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Protein

Heat shock protein beta-6

Gene

HSPB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004776-MONOMER.
SignaLinkiO14558.
SIGNORiO14558.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-6
Short name:
HspB6
Alternative name(s):
Heat shock 20 kDa-like protein p20
Gene namesi
Name:HSPB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26511. HSPB6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi126393.
OpenTargetsiENSG00000004776.
PharmGKBiPA134983584.

Polymorphism and mutation databases

BioMutaiHSPB6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259391 – 160Heat shock protein beta-6Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO14558.
PeptideAtlasiO14558.
PRIDEiO14558.

2D gel databases

REPRODUCTION-2DPAGEO14558.
UCD-2DPAGEO14558.

PTM databases

iPTMnetiO14558.
PhosphoSitePlusiO14558.

Expressioni

Gene expression databases

BgeeiENSG00000004776.
CleanExiHS_HSPB6.
ExpressionAtlasiO14558. baseline and differential.
GenevisibleiO14558. HS.

Organism-specific databases

HPAiCAB001974.
HPA044153.
HPA054811.

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CRYAAP024894EBI-739095,EBI-6875961
CRYABP025114EBI-739095,EBI-739060
HSPB8Q9UJY12EBI-739095,EBI-739074

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125988. 9 interactors.
IntActiO14558. 9 interactors.
MINTiMINT-7002024.
STRINGi9606.ENSP00000004982.

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi69 – 71Combined sources3
Beta strandi74 – 79Combined sources6
Helixi85 – 87Combined sources3
Beta strandi88 – 93Combined sources6
Beta strandi96 – 107Combined sources12
Beta strandi109 – 122Combined sources14
Helixi129 – 131Combined sources3
Beta strandi133 – 136Combined sources4
Beta strandi140 – 146Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JUSX-ray2.50A/B/C/D/E/F/G/H57-160[»]
4JUTX-ray2.20A/B/C/D/E/F/G/H57-160[»]
ProteinModelPortaliO14558.
SMRiO14558.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiO14558.
KOiK09545.
OMAiAFAPYYL.
OrthoDBiEOG091G0USC.
PhylomeDBiO14558.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPVPVQPS WLRRASAPLP GLSAPGRLFD QRFGEGLLEA ELAALCPTTL
60 70 80 90 100
APYYLRAPSV ALPVAQVPTD PGHFSVLLDV KHFSPEEIAV KVVGEHVEVH
110 120 130 140 150
ARHEERPDEH GFVAREFHRR YRLPPGVDPA AVTSALSPEG VLSIQAAPAS
160
AQAPPPAAAK
Length:160
Mass (Da):17,136
Last modified:August 2, 2002 - v2
Checksum:i3BFB1FFB5877F2E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20P → L in AAH68046 (PubMed:15489334).Curated1
Sequence conflicti64 – 66Missing in AAB81196 (PubMed:15057824).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056951 mRNA. Translation: BAB71323.1.
AC002398 Genomic DNA. Translation: AAB81196.1.
BC068046 mRNA. Translation: AAH68046.1.
CCDSiCCDS12475.1.
PIRiB53814.
T00703.
RefSeqiNP_653218.1. NM_144617.2.
UniGeneiHs.534538.
Hs.744178.

Genome annotation databases

EnsembliENST00000004982; ENSP00000004982; ENSG00000004776.
ENST00000592984; ENSP00000468057; ENSG00000004776.
GeneIDi126393.
KEGGihsa:126393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056951 mRNA. Translation: BAB71323.1.
AC002398 Genomic DNA. Translation: AAB81196.1.
BC068046 mRNA. Translation: AAH68046.1.
CCDSiCCDS12475.1.
PIRiB53814.
T00703.
RefSeqiNP_653218.1. NM_144617.2.
UniGeneiHs.534538.
Hs.744178.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JUSX-ray2.50A/B/C/D/E/F/G/H57-160[»]
4JUTX-ray2.20A/B/C/D/E/F/G/H57-160[»]
ProteinModelPortaliO14558.
SMRiO14558.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125988. 9 interactors.
IntActiO14558. 9 interactors.
MINTiMINT-7002024.
STRINGi9606.ENSP00000004982.

PTM databases

iPTMnetiO14558.
PhosphoSitePlusiO14558.

Polymorphism and mutation databases

BioMutaiHSPB6.

2D gel databases

REPRODUCTION-2DPAGEO14558.
UCD-2DPAGEO14558.

Proteomic databases

PaxDbiO14558.
PeptideAtlasiO14558.
PRIDEiO14558.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000004982; ENSP00000004982; ENSG00000004776.
ENST00000592984; ENSP00000468057; ENSG00000004776.
GeneIDi126393.
KEGGihsa:126393.

Organism-specific databases

CTDi126393.
DisGeNETi126393.
GeneCardsiHSPB6.
HGNCiHGNC:26511. HSPB6.
HPAiCAB001974.
HPA044153.
HPA054811.
MIMi610695. gene.
neXtProtiNX_O14558.
OpenTargetsiENSG00000004776.
PharmGKBiPA134983584.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiO14558.
KOiK09545.
OMAiAFAPYYL.
OrthoDBiEOG091G0USC.
PhylomeDBiO14558.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000004776-MONOMER.
SignaLinkiO14558.
SIGNORiO14558.

Miscellaneous databases

GeneWikiiHSPB6.
GenomeRNAii126393.
PROiO14558.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000004776.
CleanExiHS_HSPB6.
ExpressionAtlasiO14558. baseline and differential.
GenevisibleiO14558. HS.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB6_HUMAN
AccessioniPrimary (citable) accession number: O14558
Secondary accession number(s): O14551, Q6NVI3, Q96MG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 2, 2002
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.