O14598 (VCY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Testis-specific basic protein Y 1

Alternative name(s):
Basic charge, Y-linked 1
Variably charged protein Y

Gene names

Name:	VCY
Synonyms:	BPY1, VCY1A
AND
Name:	VCY1B
Synonyms:	BPY1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May mediate a process in spermatogenesis or may play a role in sex ratio distortion.
Tissue specificity	Expressed exclusively in testis.
Sequence similarities	Belongs to the VCX/VCY family.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Testis-specific basic protein Y 1		PRO_0000184663

Sequences

	Sequence		Length	Mass (Da)
	O14598 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: D528561A52592E6C	FASTA	125	12,917
	10 20 30 40 50 60 MSPKPRASGP PAKAKETGKR KSSSQPSPSG PKKKTTKVAE KGEAVRGGRR GKKGAATKMA 70 80 90 100 110 120 AVTAPEAESG PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQESEL EEPLSKGRPS TPLSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional coherence of the human Y chromosome." Lahn B.T., Page D.C. Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. , Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R., McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S., Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P., Waterston R.H., Wilson R.K., Rozen S., Page D.C. Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF000979 mRNA. Translation: AAC51827.1. AC006370 Genomic DNA. Translation: AAF03503.1. BC056508 mRNA. Translation: AAH56508.1.
IPI	IPI00297427.
RefSeq	NP_004670.1. NM_004679.2. NP_870996.1. NM_181880.1.
UniGene	Hs.170076. Hs.632284.
3D structure databases
ProteinModelPortal	O14598.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000250823.
PTM databases
PhosphoSite	O14598.
Proteomic databases
PRIDE	O14598.
Protocols and materials databases
DNASU	353513.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000250823; ENSP00000250823; ENSG00000129862. ENST00000250825; ENSP00000250825; ENSG00000129864.
GeneID	353513. 9084.
KEGG	hsa:353513. hsa:9084.
UCSC	uc004ftc.3. human.
Organism-specific databases
CTD	353513. 9084.
GeneCards	GC0YM016097. GC0YP016169.
H-InvDB	HIX0177810. HIX0177811.
HGNC	HGNC:12668. VCY. HGNC:31751. VCY1B.
MIM	400012. gene.
neXtProt	NX_O14598.
PharmGKB	PA37291.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000074166.
InParanoid	O14598.
OMA	DPPSDVM.
Gene expression databases
Bgee	O14598.
CleanEx	HS_VCY.
Genevestigator	O14598.
GermOnline	ENSG00000129862. Homo sapiens. ENSG00000129864. Homo sapiens.
Family and domain databases
InterPro	IPR026653. VCX/VCY1. [Graphical view]
PANTHER	PTHR15251. PTHR15251. 1 hit.
ProtoNet	Search...
Other
NextBio	34037.
SOURCE	Search...

Entry information

Entry name

VCY1_HUMAN

Accession

Primary (citable) accession number: O14598

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.