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Protein

Ubiquitin domain-containing protein UBFD1

Gene

UBFD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role as NF-kappa-B regulator.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin domain-containing protein UBFD1
Alternative name(s):
Ubiquitin-binding protein homolog
Gene namesi
Name:UBFD1
Synonyms:UBPH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30565. UBFD1.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407893.

Polymorphism and mutation databases

BioMutaiUBFD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Ubiquitin domain-containing protein UBFD1PRO_0000283075Add
BLAST

Proteomic databases

EPDiO14562.
MaxQBiO14562.
PaxDbiO14562.
PeptideAtlasiO14562.
PRIDEiO14562.

PTM databases

iPTMnetiO14562.
PhosphoSiteiO14562.

Expressioni

Gene expression databases

BgeeiENSG00000103353.
CleanExiHS_UBFD1.
ExpressionAtlasiO14562. baseline and differential.
GenevisibleiO14562. HS.

Organism-specific databases

HPAiHPA051746.

Interactioni

Subunit structurei

Binds polyubiquitin.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi121034. 40 interactions.
IntActiO14562. 1 interaction.
STRINGi9606.ENSP00000379217.

Structurei

3D structure databases

ProteinModelPortaliO14562.
SMRiO14562. Positions 83-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 15976Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1872. Eukaryota.
ENOG410XP96. LUCA.
GeneTreeiENSGT00390000012857.
HOGENOMiHOG000247033.
HOVERGENiHBG052799.
InParanoidiO14562.
OMAiIWNKNKY.
OrthoDBiEOG091G0HGN.
PhylomeDBiO14562.
TreeFamiTF333280.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGAPDGM EEPGMDTEAE TVATEAPARP VNCLEAEAAA GAAAEDSGAA
60 70 80 90 100
RGSLQPAPAQ PPGDPAAQAS VSNGEDAGGG AGRELVDLKI IWNKTKHDVK
110 120 130 140 150
FPLDSTGSEL KQKIHSITGL PPAMQKVMYK GLVPEDKTLR EIKVTSGAKI
160 170 180 190 200
MVVGSTINDV LAVNTPKDAA QQDAKAEENK KEPLCRQKQH RKVLDKGKPE
210 220 230 240 250
DVMPSVKGAQ ERLPTVPLSG MYNKSGGKVR LTFKLEQDQL WIGTKERTEK
260 270 280 290 300
LPMGSIKNVV SEPIEGHEDY HMMAFQLGPT EASYYWVYWV PTQYVDAIKD

TVLGKWQYF
Length:309
Mass (Da):33,382
Last modified:April 5, 2011 - v2
Checksum:i2608827C4A7AFED5
GO

Sequence cautioni

The sequence AAC05812 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW55818 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW55819 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092696 mRNA. Translation: BAG52599.1.
AC002400 Genomic DNA. Translation: AAC05812.1. Different initiation.
AC008870 Genomic DNA. No translation available.
CH471145 Genomic DNA. Translation: EAW55818.1. Different initiation.
CH471145 Genomic DNA. Translation: EAW55819.1. Different initiation.
CCDSiCCDS10613.2.
PIRiT00742.
RefSeqiNP_061989.2. NM_019116.2.
UniGeneiHs.3459.

Genome annotation databases

EnsembliENST00000395878; ENSP00000379217; ENSG00000103353.
GeneIDi56061.
KEGGihsa:56061.
UCSCiuc002dlv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092696 mRNA. Translation: BAG52599.1.
AC002400 Genomic DNA. Translation: AAC05812.1. Different initiation.
AC008870 Genomic DNA. No translation available.
CH471145 Genomic DNA. Translation: EAW55818.1. Different initiation.
CH471145 Genomic DNA. Translation: EAW55819.1. Different initiation.
CCDSiCCDS10613.2.
PIRiT00742.
RefSeqiNP_061989.2. NM_019116.2.
UniGeneiHs.3459.

3D structure databases

ProteinModelPortaliO14562.
SMRiO14562. Positions 83-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121034. 40 interactions.
IntActiO14562. 1 interaction.
STRINGi9606.ENSP00000379217.

PTM databases

iPTMnetiO14562.
PhosphoSiteiO14562.

Polymorphism and mutation databases

BioMutaiUBFD1.

Proteomic databases

EPDiO14562.
MaxQBiO14562.
PaxDbiO14562.
PeptideAtlasiO14562.
PRIDEiO14562.

Protocols and materials databases

DNASUi56061.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395878; ENSP00000379217; ENSG00000103353.
GeneIDi56061.
KEGGihsa:56061.
UCSCiuc002dlv.4. human.

Organism-specific databases

CTDi56061.
GeneCardsiUBFD1.
HGNCiHGNC:30565. UBFD1.
HPAiHPA051746.
neXtProtiNX_O14562.
PharmGKBiPA162407893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1872. Eukaryota.
ENOG410XP96. LUCA.
GeneTreeiENSGT00390000012857.
HOGENOMiHOG000247033.
HOVERGENiHBG052799.
InParanoidiO14562.
OMAiIWNKNKY.
OrthoDBiEOG091G0HGN.
PhylomeDBiO14562.
TreeFamiTF333280.

Miscellaneous databases

ChiTaRSiUBFD1. human.
GenomeRNAii56061.
PROiO14562.

Gene expression databases

BgeeiENSG00000103353.
CleanExiHS_UBFD1.
ExpressionAtlasiO14562. baseline and differential.
GenevisibleiO14562. HS.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBFD1_HUMAN
AccessioniPrimary (citable) accession number: O14562
Secondary accession number(s): A8MW58, D3DWF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.