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Protein

Citron Rho-interacting kinase

Gene

CIT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126ATPPROSITE-ProRule annotation1
Active sitei221Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi103 – 111ATPPROSITE-ProRule annotation9
Zinc fingeri1362 – 1411Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • PDZ domain binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • scaffold protein binding Source: BHF-UCL

GO - Biological processi

  • cytokinesis Source: UniProtKB
  • G2/M transition of mitotic cell cycle Source: Ensembl
  • generation of neurons Source: UniProtKB
  • Golgi organization Source: Ensembl
  • intracellular signal transduction Source: InterPro
  • mitotic nuclear division Source: UniProtKB
  • positive regulation of cytokinesis Source: UniProtKB
  • regulation of actin polymerization or depolymerization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS04618-MONOMER.
ReactomeiR-HSA-5625900. RHO GTPases activate CIT.
SignaLinkiO14578.

Names & Taxonomyi

Protein namesi
Recommended name:
Citron Rho-interacting kinase (EC:2.7.11.1)
Short name:
CRIK
Alternative name(s):
Serine/threonine-protein kinase 21
Gene namesi
Name:CIT
Synonyms:CRIK, KIAA0949, STK21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1985. CIT.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • Golgi cisterna Source: Ensembl
  • membrane Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi11113.
OpenTargetsiENSG00000122966.
PharmGKBiPA26522.

Chemistry databases

ChEMBLiCHEMBL5579.
GuidetoPHARMACOLOGYi1509.

Polymorphism and mutation databases

BioMutaiCIT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859081 – 2027Citron Rho-interacting kinaseAdd BLAST2027

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei1196PhosphotyrosineBy similarity1
Modified residuei1721N6-acetyllysineCombined sources1
Modified residuei1940PhosphoserineCombined sources1
Modified residuei1993PhosphoserineCombined sources1
Modified residuei2013PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO14578.
MaxQBiO14578.
PaxDbiO14578.
PeptideAtlasiO14578.
PRIDEiO14578.

PTM databases

iPTMnetiO14578.
PhosphoSitePlusiO14578.

Expressioni

Gene expression databases

BgeeiENSG00000122966.
CleanExiHS_CIT.
ExpressionAtlasiO14578. baseline and differential.
GenevisibleiO14578. HS.

Organism-specific databases

HPAiHPA019082.
HPA048812.

Interactioni

Subunit structurei

Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.By similarity2 Publications

GO - Molecular functioni

  • PDZ domain binding Source: UniProtKB
  • scaffold protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi116290. 15 interactors.
IntActiO14578. 4 interactors.
MINTiMINT-2795177.
STRINGi9606.ENSP00000376306.

Chemistry databases

BindingDBiO14578.

Structurei

3D structure databases

ProteinModelPortaliO14578.
SMRiO14578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 360Protein kinasePROSITE-ProRule annotationAdd BLAST264
Domaini361 – 431AGC-kinase C-terminalAdd BLAST71
Domaini1443 – 1563PHPROSITE-ProRule annotationAdd BLAST121
Domaini1591 – 1881CNHPROSITE-ProRule annotationAdd BLAST291

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1091 – 1302Interaction with Rho/RacAdd BLAST212

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili453 – 1297Sequence analysisAdd BLAST845

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1953 – 1958SH3-bindingSequence analysis6

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 CNH domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1362 – 1411Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, SH3-binding, Zinc-finger

Phylogenomic databases

eggNOGiKOG0612. Eukaryota.
KOG0976. Eukaryota.
ENOG410XR1Q. LUCA.
GeneTreeiENSGT00760000118994.
HOGENOMiHOG000015347.
HOVERGENiHBG071093.
InParanoidiO14578.
KOiK16308.
OMAiMKAKDQG.
OrthoDBiEOG091G00DT.
PhylomeDBiO14578.
TreeFamiTF101140.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR017405. Citron_Rho-interacting_kinase.
IPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22988:SF26. PTHR22988:SF26. 6 hits.
PfamiPF00780. CNH. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14578-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKFKYGARN PLDAGAAEPI ASRASRLNLF FQGKPPFMTQ QQMSPLSREG
60 70 80 90 100
ILDALFVLFE ECSQPALMKI KHVSNFVRKY SDTIAELQEL QPSAKDFEVR
110 120 130 140 150
SLVGCGHFAE VQVVREKATG DIYAMKVMKK KALLAQEQVS FFEEERNILS
160 170 180 190 200
RSTSPWIPQL QYAFQDKNHL YLVMEYQPGG DLLSLLNRYE DQLDENLIQF
210 220 230 240 250
YLAELILAVH SVHLMGYVHR DIKPENILVD RTGHIKLVDF GSAAKMNSNK
260 270 280 290 300
MVNAKLPIGT PDYMAPEVLT VMNGDGKGTY GLDCDWWSVG VIAYEMIYGR
310 320 330 340 350
SPFAEGTSAR TFNNIMNFQR FLKFPDDPKV SSDFLDLIQS LLCGQKERLK
360 370 380 390 400
FEGLCCHPFF SKIDWNNIRN SPPPFVPTLK SDDDTSNFDE PEKNSWVSSS
410 420 430 440 450
PCQLSPSGFS GEELPFVGFS YSKALGILGR SESVVSGLDS PAKTSSMEKK
460 470 480 490 500
LLIKSKELQD SQDKCHKMEQ EMTRLHRRVS EVEAVLSQKE VELKASETQR
510 520 530 540 550
SLLEQDLATY ITECSSLKRS LEQARMEVSQ EDDKALQLLH DIREQSRKLQ
560 570 580 590 600
EIKEQEYQAQ VEEMRLMMNQ LEEDLVSARR RSDLYESELR ESRLAAEEFK
610 620 630 640 650
RKATECQHKL LKAKDQGKPE VGEYAKLEKI NAEQQLKIQE LQEKLEKAVK
660 670 680 690 700
ASTEATELLQ NIRQAKERAE RELEKLQNRE DSSEGIRKKL VEAEELEEKH
710 720 730 740 750
REAQVSAQHL EVHLKQKEQH YEEKIKVLDN QIKKDLADKE TLENMMQRHE
760 770 780 790 800
EEAHEKGKIL SEQKAMINAM DSKIRSLEQR IVELSEANKL AANSSLFTQR
810 820 830 840 850
NMKAQEEMIS ELRQQKFYLE TQAGKLEAQN RKLEEQLEKI SHQDHSDKNR
860 870 880 890 900
LLELETRLRE VSLEHEEQKL ELKRQLTELQ LSLQERESQL TALQAARAAL
910 920 930 940 950
ESQLRQAKTE LEETTAEAEE EIQALTAHRD EIQRKFDALR NSCTVITDLE
960 970 980 990 1000
EQLNQLTEDN AELNNQNFYL SKQLDEASGA NDEIVQLRSE VDHLRREITE
1010 1020 1030 1040 1050
REMQLTSQKQ TMEALKTTCT MLEEQVMDLE ALNDELLEKE RQWEAWRSVL
1060 1070 1080 1090 1100
GDEKSQFECR VRELQRMLDT EKQSRARADQ RITESRQVVE LAVKEHKAEI
1110 1120 1130 1140 1150
LALQQALKEQ KLKAESLSDK LNDLEKKHAM LEMNARSLQQ KLETERELKQ
1160 1170 1180 1190 1200
RLLEEQAKLQ QQMDLQKNHI FRLTQGLQEA LDRADLLKTE RSDLEYQLEN
1210 1220 1230 1240 1250
IQVLYSHEKV KMEGTISQQT KLIDFLQAKM DQPAKKKKGL FSRRKEDPAL
1260 1270 1280 1290 1300
PTQVPLQYNE LKLALEKEKA RCAELEEALQ KTRIELRSAR EEAAHRKATD
1310 1320 1330 1340 1350
HPHPSTPATA RQQIAMSAIV RSPEHQPSAM SLLAPPSSRR KESSTPEEFS
1360 1370 1380 1390 1400
RRLKERMHHN IPHRFNVGLN MRATKCAVCL DTVHFGRQAS KCLECQVMCH
1410 1420 1430 1440 1450
PKCSTCLPAT CGLPAEYATH FTEAFCRDKM NSPGLQTKEP SSSLHLEGWM
1460 1470 1480 1490 1500
KVPRNNKRGQ QGWDRKYIVL EGSKVLIYDN EAREAGQRPV EEFELCLPDG
1510 1520 1530 1540 1550
DVSIHGAVGA SELANTAKAD VPYILKMESH PHTTCWPGRT LYLLAPSFPD
1560 1570 1580 1590 1600
KQRWVTALES VVAGGRVSRE KAEADAKLLG NSLLKLEGDD RLDMNCTLPF
1610 1620 1630 1640 1650
SDQVVLVGTE EGLYALNVLK NSLTHVPGIG AVFQIYIIKD LEKLLMIAGE
1660 1670 1680 1690 1700
ERALCLVDVK KVKQSLAQSH LPAQPDISPN IFEAVKGCHL FGAGKIENGL
1710 1720 1730 1740 1750
CICAAMPSKV VILRYNENLS KYCIRKEIET SEPCSCIHFT NYSILIGTNK
1760 1770 1780 1790 1800
FYEIDMKQYT LEEFLDKNDH SLAPAVFAAS SNSFPVSIVQ VNSAGQREEY
1810 1820 1830 1840 1850
LLCFHEFGVF VDSYGRRSRT DDLKWSRLPL AFAYREPYLF VTHFNSLEVI
1860 1870 1880 1890 1900
EIQARSSAGT PARAYLDIPN PRYLGPAISS GAIYLASSYQ DKLRVICCKG
1910 1920 1930 1940 1950
NLVKESGTEH HRGPSTSRSS PNKRGPPTYN EHITKRVASS PAPPEGPSHP
1960 1970 1980 1990 2000
REPSTPHRYR EGRTELRRDK SPGRPLEREK SPGRMLSTRR ERSPGRLFED
2010 2020
SSRGRLPAGA VRTPLSQVNK VWDQSSV
Length:2,027
Mass (Da):231,431
Last modified:January 4, 2005 - v2
Checksum:i6B1D8C3F661F357B
GO
Isoform 2 (identifier: O14578-2) [UniParc]FASTAAdd to basket
Also known as: Short, CRIK-SK

The sequence of this isoform differs from the canonical sequence as follows:
     481-482: EV → GG
     483-2027: Missing.

Show »
Length:482
Mass (Da):54,399
Checksum:i7F23D62DD30DC0CE
GO
Isoform 3 (identifier: O14578-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-467: Missing.
     1239-1253: Missing.
     1919-1919: Missing.

Note: No experimental confirmation available.
Show »
Length:1,544
Mass (Da):177,035
Checksum:i309A4BA63CB1419D
GO
Isoform 4 (identifier: O14578-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     694-694: E → EERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKIL

Show »
Length:2,069
Mass (Da):236,607
Checksum:iA491E1437044643D
GO

Sequence cautioni

The sequence BAA76793 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → S in AAP43922 (Ref. 2) Curated1
Sequence conflicti56F → L in AAP43922 (Ref. 2) Curated1
Sequence conflicti218V → L in AAP43922 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0404177G → E.1 PublicationCorresponds to variant rs36054900dbSNPEnsembl.1
Natural variantiVAR_0404189R → Q.1 PublicationCorresponds to variant rs56193743dbSNPEnsembl.1
Natural variantiVAR_040419183L → F.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0145071 – 467Missing in isoform 3. 1 PublicationAdd BLAST467
Alternative sequenceiVSP_012434481 – 482EV → GG in isoform 2. 1 Publication2
Alternative sequenceiVSP_012435483 – 2027Missing in isoform 2. 1 PublicationAdd BLAST1545
Alternative sequenceiVSP_043301694E → EERRHSLENKVKRLETMERR ENRLKDDIQTKSQQIQQMAD KIL in isoform 4. 1 Publication1
Alternative sequenceiVSP_0145081239 – 1253Missing in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0145091919Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY257469 mRNA. Translation: AAP13528.1.
AY209000 mRNA. Translation: AAP43922.1.
AY681966 mRNA. Translation: AAV87216.1.
AB023166 mRNA. Translation: BAA76793.2. Different initiation.
AC002563 Genomic DNA. Translation: AAB71327.1.
AC079317 Genomic DNA. No translation available.
AC004813 Genomic DNA. No translation available.
CCDSiCCDS55891.1. [O14578-4]
CCDS9192.1. [O14578-1]
RefSeqiNP_001193928.1. NM_001206999.1. [O14578-4]
NP_009105.1. NM_007174.2. [O14578-1]
UniGeneiHs.119594.

Genome annotation databases

EnsembliENST00000261833; ENSP00000261833; ENSG00000122966. [O14578-1]
ENST00000392521; ENSP00000376306; ENSG00000122966. [O14578-4]
ENST00000612548; ENSP00000482318; ENSG00000122966. [O14578-2]
GeneIDi11113.
KEGGihsa:11113.
UCSCiuc001txi.3. human. [O14578-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY257469 mRNA. Translation: AAP13528.1.
AY209000 mRNA. Translation: AAP43922.1.
AY681966 mRNA. Translation: AAV87216.1.
AB023166 mRNA. Translation: BAA76793.2. Different initiation.
AC002563 Genomic DNA. Translation: AAB71327.1.
AC079317 Genomic DNA. No translation available.
AC004813 Genomic DNA. No translation available.
CCDSiCCDS55891.1. [O14578-4]
CCDS9192.1. [O14578-1]
RefSeqiNP_001193928.1. NM_001206999.1. [O14578-4]
NP_009105.1. NM_007174.2. [O14578-1]
UniGeneiHs.119594.

3D structure databases

ProteinModelPortaliO14578.
SMRiO14578.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116290. 15 interactors.
IntActiO14578. 4 interactors.
MINTiMINT-2795177.
STRINGi9606.ENSP00000376306.

Chemistry databases

BindingDBiO14578.
ChEMBLiCHEMBL5579.
GuidetoPHARMACOLOGYi1509.

PTM databases

iPTMnetiO14578.
PhosphoSitePlusiO14578.

Polymorphism and mutation databases

BioMutaiCIT.

Proteomic databases

EPDiO14578.
MaxQBiO14578.
PaxDbiO14578.
PeptideAtlasiO14578.
PRIDEiO14578.

Protocols and materials databases

DNASUi11113.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261833; ENSP00000261833; ENSG00000122966. [O14578-1]
ENST00000392521; ENSP00000376306; ENSG00000122966. [O14578-4]
ENST00000612548; ENSP00000482318; ENSG00000122966. [O14578-2]
GeneIDi11113.
KEGGihsa:11113.
UCSCiuc001txi.3. human. [O14578-1]

Organism-specific databases

CTDi11113.
DisGeNETi11113.
GeneCardsiCIT.
HGNCiHGNC:1985. CIT.
HPAiHPA019082.
HPA048812.
MIMi605629. gene.
neXtProtiNX_O14578.
OpenTargetsiENSG00000122966.
PharmGKBiPA26522.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0612. Eukaryota.
KOG0976. Eukaryota.
ENOG410XR1Q. LUCA.
GeneTreeiENSGT00760000118994.
HOGENOMiHOG000015347.
HOVERGENiHBG071093.
InParanoidiO14578.
KOiK16308.
OMAiMKAKDQG.
OrthoDBiEOG091G00DT.
PhylomeDBiO14578.
TreeFamiTF101140.

Enzyme and pathway databases

BioCyciZFISH:HS04618-MONOMER.
ReactomeiR-HSA-5625900. RHO GTPases activate CIT.
SignaLinkiO14578.

Miscellaneous databases

ChiTaRSiCIT. human.
GeneWikiiCIT_(gene).
GenomeRNAii11113.
PROiO14578.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122966.
CleanExiHS_CIT.
ExpressionAtlasiO14578. baseline and differential.
GenevisibleiO14578. HS.

Family and domain databases

CDDicd00029. C1. 1 hit.
Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR017405. Citron_Rho-interacting_kinase.
IPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22988:SF26. PTHR22988:SF26. 6 hits.
PfamiPF00780. CNH. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTRO_HUMAN
AccessioniPrimary (citable) accession number: O14578
Secondary accession number(s): Q2M5E1
, Q6XUH8, Q86UQ9, Q9UPZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 4, 2005
Last modified: November 30, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.