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Protein

Cytochrome b561 domain-containing protein 2

Gene

CYB561D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi86Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi120Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi159Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114395-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561 domain-containing protein 2
Alternative name(s):
Putative tumor suppressor protein 101F6
Gene namesi
Name:CYB561D2
Synonyms:101F6
ORF Names:LUCA12.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30253. CYB561D2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 17CytoplasmicSequence analysisAdd BLAST16
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 222CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11068.
OpenTargetsiENSG00000114395.
PharmGKBiPA134977950.

Polymorphism and mutation databases

BioMutaiCYB561D2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001510362 – 222Cytochrome b561 domain-containing protein 2Add BLAST221

Proteomic databases

EPDiO14569.
MaxQBiO14569.
PaxDbiO14569.
PeptideAtlasiO14569.
PRIDEiO14569.

PTM databases

iPTMnetiO14569.
PhosphoSitePlusiO14569.

Expressioni

Gene expression databases

BgeeiENSG00000114395.
CleanExiHS_CYB561D2.
ExpressionAtlasiO14569. baseline and differential.
GenevisibleiO14569. HS.

Organism-specific databases

HPAiHPA042817.

Interactioni

Protein-protein interaction databases

BioGridi116252. 3 interactors.
IntActiO14569. 2 interactors.
MINTiMINT-1372696.
STRINGi9606.ENSP00000232508.

Structurei

3D structure databases

ProteinModelPortaliO14569.
SMRiO14569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 217Cytochrome b561PROSITE-ProRule annotationAdd BLAST204

Sequence similaritiesi

Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVNX. Eukaryota.
ENOG4111KF1. LUCA.
GeneTreeiENSGT00440000038072.
HOGENOMiHOG000008685.
HOVERGENiHBG050754.
InParanoidiO14569.
KOiK08371.
OMAiFKSWHGT.
OrthoDBiEOG091G0OYU.
PhylomeDBiO14569.
TreeFamiTF323584.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
[Graphical view]
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSAETESH IYRALRTASG AAAHLVALGF TIFVAVLARP GSSLFSWHPV
60 70 80 90 100
LMSLAFSFLM TEALLVFSPE SSLLHSLSRK GRARCHWVLQ LLALLCALLG
110 120 130 140 150
LGLVILHKEQ LGKAHLVTRH GQAGLLAVLW AGLQCSGGVG LLYPKLLPRW
160 170 180 190 200
PLAKLKLYHA TSGLVGYLLG SASLLLGMCS LWFTASVTGA AWYLAVLCPV
210 220
LTSLVIMNQV SNAYLYRKRI QP
Length:222
Mass (Da):23,974
Last modified:January 1, 1998 - v1
Checksum:i3AEEE64D8CB91A32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040704 mRNA. Translation: AAC70911.1.
AK291167 mRNA. Translation: BAF83856.1.
AC002481 Genomic DNA. Translation: AAB67309.1.
CH471055 Genomic DNA. Translation: EAW65113.1.
BC047691 mRNA. Translation: AAH47691.1.
CCDSiCCDS2827.1.
RefSeqiNP_001278213.1. NM_001291284.1.
NP_008953.1. NM_007022.4.
UniGeneiHs.149443.
Hs.669905.

Genome annotation databases

EnsembliENST00000232508; ENSP00000232508; ENSG00000114395.
ENST00000418577; ENSP00000391209; ENSG00000114395.
ENST00000424512; ENSP00000410663; ENSG00000114395.
ENST00000425346; ENSP00000400454; ENSG00000114395.
GeneIDi11068.
KEGGihsa:11068.
UCSCiuc003dal.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040704 mRNA. Translation: AAC70911.1.
AK291167 mRNA. Translation: BAF83856.1.
AC002481 Genomic DNA. Translation: AAB67309.1.
CH471055 Genomic DNA. Translation: EAW65113.1.
BC047691 mRNA. Translation: AAH47691.1.
CCDSiCCDS2827.1.
RefSeqiNP_001278213.1. NM_001291284.1.
NP_008953.1. NM_007022.4.
UniGeneiHs.149443.
Hs.669905.

3D structure databases

ProteinModelPortaliO14569.
SMRiO14569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116252. 3 interactors.
IntActiO14569. 2 interactors.
MINTiMINT-1372696.
STRINGi9606.ENSP00000232508.

PTM databases

iPTMnetiO14569.
PhosphoSitePlusiO14569.

Polymorphism and mutation databases

BioMutaiCYB561D2.

Proteomic databases

EPDiO14569.
MaxQBiO14569.
PaxDbiO14569.
PeptideAtlasiO14569.
PRIDEiO14569.

Protocols and materials databases

DNASUi11068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232508; ENSP00000232508; ENSG00000114395.
ENST00000418577; ENSP00000391209; ENSG00000114395.
ENST00000424512; ENSP00000410663; ENSG00000114395.
ENST00000425346; ENSP00000400454; ENSG00000114395.
GeneIDi11068.
KEGGihsa:11068.
UCSCiuc003dal.4. human.

Organism-specific databases

CTDi11068.
DisGeNETi11068.
GeneCardsiCYB561D2.
HGNCiHGNC:30253. CYB561D2.
HPAiHPA042817.
MIMi607068. gene.
neXtProtiNX_O14569.
OpenTargetsiENSG00000114395.
PharmGKBiPA134977950.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVNX. Eukaryota.
ENOG4111KF1. LUCA.
GeneTreeiENSGT00440000038072.
HOGENOMiHOG000008685.
HOVERGENiHBG050754.
InParanoidiO14569.
KOiK08371.
OMAiFKSWHGT.
OrthoDBiEOG091G0OYU.
PhylomeDBiO14569.
TreeFamiTF323584.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114395-MONOMER.

Miscellaneous databases

ChiTaRSiCYB561D2. human.
GenomeRNAii11068.
PROiO14569.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114395.
CleanExiHS_CYB561D2.
ExpressionAtlasiO14569. baseline and differential.
GenevisibleiO14569. HS.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
[Graphical view]
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC56D2_HUMAN
AccessioniPrimary (citable) accession number: O14569
Secondary accession number(s): A8K552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.