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Protein

Ubiquitin domain-containing protein UBFD1

Gene

UBFD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role as NF-kappa-B regulator.1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin domain-containing protein UBFD1
Alternative name(s):
Ubiquitin-binding protein homolog
Gene namesi
Name:UBFD1
Synonyms:UBPH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103353.15
HGNCiHGNC:30565 UBFD1
neXtProtiNX_O14562

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103353
PharmGKBiPA162407893

Polymorphism and mutation databases

BioMutaiUBFD1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830751 – 309Ubiquitin domain-containing protein UBFD1Add BLAST309

Proteomic databases

EPDiO14562
MaxQBiO14562
PaxDbiO14562
PeptideAtlasiO14562
PRIDEiO14562

PTM databases

iPTMnetiO14562
PhosphoSitePlusiO14562

Expressioni

Gene expression databases

BgeeiENSG00000103353
CleanExiHS_UBFD1
ExpressionAtlasiO14562 baseline and differential
GenevisibleiO14562 HS

Organism-specific databases

HPAiHPA051746

Interactioni

Subunit structurei

Binds polyubiquitin.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121034, 41 interactors
IntActiO14562, 1 interactor
MINTiO14562
STRINGi9606.ENSP00000379217

Structurei

3D structure databases

ProteinModelPortaliO14562
SMRiO14562
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 159Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG1872 Eukaryota
ENOG410XP96 LUCA
GeneTreeiENSGT00390000012857
HOGENOMiHOG000247033
HOVERGENiHBG052799
InParanoidiO14562
OMAiRTEKVPM
OrthoDBiEOG091G0HGN
PhylomeDBiO14562
TreeFamiTF333280

Family and domain databases

InterProiView protein in InterPro
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00299 UBIQUITIN_1, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

O14562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGAPDGM EEPGMDTEAE TVATEAPARP VNCLEAEAAA GAAAEDSGAA
60 70 80 90 100
RGSLQPAPAQ PPGDPAAQAS VSNGEDAGGG AGRELVDLKI IWNKTKHDVK
110 120 130 140 150
FPLDSTGSEL KQKIHSITGL PPAMQKVMYK GLVPEDKTLR EIKVTSGAKI
160 170 180 190 200
MVVGSTINDV LAVNTPKDAA QQDAKAEENK KEPLCRQKQH RKVLDKGKPE
210 220 230 240 250
DVMPSVKGAQ ERLPTVPLSG MYNKSGGKVR LTFKLEQDQL WIGTKERTEK
260 270 280 290 300
LPMGSIKNVV SEPIEGHEDY HMMAFQLGPT EASYYWVYWV PTQYVDAIKD

TVLGKWQYF
Length:309
Mass (Da):33,382
Last modified:April 5, 2011 - v2
Checksum:i2608827C4A7AFED5
GO

Sequence cautioni

The sequence AAC05812 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW55818 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW55819 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092696 mRNA Translation: BAG52599.1
AC002400 Genomic DNA Translation: AAC05812.1 Different initiation.
AC008870 Genomic DNA No translation available.
CH471145 Genomic DNA Translation: EAW55818.1 Different initiation.
CH471145 Genomic DNA Translation: EAW55819.1 Different initiation.
CCDSiCCDS10613.2
PIRiT00742
RefSeqiNP_061989.2, NM_019116.2
UniGeneiHs.3459

Genome annotation databases

EnsembliENST00000395878; ENSP00000379217; ENSG00000103353
GeneIDi56061
KEGGihsa:56061
UCSCiuc002dlv.4 human

Similar proteinsi

Entry informationi

Entry nameiUBFD1_HUMAN
AccessioniPrimary (citable) accession number: O14562
Secondary accession number(s): A8MW58, D3DWF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 5, 2011
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

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