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Protein

Cytochrome b561 domain-containing protein 2

Gene

CYB561D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi86 – 861Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi120 – 1201Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi159 – 1591Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561 domain-containing protein 2
Alternative name(s):
Putative tumor suppressor protein 101F6
Gene namesi
Name:CYB561D2
Synonyms:101F6
ORF Names:LUCA12.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30253. CYB561D2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1716CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Topological domaini208 – 22215CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 222221Cytochrome b561 domain-containing protein 2PRO_0000151036Add
BLAST

Proteomic databases

MaxQBiO14569.
PaxDbiO14569.
PRIDEiO14569.

Expressioni

Gene expression databases

BgeeiO14569.
CleanExiHS_CYB561D2.
ExpressionAtlasiO14569. baseline and differential.
GenevestigatoriO14569.

Organism-specific databases

HPAiHPA042817.

Interactioni

Protein-protein interaction databases

BioGridi116252. 2 interactions.
IntActiO14569. 1 interaction.
MINTiMINT-1372696.
STRINGi9606.ENSP00000232508.

Structurei

3D structure databases

ProteinModelPortaliO14569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 217204Cytochrome b561PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46402.
GeneTreeiENSGT00440000038072.
HOGENOMiHOG000008685.
HOVERGENiHBG050754.
InParanoidiO14569.
KOiK08371.
OMAiTGGVWYL.
OrthoDBiEOG7R2BKS.
PhylomeDBiO14569.
TreeFamiTF323584.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR004877. Cyt_b561_dom.
[Graphical view]
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSAETESH IYRALRTASG AAAHLVALGF TIFVAVLARP GSSLFSWHPV
60 70 80 90 100
LMSLAFSFLM TEALLVFSPE SSLLHSLSRK GRARCHWVLQ LLALLCALLG
110 120 130 140 150
LGLVILHKEQ LGKAHLVTRH GQAGLLAVLW AGLQCSGGVG LLYPKLLPRW
160 170 180 190 200
PLAKLKLYHA TSGLVGYLLG SASLLLGMCS LWFTASVTGA AWYLAVLCPV
210 220
LTSLVIMNQV SNAYLYRKRI QP
Length:222
Mass (Da):23,974
Last modified:January 1, 1998 - v1
Checksum:i3AEEE64D8CB91A32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040704 mRNA. Translation: AAC70911.1.
AK291167 mRNA. Translation: BAF83856.1.
AC002481 Genomic DNA. Translation: AAB67309.1.
CH471055 Genomic DNA. Translation: EAW65113.1.
BC047691 mRNA. Translation: AAH47691.1.
CCDSiCCDS2827.1.
RefSeqiNP_001278213.1. NM_001291284.1.
NP_008953.1. NM_007022.4.
UniGeneiHs.149443.
Hs.669905.

Genome annotation databases

EnsembliENST00000232508; ENSP00000232508; ENSG00000114395.
ENST00000418577; ENSP00000391209; ENSG00000114395.
ENST00000424512; ENSP00000410663; ENSG00000114395.
ENST00000425346; ENSP00000400454; ENSG00000114395.
GeneIDi11068.
KEGGihsa:11068.
UCSCiuc003dal.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040704 mRNA. Translation: AAC70911.1.
AK291167 mRNA. Translation: BAF83856.1.
AC002481 Genomic DNA. Translation: AAB67309.1.
CH471055 Genomic DNA. Translation: EAW65113.1.
BC047691 mRNA. Translation: AAH47691.1.
CCDSiCCDS2827.1.
RefSeqiNP_001278213.1. NM_001291284.1.
NP_008953.1. NM_007022.4.
UniGeneiHs.149443.
Hs.669905.

3D structure databases

ProteinModelPortaliO14569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116252. 2 interactions.
IntActiO14569. 1 interaction.
MINTiMINT-1372696.
STRINGi9606.ENSP00000232508.

Proteomic databases

MaxQBiO14569.
PaxDbiO14569.
PRIDEiO14569.

Protocols and materials databases

DNASUi11068.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000232508; ENSP00000232508; ENSG00000114395.
ENST00000418577; ENSP00000391209; ENSG00000114395.
ENST00000424512; ENSP00000410663; ENSG00000114395.
ENST00000425346; ENSP00000400454; ENSG00000114395.
GeneIDi11068.
KEGGihsa:11068.
UCSCiuc003dal.3. human.

Organism-specific databases

CTDi11068.
GeneCardsiGC03P050388.
HGNCiHGNC:30253. CYB561D2.
HPAiHPA042817.
MIMi607068. gene.
neXtProtiNX_O14569.
PharmGKBiPA134977950.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46402.
GeneTreeiENSGT00440000038072.
HOGENOMiHOG000008685.
HOVERGENiHBG050754.
InParanoidiO14569.
KOiK08371.
OMAiTGGVWYL.
OrthoDBiEOG7R2BKS.
PhylomeDBiO14569.
TreeFamiTF323584.

Miscellaneous databases

ChiTaRSiCYB561D2. human.
GenomeRNAii11068.
NextBioi42076.
PROiO14569.
SOURCEiSearch...

Gene expression databases

BgeeiO14569.
CleanExiHS_CYB561D2.
ExpressionAtlasiO14569. baseline and differential.
GenevestigatoriO14569.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR004877. Cyt_b561_dom.
[Graphical view]
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new candidate tumor suppressor gene located in the 3p21.3 small cell lung cancer homozygous deletion region."
    Bader S., Lee C.-C., Latif F., Sekido Y., Duh F.-M., Wei M.-H., Cundiff S., Lerman M.I., Minna J.D.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  6. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
    Xu G., Shin S.B., Jaffrey S.R.
    Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 2-14.
    Tissue: Leukemic T-cell.
  7. "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes."
    The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
    Lerman M.I., Minna J.D.
    Cancer Res. 60:6116-6133(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiC56D2_HUMAN
AccessioniPrimary (citable) accession number: O14569
Secondary accession number(s): A8K552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: January 1, 1998
Last modified: April 1, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.