O14569 (C56D2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome b561 domain-containing protein 2

Alternative name(s):
Putative tumor suppressor protein 101F6

Gene names

Name:	CYB561D2
Synonyms:	101F6
ORF Names:	LUCA12.2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Binds 2 heme groups non-covalently By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Sequence similarities	Contains 1 cytochrome b561 domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.6
	Chain	2 – 222	221	Cytochrome b561 domain-containing protein 2		PRO_0000151036
Regions
	Topological domain	2 – 17	16	Cytoplasmic Potential
	Transmembrane	18 – 38	21	Helical; Potential
	Transmembrane	47 – 67	21	Helical; Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Transmembrane	123 – 143	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Topological domain	208 – 222	15	Cytoplasmic Potential
	Domain	14 – 217	204	Cytochrome b561
Sites
	Metal binding	48	1	Iron (heme axial ligand) Potential
	Metal binding	86	1	Iron (heme axial ligand) Potential
	Metal binding	120	1	Iron (heme axial ligand) Potential
	Metal binding	159	1	Iron (heme axial ligand) Potential

Sequences

	Sequence		Length	Mass (Da)
	O14569 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 3AEEE64D8CB91A32	FASTA	222	23,974
	10 20 30 40 50 60 MALSAETESH IYRALRTASG AAAHLVALGF TIFVAVLARP GSSLFSWHPV LMSLAFSFLM 70 80 90 100 110 120 TEALLVFSPE SSLLHSLSRK GRARCHWVLQ LLALLCALLG LGLVILHKEQ LGKAHLVTRH 130 140 150 160 170 180 GQAGLLAVLW AGLQCSGGVG LLYPKLLPRW PLAKLKLYHA TSGLVGYLLG SASLLLGMCS 190 200 210 220 LWFTASVTGA AWYLAVLCPV LTSLVIMNQV SNAYLYRKRI QP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new candidate tumor suppressor gene located in the 3p21.3 small cell lung cancer homozygous deletion region." Bader S., Lee C.-C., Latif F., Sekido Y., Duh F.-M., Wei M.-H., Cundiff S., Lerman M.I., Minna J.D. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[6]	"Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini." Xu G., Shin S.B., Jaffrey S.R. Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 2-14. Tissue: Leukemic T-cell.
[7]	"The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes." The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium Lerman M.I., Minna J.D. Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract] Cited for: DISCUSSION OF SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF040704 mRNA. Translation: AAC70911.1. AK291167 mRNA. Translation: BAF83856.1. AC002481 Genomic DNA. Translation: AAB67309.1. CH471055 Genomic DNA. Translation: EAW65113.1. BC047691 mRNA. Translation: AAH47691.1.
IPI	IPI00013026.
RefSeq	NP_008953.1. NM_007022.3.
UniGene	Hs.149443.
3D structure databases
ProteinModelPortal	O14569.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14569. 1 interaction.
MINT	MINT-1372696.
STRING	9606.ENSP00000232508.
Proteomic databases
PaxDb	O14569.
PRIDE	O14569.
Protocols and materials databases
DNASU	11068.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000232508; ENSP00000232508; ENSG00000114395. ENST00000418577; ENSP00000391209; ENSG00000114395. ENST00000424512; ENSP00000410663; ENSG00000114395. ENST00000425346; ENSP00000400454; ENSG00000114395.
GeneID	11068.
KEGG	hsa:11068.
UCSC	uc003dal.3. human.
Organism-specific databases
CTD	11068.
GeneCards	GC03P050388.
HGNC	HGNC:30253. CYB561D2.
HPA	HPA042817.
MIM	607068. gene.
neXtProt	NX_O14569.
PharmGKB	PA134977950.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46402.
HOGENOM	HOG000008685.
HOVERGEN	HBG050754.
InParanoid	O14569.
KO	K08371.
OMA	LWFTATV.
OrthoDB	EOG4FTW1X.
PhylomeDB	O14569.
Gene expression databases
Bgee	O14569.
CleanEx	HS_CYB561D2.
Genevestigator	O14569.
GermOnline	ENSG00000114395. Homo sapiens.
Family and domain databases
InterPro	IPR006593. Cyt_b561/ferric_Rdtase_TM. IPR004877. Cyt_b561_euk. [Graphical view]
Pfam	PF03188. Cytochrom_B561. 1 hit. [Graphical view]
SMART	SM00665. B561. 1 hit. [Graphical view]
PROSITE	PS50939. CYTOCHROME_B561. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	11068.
NextBio	42076.
SOURCE	Search...

Entry information

Entry name

C56D2_HUMAN

Accession

Primary (citable) accession number: O14569
Secondary accession number(s): A8K552

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.