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Protein

Testis-specific basic protein Y 1

Gene

VCY

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific basic protein Y 1
Alternative name(s):
Basic charge, Y-linked 1
Variably charged protein Y
Gene namesi
Name:VCY
Synonyms:BPY1, VCY1A
AND
Name:VCY1B
Synonyms:BPY1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y

Organism-specific databases

HGNCiHGNC:12668. VCY.
HGNC:31751. VCY1B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37291.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125Testis-specific basic protein Y 1PRO_0000184663Add
BLAST

Proteomic databases

PRIDEiO14598.

PTM databases

PhosphoSiteiO14598.

Expressioni

Tissue specificityi

Expressed exclusively in testis.

Gene expression databases

BgeeiO14598.
CleanExiHS_VCY.
GenevestigatoriO14598.

Organism-specific databases

HPAiHPA044996.
HPA049357.

Interactioni

Protein-protein interaction databases

BioGridi131701. 1 interaction.
IntActiO14598. 1 interaction.
STRINGi9606.ENSP00000250823.

Structurei

3D structure databases

ProteinModelPortaliO14598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VCX/VCY family.Curated

Phylogenomic databases

GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiO14598.
OMAiDPPSDVM.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14598-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPKPRASGP PAKAKETGKR KSSSQPSPSG PKKKTTKVAE KGEAVRGGRR
60 70 80 90 100
GKKGAATKMA AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ
110 120
HDPLSQESEL EEPLSKGRPS TPLSP
Length:125
Mass (Da):12,917
Last modified:January 1, 1998 - v1
Checksum:iD528561A52592E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000979 mRNA. Translation: AAC51827.1.
AC006370 Genomic DNA. Translation: AAF03503.1.
BC056508 mRNA. Translation: AAH56508.1.
CCDSiCCDS56617.1.
CCDS56618.1.
RefSeqiNP_004670.1. NM_004679.2.
NP_870996.1. NM_181880.1.
UniGeneiHs.170076.
Hs.632284.

Genome annotation databases

EnsembliENST00000250823; ENSP00000250823; ENSG00000129862.
ENST00000250825; ENSP00000250825; ENSG00000129864.
ENST00000623245; ENSP00000485471; ENSG00000279451.
ENST00000624464; ENSP00000485441; ENSG00000279158.
GeneIDi353513.
9084.
KEGGihsa:353513.
hsa:9084.
UCSCiuc004ftc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000979 mRNA. Translation: AAC51827.1.
AC006370 Genomic DNA. Translation: AAF03503.1.
BC056508 mRNA. Translation: AAH56508.1.
CCDSiCCDS56617.1.
CCDS56618.1.
RefSeqiNP_004670.1. NM_004679.2.
NP_870996.1. NM_181880.1.
UniGeneiHs.170076.
Hs.632284.

3D structure databases

ProteinModelPortaliO14598.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131701. 1 interaction.
IntActiO14598. 1 interaction.
STRINGi9606.ENSP00000250823.

PTM databases

PhosphoSiteiO14598.

Proteomic databases

PRIDEiO14598.

Protocols and materials databases

DNASUi353513.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250823; ENSP00000250823; ENSG00000129862.
ENST00000250825; ENSP00000250825; ENSG00000129864.
ENST00000623245; ENSP00000485471; ENSG00000279451.
ENST00000624464; ENSP00000485441; ENSG00000279158.
GeneIDi353513.
9084.
KEGGihsa:353513.
hsa:9084.
UCSCiuc004ftc.3. human.

Organism-specific databases

CTDi353513.
9084.
GeneCardsiGC0YM016098.
GC0YP016170.
GeneReviewsiVCY.
H-InvDBHIX0177810.
HIX0177811.
HGNCiHGNC:12668. VCY.
HGNC:31751. VCY1B.
HPAiHPA044996.
HPA049357.
MIMi400012. gene.
neXtProtiNX_O14598.
PharmGKBiPA37291.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00440000034745.
HOGENOMiHOG000074166.
InParanoidiO14598.
OMAiDPPSDVM.

Miscellaneous databases

NextBioi34037.
PROiO14598.
SOURCEiSearch...

Gene expression databases

BgeeiO14598.
CleanExiHS_VCY.
GenevestigatoriO14598.

Family and domain databases

InterProiIPR026653. VCX/VCY1.
[Graphical view]
PANTHERiPTHR15251. PTHR15251. 1 hit.
PfamiPF15231. VCX_VCY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional coherence of the human Y chromosome."
    Lahn B.T., Page D.C.
    Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiVCY1_HUMAN
AccessioniPrimary (citable) accession number: O14598
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.