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O14598 (VCY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testis-specific basic protein Y 1
Alternative name(s):
Basic charge, Y-linked 1
Variably charged protein Y
Gene names
Name:VCY
Synonyms:BPY1, VCY1A
AND
Name:VCY1B
Synonyms:BPY1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May mediate a process in spermatogenesis or may play a role in sex ratio distortion.

Tissue specificity

Expressed exclusively in testis.

Sequence similarities

Belongs to the VCX/VCY family.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 125125Testis-specific basic protein Y 1
PRO_0000184663

Sequences

Sequence LengthMass (Da)Tools
O14598 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D528561A52592E6C

FASTA12512,917
        10         20         30         40         50         60 
MSPKPRASGP PAKAKETGKR KSSSQPSPSG PKKKTTKVAE KGEAVRGGRR GKKGAATKMA 

        70         80         90        100        110        120 
AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQESEL EEPLSKGRPS 


TPLSP 

« Hide

References

« Hide 'large scale' references
[1]"Functional coherence of the human Y chromosome."
Lahn B.T., Page D.C.
Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes."
Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. expand/collapse author list , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C.
Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF000979 mRNA. Translation: AAC51827.1.
AC006370 Genomic DNA. Translation: AAF03503.1.
BC056508 mRNA. Translation: AAH56508.1.
CCDSCCDS56617.1.
CCDS56618.1.
RefSeqNP_004670.1. NM_004679.2.
NP_870996.1. NM_181880.1.
UniGeneHs.170076.
Hs.632284.

3D structure databases

ProteinModelPortalO14598.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131701. 1 interaction.
IntActO14598. 1 interaction.
STRING9606.ENSP00000250823.

PTM databases

PhosphoSiteO14598.

Proteomic databases

PRIDEO14598.

Protocols and materials databases

DNASU353513.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000250823; ENSP00000250823; ENSG00000129862.
ENST00000250825; ENSP00000250825; ENSG00000129864.
GeneID353513.
9084.
KEGGhsa:353513.
hsa:9084.
UCSCuc004ftc.3. human.

Organism-specific databases

CTD353513.
9084.
GeneCardsGC0YM016098.
GC0YP016170.
GeneReviewsVCY.
H-InvDBHIX0177810.
HIX0177811.
HGNCHGNC:12668. VCY.
HGNC:31751. VCY1B.
HPAHPA044996.
HPA049357.
MIM400012. gene.
neXtProtNX_O14598.
PharmGKBPA37291.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000074166.
InParanoidO14598.
OMADPPSDVM.

Gene expression databases

BgeeO14598.
CleanExHS_VCY.
GenevestigatorO14598.

Family and domain databases

InterProIPR026653. VCX/VCY1.
[Graphical view]
PANTHERPTHR15251. PTHR15251. 1 hit.
PfamPF15231. VCX_VCY. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio34037.
PROO14598.
SOURCESearch...

Entry information

Entry nameVCY1_HUMAN
AccessionPrimary (citable) accession number: O14598
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM