Reviewed, UniProtKB/Swiss-Prot O14558 (HSPB6_HUMAN)

Names and origin

Protein names

Recommended name:
    Heat shock protein beta-6
      Short name=HspB6
Alternative name(s):
    Heat shock 20 kDa-like protein p20

Gene names

Name:

HSPB6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Homodimer By similarity.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Belongs to the small heat shock protein (HSP20) family.

Ontologies

Keywords
Biological process	Stress response
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	response to heat Inferred from electronic annotation. Source: InterPro
Molecular function	protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSPB8	Q9UJY1	1	EBI-739095,EBI-739074

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	Heat shock protein beta-6		PRO_0000125939
Amino acid modifications
	Modified residue	16	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	20	1	P → L in AAH68046. Ref.3
	Sequence conflict	64 – 66	3	Missing in AAB81196. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O14558-1 [UniParc]. Last modified August 2, 2002. Version 2. Checksum: 3BFB1FFB5877F2E7	FASTA	160	17,136
	10 20 30 40 50 60 MEIPVPVQPS WLRRASAPLP GLSAPGRLFD QRFGEGLLEA ELAALCPTTL APYYLRAPSV 70 80 90 100 110 120 ALPVAQVPTD PGHFSVLLDV KHFSPEEIAV KVVGEHVEVH ARHEERPDEH GFVAREFHRR 130 140 150 160 YRLPPGVDPA AVTSALSPEG VLSIQAAPAS AQAPPPAAAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[4]	"Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin." Kato K., Goto S., Inaguma Y., Hasegawa K., Morishita R., Asano T. J. Biol. Chem. 269:15302-15309(1994) [PubMed: 8195168] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-160, CHARACTERIZATION. Tissue: Muscle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK056951 mRNA. Translation: BAB71323.1. AC002398 Genomic DNA. Translation: AAB81196.1. BC068046 mRNA. Translation: AAH68046.1.
IPI	IPI00022433.
PIR	B53814. T00703.
RefSeq	NP_653218.1.
UniGene	Hs.534538
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O14558. 1 interaction.
STRING	O14558.
PTM databases
PhosphoSite	O14558.
2-D gel databases
REPRODUCTION-2DPAGE	O14558.
Proteomic databases
PRIDE	O14558.
Genome annotation databases
Ensembl	ENST00000004982; ENSP00000004982; ENSG00000004776; Homo sapiens. [Genome view]
GeneID	126393.
KEGG	hsa:126393.
UCSC	uc002obn.1. human.
Organism-specific databases
CTD	126393.
GeneCards	GC19M040939.
H-InvDB	HIX0015041.
HGNC	HGNC:26511. HSPB6.
HPA	CAB001974.
MIM	610695. gene.
PharmGKB	PA134983584.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O14558.
InParanoid	O14558.
OrthoDB	EOG966Z58.
Gene expression databases
ArrayExpress	O14558.
Bgee	O14558.
CleanEx	HS_HSPB6.
Genevestigator	O14558.
GermOnline	ENSG00000004776. Homo sapiens.
Family and domain databases
InterPro	IPR001436. Alpha-crystallin/HSP. IPR002068. Hsp20. IPR008978. HSP20-like_chaperone. [Graphical view]
Pfam	PF00011. HSP20. 1 hit. [Graphical view]
PRINTS	PR00299. ACRYSTALLIN.
PROSITE	PS01031. HSP20. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	81816.
SOURCE	Search...

Entry information

Entry name

HSPB6_HUMAN

Accession

Primary (citable) accession number: O14558
Secondary accession number(s): O14551, Q6NVI3, Q96MG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 2, 2002
Last modified:	December 15, 2009
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.