Neurocan core protein precursor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot O14594 (NCAN_HUMAN)

Last modified November 3, 2009. Version 89. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Neurocan core protein
Alternative name(s):
Chondroitin sulfate proteoglycan 3

Gene names

Name:	NCAN
Synonyms:	CSPG3, NEUR

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Tissue specificity

Brain.

Sequence similarities

Belongs to the aggrecan/versican proteoglycan family.

Contains 1 C-type lectin domain.

Contains 2 EGF-like domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Contains 2 Link domains.

Contains 1 Sushi (CCP/SCR) domain.

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Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	EGF-like domain Immunoglobulin domain Repeat Signal Sushi
Ligand	Calcium Hyaluronic acid Lectin
PTM	Disulfide bond Glycoprotein Proteoglycan
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW hyaluronic acid binding Inferred from electronic annotation. Source: UniProtKB-KW sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

Potential

Chain

23 – 1321

1299

Neurocan core protein

PRO_0000017516

Regions

Domain

38 – 153

116

Ig-like V-type

Domain

160 – 255

Link 1

Domain

259 – 357

Link 2

Domain

1008 – 1044

EGF-like 1

Domain

1046 – 1082

EGF-like 2; calcium-binding Potential

Domain

1084 – 1213

130

C-type lectin

Domain

1213 – 1273

Sushi

Amino acid modifications

Glycosylation

122

N-linked (GlcNAc...) Potential

Glycosylation

340

N-linked (GlcNAc...) Potential

Glycosylation

1026

N-linked (GlcNAc...) Potential

Glycosylation

1223

N-linked (GlcNAc...) Potential

Disulfide bond

59 ↔ 140

By similarity

Disulfide bond

182 ↔ 253

By similarity

Disulfide bond

206 ↔ 227

By similarity

Disulfide bond

280 ↔ 355

By similarity

Disulfide bond

304 ↔ 325

By similarity

Disulfide bond

1012 ↔ 1023

By similarity

Disulfide bond

1017 ↔ 1032

By similarity

Disulfide bond

1034 ↔ 1043

By similarity

Disulfide bond

1050 ↔ 1061

By similarity

Disulfide bond

1055 ↔ 1070

By similarity

Disulfide bond

1072 ↔ 1081

By similarity

Disulfide bond

1088 ↔ 1099

By similarity

Disulfide bond

1116 ↔ 1208

By similarity

Disulfide bond

1184 ↔ 1200

By similarity

Disulfide bond

1215 ↔ 1258

By similarity

Disulfide bond

1244 ↔ 1271

By similarity

Natural variations

Natural variant

A → T: dbSNP rs2228601.

VAR_024521

Natural variant

P → S: dbSNP rs2228603.

VAR_020213

Natural variant

1254

A → V: dbSNP rs1064389. Ref.1

VAR_016176

Experimental info

Sequence conflict

1234

Y → N in AAC80576. Ref.1

Sequence conflict

1282

R → G in AAC80576. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

O14594-1 [UniParc].

Last modified November 13, 2007. Version 3.
Checksum: 22E21FFA24CE9FB2
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FASTA

1,321

143,093

        10         20         30         40         50         60 
MGAPFVWALG LLMLQMLLFV AGEQGTQDIT DASERGLHMQ KLGSGSVQAA LAELVALPCL 

        70         80         90        100        110        120 
FTLQPRPSAA RDAPRIKWTK VRTASGQRQD LPILVAKDNV VRVAKSWQGR VSLPSYPRRR 

       130        140        150        160        170        180 
ANATLLLGPL RASDSGLYRC QVVRGIEDEQ DLVPLEVTGV VFHYRSARDR YALTFAEAQE 

       190        200        210        220        230        240 
ACRLSSAIIA APRHLQAAFE DGFDNCDAGW LSDRTVRYPI TQSRPGCYGD RSSLPGVRSY 

       250        260        270        280        290        300 
GRRNPQELYD VYCFARELGG EVFYVGPARR LTLAGARAQC RRQGAALASV GQLHLAWHEG 

       310        320        330        340        350        360 
LDQCDPGWLA DGSVRYPIQT PRRRCGGPAP GVRTVYRFAN RTGFPSPAER FDAYCFRAHH 

       370        380        390        400        410        420 
PTSQHGDLET PSSGDEGEIL SAEGPPVREL EPTLEEEEVV TPDFQEPLVS SGEEETLILE 

       430        440        450        460        470        480 
EKQESQQTLS PTPGDPMLAS WPTGEVWLST VAPSPSDMGA GTAASSHTEV APTDPMPRRR 

       490        500        510        520        530        540 
GRFKGLNGRY FQQQEPEPGL QGGMEASAQP PTSEAAVNQM EPPLAMAVTE MLGSGQSRSP 

       550        560        570        580        590        600 
WADLTNEVDM PGAGSAGGKS SPEPWLWPPT MVPPSISGHS RAPVLELEKA EGPSARPATP 

       610        620        630        640        650        660 
DLFWSPLEAT VSAPSPAPWE AFPVATSPDL PMMAMLRGPK EWMLPHPTPI STEANRVEAH 

       670        680        690        700        710        720 
GEATATAPPS PAAETKVYSL PLSLTPTGQG GEAMPTTPES PRADFRETGE TSPAQVNKAE 

       730        740        750        760        770        780 
HSSSSPWPSV NRNVAVGFVP TETATEPTGL RGIPGSESGV FDTAESPTSG LQATVDEVQD 

       790        800        810        820        830        840 
PWPSVYSKGL DASSPSAPLG SPGVFLVPKV TPNLEPWVAT DEGPTVNPMD STVTPAPSDA 

       850        860        870        880        890        900 
SGIWEPGSQV FEEAESTTLS PQVALDTSIV TPLTTLEQGD KVGVPAMSTL GSSSSQPHPE 

       910        920        930        940        950        960 
PEDQVETQGT SGASVPPHQS SPLGKPAVPP GTPTAASVGE SASVSSGEPT VPWDPSSTLL 

       970        980        990       1000       1010       1020 
PVTLGIEDFE LEVLAGSPGV ESFWEEVASG EEPALPGTPM NAGAEEVHSD PCENNPCLHG 

      1030       1040       1050       1060       1070       1080 
GTCNANGTMY GCSCDQGFAG ENCEIDIDDC LCSPCENGGT CIDEVNGFVC LCLPSYGGSF 

      1090       1100       1110       1120       1130       1140 
CEKDTEGCDR GWHKFQGHCY RYFAHRRAWE DAEKDCRRRS GHLTSVHSPE EHSFINSFGH 

      1150       1160       1170       1180       1190       1200 
ENTWIGLNDR IVERDFQWTD NTGLQFENWR ENQPDNFFAG GEDCVVMVAH ESGRWNDVPC 

      1210       1220       1230       1240       1250       1260 
NYNLPYVCKK GTVLCGPPPA VENASLIGAR KAKYNVHATV RYQCNEGFAQ HHVATIRCRS 

      1270       1280       1290       1300       1310       1320 
NGKWDRPQIV CTKPRRSHRM RRHHHHHQHH HQHHHHKSRK ERRKHKKHPT EDWEKDEGNF 


C

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human neurocan gene, CSPG3." Prange C.K., Pennacchio L.A., Lieuallen K., Fan W., Lennon G.G. Gene 221:199-205(1998) [PubMed: 9795216] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-1254.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

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Web resources

Functional Glycomics Gateway - Glycan Binding

Neurocan

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Cross-references

Sequence databases
	AF026547 mRNA. Translation: AAC80576.1. AC003110 Genomic DNA. Translation: AAB86655.1. AC005254 Genomic DNA. Translation: AAC25581.1.
IPI	IPI00159927.
RefSeq	NP_004377.2.
UniGene	Hs.169047
3D structure databases
HSSP	HSSP built from PDB template 1EDM based on UniProtKB P00740.
ModBase	Search...
Protein-protein interaction databases
STRING	O14594.
Proteomic databases
PRIDE	O14594.
Genome annotation databases
Ensembl	ENST00000252575; ENSP00000252575; ENSG00000130287; Homo sapiens. [Genome view]
GeneID	1463.
KEGG	hsa:1463.
UCSC	uc002nlz.1. human.
Organism-specific databases
CTD	1463.
GeneCards	GC19P019183.
H-InvDB	HIX0027449.
HGNC	HGNC:2465. NCAN.
MIM	600826. gene.
PharmGKB	PA26962.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O14594.
OMA	QPHPEPE.
Enzyme and pathway databases
Pathway_Interaction_DB	syndecan_3_pathway. Syndecan-3-mediated signaling events.
Reactome	REACT_18266. Axon guidance.
Gene expression databases
ArrayExpress	O14594.
Bgee	O14594.
CleanEx	HS_NCAN.
Genevestigator	O14594.
GermOnline	ENSG00000130287. Homo sapiens.
Family and domain databases
InterPro	IPR002353. AntifreezeII. IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR018378. C-type_lectin_CS. IPR016060. Complement_control_module. IPR006209. EGF. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR000742. EGF_3. IPR001881. EGF_Ca_bd. IPR018097. EGF_Ca_bd_CS. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR000538. Link. IPR000436. Sushi_SCR_CCP. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 3 hits. G3DSA:2.10.70.10. Complement_control_module. 1 hit. G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF00008. EGF. 2 hits. PF00059. Lectin_C. 1 hit. PF00084. Sushi. 1 hit. PF00193. Xlink. 2 hits. [Graphical view]
PRINTS	PR00356. ANTIFREEZEII. PR01265. LINKMODULE.
ProDom	PD000918. Link. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00032. CCP. 1 hit. SM00034. CLECT. 1 hit. SM00181. EGF. 1 hit. SM00179. EGF_CA. 1 hit. SM00409. IG. 1 hit. SM00445. LINK. 2 hits. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit. PS00022. EGF_1. 3 hits. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 2 hits. PS01187. EGF_CA. 1 hit. PS50835. IG_LIKE. 1 hit. PS01241. LINK_1. 2 hits. PS50963. LINK_2. 2 hits. PS50923. SUSHI. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	6009.
SOURCE	Search...

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Entry information

Entry name

NCAN_HUMAN

Accession

Primary (citable) accession number: O14594
Secondary accession number(s): Q9UPK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 89 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents