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Protein

Neurocan core protein

Gene

NCAN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Hyaluronic acid, Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130287-MONOMER.
ReactomeiR-HSA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-HSA-2022870. Chondroitin sulfate biosynthesis.
R-HSA-2022923. Dermatan sulfate biosynthesis.
R-HSA-2024101. CS/DS degradation.
R-HSA-3000178. ECM proteoglycans.
R-HSA-3560783. Defective B4GALT7 causes EDS, progeroid type.
R-HSA-3560801. Defective B3GAT3 causes JDSSDHD.
R-HSA-3595172. Defective CHST3 causes SEDCJD.
R-HSA-3595174. Defective CHST14 causes EDS, musculocontractural type.
R-HSA-3595177. Defective CHSY1 causes TPBS.
R-HSA-373760. L1CAM interactions.
R-HSA-419037. NCAM1 interactions.
R-HSA-4420332. Defective B3GALT6 causes EDSP2 and SEMDJL1.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocan core protein
Alternative name(s):
Chondroitin sulfate proteoglycan 3
Gene namesi
Name:NCAN
Synonyms:CSPG3, NEUR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:2465. NCAN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1463.
OpenTargetsiENSG00000130287.
PharmGKBiPA162396986.

Chemistry databases

DrugBankiDB08818. Hyaluronic acid.

Polymorphism and mutation databases

BioMutaiNCAN.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001751623 – 1321Neurocan core proteinAdd BLAST1299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 140By similarity
Glycosylationi122N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi182 ↔ 253By similarity
Disulfide bondi206 ↔ 227By similarity
Disulfide bondi280 ↔ 355By similarity
Disulfide bondi304 ↔ 325By similarity
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1012 ↔ 1023By similarity
Disulfide bondi1017 ↔ 1032By similarity
Glycosylationi1026N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1034 ↔ 1043By similarity
Disulfide bondi1050 ↔ 1061By similarity
Disulfide bondi1055 ↔ 1070By similarity
Disulfide bondi1072 ↔ 1081By similarity
Disulfide bondi1088 ↔ 1099By similarity
Disulfide bondi1116 ↔ 1208By similarity
Disulfide bondi1184 ↔ 1200By similarity
Disulfide bondi1215 ↔ 1258By similarity
Glycosylationi1223N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1244 ↔ 1271By similarity

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiO14594.
PeptideAtlasiO14594.
PRIDEiO14594.

PTM databases

iPTMnetiO14594.
PhosphoSitePlusiO14594.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000130287.
CleanExiHS_NCAN.
ExpressionAtlasiO14594. baseline and differential.
GenevisibleiO14594. HS.

Organism-specific databases

HPAiHPA036814.

Interactioni

Protein-protein interaction databases

BioGridi107845. 5 interactors.
IntActiO14594. 1 interactor.
STRINGi9606.ENSP00000252575.

Structurei

3D structure databases

ProteinModelPortaliO14594.
SMRiO14594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 153Ig-like V-typeAdd BLAST116
Domaini160 – 255Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini259 – 357Link 2PROSITE-ProRule annotationAdd BLAST99
Domaini1008 – 1044EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini1046 – 1082EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1084 – 1213C-type lectinPROSITE-ProRule annotationAdd BLAST130
Domaini1213 – 1273SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni708 – 712O-glycosylated at one site5

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 2 Link domains.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IJ1R. Eukaryota.
ENOG410YR39. LUCA.
GeneTreeiENSGT00760000119025.
HOVERGENiHBG078994.
InParanoidiO14594.
KOiK06794.
OMAiDWEKDEG.
OrthoDBiEOG091G0KN3.
PhylomeDBiO14594.
TreeFamiTF332134.

Family and domain databases

CDDicd00033. CCP. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14594-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPFVWALG LLMLQMLLFV AGEQGTQDIT DASERGLHMQ KLGSGSVQAA
60 70 80 90 100
LAELVALPCL FTLQPRPSAA RDAPRIKWTK VRTASGQRQD LPILVAKDNV
110 120 130 140 150
VRVAKSWQGR VSLPSYPRRR ANATLLLGPL RASDSGLYRC QVVRGIEDEQ
160 170 180 190 200
DLVPLEVTGV VFHYRSARDR YALTFAEAQE ACRLSSAIIA APRHLQAAFE
210 220 230 240 250
DGFDNCDAGW LSDRTVRYPI TQSRPGCYGD RSSLPGVRSY GRRNPQELYD
260 270 280 290 300
VYCFARELGG EVFYVGPARR LTLAGARAQC RRQGAALASV GQLHLAWHEG
310 320 330 340 350
LDQCDPGWLA DGSVRYPIQT PRRRCGGPAP GVRTVYRFAN RTGFPSPAER
360 370 380 390 400
FDAYCFRAHH PTSQHGDLET PSSGDEGEIL SAEGPPVREL EPTLEEEEVV
410 420 430 440 450
TPDFQEPLVS SGEEETLILE EKQESQQTLS PTPGDPMLAS WPTGEVWLST
460 470 480 490 500
VAPSPSDMGA GTAASSHTEV APTDPMPRRR GRFKGLNGRY FQQQEPEPGL
510 520 530 540 550
QGGMEASAQP PTSEAAVNQM EPPLAMAVTE MLGSGQSRSP WADLTNEVDM
560 570 580 590 600
PGAGSAGGKS SPEPWLWPPT MVPPSISGHS RAPVLELEKA EGPSARPATP
610 620 630 640 650
DLFWSPLEAT VSAPSPAPWE AFPVATSPDL PMMAMLRGPK EWMLPHPTPI
660 670 680 690 700
STEANRVEAH GEATATAPPS PAAETKVYSL PLSLTPTGQG GEAMPTTPES
710 720 730 740 750
PRADFRETGE TSPAQVNKAE HSSSSPWPSV NRNVAVGFVP TETATEPTGL
760 770 780 790 800
RGIPGSESGV FDTAESPTSG LQATVDEVQD PWPSVYSKGL DASSPSAPLG
810 820 830 840 850
SPGVFLVPKV TPNLEPWVAT DEGPTVNPMD STVTPAPSDA SGIWEPGSQV
860 870 880 890 900
FEEAESTTLS PQVALDTSIV TPLTTLEQGD KVGVPAMSTL GSSSSQPHPE
910 920 930 940 950
PEDQVETQGT SGASVPPHQS SPLGKPAVPP GTPTAASVGE SASVSSGEPT
960 970 980 990 1000
VPWDPSSTLL PVTLGIEDFE LEVLAGSPGV ESFWEEVASG EEPALPGTPM
1010 1020 1030 1040 1050
NAGAEEVHSD PCENNPCLHG GTCNANGTMY GCSCDQGFAG ENCEIDIDDC
1060 1070 1080 1090 1100
LCSPCENGGT CIDEVNGFVC LCLPSYGGSF CEKDTEGCDR GWHKFQGHCY
1110 1120 1130 1140 1150
RYFAHRRAWE DAEKDCRRRS GHLTSVHSPE EHSFINSFGH ENTWIGLNDR
1160 1170 1180 1190 1200
IVERDFQWTD NTGLQFENWR ENQPDNFFAG GEDCVVMVAH ESGRWNDVPC
1210 1220 1230 1240 1250
NYNLPYVCKK GTVLCGPPPA VENASLIGAR KAKYNVHATV RYQCNEGFAQ
1260 1270 1280 1290 1300
HHVATIRCRS NGKWDRPQIV CTKPRRSHRM RRHHHHHQHH HQHHHHKSRK
1310 1320
ERRKHKKHPT EDWEKDEGNF C
Length:1,321
Mass (Da):143,093
Last modified:November 13, 2007 - v3
Checksum:i22E21FFA24CE9FB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1234Y → N in AAC80576 (PubMed:9795216).Curated1
Sequence conflicti1282R → G in AAC80576 (PubMed:9795216).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02452170A → T.Corresponds to variant rs2228601dbSNPEnsembl.1
Natural variantiVAR_02021392P → S.Corresponds to variant rs2228603dbSNPEnsembl.1
Natural variantiVAR_0161761254A → V.1 PublicationCorresponds to variant rs1064389dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026547 mRNA. Translation: AAC80576.1.
AC003110 Genomic DNA. Translation: AAB86655.1.
AC005254 Genomic DNA. Translation: AAC25581.1.
CCDSiCCDS12397.1.
RefSeqiNP_004377.2. NM_004386.2.
UniGeneiHs.169047.

Genome annotation databases

EnsembliENST00000252575; ENSP00000252575; ENSG00000130287.
GeneIDi1463.
KEGGihsa:1463.
UCSCiuc002nlz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Neurocan

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026547 mRNA. Translation: AAC80576.1.
AC003110 Genomic DNA. Translation: AAB86655.1.
AC005254 Genomic DNA. Translation: AAC25581.1.
CCDSiCCDS12397.1.
RefSeqiNP_004377.2. NM_004386.2.
UniGeneiHs.169047.

3D structure databases

ProteinModelPortaliO14594.
SMRiO14594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107845. 5 interactors.
IntActiO14594. 1 interactor.
STRINGi9606.ENSP00000252575.

Chemistry databases

DrugBankiDB08818. Hyaluronic acid.

PTM databases

iPTMnetiO14594.
PhosphoSitePlusiO14594.

Polymorphism and mutation databases

BioMutaiNCAN.

Proteomic databases

PaxDbiO14594.
PeptideAtlasiO14594.
PRIDEiO14594.

Protocols and materials databases

DNASUi1463.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252575; ENSP00000252575; ENSG00000130287.
GeneIDi1463.
KEGGihsa:1463.
UCSCiuc002nlz.4. human.

Organism-specific databases

CTDi1463.
DisGeNETi1463.
GeneCardsiNCAN.
H-InvDBHIX0027449.
HGNCiHGNC:2465. NCAN.
HPAiHPA036814.
MIMi600826. gene.
neXtProtiNX_O14594.
OpenTargetsiENSG00000130287.
PharmGKBiPA162396986.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ1R. Eukaryota.
ENOG410YR39. LUCA.
GeneTreeiENSGT00760000119025.
HOVERGENiHBG078994.
InParanoidiO14594.
KOiK06794.
OMAiDWEKDEG.
OrthoDBiEOG091G0KN3.
PhylomeDBiO14594.
TreeFamiTF332134.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130287-MONOMER.
ReactomeiR-HSA-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-HSA-2022870. Chondroitin sulfate biosynthesis.
R-HSA-2022923. Dermatan sulfate biosynthesis.
R-HSA-2024101. CS/DS degradation.
R-HSA-3000178. ECM proteoglycans.
R-HSA-3560783. Defective B4GALT7 causes EDS, progeroid type.
R-HSA-3560801. Defective B3GAT3 causes JDSSDHD.
R-HSA-3595172. Defective CHST3 causes SEDCJD.
R-HSA-3595174. Defective CHST14 causes EDS, musculocontractural type.
R-HSA-3595177. Defective CHSY1 causes TPBS.
R-HSA-373760. L1CAM interactions.
R-HSA-419037. NCAM1 interactions.
R-HSA-4420332. Defective B3GALT6 causes EDSP2 and SEMDJL1.

Miscellaneous databases

ChiTaRSiNCAN. human.
GeneWikiiNeurocan.
GenomeRNAii1463.
PROiO14594.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130287.
CleanExiHS_NCAN.
ExpressionAtlasiO14594. baseline and differential.
GenevisibleiO14594. HS.

Family and domain databases

CDDicd00033. CCP. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNCAN_HUMAN
AccessioniPrimary (citable) accession number: O14594
Secondary accession number(s): Q9UPK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.