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Protein

Rho GTPase-activating protein 33

Gene

ARHGAP33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004777-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
SIGNORiO14559.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 33
Alternative name(s):
Rho-type GTPase-activating protein 33
Sorting nexin-26
Tc10/CDC42 GTPase-activating protein
Gene namesi
Name:ARHGAP33
Synonyms:SNX26, TCGAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23085. ARHGAP33.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000004777.
PharmGKBiPA165393003.

Polymorphism and mutation databases

BioMutaiARHGAP33.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567211 – 1287Rho GTPase-activating protein 33Add BLAST1287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei570PhosphoserineBy similarity1
Modified residuei636PhosphoserineCombined sources1
Modified residuei727PhosphoserineBy similarity1
Modified residuei1169PhosphotyrosineBy similarity1
Modified residuei1244Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiO14559.
PaxDbiO14559.
PeptideAtlasiO14559.
PRIDEiO14559.

PTM databases

iPTMnetiO14559.
PhosphoSitePlusiO14559.

Expressioni

Gene expression databases

BgeeiENSG00000004777.
CleanExiHS_SNX26.
ExpressionAtlasiO14559. baseline and differential.
GenevisibleiO14559. HS.

Organism-specific databases

HPAiHPA030117.
HPA030118.

Interactioni

Subunit structurei

Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain (By similarity). Interacts with NEK6.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FYNP062412EBI-1210010,EBI-515315

Protein-protein interaction databases

BioGridi125448. 2 interactors.
IntActiO14559. 2 interactors.
STRINGi9606.ENSP00000320038.

Structurei

3D structure databases

ProteinModelPortaliO14559.
SMRiO14559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 168PX; atypicalAdd BLAST110
Domaini186 – 248SH3PROSITE-ProRule annotationAdd BLAST63
Domaini315 – 510Rho-GAPPROSITE-ProRule annotationAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi126 – 129Poly-Pro4
Compositional biasi677 – 699Poly-SerAdd BLAST23
Compositional biasi874 – 879Poly-Pro6
Compositional biasi889 – 893Poly-Pro5
Compositional biasi1006 – 1009Poly-Gly4
Compositional biasi1183 – 1188Poly-Ser6
Compositional biasi1266 – 1273Poly-Pro8

Sequence similaritiesi

Belongs to the PX domain-containing GAP family.Curated
Contains 1 PX (phox homology) domain.Curated
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG1449. Eukaryota.
ENOG41112VR. LUCA.
GeneTreeiENSGT00840000129752.
HOGENOMiHOG000154522.
HOVERGENiHBG079688.
InParanoidiO14559.
KOiK17933.
OMAiCQQEISS.
OrthoDBiEOG091G02IN.
PhylomeDBiO14559.
TreeFamiTF351451.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14559-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVARSTDSLD GPGEGSVQPL PTAGGPSVKG KPGKRLSAPR GPFPRLADCA
60 70 80 90 100
HFHYENVDFG HIQLLLSPDR EGPSLSGENE LVFGVQVTCQ GRSWPVLRSY
110 120 130 140 150
DDFRSLDAHL HRCIFDRRFS CLPELPPPPE GARAAQMLVP LLLQYLETLS
160 170 180 190 200
GLVDSNLNCG PVLTWMELDN HGRRLLLSEE ASLNIPAVAA AHVIKRYTAQ
210 220 230 240 250
APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS ECVELFTERP
260 270 280 290 300
GPGLKADADG PPCGIPAPQG ISSLTSAVPR PRGKLAGLLR TFMRSRPSRQ
310 320 330 340 350
RLRQRGILRQ RVFGCDLGEH LSNSGQDVPQ VLRCCSEFIE AHGVVDGIYR
360 370 380 390 400
LSGVSSNIQR LRHEFDSERI PELSGPAFLQ DIHSVSSLCK LYFRELPNPL
410 420 430 440 450
LTYQLYGKFS EAMSVPGEEE RLVRVHDVIQ QLPPPHYRTL EYLLRHLARM
460 470 480 490 500
ARHSANTSMH ARNLAIVWAP NLLRSMELES VGMGGAAAFR EVRVQSVVVE
510 520 530 540 550
FLLTHVDVLF SDTFTSAGLD PAGRCLLPRP KSLAGSCPST RLLTLEEAQA
560 570 580 590 600
RTQGRLGTPT EPTTPKAPAS PAERRKGERG EKQRKPGGSS WKTFFALGRG
610 620 630 640 650
PSVPRKKPLP WLGGTRAPPQ PSGSRPDTVT LRSAKSEESL SSQASGAGLQ
660 670 680 690 700
RLHRLRRPHS SSDAFPVGPA PAGSCESLSS SSSSESSSSE SSSSSSESSA
710 720 730 740 750
AGLGALSGSP SHRTSAWLDD GDELDFSPPR CLEGLRGLDF DPLTFRCSSP
760 770 780 790 800
TPGDPAPPAS PAPPAPASAF PPRVTPQAIS PRGPTSPASP AALDISEPLA
810 820 830 840 850
VSVPPAVLEL LGAGGAPASA TPTPALSPGR SLRPHLIPLL LRGAEAPLTD
860 870 880 890 900
ACQQEMCSKL RGAQGPLGPD MESPLPPPPL SLLRPGGAPP PPPKNPARLM
910 920 930 940 950
ALALAERAQQ VAEQQSQQEC GGTPPASQSP FHRSLSLEVG GEPLGTSGSG
960 970 980 990 1000
PPPNSLAHPG AWVPGPPPYL PRQQSDGSLL RSQRPMGTSR RGLRGPAQVS
1010 1020 1030 1040 1050
AQLRAGGGGR DAPEAAAQSP CSVPSQVPTP GFFSPAPREC LPPFLGVPKP
1060 1070 1080 1090 1100
GLYPLGPPSF QPSSPAPVWR SSLGPPAPLD RGENLYYEIG ASEGSPYSGP
1110 1120 1130 1140 1150
TRSWSPFRSM PPDRLNASYG MLGQSPPLHR SPDFLLSYPP APSCFPPDHL
1160 1170 1180 1190 1200
GYSAPQHPAR RPTPPEPLYV NLALGPRGPS PASSSSSSPP AHPRSRSDPG
1210 1220 1230 1240 1250
PPVPRLPQKQ RAPWGPRTPH RVPGPWGPPE PLLLYRAAPP AYGRGGELHR
1260 1270 1280
GSLYRNGGQR GEGAGPPPPY PTPSWSLHSE GQTRSYC
Note: No experimental confirmation available.
Length:1,287
Mass (Da):137,213
Last modified:July 5, 2005 - v2
Checksum:i802900F18B640DC0
GO
Isoform 2 (identifier: O14559-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.
     998-1025: Missing.

Show »
Length:1,123
Mass (Da):119,780
Checksum:i995F8936B26AF59F
GO
Isoform 3 (identifier: O14559-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     648-808: Missing.

Show »
Length:1,126
Mass (Da):121,066
Checksum:i53E7DA764B6C1919
GO
Isoform 4 (identifier: O14559-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MV → MLSLSLCSHLWGPLILSALQ
     168-228: LDNHGRRLLL...PPTEDRSWWR → VGLGRGLGDS...SLWVGESWDM
     229-1287: Missing.

Show »
Length:246
Mass (Da):26,858
Checksum:i88093F56B6055CEA
GO

Sequence cautioni

The sequence AAB81198 differs from that shown. Reason: Erroneous gene model prediction.Curated
Isoform 2 : The sequence BAC86902 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119F → S in AK096338 (PubMed:14702039).Curated1
Sequence conflicti1100P → L in CAB70821 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0142871 – 136Missing in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_0142881 – 2MV → MLSLSLCSHLWGPLILSALQ in isoform 4. 1 Publication2
Alternative sequenceiVSP_014289168 – 228LDNHG…RSWWR → VGLGRGLGDSEWVRGCVCHH AQHREILDGNRVASAVEDEG AEVDGEAFRWGSLWVGESWD M in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_014290229 – 1287Missing in isoform 4. 1 PublicationAdd BLAST1059
Alternative sequenceiVSP_014291648 – 808Missing in isoform 3. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_014292998 – 1025Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044864 mRNA. Translation: AAK97795.1.
AK096338 mRNA. No translation available.
AK127255 mRNA. Translation: BAC86902.1. Frameshift.
AC002398 Genomic DNA. Translation: AAB81197.1.
AC002398 Genomic DNA. Translation: AAB81198.1. Sequence problems.
AL137579 mRNA. Translation: CAB70821.1.
BC014084 mRNA. Translation: AAH14084.2.
CCDSiCCDS12477.1. [O14559-11]
CCDS54254.1. [O14559-10]
PIRiT00704.
T00705.
T46289.
RefSeqiNP_001166101.1. NM_001172630.1. [O14559-10]
NP_443180.2. NM_052948.3. [O14559-11]
XP_005258545.1. XM_005258488.1. [O14559-1]
XP_011524721.1. XM_011526419.1. [O14559-10]
UniGeneiHs.515364.

Genome annotation databases

EnsembliENST00000314737; ENSP00000320038; ENSG00000004777. [O14559-11]
ENST00000378944; ENSP00000368227; ENSG00000004777. [O14559-10]
GeneIDi115703.
KEGGihsa:115703.
UCSCiuc002obs.3. human. [O14559-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044864 mRNA. Translation: AAK97795.1.
AK096338 mRNA. No translation available.
AK127255 mRNA. Translation: BAC86902.1. Frameshift.
AC002398 Genomic DNA. Translation: AAB81197.1.
AC002398 Genomic DNA. Translation: AAB81198.1. Sequence problems.
AL137579 mRNA. Translation: CAB70821.1.
BC014084 mRNA. Translation: AAH14084.2.
CCDSiCCDS12477.1. [O14559-11]
CCDS54254.1. [O14559-10]
PIRiT00704.
T00705.
T46289.
RefSeqiNP_001166101.1. NM_001172630.1. [O14559-10]
NP_443180.2. NM_052948.3. [O14559-11]
XP_005258545.1. XM_005258488.1. [O14559-1]
XP_011524721.1. XM_011526419.1. [O14559-10]
UniGeneiHs.515364.

3D structure databases

ProteinModelPortaliO14559.
SMRiO14559.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125448. 2 interactors.
IntActiO14559. 2 interactors.
STRINGi9606.ENSP00000320038.

PTM databases

iPTMnetiO14559.
PhosphoSitePlusiO14559.

Polymorphism and mutation databases

BioMutaiARHGAP33.

Proteomic databases

MaxQBiO14559.
PaxDbiO14559.
PeptideAtlasiO14559.
PRIDEiO14559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314737; ENSP00000320038; ENSG00000004777. [O14559-11]
ENST00000378944; ENSP00000368227; ENSG00000004777. [O14559-10]
GeneIDi115703.
KEGGihsa:115703.
UCSCiuc002obs.3. human. [O14559-1]

Organism-specific databases

CTDi115703.
GeneCardsiARHGAP33.
HGNCiHGNC:23085. ARHGAP33.
HPAiHPA030117.
HPA030118.
MIMi614902. gene.
neXtProtiNX_O14559.
OpenTargetsiENSG00000004777.
PharmGKBiPA165393003.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1449. Eukaryota.
ENOG41112VR. LUCA.
GeneTreeiENSGT00840000129752.
HOGENOMiHOG000154522.
HOVERGENiHBG079688.
InParanoidiO14559.
KOiK17933.
OMAiCQQEISS.
OrthoDBiEOG091G02IN.
PhylomeDBiO14559.
TreeFamiTF351451.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004777-MONOMER.
ReactomeiR-HSA-194840. Rho GTPase cycle.
SIGNORiO14559.

Miscellaneous databases

GeneWikiiSNX26.
GenomeRNAii115703.
PROiO14559.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000004777.
CleanExiHS_SNX26.
ExpressionAtlasiO14559. baseline and differential.
GenevisibleiO14559. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHG33_HUMAN
AccessioniPrimary (citable) accession number: O14559
Secondary accession number(s): O14552
, O14560, Q6ZSP6, Q96CP3, Q9NT23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 5, 2005
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.