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O14561

- ACPM_HUMAN

UniProt

O14561 - ACPM_HUMAN

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Protein

Acyl carrier protein, mitochondrial

Gene

NDUFAB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain By similarity.By similarity

GO - Molecular functioni

  1. ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Source: UniProtKB
  2. calcium ion binding Source: UniProtKB
  3. fatty acid binding Source: UniProtKB
  4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. fatty acid biosynthetic process Source: UniProtKB
  3. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  4. protein lipoylation Source: UniProtKB
  5. respiratory electron transport chain Source: Reactome
  6. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein, mitochondrial
Short name:
ACP
Alternative name(s):
CI-SDAP
NADH-ubiquinone oxidoreductase 9.6 kDa subunit
Gene namesi
Name:NDUFAB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:7694. NDUFAB1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial matrix Source: UniProtKB
  3. mitochondrial membrane Source: UniProtKB
  4. mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6868Mitochondrion1 PublicationAdd
BLAST
Chaini69 – 15688Acyl carrier protein, mitochondrialPRO_0000000561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei88 – 881N6-acetyllysineBy similarity
Modified residuei112 – 1121O-(pantetheine 4'-phosphoryl)serineSequence Analysis

Keywords - PTMi

Acetylation, Phosphopantetheine, Phosphoprotein

Proteomic databases

MaxQBiO14561.
PaxDbiO14561.
PeptideAtlasiO14561.
PRIDEiO14561.

PTM databases

PhosphoSiteiO14561.

Expressioni

Gene expression databases

BgeeiO14561.
CleanExiHS_NDUFAB1.
ExpressionAtlasiO14561. baseline and differential.
GenevestigatoriO14561.

Organism-specific databases

HPAiHPA054364.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

BioGridi110786. 16 interactions.
IntActiO14561. 4 interactions.
STRINGi9606.ENSP00000007516.

Structurei

Secondary structure

1
156
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi76 – 8914Combined sources
Turni95 – 973Combined sources
Helixi104 – 1085Combined sources
Helixi112 – 12514Combined sources
Helixi132 – 1354Combined sources
Helixi141 – 15111Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DNWNMR-A71-156[»]
ProteinModelPortaliO14561.
SMRiO14561. Positions 69-156.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14561.

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0236.
GeneTreeiENSGT00390000002127.
HOGENOMiHOG000178184.
HOVERGENiHBG024318.
InParanoidiO14561.
KOiK03955.
OMAiTHLCRQY.
OrthoDBiEOG77HDGQ.
PhylomeDBiO14561.
TreeFamiTF314361.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_01217. Acyl_carrier.
InterProiIPR003231. Acyl_carrier.
IPR009081. Acyl_carrier_prot-like.
IPR006162. PPantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
ProDomiPD000887. PD000887. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR00517. acyl_carrier. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14561-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASRVLSAYV SRLPAAFAPL PRVRMLAVAR PLSTALCSAG TQTRLGTLQP
60 70 80 90 100
ALVLAQVPGR VTQLCRQYSD MPPLTLEGIQ DRVLYVLKLY DKIDPEKLSV
110 120 130 140 150
NSHFMKDLGL DSLDQVEIIM AMEDEFGFEI PDIDAEKLMC PQEIVDYIAD

KKDVYE
Length:156
Mass (Da):17,417
Last modified:July 11, 2002 - v3
Checksum:i0FCE3C3EC6D97AE2
GO

Sequence cautioni

The sequence AAC05814.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321D → Y in AAH58920. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087660 mRNA. Translation: AAD23566.1.
AK311877 mRNA. Translation: BAG34818.1.
AC002400 Genomic DNA. Translation: AAC05814.1. Different initiation.
CH471145 Genomic DNA. Translation: EAW55816.1.
BC058920 mRNA. Translation: AAH58920.1.
CCDSiCCDS10614.1.
PIRiT00741.
RefSeqiNP_004994.1. NM_005003.2.
UniGeneiHs.189716.

Genome annotation databases

EnsembliENST00000007516; ENSP00000007516; ENSG00000004779.
ENST00000570319; ENSP00000458770; ENSG00000004779.
GeneIDi4706.
KEGGihsa:4706.
UCSCiuc002dlw.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087660 mRNA. Translation: AAD23566.1 .
AK311877 mRNA. Translation: BAG34818.1 .
AC002400 Genomic DNA. Translation: AAC05814.1 . Different initiation.
CH471145 Genomic DNA. Translation: EAW55816.1 .
BC058920 mRNA. Translation: AAH58920.1 .
CCDSi CCDS10614.1.
PIRi T00741.
RefSeqi NP_004994.1. NM_005003.2.
UniGenei Hs.189716.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DNW NMR - A 71-156 [» ]
ProteinModelPortali O14561.
SMRi O14561. Positions 69-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110786. 16 interactions.
IntActi O14561. 4 interactions.
STRINGi 9606.ENSP00000007516.

Chemistry

ChEMBLi CHEMBL2363065.

PTM databases

PhosphoSitei O14561.

Proteomic databases

MaxQBi O14561.
PaxDbi O14561.
PeptideAtlasi O14561.
PRIDEi O14561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000007516 ; ENSP00000007516 ; ENSG00000004779 .
ENST00000570319 ; ENSP00000458770 ; ENSG00000004779 .
GeneIDi 4706.
KEGGi hsa:4706.
UCSCi uc002dlw.3. human.

Organism-specific databases

CTDi 4706.
GeneCardsi GC16M023592.
HGNCi HGNC:7694. NDUFAB1.
HPAi HPA054364.
MIMi 603836. gene.
neXtProti NX_O14561.
PharmGKBi PA31500.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0236.
GeneTreei ENSGT00390000002127.
HOGENOMi HOG000178184.
HOVERGENi HBG024318.
InParanoidi O14561.
KOi K03955.
OMAi THLCRQY.
OrthoDBi EOG77HDGQ.
PhylomeDBi O14561.
TreeFami TF314361.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTracei O14561.
GenomeRNAii 4706.
NextBioi 18148.
PROi O14561.
SOURCEi Search...

Gene expression databases

Bgeei O14561.
CleanExi HS_NDUFAB1.
ExpressionAtlasi O14561. baseline and differential.
Genevestigatori O14561.

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
HAMAPi MF_01217. Acyl_carrier.
InterProi IPR003231. Acyl_carrier.
IPR009081. Acyl_carrier_prot-like.
IPR006162. PPantetheine_attach_site.
[Graphical view ]
Pfami PF00550. PP-binding. 1 hit.
[Graphical view ]
ProDomi PD000887. PD000887. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF47336. SSF47336. 1 hit.
TIGRFAMsi TIGR00517. acyl_carrier. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
    Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M.
    Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
    Xu G., Shin S.B., Jaffrey S.R.
    Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 69-83.
    Tissue: Leukemic T-cell.
  7. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
    Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
    J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Solution structure of RSGI RUH-059, an ACP domain of acyl carrier protein, mitochondrial from human."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 69-156.

Entry informationi

Entry nameiACPM_HUMAN
AccessioniPrimary (citable) accession number: O14561
Secondary accession number(s): B2R4M1, Q9UNV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 11, 2002
Last modified: October 29, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3