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O14559

- RHG33_HUMAN

UniProt

O14559 - RHG33_HUMAN

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Protein

Rho GTPase-activating protein 33

Gene
ARHGAP33, SNX26, TCGAP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport By similarity.

GO - Molecular functioni

  1. phosphatidylinositol binding Source: InterPro
  2. protein binding Source: IntAct
  3. Rac GTPase activator activity Source: Ensembl

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. regulation of small GTPase mediated signal transduction Source: Reactome
  3. small GTPase mediated signal transduction Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 33
Alternative name(s):
Rho-type GTPase-activating protein 33
Sorting nexin-26
Tc10/CDC42 GTPase-activating protein
Gene namesi
Synonyms:SNX26, TCGAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23085. ARHGAP33.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165393003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12871287Rho GTPase-activating protein 33PRO_0000056721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei570 – 5701Phosphoserine By similarity
Modified residuei636 – 6361Phosphoserine1 Publication
Modified residuei1169 – 11691Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO14559.
PRIDEiO14559.

PTM databases

PhosphoSiteiO14559.

Expressioni

Gene expression databases

ArrayExpressiO14559.
BgeeiO14559.
CleanExiHS_SNX26.
GenevestigatoriO14559.

Organism-specific databases

HPAiHPA030117.
HPA030118.

Interactioni

Subunit structurei

Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain By similarity. Interacts with NEK6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FYNP062412EBI-1210010,EBI-515315

Protein-protein interaction databases

BioGridi125448. 2 interactions.
IntActiO14559. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO14559.
SMRiO14559. Positions 197-248, 311-511.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 168110PX; atypicalAdd
BLAST
Domaini186 – 24863SH3Add
BLAST
Domaini315 – 510196Rho-GAPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi126 – 1294Poly-Pro
Compositional biasi677 – 69923Poly-SerAdd
BLAST
Compositional biasi874 – 8796Poly-Pro
Compositional biasi889 – 8935Poly-Pro
Compositional biasi1006 – 10094Poly-Gly
Compositional biasi1183 – 11886Poly-Ser
Compositional biasi1266 – 12738Poly-Pro

Sequence similaritiesi

Contains 1 Rho-GAP domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG311367.
HOGENOMiHOG000154522.
HOVERGENiHBG079688.
InParanoidiO14559.
KOiK17933.
OMAiCFPPDHL.
OrthoDBiEOG7WMCHV.
PhylomeDBiO14559.
TreeFamiTF351451.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR001683. Phox.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O14559-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVARSTDSLD GPGEGSVQPL PTAGGPSVKG KPGKRLSAPR GPFPRLADCA     50
HFHYENVDFG HIQLLLSPDR EGPSLSGENE LVFGVQVTCQ GRSWPVLRSY 100
DDFRSLDAHL HRCIFDRRFS CLPELPPPPE GARAAQMLVP LLLQYLETLS 150
GLVDSNLNCG PVLTWMELDN HGRRLLLSEE ASLNIPAVAA AHVIKRYTAQ 200
APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS ECVELFTERP 250
GPGLKADADG PPCGIPAPQG ISSLTSAVPR PRGKLAGLLR TFMRSRPSRQ 300
RLRQRGILRQ RVFGCDLGEH LSNSGQDVPQ VLRCCSEFIE AHGVVDGIYR 350
LSGVSSNIQR LRHEFDSERI PELSGPAFLQ DIHSVSSLCK LYFRELPNPL 400
LTYQLYGKFS EAMSVPGEEE RLVRVHDVIQ QLPPPHYRTL EYLLRHLARM 450
ARHSANTSMH ARNLAIVWAP NLLRSMELES VGMGGAAAFR EVRVQSVVVE 500
FLLTHVDVLF SDTFTSAGLD PAGRCLLPRP KSLAGSCPST RLLTLEEAQA 550
RTQGRLGTPT EPTTPKAPAS PAERRKGERG EKQRKPGGSS WKTFFALGRG 600
PSVPRKKPLP WLGGTRAPPQ PSGSRPDTVT LRSAKSEESL SSQASGAGLQ 650
RLHRLRRPHS SSDAFPVGPA PAGSCESLSS SSSSESSSSE SSSSSSESSA 700
AGLGALSGSP SHRTSAWLDD GDELDFSPPR CLEGLRGLDF DPLTFRCSSP 750
TPGDPAPPAS PAPPAPASAF PPRVTPQAIS PRGPTSPASP AALDISEPLA 800
VSVPPAVLEL LGAGGAPASA TPTPALSPGR SLRPHLIPLL LRGAEAPLTD 850
ACQQEMCSKL RGAQGPLGPD MESPLPPPPL SLLRPGGAPP PPPKNPARLM 900
ALALAERAQQ VAEQQSQQEC GGTPPASQSP FHRSLSLEVG GEPLGTSGSG 950
PPPNSLAHPG AWVPGPPPYL PRQQSDGSLL RSQRPMGTSR RGLRGPAQVS 1000
AQLRAGGGGR DAPEAAAQSP CSVPSQVPTP GFFSPAPREC LPPFLGVPKP 1050
GLYPLGPPSF QPSSPAPVWR SSLGPPAPLD RGENLYYEIG ASEGSPYSGP 1100
TRSWSPFRSM PPDRLNASYG MLGQSPPLHR SPDFLLSYPP APSCFPPDHL 1150
GYSAPQHPAR RPTPPEPLYV NLALGPRGPS PASSSSSSPP AHPRSRSDPG 1200
PPVPRLPQKQ RAPWGPRTPH RVPGPWGPPE PLLLYRAAPP AYGRGGELHR 1250
GSLYRNGGQR GEGAGPPPPY PTPSWSLHSE GQTRSYC 1287

Note: No experimental confirmation available.

Length:1,287
Mass (Da):137,213
Last modified:July 5, 2005 - v2
Checksum:i802900F18B640DC0
GO
Isoform 2 (identifier: O14559-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.
     998-1025: Missing.

Show »
Length:1,123
Mass (Da):119,780
Checksum:i995F8936B26AF59F
GO
Isoform 3 (identifier: O14559-11) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     648-808: Missing.

Show »
Length:1,126
Mass (Da):121,066
Checksum:i53E7DA764B6C1919
GO
Isoform 4 (identifier: O14559-12) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MV → MLSLSLCSHLWGPLILSALQ
     168-228: LDNHGRRLLL...PPTEDRSWWR → VGLGRGLGDS...SLWVGESWDM
     229-1287: Missing.

Show »
Length:246
Mass (Da):26,858
Checksum:i88093F56B6055CEA
GO

Sequence cautioni

Isoform 2 : The sequence BAC86902.1 differs from that shown. Reason: Frameshift at several positions.
The sequence AAB81198.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 136136Missing in isoform 2. VSP_014287Add
BLAST
Alternative sequencei1 – 22MV → MLSLSLCSHLWGPLILSALQ in isoform 4. VSP_014288
Alternative sequencei168 – 22861LDNHG…RSWWR → VGLGRGLGDSEWVRGCVCHH AQHREILDGNRVASAVEDEG AEVDGEAFRWGSLWVGESWD M in isoform 4. VSP_014289Add
BLAST
Alternative sequencei229 – 12871059Missing in isoform 4. VSP_014290Add
BLAST
Alternative sequencei648 – 808161Missing in isoform 3. VSP_014291Add
BLAST
Alternative sequencei998 – 102528Missing in isoform 2. VSP_014292Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191F → S in AK096338. 1 Publication
Sequence conflicti1100 – 11001P → L in CAB70821. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY044864 mRNA. Translation: AAK97795.1.
AK096338 mRNA. No translation available.
AK127255 mRNA. Translation: BAC86902.1. Frameshift.
AC002398 Genomic DNA. Translation: AAB81197.1.
AC002398 Genomic DNA. Translation: AAB81198.1. Sequence problems.
AL137579 mRNA. Translation: CAB70821.1.
BC014084 mRNA. Translation: AAH14084.2.
CCDSiCCDS12477.1. [O14559-11]
CCDS54254.1. [O14559-10]
PIRiT00704.
T00705.
T46289.
RefSeqiNP_001166101.1. NM_001172630.1. [O14559-10]
NP_443180.2. NM_052948.3. [O14559-11]
XP_005258545.1. XM_005258488.1. [O14559-1]
UniGeneiHs.515364.

Genome annotation databases

EnsembliENST00000007510; ENSP00000007510; ENSG00000004777. [O14559-1]
ENST00000314737; ENSP00000320038; ENSG00000004777. [O14559-11]
ENST00000378944; ENSP00000368227; ENSG00000004777. [O14559-10]
GeneIDi115703.
KEGGihsa:115703.
UCSCiuc002obr.2. human. [O14559-1]
uc002obs.2. human. [O14559-11]
uc002obt.2. human. [O14559-10]
uc010eek.2. human. [O14559-12]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY044864 mRNA. Translation: AAK97795.1 .
AK096338 mRNA. No translation available.
AK127255 mRNA. Translation: BAC86902.1 . Frameshift.
AC002398 Genomic DNA. Translation: AAB81197.1 .
AC002398 Genomic DNA. Translation: AAB81198.1 . Sequence problems.
AL137579 mRNA. Translation: CAB70821.1 .
BC014084 mRNA. Translation: AAH14084.2 .
CCDSi CCDS12477.1. [O14559-11 ]
CCDS54254.1. [O14559-10 ]
PIRi T00704.
T00705.
T46289.
RefSeqi NP_001166101.1. NM_001172630.1. [O14559-10 ]
NP_443180.2. NM_052948.3. [O14559-11 ]
XP_005258545.1. XM_005258488.1. [O14559-1 ]
UniGenei Hs.515364.

3D structure databases

ProteinModelPortali O14559.
SMRi O14559. Positions 197-248, 311-511.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125448. 2 interactions.
IntActi O14559. 2 interactions.

PTM databases

PhosphoSitei O14559.

Proteomic databases

PaxDbi O14559.
PRIDEi O14559.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000007510 ; ENSP00000007510 ; ENSG00000004777 . [O14559-1 ]
ENST00000314737 ; ENSP00000320038 ; ENSG00000004777 . [O14559-11 ]
ENST00000378944 ; ENSP00000368227 ; ENSG00000004777 . [O14559-10 ]
GeneIDi 115703.
KEGGi hsa:115703.
UCSCi uc002obr.2. human. [O14559-1 ]
uc002obs.2. human. [O14559-11 ]
uc002obt.2. human. [O14559-10 ]
uc010eek.2. human. [O14559-12 ]

Organism-specific databases

CTDi 115703.
GeneCardsi GC19P036266.
HGNCi HGNC:23085. ARHGAP33.
HPAi HPA030117.
HPA030118.
MIMi 614902. gene.
neXtProti NX_O14559.
PharmGKBi PA165393003.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311367.
HOGENOMi HOG000154522.
HOVERGENi HBG079688.
InParanoidi O14559.
KOi K17933.
OMAi CFPPDHL.
OrthoDBi EOG7WMCHV.
PhylomeDBi O14559.
TreeFami TF351451.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.

Miscellaneous databases

GeneWikii SNX26.
GenomeRNAii 115703.
NextBioi 79650.
PROi O14559.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14559.
Bgeei O14559.
CleanExi HS_SNX26.
Genevestigatori O14559.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR001683. Phox.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel member (SNX26) of the sorting nexin family."
    Hong W.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Hippocampus.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 426-1287.
    Tissue: Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 993-1287.
    Tissue: Pancreas.
  6. "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
    Vaz Meirelles G., Ferreira Lanza D.C., da Silva J.C., Santana Bernachi J., Paes Leme A.F., Kobarg J.
    J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NEK6.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-636, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRHG33_HUMAN
AccessioniPrimary (citable) accession number: O14559
Secondary accession number(s): O14552
, O14560, Q6ZSP6, Q96CP3, Q9NT23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi