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O14594

- NCAN_HUMAN

UniProt

O14594 - NCAN_HUMAN

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Protein

Neurocan core protein

Gene
NCAN, CSPG3, NEUR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. carbohydrate binding Source: InterPro
  3. hyaluronic acid binding Source: UniProtKB-KW

GO - Biological processi

  1. axon guidance Source: Reactome
  2. carbohydrate metabolic process Source: Reactome
  3. cell adhesion Source: UniProtKB-KW
  4. chondroitin sulfate biosynthetic process Source: Reactome
  5. chondroitin sulfate catabolic process Source: Reactome
  6. chondroitin sulfate metabolic process Source: Reactome
  7. dermatan sulfate biosynthetic process Source: Reactome
  8. extracellular matrix organization Source: Reactome
  9. glycosaminoglycan metabolic process Source: Reactome
  10. regulation of synapse structural plasticity Source: Ensembl
  11. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Hyaluronic acid, Lectin

Enzyme and pathway databases

ReactomeiREACT_120800. Dermatan sulfate biosynthesis.
REACT_120888. CS/DS degradation.
REACT_120989. Chondroitin sulfate biosynthesis.
REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_163906. ECM proteoglycans.
REACT_18312. NCAM1 interactions.
REACT_22205. L1CAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocan core protein
Alternative name(s):
Chondroitin sulfate proteoglycan 3
Gene namesi
Name:NCAN
Synonyms:CSPG3, NEUR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:2465. NCAN.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. Golgi lumen Source: Reactome
  3. lysosomal lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396986.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 13211299Neurocan core proteinPRO_0000017516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 140 By similarity
Glycosylationi122 – 1221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi182 ↔ 253 By similarity
Disulfide bondi206 ↔ 227 By similarity
Disulfide bondi280 ↔ 355 By similarity
Disulfide bondi304 ↔ 325 By similarity
Glycosylationi340 – 3401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1012 ↔ 1023 By similarity
Disulfide bondi1017 ↔ 1032 By similarity
Glycosylationi1026 – 10261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1034 ↔ 1043 By similarity
Disulfide bondi1050 ↔ 1061 By similarity
Disulfide bondi1055 ↔ 1070 By similarity
Disulfide bondi1072 ↔ 1081 By similarity
Disulfide bondi1088 ↔ 1099 By similarity
Disulfide bondi1116 ↔ 1208 By similarity
Disulfide bondi1184 ↔ 1200 By similarity
Disulfide bondi1215 ↔ 1258 By similarity
Glycosylationi1223 – 12231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1244 ↔ 1271 By similarity

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiO14594.
PRIDEiO14594.

PTM databases

PhosphoSiteiO14594.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

ArrayExpressiO14594.
BgeeiO14594.
CleanExiHS_NCAN.
GenevestigatoriO14594.

Organism-specific databases

HPAiHPA036814.

Interactioni

Protein-protein interaction databases

BioGridi107845. 6 interactions.
IntActiO14594. 1 interaction.
STRINGi9606.ENSP00000252575.

Structurei

3D structure databases

ProteinModelPortaliO14594.
SMRiO14594. Positions 39-148, 161-254, 270-359, 986-1083, 1086-1211.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 153116Ig-like V-typeAdd
BLAST
Domaini160 – 25596Link 1Add
BLAST
Domaini259 – 35799Link 2Add
BLAST
Domaini1008 – 104437EGF-like 1Add
BLAST
Domaini1046 – 108237EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST
Domaini1084 – 1213130C-type lectinAdd
BLAST
Domaini1213 – 127361SushiAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni708 – 7125O-glycosylated at one site

Sequence similaritiesi

Contains 2 EGF-like domains.
Contains 2 Link domains.

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG147231.
HOVERGENiHBG078994.
InParanoidiO14594.
KOiK06794.
OMAiCSPCENG.
OrthoDBiEOG7FFMQR.
PhylomeDBiO14594.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14594-1 [UniParc]FASTAAdd to Basket

« Hide

MGAPFVWALG LLMLQMLLFV AGEQGTQDIT DASERGLHMQ KLGSGSVQAA     50
LAELVALPCL FTLQPRPSAA RDAPRIKWTK VRTASGQRQD LPILVAKDNV 100
VRVAKSWQGR VSLPSYPRRR ANATLLLGPL RASDSGLYRC QVVRGIEDEQ 150
DLVPLEVTGV VFHYRSARDR YALTFAEAQE ACRLSSAIIA APRHLQAAFE 200
DGFDNCDAGW LSDRTVRYPI TQSRPGCYGD RSSLPGVRSY GRRNPQELYD 250
VYCFARELGG EVFYVGPARR LTLAGARAQC RRQGAALASV GQLHLAWHEG 300
LDQCDPGWLA DGSVRYPIQT PRRRCGGPAP GVRTVYRFAN RTGFPSPAER 350
FDAYCFRAHH PTSQHGDLET PSSGDEGEIL SAEGPPVREL EPTLEEEEVV 400
TPDFQEPLVS SGEEETLILE EKQESQQTLS PTPGDPMLAS WPTGEVWLST 450
VAPSPSDMGA GTAASSHTEV APTDPMPRRR GRFKGLNGRY FQQQEPEPGL 500
QGGMEASAQP PTSEAAVNQM EPPLAMAVTE MLGSGQSRSP WADLTNEVDM 550
PGAGSAGGKS SPEPWLWPPT MVPPSISGHS RAPVLELEKA EGPSARPATP 600
DLFWSPLEAT VSAPSPAPWE AFPVATSPDL PMMAMLRGPK EWMLPHPTPI 650
STEANRVEAH GEATATAPPS PAAETKVYSL PLSLTPTGQG GEAMPTTPES 700
PRADFRETGE TSPAQVNKAE HSSSSPWPSV NRNVAVGFVP TETATEPTGL 750
RGIPGSESGV FDTAESPTSG LQATVDEVQD PWPSVYSKGL DASSPSAPLG 800
SPGVFLVPKV TPNLEPWVAT DEGPTVNPMD STVTPAPSDA SGIWEPGSQV 850
FEEAESTTLS PQVALDTSIV TPLTTLEQGD KVGVPAMSTL GSSSSQPHPE 900
PEDQVETQGT SGASVPPHQS SPLGKPAVPP GTPTAASVGE SASVSSGEPT 950
VPWDPSSTLL PVTLGIEDFE LEVLAGSPGV ESFWEEVASG EEPALPGTPM 1000
NAGAEEVHSD PCENNPCLHG GTCNANGTMY GCSCDQGFAG ENCEIDIDDC 1050
LCSPCENGGT CIDEVNGFVC LCLPSYGGSF CEKDTEGCDR GWHKFQGHCY 1100
RYFAHRRAWE DAEKDCRRRS GHLTSVHSPE EHSFINSFGH ENTWIGLNDR 1150
IVERDFQWTD NTGLQFENWR ENQPDNFFAG GEDCVVMVAH ESGRWNDVPC 1200
NYNLPYVCKK GTVLCGPPPA VENASLIGAR KAKYNVHATV RYQCNEGFAQ 1250
HHVATIRCRS NGKWDRPQIV CTKPRRSHRM RRHHHHHQHH HQHHHHKSRK 1300
ERRKHKKHPT EDWEKDEGNF C 1321
Length:1,321
Mass (Da):143,093
Last modified:November 13, 2007 - v3
Checksum:i22E21FFA24CE9FB2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701A → T.
Corresponds to variant rs2228601 [ dbSNP | Ensembl ].
VAR_024521
Natural varianti92 – 921P → S.
Corresponds to variant rs2228603 [ dbSNP | Ensembl ].
VAR_020213
Natural varianti1254 – 12541A → V.1 Publication
Corresponds to variant rs1064389 [ dbSNP | Ensembl ].
VAR_016176

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1234 – 12341Y → N in AAC80576. 1 Publication
Sequence conflicti1282 – 12821R → G in AAC80576. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF026547 mRNA. Translation: AAC80576.1.
AC003110 Genomic DNA. Translation: AAB86655.1.
AC005254 Genomic DNA. Translation: AAC25581.1.
CCDSiCCDS12397.1.
RefSeqiNP_004377.2. NM_004386.2.
XP_005259802.1. XM_005259745.1.
XP_005259803.1. XM_005259746.1.
UniGeneiHs.169047.

Genome annotation databases

EnsembliENST00000252575; ENSP00000252575; ENSG00000130287.
GeneIDi1463.
KEGGihsa:1463.
UCSCiuc002nlz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Neurocan

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF026547 mRNA. Translation: AAC80576.1 .
AC003110 Genomic DNA. Translation: AAB86655.1 .
AC005254 Genomic DNA. Translation: AAC25581.1 .
CCDSi CCDS12397.1.
RefSeqi NP_004377.2. NM_004386.2.
XP_005259802.1. XM_005259745.1.
XP_005259803.1. XM_005259746.1.
UniGenei Hs.169047.

3D structure databases

ProteinModelPortali O14594.
SMRi O14594. Positions 39-148, 161-254, 270-359, 986-1083, 1086-1211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107845. 6 interactions.
IntActi O14594. 1 interaction.
STRINGi 9606.ENSP00000252575.

PTM databases

PhosphoSitei O14594.

Proteomic databases

PaxDbi O14594.
PRIDEi O14594.

Protocols and materials databases

DNASUi 1463.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252575 ; ENSP00000252575 ; ENSG00000130287 .
GeneIDi 1463.
KEGGi hsa:1463.
UCSCi uc002nlz.3. human.

Organism-specific databases

CTDi 1463.
GeneCardsi GC19P019322.
H-InvDB HIX0027449.
HGNCi HGNC:2465. NCAN.
HPAi HPA036814.
MIMi 600826. gene.
neXtProti NX_O14594.
PharmGKBi PA162396986.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147231.
HOVERGENi HBG078994.
InParanoidi O14594.
KOi K06794.
OMAi CSPCENG.
OrthoDBi EOG7FFMQR.
PhylomeDBi O14594.
TreeFami TF332134.

Enzyme and pathway databases

Reactomei REACT_120800. Dermatan sulfate biosynthesis.
REACT_120888. CS/DS degradation.
REACT_120989. Chondroitin sulfate biosynthesis.
REACT_121408. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_163906. ECM proteoglycans.
REACT_18312. NCAM1 interactions.
REACT_22205. L1CAM interactions.

Miscellaneous databases

GeneWikii Neurocan.
GenomeRNAii 1463.
NextBioi 6009.
PROi O14594.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14594.
Bgeei O14594.
CleanExi HS_NCAN.
Genevestigatori O14594.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view ]
PRINTSi PR01265. LINKMODULE.
SMARTi SM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
SM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human neurocan gene, CSPG3."
    Prange C.K., Pennacchio L.A., Lieuallen K., Fan W., Lennon G.G.
    Gene 221:199-205(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-1254.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
    Halim A., Ruetschi U., Larson G., Nilsson J.
    J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiNCAN_HUMAN
AccessioniPrimary (citable) accession number: O14594
Secondary accession number(s): Q9UPK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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