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O14561

- ACPM_HUMAN

UniProt

O14561 - ACPM_HUMAN

Protein

Acyl carrier protein, mitochondrial

Gene

NDUFAB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain By similarity.By similarity

    GO - Molecular functioni

    1. ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Source: UniProtKB
    2. calcium ion binding Source: UniProtKB
    3. fatty acid binding Source: UniProtKB
    4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. fatty acid biosynthetic process Source: UniProtKB
    3. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
    4. protein lipoylation Source: UniProtKB
    5. respiratory electron transport chain Source: Reactome
    6. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Respiratory chain, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl carrier protein, mitochondrial
    Short name:
    ACP
    Alternative name(s):
    CI-SDAP
    NADH-ubiquinone oxidoreductase 9.6 kDa subunit
    Gene namesi
    Name:NDUFAB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:7694. NDUFAB1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Reactome
    2. mitochondrial matrix Source: UniProtKB
    3. mitochondrial membrane Source: UniProtKB
    4. mitochondrial respiratory chain complex I Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31500.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6868Mitochondrion1 PublicationAdd
    BLAST
    Chaini69 – 15688Acyl carrier protein, mitochondrialPRO_0000000561Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei88 – 881N6-acetyllysineBy similarity
    Modified residuei112 – 1121O-(pantetheine 4'-phosphoryl)serineSequence Analysis

    Keywords - PTMi

    Acetylation, Phosphopantetheine, Phosphoprotein

    Proteomic databases

    MaxQBiO14561.
    PaxDbiO14561.
    PeptideAtlasiO14561.
    PRIDEiO14561.

    PTM databases

    PhosphoSiteiO14561.

    Expressioni

    Gene expression databases

    ArrayExpressiO14561.
    BgeeiO14561.
    CleanExiHS_NDUFAB1.
    GenevestigatoriO14561.

    Organism-specific databases

    HPAiHPA054364.

    Interactioni

    Subunit structurei

    Mammalian complex I is composed of 45 different subunits.1 Publication

    Protein-protein interaction databases

    BioGridi110786. 5 interactions.
    IntActiO14561. 4 interactions.
    STRINGi9606.ENSP00000007516.

    Structurei

    Secondary structure

    1
    156
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi76 – 8914
    Turni95 – 973
    Helixi104 – 1085
    Helixi112 – 12514
    Helixi132 – 1354
    Helixi141 – 15111

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DNWNMR-A71-156[»]
    ProteinModelPortaliO14561.
    SMRiO14561. Positions 69-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14561.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 acyl carrier domain.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0236.
    HOGENOMiHOG000178184.
    HOVERGENiHBG024318.
    InParanoidiO14561.
    KOiK03955.
    OMAiTHLCRQY.
    OrthoDBiEOG77HDGQ.
    PhylomeDBiO14561.
    TreeFamiTF314361.

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    HAMAPiMF_01217. Acyl_carrier.
    InterProiIPR003231. Acyl_carrier.
    IPR009081. Acyl_carrier_prot-like.
    IPR006162. PPantetheine_attach_site.
    [Graphical view]
    PfamiPF00550. PP-binding. 1 hit.
    [Graphical view]
    ProDomiPD000887. PD000887. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47336. SSF47336. 1 hit.
    TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14561-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASRVLSAYV SRLPAAFAPL PRVRMLAVAR PLSTALCSAG TQTRLGTLQP    50
    ALVLAQVPGR VTQLCRQYSD MPPLTLEGIQ DRVLYVLKLY DKIDPEKLSV 100
    NSHFMKDLGL DSLDQVEIIM AMEDEFGFEI PDIDAEKLMC PQEIVDYIAD 150
    KKDVYE 156
    Length:156
    Mass (Da):17,417
    Last modified:July 11, 2002 - v3
    Checksum:i0FCE3C3EC6D97AE2
    GO

    Sequence cautioni

    The sequence AAC05814.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321D → Y in AAH58920. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087660 mRNA. Translation: AAD23566.1.
    AK311877 mRNA. Translation: BAG34818.1.
    AC002400 Genomic DNA. Translation: AAC05814.1. Different initiation.
    CH471145 Genomic DNA. Translation: EAW55816.1.
    BC058920 mRNA. Translation: AAH58920.1.
    CCDSiCCDS10614.1.
    PIRiT00741.
    RefSeqiNP_004994.1. NM_005003.2.
    UniGeneiHs.189716.

    Genome annotation databases

    EnsembliENST00000007516; ENSP00000007516; ENSG00000004779.
    ENST00000570319; ENSP00000458770; ENSG00000004779.
    GeneIDi4706.
    KEGGihsa:4706.
    UCSCiuc002dlw.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087660 mRNA. Translation: AAD23566.1 .
    AK311877 mRNA. Translation: BAG34818.1 .
    AC002400 Genomic DNA. Translation: AAC05814.1 . Different initiation.
    CH471145 Genomic DNA. Translation: EAW55816.1 .
    BC058920 mRNA. Translation: AAH58920.1 .
    CCDSi CCDS10614.1.
    PIRi T00741.
    RefSeqi NP_004994.1. NM_005003.2.
    UniGenei Hs.189716.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DNW NMR - A 71-156 [» ]
    ProteinModelPortali O14561.
    SMRi O14561. Positions 69-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110786. 5 interactions.
    IntActi O14561. 4 interactions.
    STRINGi 9606.ENSP00000007516.

    Chemistry

    ChEMBLi CHEMBL2363065.

    PTM databases

    PhosphoSitei O14561.

    Proteomic databases

    MaxQBi O14561.
    PaxDbi O14561.
    PeptideAtlasi O14561.
    PRIDEi O14561.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000007516 ; ENSP00000007516 ; ENSG00000004779 .
    ENST00000570319 ; ENSP00000458770 ; ENSG00000004779 .
    GeneIDi 4706.
    KEGGi hsa:4706.
    UCSCi uc002dlw.3. human.

    Organism-specific databases

    CTDi 4706.
    GeneCardsi GC16M023592.
    HGNCi HGNC:7694. NDUFAB1.
    HPAi HPA054364.
    MIMi 603836. gene.
    neXtProti NX_O14561.
    PharmGKBi PA31500.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0236.
    HOGENOMi HOG000178184.
    HOVERGENi HBG024318.
    InParanoidi O14561.
    KOi K03955.
    OMAi THLCRQY.
    OrthoDBi EOG77HDGQ.
    PhylomeDBi O14561.
    TreeFami TF314361.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    EvolutionaryTracei O14561.
    GenomeRNAii 4706.
    NextBioi 18148.
    PROi O14561.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14561.
    Bgeei O14561.
    CleanExi HS_NDUFAB1.
    Genevestigatori O14561.

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    HAMAPi MF_01217. Acyl_carrier.
    InterProi IPR003231. Acyl_carrier.
    IPR009081. Acyl_carrier_prot-like.
    IPR006162. PPantetheine_attach_site.
    [Graphical view ]
    Pfami PF00550. PP-binding. 1 hit.
    [Graphical view ]
    ProDomi PD000887. PD000887. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47336. SSF47336. 1 hit.
    TIGRFAMsi TIGR00517. acyl_carrier. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
      Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M.
      Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    6. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
      Xu G., Shin S.B., Jaffrey S.R.
      Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 69-83.
      Tissue: Leukemic T-cell.
    7. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
      Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
      J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Solution structure of RSGI RUH-059, an ACP domain of acyl carrier protein, mitochondrial from human."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 69-156.

    Entry informationi

    Entry nameiACPM_HUMAN
    AccessioniPrimary (citable) accession number: O14561
    Secondary accession number(s): B2R4M1, Q9UNV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 11, 2002
    Last modified: October 1, 2014
    This is version 141 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3