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Protein

Acyl carrier protein, mitochondrial

Gene

NDUFAB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain.1 Publication

GO - Molecular functioni

  • ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • fatty acid binding Source: UniProtKB
  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  • fatty acid biosynthetic process Source: UniProtKB
  • glyoxylate metabolic process Source: Reactome
  • mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  • mitochondrial respiratory chain complex I assembly Source: Reactome
  • protein lipoylation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004779-MONOMER.
ReactomeiR-HSA-389661. Glyoxylate metabolism and glycine degradation.
R-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.
R-HSA-77289. Mitochondrial Fatty Acid Beta-Oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein, mitochondrial
Short name:
ACP
Alternative name(s):
CI-SDAP
NADH-ubiquinone oxidoreductase 9.6 kDa subunit
Gene namesi
Name:NDUFAB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7694. NDUFAB1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi4706.
OpenTargetsiENSG00000004779.
PharmGKBiPA31500.

Chemistry databases

ChEMBLiCHEMBL2363065.

Polymorphism and mutation databases

BioMutaiNDUFAB1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 68MitochondrionCombined sources1 PublicationAdd BLAST68
ChainiPRO_000000056169 – 156Acyl carrier protein, mitochondrialAdd BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88N6-acetyllysineBy similarity1
Modified residuei112O-(pantetheine 4'-phosphoryl)serineSequence analysis1

Keywords - PTMi

Acetylation, Phosphopantetheine, Phosphoprotein

Proteomic databases

EPDiO14561.
MaxQBiO14561.
PaxDbiO14561.
PeptideAtlasiO14561.
PRIDEiO14561.
TopDownProteomicsiO14561.

PTM databases

iPTMnetiO14561.
PhosphoSitePlusiO14561.
SwissPalmiO14561.

Expressioni

Gene expression databases

BgeeiENSG00000004779.
CleanExiHS_NDUFAB1.
ExpressionAtlasiO14561. baseline and differential.
GenevisibleiO14561. HS.

Organism-specific databases

HPAiHPA054364.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits (PubMed:12611891). Interacts with ETFRF1 (PubMed:27499296).2 Publications

Protein-protein interaction databases

BioGridi110786. 27 interactors.
IntActiO14561. 10 interactors.
STRINGi9606.ENSP00000007516.

Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi76 – 89Combined sources14
Turni95 – 97Combined sources3
Helixi104 – 108Combined sources5
Helixi112 – 125Combined sources14
Helixi132 – 135Combined sources4
Helixi141 – 151Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNWNMR-A71-156[»]
ProteinModelPortaliO14561.
SMRiO14561.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14561.

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1748. Eukaryota.
COG0236. LUCA.
GeneTreeiENSGT00390000002127.
HOGENOMiHOG000178184.
HOVERGENiHBG024318.
InParanoidiO14561.
KOiK03955.
OMAiDRARINP.
OrthoDBiEOG091G0UIC.
PhylomeDBiO14561.
TreeFamiTF314361.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier. 1 hit.
InterProiIPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14561-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRVLSAYV SRLPAAFAPL PRVRMLAVAR PLSTALCSAG TQTRLGTLQP
60 70 80 90 100
ALVLAQVPGR VTQLCRQYSD MPPLTLEGIQ DRVLYVLKLY DKIDPEKLSV
110 120 130 140 150
NSHFMKDLGL DSLDQVEIIM AMEDEFGFEI PDIDAEKLMC PQEIVDYIAD

KKDVYE
Length:156
Mass (Da):17,417
Last modified:July 11, 2002 - v3
Checksum:i0FCE3C3EC6D97AE2
GO

Sequence cautioni

The sequence AAC05814 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132D → Y in AAH58920 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087660 mRNA. Translation: AAD23566.1.
AK311877 mRNA. Translation: BAG34818.1.
AC002400 Genomic DNA. Translation: AAC05814.1. Different initiation.
CH471145 Genomic DNA. Translation: EAW55816.1.
BC058920 mRNA. Translation: AAH58920.1.
CCDSiCCDS10614.1.
PIRiT00741.
RefSeqiNP_004994.1. NM_005003.2.
UniGeneiHs.189716.

Genome annotation databases

EnsembliENST00000007516; ENSP00000007516; ENSG00000004779.
ENST00000570319; ENSP00000458770; ENSG00000004779.
GeneIDi4706.
KEGGihsa:4706.
UCSCiuc002dlw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087660 mRNA. Translation: AAD23566.1.
AK311877 mRNA. Translation: BAG34818.1.
AC002400 Genomic DNA. Translation: AAC05814.1. Different initiation.
CH471145 Genomic DNA. Translation: EAW55816.1.
BC058920 mRNA. Translation: AAH58920.1.
CCDSiCCDS10614.1.
PIRiT00741.
RefSeqiNP_004994.1. NM_005003.2.
UniGeneiHs.189716.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DNWNMR-A71-156[»]
ProteinModelPortaliO14561.
SMRiO14561.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110786. 27 interactors.
IntActiO14561. 10 interactors.
STRINGi9606.ENSP00000007516.

Chemistry databases

ChEMBLiCHEMBL2363065.

PTM databases

iPTMnetiO14561.
PhosphoSitePlusiO14561.
SwissPalmiO14561.

Polymorphism and mutation databases

BioMutaiNDUFAB1.

Proteomic databases

EPDiO14561.
MaxQBiO14561.
PaxDbiO14561.
PeptideAtlasiO14561.
PRIDEiO14561.
TopDownProteomicsiO14561.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000007516; ENSP00000007516; ENSG00000004779.
ENST00000570319; ENSP00000458770; ENSG00000004779.
GeneIDi4706.
KEGGihsa:4706.
UCSCiuc002dlw.4. human.

Organism-specific databases

CTDi4706.
DisGeNETi4706.
GeneCardsiNDUFAB1.
HGNCiHGNC:7694. NDUFAB1.
HPAiHPA054364.
MIMi603836. gene.
neXtProtiNX_O14561.
OpenTargetsiENSG00000004779.
PharmGKBiPA31500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1748. Eukaryota.
COG0236. LUCA.
GeneTreeiENSGT00390000002127.
HOGENOMiHOG000178184.
HOVERGENiHBG024318.
InParanoidiO14561.
KOiK03955.
OMAiDRARINP.
OrthoDBiEOG091G0UIC.
PhylomeDBiO14561.
TreeFamiTF314361.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004779-MONOMER.
ReactomeiR-HSA-389661. Glyoxylate metabolism and glycine degradation.
R-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.
R-HSA-77289. Mitochondrial Fatty Acid Beta-Oxidation.

Miscellaneous databases

ChiTaRSiNDUFAB1. human.
EvolutionaryTraceiO14561.
GenomeRNAii4706.
PROiO14561.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000004779.
CleanExiHS_NDUFAB1.
ExpressionAtlasiO14561. baseline and differential.
GenevisibleiO14561. HS.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier. 1 hit.
InterProiIPR003231. Acyl_carrier.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACPM_HUMAN
AccessioniPrimary (citable) accession number: O14561
Secondary accession number(s): B2R4M1, Q9UNV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 11, 2002
Last modified: November 30, 2016
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.