Reviewed, UniProtKB/Swiss-Prot O14576 (DC1I1_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytoplasmic dynein 1 intermediate chain 1
Alternative name(s):
    Cytoplasmic dynein intermediate chain 1
    Dynein intermediate chain 1, cytosolic
      Short name=DH IC-1

Gene names

Name:	DYNC1I1
Synonyms:	DNCI1, DNCIC1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	645 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The intermediate chains seem to help dynein bind to dynactin 150 kDa component. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Subunit structure	Consists of at least two heavy chains and a number of intermediate and light chains.
Sequence similarities	Belongs to the dynein intermediate chain family. Contains 7 WD repeats.

Ontologies

Keywords
Cellular component	Dynein Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	vesicle transport along microtubule Inferred from sequence or structural similarity. Source: HGNC
Cellular component	cytoplasmic dynein complex Ref.1 Traceable author statement. Source: ProtInc microtubule Inferred from electronic annotation. Source: UniProtKB-KW perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: HGNC
Molecular function	microtubule binding Inferred from sequence or structural similarity. Source: HGNC microtubule motor activity Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14576-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14576-2)

The sequence of this isoform differs from the canonical sequence as follows:
     74-90: Missing.

Isoform 3 (identifier: O14576-3)

The sequence of this isoform differs from the canonical sequence as follows:
     74-90: Missing.
     123-142: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 645	645	Cytoplasmic dynein 1 intermediate chain 1		PRO_0000114652
Regions
	Repeat	285 – 334	50	WD 1
	Repeat	338 – 378	41	WD 2
	Repeat	387 – 428	42	WD 3
	Repeat	437 – 477	41	WD 4
	Repeat	482 – 527	46	WD 5
	Repeat	530 – 570	41	WD 6
	Repeat	576 – 615	40	WD 7
Amino acid modifications
	Modified residue	635	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	74 – 90	17	Missing in isoform 2 and isoform 3.		VSP_001332
	Alternative sequence	123 – 142	20	Missing in isoform 3.		VSP_001333
	Natural variant	582	1	N → T: dbSNP rs35077523.		VAR_048905

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 2. Checksum: 55A6FF971E632DA0	FASTA	645	72,955
	10 20 30 40 50 60 MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE 70 80 90 100 110 120 ALLQSIGISP EPPLVQPLHF LTWDTCYFHY LVPTPMSPSS KSVSTPSEAG SQDSGDLGPL 130 140 150 160 170 180 TRTLQWDTDP SVLQLQSDSE LGRRLHKLGV SKVTQVDFLP REVVSYSKET QTPLATHQSE 190 200 210 220 230 240 EDEEDEEMVE SKVGQDSELE NQDKKQEVKE APPRELTEEE KQQILHSEEF LIFFDRTIRV 250 260 270 280 290 300 IERALAEDSD IFFDYSGREL EEKDGDVQAG ANLSFNRQFY DEHWSKHRVV TCMDWSLQYP 310 320 330 340 350 360 ELMVASYNNN EDAPHEPDGV ALVWNMKFKK TTPEYVFHCQ SSVMSVCFAR FHPNLVVGGT 370 380 390 400 410 420 YSGQIVLWDN RSHRRTPVQR TPLSAAAHTH PVYCVNVVGT QNAHNLITVS TDGKMCSWSL 430 440 450 460 470 480 DMLSTPQESM ELVYNKSKPV AVTGMAFPTG DVNNFVVGSE EGTVYTACRH GSKAGIGEVF 490 500 510 520 530 540 EGHQGPVTGI NCHMAVGPID FSHLFVTSSF DWTVKLWTTK HNKPLYSFED NADYVYDVMW 550 560 570 580 590 600 SPVHPALFAC VDGMGRLDLW NLNNDTEVPT ASVAIEGASA LNRVRWAQAG KEVAVGDSEG 610 620 630 640 RIWVYDVGEL AVPHNDEWTR FARTLVEIRA NRADSEEEGT VELSA
	Isoform 2. Checksum: 0360B15D5295971F	FASTA	628	70,790
	10 20 30 40 50 60 MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE 70 80 90 100 110 120 ALLQSIGISP EPPLVPTPMS PSSKSVSTPS EAGSQDSGDL GPLTRTLQWD TDPSVLQLQS 130 140 150 160 170 180 DSELGRRLHK LGVSKVTQVD FLPREVVSYS KETQTPLATH QSEEDEEDEE MVESKVGQDS 190 200 210 220 230 240 ELENQDKKQE VKEAPPRELT EEEKQQILHS EEFLIFFDRT IRVIERALAE DSDIFFDYSG 250 260 270 280 290 300 RELEEKDGDV QAGANLSFNR QFYDEHWSKH RVVTCMDWSL QYPELMVASY NNNEDAPHEP 310 320 330 340 350 360 DGVALVWNMK FKKTTPEYVF HCQSSVMSVC FARFHPNLVV GGTYSGQIVL WDNRSHRRTP 370 380 390 400 410 420 VQRTPLSAAA HTHPVYCVNV VGTQNAHNLI TVSTDGKMCS WSLDMLSTPQ ESMELVYNKS 430 440 450 460 470 480 KPVAVTGMAF PTGDVNNFVV GSEEGTVYTA CRHGSKAGIG EVFEGHQGPV TGINCHMAVG 490 500 510 520 530 540 PIDFSHLFVT SSFDWTVKLW TTKHNKPLYS FEDNADYVYD VMWSPVHPAL FACVDGMGRL 550 560 570 580 590 600 DLWNLNNDTE VPTASVAIEG ASALNRVRWA QAGKEVAVGD SEGRIWVYDV GELAVPHNDE 610 620 WTRFARTLVE IRANRADSEE EGTVELSA
	Isoform 3. Checksum: D88D3EB3D1FC82B2	FASTA	608	68,575
	10 20 30 40 50 60 MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVQDDS DLDRKRRETE 70 80 90 100 110 120 ALLQSIGISP EPPLVPTPMS PSSKSVSTPS EAGSQDSGDL GPLTRRRLHK LGVSKVTQVD 130 140 150 160 170 180 FLPREVVSYS KETQTPLATH QSEEDEEDEE MVESKVGQDS ELENQDKKQE VKEAPPRELT 190 200 210 220 230 240 EEEKQQILHS EEFLIFFDRT IRVIERALAE DSDIFFDYSG RELEEKDGDV QAGANLSFNR 250 260 270 280 290 300 QFYDEHWSKH RVVTCMDWSL QYPELMVASY NNNEDAPHEP DGVALVWNMK FKKTTPEYVF 310 320 330 340 350 360 HCQSSVMSVC FARFHPNLVV GGTYSGQIVL WDNRSHRRTP VQRTPLSAAA HTHPVYCVNV 370 380 390 400 410 420 VGTQNAHNLI TVSTDGKMCS WSLDMLSTPQ ESMELVYNKS KPVAVTGMAF PTGDVNNFVV 430 440 450 460 470 480 GSEEGTVYTA CRHGSKAGIG EVFEGHQGPV TGINCHMAVG PIDFSHLFVT SSFDWTVKLW 490 500 510 520 530 540 TTKHNKPLYS FEDNADYVYD VMWSPVHPAL FACVDGMGRL DLWNLNNDTE VPTASVAIEG 550 560 570 580 590 600 ASALNRVRWA QAGKEVAVGD SEGRIWVYDV GELAVPHNDE WTRFARTLVE IRANRADSEE EGTVELSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human." Crackower M.A., Sinasac D.S., Xia J., Motoyama J., Prochazka M., Rommens J.M., Scherer S.W., Tsui L.-C. Genomics 55:257-267(1999) [PubMed: 10049579] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Molecular cloning of a cytoplasmic dynein gene." Li G., Jin J., Hu S., Li W., Yuan J., Qiang B. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-635, MASS SPECTROMETRY. Tissue: T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF063228 mRNA. Translation: AAC33443.1. AF123074 mRNA. Translation: AAD26852.1. AK091339 mRNA. Translation: BAC03639.1. AC022261 Genomic DNA. No translation available. AC091779 Genomic DNA. No translation available. AC002452 Genomic DNA. Translation: AAB67047.2. AC002540 Genomic DNA. Translation: AAB70113.1.
IPI	IPI00022461. IPI00220137. IPI00220138.
RefSeq	NP_001129028.1. NP_001129029.1. NP_004402.1.
UniGene	Hs.440364
3D structure databases
SMR	O14576. Positions 147-173, 289-611.
DisProt	DP00360.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14576. 2 interactions.
STRING	O14576.
PTM databases
PhosphoSite	O14576.
Proteomic databases
PRIDE	O14576.
Genome annotation databases
Ensembl	ENST00000324972; ENSP00000320130; ENSG00000158560; Homo sapiens. [Genome view]
GeneID	1780.
KEGG	hsa:1780.
UCSC	uc003uob.1. human. uc003uoc.2. human. uc003uod.2. human.
Organism-specific databases
CTD	1780.
GeneCards	GC07P095239.
H-InvDB	HIX0022988.
HGNC	HGNC:2963. DYNC1I1.
HPA	HPA021315.
MIM	603772. gene.
PharmGKB	PA27434.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG446681.
HOVERGEN	O14576.
InParanoid	O14576.
OMA	SLHFLTW.
OrthoDB	EOG9323JG.
PhylomeDB	O14576.
Gene expression databases
ArrayExpress	O14576.
Bgee	O14576.
CleanEx	HS_DYNC1I1.
Genevestigator	O14576.
GermOnline	ENSG00000158560. Homo sapiens.
Family and domain databases
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 3 hits. [Graphical view]
SMART	SM00320. WD40. 5 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	7243.
SOURCE	Search...

Entry information

Entry name

DC1I1_HUMAN

Accession

Primary (citable) accession number: O14576
Secondary accession number(s): Q9Y2X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	January 19, 2010
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.