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O14558

- HSPB6_HUMAN

UniProt

O14558 - HSPB6_HUMAN

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Protein
Heat shock protein beta-6
Gene
HSPB6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein homodimerization activity Source: UniProtKB
  3. structural constituent of eye lens Source: InterPro

GO - Biological processi

  1. regulation of muscle contraction Source: Ensembl
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

SignaLinkiO14558.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-6
Short name:
HspB6
Alternative name(s):
Heat shock 20 kDa-like protein p20
Gene namesi
Name:HSPB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26511. HSPB6.

Subcellular locationi

Cytoplasm. Nucleus
Note: Translocates to nuclear foci during heat shock.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134983584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Heat shock protein beta-6
PRO_0000125939Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PaxDbiO14558.
PRIDEiO14558.

2D gel databases

REPRODUCTION-2DPAGEO14558.
UCD-2DPAGEO14558.

PTM databases

PhosphoSiteiO14558.

Expressioni

Gene expression databases

ArrayExpressiO14558.
BgeeiO14558.
CleanExiHS_HSPB6.
GenevestigatoriO14558.

Organism-specific databases

HPAiCAB001974.
HPA044153.

Interactioni

Subunit structurei

Homodimer By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
HSPB8Q9UJY12EBI-739095,EBI-739074

Protein-protein interaction databases

BioGridi125988. 3 interactions.
IntActiO14558. 3 interactions.
MINTiMINT-7002024.
STRINGi9606.ENSP00000004982.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi74 – 796
Helixi85 – 873
Beta strandi88 – 936
Beta strandi96 – 10712
Beta strandi109 – 12214
Helixi129 – 1313
Beta strandi133 – 1364
Beta strandi140 – 1467

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JUSX-ray2.50A/B/C/D/E/F/G/H57-160[»]
4JUTX-ray2.20A/B/C/D/E/F/G/H57-160[»]
ProteinModelPortaliO14558.
SMRiO14558. Positions 5-154.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG236548.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiO14558.
KOiK09545.
OMAiFIAREFH.
OrthoDBiEOG7WHHBK.
PhylomeDBiO14558.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR003090. Alpha-crystallin_N.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14558-1 [UniParc]FASTAAdd to Basket

« Hide

MEIPVPVQPS WLRRASAPLP GLSAPGRLFD QRFGEGLLEA ELAALCPTTL    50
APYYLRAPSV ALPVAQVPTD PGHFSVLLDV KHFSPEEIAV KVVGEHVEVH 100
ARHEERPDEH GFVAREFHRR YRLPPGVDPA AVTSALSPEG VLSIQAAPAS 150
AQAPPPAAAK 160
Length:160
Mass (Da):17,136
Last modified:August 2, 2002 - v2
Checksum:i3BFB1FFB5877F2E7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201P → L in AAH68046. 1 Publication
Sequence conflicti64 – 663Missing in AAB81196. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056951 mRNA. Translation: BAB71323.1.
AC002398 Genomic DNA. Translation: AAB81196.1.
BC068046 mRNA. Translation: AAH68046.1.
CCDSiCCDS12475.1.
PIRiB53814.
T00703.
RefSeqiNP_653218.1. NM_144617.2.
UniGeneiHs.534538.
Hs.744178.

Genome annotation databases

EnsembliENST00000004982; ENSP00000004982; ENSG00000004776.
ENST00000592984; ENSP00000468057; ENSG00000004776.
GeneIDi126393.
KEGGihsa:126393.
UCSCiuc002obn.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056951 mRNA. Translation: BAB71323.1 .
AC002398 Genomic DNA. Translation: AAB81196.1 .
BC068046 mRNA. Translation: AAH68046.1 .
CCDSi CCDS12475.1.
PIRi B53814.
T00703.
RefSeqi NP_653218.1. NM_144617.2.
UniGenei Hs.534538.
Hs.744178.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4JUS X-ray 2.50 A/B/C/D/E/F/G/H 57-160 [» ]
4JUT X-ray 2.20 A/B/C/D/E/F/G/H 57-160 [» ]
ProteinModelPortali O14558.
SMRi O14558. Positions 5-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125988. 3 interactions.
IntActi O14558. 3 interactions.
MINTi MINT-7002024.
STRINGi 9606.ENSP00000004982.

PTM databases

PhosphoSitei O14558.

2D gel databases

REPRODUCTION-2DPAGE O14558.
UCD-2DPAGE O14558.

Proteomic databases

PaxDbi O14558.
PRIDEi O14558.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000004982 ; ENSP00000004982 ; ENSG00000004776 .
ENST00000592984 ; ENSP00000468057 ; ENSG00000004776 .
GeneIDi 126393.
KEGGi hsa:126393.
UCSCi uc002obn.2. human.

Organism-specific databases

CTDi 126393.
GeneCardsi GC19M036245.
HGNCi HGNC:26511. HSPB6.
HPAi CAB001974.
HPA044153.
MIMi 610695. gene.
neXtProti NX_O14558.
PharmGKBi PA134983584.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236548.
HOGENOMi HOG000233954.
HOVERGENi HBG054766.
InParanoidi O14558.
KOi K09545.
OMAi FIAREFH.
OrthoDBi EOG7WHHBK.
PhylomeDBi O14558.

Enzyme and pathway databases

SignaLinki O14558.

Miscellaneous databases

GeneWikii HSPB6.
GenomeRNAii 126393.
NextBioi 81816.
PROi O14558.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14558.
Bgeei O14558.
CleanExi HS_HSPB6.
Genevestigatori O14558.

Family and domain databases

Gene3Di 2.60.40.790. 1 hit.
InterProi IPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR003090. Alpha-crystallin_N.
IPR008978. HSP20-like_chaperone.
[Graphical view ]
Pfami PF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view ]
PIRSFi PIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSi PR00299. ACRYSTALLIN.
SUPFAMi SSF49764. SSF49764. 1 hit.
PROSITEi PS01031. HSP20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  4. "Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin."
    Kato K., Goto S., Inaguma Y., Hasegawa K., Morishita R., Asano T.
    J. Biol. Chem. 269:15302-15309(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-160, CHARACTERIZATION.
    Tissue: Muscle.
  5. "HSPB7 is a SC35 speckle resident small heat shock protein."
    Vos M.J., Kanon B., Kampinga H.H.
    Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHSPB6_HUMAN
AccessioniPrimary (citable) accession number: O14558
Secondary accession number(s): O14551, Q6NVI3, Q96MG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 2, 2002
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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