Reviewed,
UniProtKB/Swiss-Prot O14558 (HSPB6_HUMAN)
Last modified
December 15, 2009.
Version 83.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Heat shock protein beta-6 Short name=HspB6 Alternative name(s): Heat shock 20 kDa-like protein p20 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 160 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subunit structure | Homodimer By similarity. |
| Post-translational modification | The N-terminus is blocked. |
| Sequence similarities | Belongs to the small heat shock protein (HSP20) family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Stress response |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | response to heat Inferred from electronic annotation. Source: InterPro |
| Molecular function | protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 160 | 160 | Heat shock protein beta-6 | PRO_0000125939 | |||||
Amino acid modifications | |||||||||
| Modified residue | 16 | 1 | Phosphoserine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 20 | 1 | P → L in AAH68046. Ref.3 | ||||||
| Sequence conflict | 64 – 66 | 3 | Missing in AAB81196. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skeletal muscle. |
| [2] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin. |
| [4] | "Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin." Kato K., Goto S., Inaguma Y., Hasegawa K., Morishita R., Asano T. J. Biol. Chem. 269:15302-15309(1994) [PubMed: 8195168] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-160, CHARACTERIZATION. Tissue: Muscle. |
Cross-references
Sequence databases | |
|---|---|
| AK056951 mRNA. Translation: BAB71323.1. AC002398 Genomic DNA. Translation: AAB81196.1. BC068046 mRNA. Translation: AAH68046.1. | |
| IPI | IPI00022433. |
| PIR | B53814. T00703. |
| RefSeq | NP_653218.1. |
| UniGene | Hs.534538 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O14558. 1 interaction. |
| STRING | O14558. |
PTM databases | |
| PhosphoSite | O14558. |
2-D gel databases | |
| REPRODUCTION-2DPAGE | O14558. |
Proteomic databases | |
| PRIDE | O14558. |
Genome annotation databases | |
| Ensembl | ENST00000004982; ENSP00000004982; ENSG00000004776; Homo sapiens. [Genome view] |
| GeneID | 126393. |
| KEGG | hsa:126393. |
| UCSC | uc002obn.1. human. |
Organism-specific databases | |
| CTD | 126393. |
| GeneCards | GC19M040939. |
| H-InvDB | HIX0015041. |
| HGNC | HGNC:26511. HSPB6. |
| HPA | CAB001974. |
| MIM | 610695. gene. |
| PharmGKB | PA134983584. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | O14558. |
| InParanoid | O14558. |
| OrthoDB | EOG966Z58. |
Gene expression databases | |
| ArrayExpress | O14558. |
| Bgee | O14558. |
| CleanEx | HS_HSPB6. |
| Genevestigator | O14558. |
| GermOnline | ENSG00000004776. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001436. Alpha-crystallin/HSP. IPR002068. Hsp20. IPR008978. HSP20-like_chaperone. [Graphical view] |
| Pfam | PF00011. HSP20. 1 hit. [Graphical view] |
| PRINTS | PR00299. ACRYSTALLIN. |
| PROSITE | PS01031. HSP20. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 81816. |
| SOURCE | Search... |
Entry information
| Entry name | HSPB6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O14558 Secondary accession number(s): O14551, Q6NVI3, Q96MG9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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