O14559 (RHG33_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho GTPase-activating protein 33

Alternative name(s):
Rho-type GTPase-activating protein 33
Sorting nexin-26
Tc10/CDC42 GTPase-activating protein

Gene names

Name:	ARHGAP33
Synonyms:	SNX26, TCGAP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1287 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport By similarity.
Subunit structure	Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain By similarity. Interacts with NEK6. Ref.6
Sequence similarities	Belongs to the PX domain-containing GAP family. Contains 1 PX (phox homology) domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain.
Sequence caution	The sequence AAB81198.1 differs from that shown. Reason: Erroneous gene model prediction. Isoform 2: The sequence BAC86902.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Biological process	Protein transport Transport
Coding sequence diversity	Alternative splicing
Domain	SH3 domain
Molecular function	GTPase activation
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	Rac GTPase activator activity Inferred from electronic annotation. Source: Compara phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FYN	P06241	2	EBI-1210010,EBI-515315

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14559-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: O14559-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.
     998-1025: Missing.

Isoform 3 (identifier: O14559-11)

The sequence of this isoform differs from the canonical sequence as follows:
     648-808: Missing.

Isoform 4 (identifier: O14559-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MV → MLSLSLCSHLWGPLILSALQ
     168-228: LDNHGRRLLL...PPTEDRSWWR → VGLGRGLGDS...SLWVGESWDM
     229-1287: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1287	1287	Rho GTPase-activating protein 33		PRO_0000056721
Regions
	Domain	59 – 168	110	PX; atypical
	Domain	186 – 248	63	SH3
	Domain	315 – 510	196	Rho-GAP
	Compositional bias	126 – 129	4	Poly-Pro
	Compositional bias	677 – 699	23	Poly-Ser
	Compositional bias	874 – 879	6	Poly-Pro
	Compositional bias	889 – 893	5	Poly-Pro
	Compositional bias	1006 – 1009	4	Poly-Gly
	Compositional bias	1183 – 1188	6	Poly-Ser
	Compositional bias	1266 – 1273	8	Poly-Pro
Amino acid modifications
	Modified residue	570	1	Phosphoserine By similarity
	Modified residue	636	1	Phosphoserine Ref.7
	Modified residue	1169	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	1 – 136	136	Missing in isoform 2.		VSP_014287
	Alternative sequence	1 – 2	2	MV → MLSLSLCSHLWGPLILSALQ in isoform 4.		VSP_014288
	Alternative sequence	168 – 228	61	LDNHG…RSWWR → VGLGRGLGDSEWVRGCVCHH AQHREILDGNRVASAVEDEG AEVDGEAFRWGSLWVGESWD M in isoform 4.		VSP_014289
	Alternative sequence	229 – 1287	1059	Missing in isoform 4.		VSP_014290
	Alternative sequence	648 – 808	161	Missing in isoform 3.		VSP_014291
	Alternative sequence	998 – 1025	28	Missing in isoform 2.		VSP_014292
Experimental info
	Sequence conflict	119	1	F → S in AK096338. Ref.2
	Sequence conflict	1100	1	P → L in CAB70821. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: 802900F18B640DC0	FASTA	1,287	137,213
	10 20 30 40 50 60 MVARSTDSLD GPGEGSVQPL PTAGGPSVKG KPGKRLSAPR GPFPRLADCA HFHYENVDFG 70 80 90 100 110 120 HIQLLLSPDR EGPSLSGENE LVFGVQVTCQ GRSWPVLRSY DDFRSLDAHL HRCIFDRRFS 130 140 150 160 170 180 CLPELPPPPE GARAAQMLVP LLLQYLETLS GLVDSNLNCG PVLTWMELDN HGRRLLLSEE 190 200 210 220 230 240 ASLNIPAVAA AHVIKRYTAQ APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS 250 260 270 280 290 300 ECVELFTERP GPGLKADADG PPCGIPAPQG ISSLTSAVPR PRGKLAGLLR TFMRSRPSRQ 310 320 330 340 350 360 RLRQRGILRQ RVFGCDLGEH LSNSGQDVPQ VLRCCSEFIE AHGVVDGIYR LSGVSSNIQR 370 380 390 400 410 420 LRHEFDSERI PELSGPAFLQ DIHSVSSLCK LYFRELPNPL LTYQLYGKFS EAMSVPGEEE 430 440 450 460 470 480 RLVRVHDVIQ QLPPPHYRTL EYLLRHLARM ARHSANTSMH ARNLAIVWAP NLLRSMELES 490 500 510 520 530 540 VGMGGAAAFR EVRVQSVVVE FLLTHVDVLF SDTFTSAGLD PAGRCLLPRP KSLAGSCPST 550 560 570 580 590 600 RLLTLEEAQA RTQGRLGTPT EPTTPKAPAS PAERRKGERG EKQRKPGGSS WKTFFALGRG 610 620 630 640 650 660 PSVPRKKPLP WLGGTRAPPQ PSGSRPDTVT LRSAKSEESL SSQASGAGLQ RLHRLRRPHS 670 680 690 700 710 720 SSDAFPVGPA PAGSCESLSS SSSSESSSSE SSSSSSESSA AGLGALSGSP SHRTSAWLDD 730 740 750 760 770 780 GDELDFSPPR CLEGLRGLDF DPLTFRCSSP TPGDPAPPAS PAPPAPASAF PPRVTPQAIS 790 800 810 820 830 840 PRGPTSPASP AALDISEPLA VSVPPAVLEL LGAGGAPASA TPTPALSPGR SLRPHLIPLL 850 860 870 880 890 900 LRGAEAPLTD ACQQEMCSKL RGAQGPLGPD MESPLPPPPL SLLRPGGAPP PPPKNPARLM 910 920 930 940 950 960 ALALAERAQQ VAEQQSQQEC GGTPPASQSP FHRSLSLEVG GEPLGTSGSG PPPNSLAHPG 970 980 990 1000 1010 1020 AWVPGPPPYL PRQQSDGSLL RSQRPMGTSR RGLRGPAQVS AQLRAGGGGR DAPEAAAQSP 1030 1040 1050 1060 1070 1080 CSVPSQVPTP GFFSPAPREC LPPFLGVPKP GLYPLGPPSF QPSSPAPVWR SSLGPPAPLD 1090 1100 1110 1120 1130 1140 RGENLYYEIG ASEGSPYSGP TRSWSPFRSM PPDRLNASYG MLGQSPPLHR SPDFLLSYPP 1150 1160 1170 1180 1190 1200 APSCFPPDHL GYSAPQHPAR RPTPPEPLYV NLALGPRGPS PASSSSSSPP AHPRSRSDPG 1210 1220 1230 1240 1250 1260 PPVPRLPQKQ RAPWGPRTPH RVPGPWGPPE PLLLYRAAPP AYGRGGELHR GSLYRNGGQR 1270 1280 GEGAGPPPPY PTPSWSLHSE GQTRSYC
	Isoform 2 [UniParc]. Checksum: 995F8936B26AF59F	FASTA	1,123	119,780
	10 20 30 40 50 60 MLVPLLLQYL ETLSGLVDSN LNCGPVLTWM ELDNHGRRLL LSEEASLNIP AVAAAHVIKR 70 80 90 100 110 120 YTAQAPDELS FEVGDIVSVI DMPPTEDRSW WRGKRGFQVG FFPSECVELF TERPGPGLKA 130 140 150 160 170 180 DADGPPCGIP APQGISSLTS AVPRPRGKLA GLLRTFMRSR PSRQRLRQRG ILRQRVFGCD 190 200 210 220 230 240 LGEHLSNSGQ DVPQVLRCCS EFIEAHGVVD GIYRLSGVSS NIQRLRHEFD SERIPELSGP 250 260 270 280 290 300 AFLQDIHSVS SLCKLYFREL PNPLLTYQLY GKFSEAMSVP GEEERLVRVH DVIQQLPPPH 310 320 330 340 350 360 YRTLEYLLRH LARMARHSAN TSMHARNLAI VWAPNLLRSM ELESVGMGGA AAFREVRVQS 370 380 390 400 410 420 VVVEFLLTHV DVLFSDTFTS AGLDPAGRCL LPRPKSLAGS CPSTRLLTLE EAQARTQGRL 430 440 450 460 470 480 GTPTEPTTPK APASPAERRK GERGEKQRKP GGSSWKTFFA LGRGPSVPRK KPLPWLGGTR 490 500 510 520 530 540 APPQPSGSRP DTVTLRSAKS EESLSSQASG AGLQRLHRLR RPHSSSDAFP VGPAPAGSCE 550 560 570 580 590 600 SLSSSSSSES SSSESSSSSS ESSAAGLGAL SGSPSHRTSA WLDDGDELDF SPPRCLEGLR 610 620 630 640 650 660 GLDFDPLTFR CSSPTPGDPA PPASPAPPAP ASAFPPRVTP QAISPRGPTS PASPAALDIS 670 680 690 700 710 720 EPLAVSVPPA VLELLGAGGA PASATPTPAL SPGRSLRPHL IPLLLRGAEA PLTDACQQEM 730 740 750 760 770 780 CSKLRGAQGP LGPDMESPLP PPPLSLLRPG GAPPPPPKNP ARLMALALAE RAQQVAEQQS 790 800 810 820 830 840 QQECGGTPPA SQSPFHRSLS LEVGGEPLGT SGSGPPPNSL AHPGAWVPGP PPYLPRQQSD 850 860 870 880 890 900 GSLLRSQRPM GTSRRGLRGP AQVPTPGFFS PAPRECLPPF LGVPKPGLYP LGPPSFQPSS 910 920 930 940 950 960 PAPVWRSSLG PPAPLDRGEN LYYEIGASEG SPYSGPTRSW SPFRSMPPDR LNASYGMLGQ 970 980 990 1000 1010 1020 SPPLHRSPDF LLSYPPAPSC FPPDHLGYSA PQHPARRPTP PEPLYVNLAL GPRGPSPASS 1030 1040 1050 1060 1070 1080 SSSSPPAHPR SRSDPGPPVP RLPQKQRAPW GPRTPHRVPG PWGPPEPLLL YRAAPPAYGR 1090 1100 1110 1120 GGELHRGSLY RNGGQRGEGA GPPPPYPTPS WSLHSEGQTR SYC
	Isoform 3 [UniParc]. Checksum: 53E7DA764B6C1919	FASTA	1,126	121,066
	10 20 30 40 50 60 MVARSTDSLD GPGEGSVQPL PTAGGPSVKG KPGKRLSAPR GPFPRLADCA HFHYENVDFG 70 80 90 100 110 120 HIQLLLSPDR EGPSLSGENE LVFGVQVTCQ GRSWPVLRSY DDFRSLDAHL HRCIFDRRFS 130 140 150 160 170 180 CLPELPPPPE GARAAQMLVP LLLQYLETLS GLVDSNLNCG PVLTWMELDN HGRRLLLSEE 190 200 210 220 230 240 ASLNIPAVAA AHVIKRYTAQ APDELSFEVG DIVSVIDMPP TEDRSWWRGK RGFQVGFFPS 250 260 270 280 290 300 ECVELFTERP GPGLKADADG PPCGIPAPQG ISSLTSAVPR PRGKLAGLLR TFMRSRPSRQ 310 320 330 340 350 360 RLRQRGILRQ RVFGCDLGEH LSNSGQDVPQ VLRCCSEFIE AHGVVDGIYR LSGVSSNIQR 370 380 390 400 410 420 LRHEFDSERI PELSGPAFLQ DIHSVSSLCK LYFRELPNPL LTYQLYGKFS EAMSVPGEEE 430 440 450 460 470 480 RLVRVHDVIQ QLPPPHYRTL EYLLRHLARM ARHSANTSMH ARNLAIVWAP NLLRSMELES 490 500 510 520 530 540 VGMGGAAAFR EVRVQSVVVE FLLTHVDVLF SDTFTSAGLD PAGRCLLPRP KSLAGSCPST 550 560 570 580 590 600 RLLTLEEAQA RTQGRLGTPT EPTTPKAPAS PAERRKGERG EKQRKPGGSS WKTFFALGRG 610 620 630 640 650 660 PSVPRKKPLP WLGGTRAPPQ PSGSRPDTVT LRSAKSEESL SSQASGAELL GAGGAPASAT 670 680 690 700 710 720 PTPALSPGRS LRPHLIPLLL RGAEAPLTDA CQQEMCSKLR GAQGPLGPDM ESPLPPPPLS 730 740 750 760 770 780 LLRPGGAPPP PPKNPARLMA LALAERAQQV AEQQSQQECG GTPPASQSPF HRSLSLEVGG 790 800 810 820 830 840 EPLGTSGSGP PPNSLAHPGA WVPGPPPYLP RQQSDGSLLR SQRPMGTSRR GLRGPAQVSA 850 860 870 880 890 900 QLRAGGGGRD APEAAAQSPC SVPSQVPTPG FFSPAPRECL PPFLGVPKPG LYPLGPPSFQ 910 920 930 940 950 960 PSSPAPVWRS SLGPPAPLDR GENLYYEIGA SEGSPYSGPT RSWSPFRSMP PDRLNASYGM 970 980 990 1000 1010 1020 LGQSPPLHRS PDFLLSYPPA PSCFPPDHLG YSAPQHPARR PTPPEPLYVN LALGPRGPSP 1030 1040 1050 1060 1070 1080 ASSSSSSPPA HPRSRSDPGP PVPRLPQKQR APWGPRTPHR VPGPWGPPEP LLLYRAAPPA 1090 1100 1110 1120 YGRGGELHRG SLYRNGGQRG EGAGPPPPYP TPSWSLHSEG QTRSYC
	Isoform 4 [UniParc]. Checksum: 88093F56B6055CEA	FASTA	246	26,858
	10 20 30 40 50 60 MLSLSLCSHL WGPLILSALQ ARSTDSLDGP GEGSVQPLPT AGGPSVKGKP GKRLSAPRGP 70 80 90 100 110 120 FPRLADCAHF HYENVDFGHI QLLLSPDREG PSLSGENELV FGVQVTCQGR SWPVLRSYDD 130 140 150 160 170 180 FRSLDAHLHR CIFDRRFSCL PELPPPPEGA RAAQMLVPLL LQYLETLSGL VDSNLNCGPV 190 200 210 220 230 240 LTWMEVGLGR GLGDSEWVRG CVCHHAQHRE ILDGNRVASA VEDEGAEVDG EAFRWGSLWV GESWDM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel member (SNX26) of the sorting nexin family." Hong W. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Hippocampus.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 426-1287. Tissue: Testis.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 993-1287. Tissue: Pancreas.
[6]	"Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome." Vaz Meirelles G., Ferreira Lanza D.C., da Silva J.C., Santana Bernachi J., Paes Leme A.F., Kobarg J. J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH NEK6.
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-636, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY044864 mRNA. Translation: AAK97795.1. AK096338 mRNA. No translation available. AK127255 mRNA. Translation: BAC86902.1. Frameshift. AC002398 Genomic DNA. Translation: AAB81197.1. AC002398 Genomic DNA. Translation: AAB81198.1. Sequence problems. AL137579 mRNA. Translation: CAB70821.1. BC014084 mRNA. Translation: AAH14084.2.
IPI	IPI00022715. IPI00418896. IPI00549274. IPI00607892.
PIR	T00704. T00705. T46289.
RefSeq	NP_001166101.1. NM_001172630.1. NP_443180.2. NM_052948.3.
UniGene	Hs.515364.
3D structure databases
ProteinModelPortal	O14559.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14559. 2 interactions.
PTM databases
PhosphoSite	O14559.
Proteomic databases
PaxDb	O14559.
PRIDE	O14559.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000007510; ENSP00000007510; ENSG00000004777. ENST00000221905; ENSP00000221905; ENSG00000004777. ENST00000314737; ENSP00000320038; ENSG00000004777. ENST00000378944; ENSP00000368227; ENSG00000004777.
GeneID	115703.
KEGG	hsa:115703.
UCSC	uc002obr.2. human. uc002obs.2. human. uc002obt.2. human. uc010eek.2. human.
Organism-specific databases
CTD	115703.
GeneCards	GC19P036266.
HGNC	HGNC:23085. ARHGAP33.
HPA	HPA030117. HPA030118.
MIM	614902. gene.
neXtProt	NX_O14559.
PharmGKB	PA165393003.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG311367.
HOGENOM	HOG000154522.
HOVERGEN	HBG079688.
InParanoid	O14559.
OMA	QSPCSVP.
Gene expression databases
ArrayExpress	O14559.
Bgee	O14559.
CleanEx	HS_SNX26.
Genevestigator	O14559.
GermOnline	ENSG00000004777. Homo sapiens.
Family and domain databases
Gene3D	1.10.555.10. 1 hit.
InterPro	IPR001683. Phox. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00620. RhoGAP. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00324. RhoGAP. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF64268. PX. 1 hit. SSF48350. Rho_GAP. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS50195. PX. False negative. PS50238. RHOGAP. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	115703.
NextBio	79650.
SOURCE	Search...

Entry information

Entry name

RHG33_HUMAN

Accession

Primary (citable) accession number: O14559
Secondary accession number(s): O14552 , O14560, Q6ZSP6, Q96CP3, Q9NT23

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.