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O14598

- VCY1_HUMAN

UniProt

O14598 - VCY1_HUMAN

Protein

Testis-specific basic protein Y 1

Gene

VCY

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-specific basic protein Y 1
    Alternative name(s):
    Basic charge, Y-linked 1
    Variably charged protein Y
    Gene namesi
    Name:VCY
    Synonyms:BPY1, VCY1A
    AND
    Name:VCY1B
    Synonyms:BPY1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome Y

    Organism-specific databases

    HGNCiHGNC:12668. VCY.
    HGNC:31751. VCY1B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37291.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 125125Testis-specific basic protein Y 1PRO_0000184663Add
    BLAST

    Proteomic databases

    PRIDEiO14598.

    PTM databases

    PhosphoSiteiO14598.

    Expressioni

    Tissue specificityi

    Expressed exclusively in testis.

    Gene expression databases

    BgeeiO14598.
    CleanExiHS_VCY.
    GenevestigatoriO14598.

    Organism-specific databases

    HPAiHPA044996.
    HPA049357.

    Interactioni

    Protein-protein interaction databases

    BioGridi131701. 1 interaction.
    IntActiO14598. 1 interaction.
    STRINGi9606.ENSP00000250823.

    Structurei

    3D structure databases

    ProteinModelPortaliO14598.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the VCX/VCY family.Curated

    Phylogenomic databases

    HOGENOMiHOG000074166.
    InParanoidiO14598.
    OMAiDPPSDVM.

    Family and domain databases

    InterProiIPR026653. VCX/VCY1.
    [Graphical view]
    PANTHERiPTHR15251. PTHR15251. 1 hit.
    PfamiPF15231. VCX_VCY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14598-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPKPRASGP PAKAKETGKR KSSSQPSPSG PKKKTTKVAE KGEAVRGGRR    50
    GKKGAATKMA AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ 100
    HDPLSQESEL EEPLSKGRPS TPLSP 125
    Length:125
    Mass (Da):12,917
    Last modified:January 1, 1998 - v1
    Checksum:iD528561A52592E6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000979 mRNA. Translation: AAC51827.1.
    AC006370 Genomic DNA. Translation: AAF03503.1.
    BC056508 mRNA. Translation: AAH56508.1.
    CCDSiCCDS56617.1.
    CCDS56618.1.
    RefSeqiNP_004670.1. NM_004679.2.
    NP_870996.1. NM_181880.1.
    UniGeneiHs.170076.
    Hs.632284.

    Genome annotation databases

    EnsembliENST00000250823; ENSP00000250823; ENSG00000129862.
    ENST00000250825; ENSP00000250825; ENSG00000129864.
    GeneIDi353513.
    9084.
    KEGGihsa:353513.
    hsa:9084.
    UCSCiuc004ftc.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000979 mRNA. Translation: AAC51827.1 .
    AC006370 Genomic DNA. Translation: AAF03503.1 .
    BC056508 mRNA. Translation: AAH56508.1 .
    CCDSi CCDS56617.1.
    CCDS56618.1.
    RefSeqi NP_004670.1. NM_004679.2.
    NP_870996.1. NM_181880.1.
    UniGenei Hs.170076.
    Hs.632284.

    3D structure databases

    ProteinModelPortali O14598.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131701. 1 interaction.
    IntActi O14598. 1 interaction.
    STRINGi 9606.ENSP00000250823.

    PTM databases

    PhosphoSitei O14598.

    Proteomic databases

    PRIDEi O14598.

    Protocols and materials databases

    DNASUi 353513.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000250823 ; ENSP00000250823 ; ENSG00000129862 .
    ENST00000250825 ; ENSP00000250825 ; ENSG00000129864 .
    GeneIDi 353513.
    9084.
    KEGGi hsa:353513.
    hsa:9084.
    UCSCi uc004ftc.3. human.

    Organism-specific databases

    CTDi 353513.
    9084.
    GeneCardsi GC0YM016098.
    GC0YP016170.
    GeneReviewsi VCY.
    H-InvDB HIX0177810.
    HIX0177811.
    HGNCi HGNC:12668. VCY.
    HGNC:31751. VCY1B.
    HPAi HPA044996.
    HPA049357.
    MIMi 400012. gene.
    neXtProti NX_O14598.
    PharmGKBi PA37291.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000074166.
    InParanoidi O14598.
    OMAi DPPSDVM.

    Miscellaneous databases

    NextBioi 34037.
    PROi O14598.
    SOURCEi Search...

    Gene expression databases

    Bgeei O14598.
    CleanExi HS_VCY.
    Genevestigatori O14598.

    Family and domain databases

    InterProi IPR026653. VCX/VCY1.
    [Graphical view ]
    PANTHERi PTHR15251. PTHR15251. 1 hit.
    Pfami PF15231. VCX_VCY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional coherence of the human Y chromosome."
      Lahn B.T., Page D.C.
      Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiVCY1_HUMAN
    AccessioniPrimary (citable) accession number: O14598
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3