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Protein

Olfactory receptor 7A17

Gene

OR7A17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 7A17
Gene namesi
Name:OR7A17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:8363. OR7A17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 30917CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32616.

Polymorphism and mutation databases

BioMutaiOR7A17.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 7A17PRO_0000150645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14581.
PRIDEiO14581.

PTM databases

iPTMnetiO14581.
PhosphoSiteiO14581.

Expressioni

Gene expression databases

BgeeiENSG00000185385.
CleanExiHS_OR7A17.
GenevisibleiO14581. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328144.

Structurei

3D structure databases

ProteinModelPortaliO14581.
SMRiO14581. Positions 22-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO14581.
KOiK04257.
OMAiWMIAALN.
OrthoDBiEOG091G0B53.
PhylomeDBiO14581.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPENDTGIS EFVLLGLSEE PELQPFLFGL FLSMYLVTVL GNLLIILATI
60 70 80 90 100
SDSHLHTPMY FFLSNLSFAD ICFISTTIPK MLINIQTQSR VITYAGCITQ
110 120 130 140 150
MCFFVLFGGL DSLLLAVMAY DRFVAICHPL HYTVIMNPRL CGLLVLASWM
160 170 180 190 200
IAALNSLSQS LMVLWLSFCT DLEIPHFFCE LNQVIHLACS DTFLNDMGMY
210 220 230 240 250
FAAGLLAGGP LVGILCSYSK IVSSIRAISS AQGKYKAFST CASHLSVVSL
260 270 280 290 300
FCCTGLGVYL TSAATHNSHT SATASVMYTV ATPMLNPFIY SLRNKDIKRA

LKMSFRGKQ
Length:309
Mass (Da):34,013
Last modified:January 1, 1998 - v1
Checksum:i7D3CED8A480C13D0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371V → A.
Corresponds to variant rs10405148 [ dbSNP | Ensembl ].
VAR_053228
Natural varianti46 – 461I → T.
Corresponds to variant rs10405129 [ dbSNP | Ensembl ].
VAR_053229
Natural varianti69 – 691A → S.
Corresponds to variant rs10404119 [ dbSNP | Ensembl ].
VAR_053230
Natural varianti237 – 2371A → T.
Corresponds to variant rs13345394 [ dbSNP | Ensembl ].
VAR_053231

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002988 Genomic DNA. Translation: AAB82060.1.
BC101587 mRNA. Translation: AAI01588.1.
BC117357 mRNA. Translation: AAI17358.1.
AF399541 Genomic DNA. Translation: AAK95026.1.
BK004206 Genomic DNA. Translation: DAA04604.1.
CCDSiCCDS12319.1.
RefSeqiNP_112163.1. NM_030901.1.
UniGeneiHs.247717.

Genome annotation databases

EnsembliENST00000327462; ENSP00000328144; ENSG00000185385.
GeneIDi26333.
KEGGihsa:26333.
UCSCiuc010xob.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002988 Genomic DNA. Translation: AAB82060.1.
BC101587 mRNA. Translation: AAI01588.1.
BC117357 mRNA. Translation: AAI17358.1.
AF399541 Genomic DNA. Translation: AAK95026.1.
BK004206 Genomic DNA. Translation: DAA04604.1.
CCDSiCCDS12319.1.
RefSeqiNP_112163.1. NM_030901.1.
UniGeneiHs.247717.

3D structure databases

ProteinModelPortaliO14581.
SMRiO14581. Positions 22-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328144.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO14581.
PhosphoSiteiO14581.

Polymorphism and mutation databases

BioMutaiOR7A17.

Proteomic databases

PaxDbiO14581.
PRIDEiO14581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327462; ENSP00000328144; ENSG00000185385.
GeneIDi26333.
KEGGihsa:26333.
UCSCiuc010xob.3. human.

Organism-specific databases

CTDi26333.
GeneCardsiOR7A17.
HGNCiHGNC:8363. OR7A17.
neXtProtiNX_O14581.
PharmGKBiPA32616.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVB1. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118801.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiO14581.
KOiK04257.
OMAiWMIAALN.
OrthoDBiEOG091G0B53.
PhylomeDBiO14581.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR7A17.
GenomeRNAii26333.
PROiO14581.

Gene expression databases

BgeeiENSG00000185385.
CleanExiHS_OR7A17.
GenevisibleiO14581. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR7AH_HUMAN
AccessioniPrimary (citable) accession number: O14581
Secondary accession number(s): Q6IFQ6, Q96R98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.