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Protein

Testis-specific basic protein Y 1

Gene

VCY

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific basic protein Y 1
Alternative name(s):
Basic charge, Y-linked 1
Variably charged protein Y
Gene namesi
Name:VCY
Synonyms:BPY1, VCY1A
AND
Name:VCY1B
Synonyms:BPY1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:12668. VCY.
HGNC:31751. VCY1B.

Pathology & Biotechi

Organism-specific databases

DisGeNETi9084.
GeneReviewsiVCY.
OpenTargetsiENSG00000129862.
PharmGKBiPA37291.

Polymorphism and mutation databases

BioMutaiVCY.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001846631 – 125Testis-specific basic protein Y 1Add BLAST125

Proteomic databases

PaxDbiO14598.
PeptideAtlasiO14598.
PRIDEiO14598.

PTM databases

iPTMnetiO14598.
PhosphoSitePlusiO14598.

Expressioni

Tissue specificityi

Expressed exclusively in testis.

Gene expression databases

BgeeiENSG00000129862.
CleanExiHS_VCY.
GenevisibleiO14598. HS.

Organism-specific databases

HPAiHPA044996.
HPA049357.

Interactioni

Protein-protein interaction databases

BioGridi114540. 3 interactors.
131701. 1 interactor.
IntActiO14598. 2 interactors.
STRINGi9606.ENSP00000250825.

Structurei

3D structure databases

ProteinModelPortaliO14598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VCX/VCY family.Curated

Phylogenomic databases

eggNOGiENOG410J6ZU. Eukaryota.
ENOG4111QYX. LUCA.
GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiO14598.
OMAiDPPSDVM.
OrthoDBiEOG09370HFD.

Family and domain databases

InterProiView protein in InterPro
IPR026653. VCX/VCY1.
PANTHERiPTHR15251:SF2. PTHR15251:SF2. 1 hit.
PfamiView protein in Pfam
PF15231. VCX_VCY. 1 hit.

Sequencei

Sequence statusi: Complete.

O14598-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPKPRASGP PAKAKETGKR KSSSQPSPSG PKKKTTKVAE KGEAVRGGRR
60 70 80 90 100
GKKGAATKMA AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ
110 120
HDPLSQESEL EEPLSKGRPS TPLSP
Length:125
Mass (Da):12,917
Last modified:January 1, 1998 - v1
Checksum:iD528561A52592E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000979 mRNA. Translation: AAC51827.1.
AC006370 Genomic DNA. Translation: AAF03503.1.
BC056508 mRNA. Translation: AAH56508.1.
CCDSiCCDS56617.1.
CCDS56618.1.
RefSeqiNP_004670.1. NM_004679.2.
NP_870996.1. NM_181880.1.
UniGeneiHs.170076.
Hs.632284.

Genome annotation databases

EnsembliENST00000250823; ENSP00000250823; ENSG00000129862.
ENST00000250825; ENSP00000250825; ENSG00000129864.
GeneIDi353513.
9084.
KEGGihsa:353513.
hsa:9084.
UCSCiuc004ftc.4. human.

Similar proteinsi

Entry informationi

Entry nameiVCY1_HUMAN
AccessioniPrimary (citable) accession number: O14598
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families