287 ; ENSP00000371724 ; ENSG00000185894 .
ENST00000382392 ; ENSP00000371829 ; ENSG00000183795 .
ENST00000382585 ; ENSP00000372028 ; ENSG00000183753 .
ENST00000615850 ; ENSP00000480184 ; ENSG00000183795 .
ENST00000618574 ; ENSP00000480751 ; ENSG00000185894 .
ENST00000624671 ; ENSP00000485508 ; ENSG00000280052 .
ENST00000624972 ; ENSP00000485496 ; ENSG00000279258 .
ENST00000625021 ; ENSP00000485116 ; ENSG00000279564 .
GeneIDi 442867.
442868.
9083.
KEGGi hsa:442867.
hsa:442868.
hsa:9083.
UCSCi uc004fvj.3. human.

Organism-specific databases

CTDi 442867.
442868.
9083.
GeneCardsi GC0YM027177.
GC0YP025130.
GC0YP026764.
GeneReviewsi BPY2.
H-InvDB HIX0177613.
HIX0177614.
HIX0177615.
HGNCi HGNC:13508. BPY2.
HGNC:25449. BPY2B.
HGNC:18225. BPY2C.
MIMi 400013. gene.
neXtProti NX_O14599.
PharmGKBi PA37794.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000015738.
HOGENOMi HOG000206609.
InParanoidi O14599.
OMAi LTEGIMT.
OrthoDBi EOG7M0NTQ.
PhylomeDBi O14599.
TreeFami TF342588.

Miscellaneous databases

GeneWikii BPY2.
NextBioi 34033.
PROi O14599.
SOURCEi Search...

Gene expression databases

Bgeei O14599.
CleanExi HS_BPY2.
HS_BPY2B.
Genevestigatori O14599.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Functional coherence of the human Y chromosome."
    Lahn B.T., Page D.C.
    Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A."
    Wong E.Y., Tse J.Y., Yao K.M., Tam P.C., Yeung W.S.
    Biochem. Biophys. Res. Commun. 296:1104-1111(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBE3A, TISSUE SPECIFICITY.
  4. "Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility."
    Tse J.Y., Wong E.Y., Cheung A.N., O W.S., Tam P.C., Yeung W.S.
    Biol. Reprod. 69:746-751(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Identification and characterization of a VCY2 interacting protein-1; VCY2IP-1, a MAP-like protein."
    Wong E.Y., Tse J.Y., Yao K.-M., Lui V.C., Tam P.-C., Yeung W.S.
    Biol. Reprod. 70:775-784(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAP1S, TISSUE SPECIFICITY.

Entry informationi

Entry nameiVCY2_HUMAN
AccessioniPrimary (citable) accession number: O14599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 14, 2009
Last modified: November 26, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3