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O14569

- C56D2_HUMAN

UniProt

O14569 - C56D2_HUMAN

Protein

Cytochrome b561 domain-containing protein 2

Gene

CYB561D2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 2 heme groups non-covalently.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi48 – 481Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi86 – 861Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi120 – 1201Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi159 – 1591Iron (heme axial ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b561 domain-containing protein 2
    Alternative name(s):
    Putative tumor suppressor protein 101F6
    Gene namesi
    Name:CYB561D2
    Synonyms:101F6
    ORF Names:LUCA12.2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30253. CYB561D2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134977950.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 222221Cytochrome b561 domain-containing protein 2PRO_0000151036Add
    BLAST

    Proteomic databases

    MaxQBiO14569.
    PaxDbiO14569.
    PRIDEiO14569.

    Expressioni

    Gene expression databases

    BgeeiO14569.
    CleanExiHS_CYB561D2.
    GenevestigatoriO14569.

    Organism-specific databases

    HPAiHPA042817.

    Interactioni

    Protein-protein interaction databases

    BioGridi116252. 2 interactions.
    IntActiO14569. 1 interaction.
    MINTiMINT-1372696.
    STRINGi9606.ENSP00000232508.

    Structurei

    3D structure databases

    ProteinModelPortaliO14569.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini208 – 22215CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 217204Cytochrome b561PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46402.
    HOGENOMiHOG000008685.
    HOVERGENiHBG050754.
    InParanoidiO14569.
    KOiK08371.
    OMAiLCPILTS.
    OrthoDBiEOG7R2BKS.
    PhylomeDBiO14569.
    TreeFamiTF323584.

    Family and domain databases

    InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
    IPR004877. Cyt_b561_euk.
    [Graphical view]
    PfamiPF03188. Cytochrom_B561. 1 hit.
    [Graphical view]
    SMARTiSM00665. B561. 1 hit.
    [Graphical view]
    PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14569-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSAETESH IYRALRTASG AAAHLVALGF TIFVAVLARP GSSLFSWHPV    50
    LMSLAFSFLM TEALLVFSPE SSLLHSLSRK GRARCHWVLQ LLALLCALLG 100
    LGLVILHKEQ LGKAHLVTRH GQAGLLAVLW AGLQCSGGVG LLYPKLLPRW 150
    PLAKLKLYHA TSGLVGYLLG SASLLLGMCS LWFTASVTGA AWYLAVLCPV 200
    LTSLVIMNQV SNAYLYRKRI QP 222
    Length:222
    Mass (Da):23,974
    Last modified:January 1, 1998 - v1
    Checksum:i3AEEE64D8CB91A32
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040704 mRNA. Translation: AAC70911.1.
    AK291167 mRNA. Translation: BAF83856.1.
    AC002481 Genomic DNA. Translation: AAB67309.1.
    CH471055 Genomic DNA. Translation: EAW65113.1.
    BC047691 mRNA. Translation: AAH47691.1.
    CCDSiCCDS2827.1.
    RefSeqiNP_001278213.1. NM_001291284.1.
    NP_008953.1. NM_007022.4.
    UniGeneiHs.149443.
    Hs.669905.

    Genome annotation databases

    EnsembliENST00000232508; ENSP00000232508; ENSG00000114395.
    ENST00000418577; ENSP00000391209; ENSG00000114395.
    ENST00000424512; ENSP00000410663; ENSG00000114395.
    ENST00000425346; ENSP00000400454; ENSG00000114395.
    GeneIDi11068.
    KEGGihsa:11068.
    UCSCiuc003dal.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040704 mRNA. Translation: AAC70911.1 .
    AK291167 mRNA. Translation: BAF83856.1 .
    AC002481 Genomic DNA. Translation: AAB67309.1 .
    CH471055 Genomic DNA. Translation: EAW65113.1 .
    BC047691 mRNA. Translation: AAH47691.1 .
    CCDSi CCDS2827.1.
    RefSeqi NP_001278213.1. NM_001291284.1.
    NP_008953.1. NM_007022.4.
    UniGenei Hs.149443.
    Hs.669905.

    3D structure databases

    ProteinModelPortali O14569.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116252. 2 interactions.
    IntActi O14569. 1 interaction.
    MINTi MINT-1372696.
    STRINGi 9606.ENSP00000232508.

    Proteomic databases

    MaxQBi O14569.
    PaxDbi O14569.
    PRIDEi O14569.

    Protocols and materials databases

    DNASUi 11068.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000232508 ; ENSP00000232508 ; ENSG00000114395 .
    ENST00000418577 ; ENSP00000391209 ; ENSG00000114395 .
    ENST00000424512 ; ENSP00000410663 ; ENSG00000114395 .
    ENST00000425346 ; ENSP00000400454 ; ENSG00000114395 .
    GeneIDi 11068.
    KEGGi hsa:11068.
    UCSCi uc003dal.3. human.

    Organism-specific databases

    CTDi 11068.
    GeneCardsi GC03P050388.
    HGNCi HGNC:30253. CYB561D2.
    HPAi HPA042817.
    MIMi 607068. gene.
    neXtProti NX_O14569.
    PharmGKBi PA134977950.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46402.
    HOGENOMi HOG000008685.
    HOVERGENi HBG050754.
    InParanoidi O14569.
    KOi K08371.
    OMAi LCPILTS.
    OrthoDBi EOG7R2BKS.
    PhylomeDBi O14569.
    TreeFami TF323584.

    Miscellaneous databases

    GenomeRNAii 11068.
    NextBioi 42076.
    PROi O14569.
    SOURCEi Search...

    Gene expression databases

    Bgeei O14569.
    CleanExi HS_CYB561D2.
    Genevestigatori O14569.

    Family and domain databases

    InterProi IPR006593. Cyt_b561/ferric_Rdtase_TM.
    IPR004877. Cyt_b561_euk.
    [Graphical view ]
    Pfami PF03188. Cytochrom_B561. 1 hit.
    [Graphical view ]
    SMARTi SM00665. B561. 1 hit.
    [Graphical view ]
    PROSITEi PS50939. CYTOCHROME_B561. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new candidate tumor suppressor gene located in the 3p21.3 small cell lung cancer homozygous deletion region."
      Bader S., Lee C.-C., Latif F., Sekido Y., Duh F.-M., Wei M.-H., Cundiff S., Lerman M.I., Minna J.D.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    6. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
      Xu G., Shin S.B., Jaffrey S.R.
      Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 2-14.
      Tissue: Leukemic T-cell.
    7. "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
      The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
      Lerman M.I., Minna J.D.
      Cancer Res. 60:6116-6133(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.

    Entry informationi

    Entry nameiC56D2_HUMAN
    AccessioniPrimary (citable) accession number: O14569
    Secondary accession number(s): A8K552
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3