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Protein

Cytochrome c oxidase subunit 7A-related protein, mitochondrial

Gene

COX7A2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).By similarity

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A-related protein, mitochondrial
Alternative name(s):
COX7a-related protein
Cytochrome c oxidase subunit VIIa-related protein
EB1
Gene namesi
Name:COX7A2L
Synonyms:COX7AR, COX7RP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:2289. COX7A2L.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9167.
OpenTargetsiENSG00000115944.
PharmGKBiPA26807.

Polymorphism and mutation databases

BioMutaiCOX7A2L.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionSequence analysisAdd BLAST55
ChainiPRO_000000615456 – 114Cytochrome c oxidase subunit 7A-related protein, mitochondrialAdd BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO14548.
PaxDbiO14548.
PeptideAtlasiO14548.
PRIDEiO14548.
TopDownProteomicsiO14548.

PTM databases

iPTMnetiO14548.
PhosphoSitePlusiO14548.

Expressioni

Inductioni

By estrogen.

Gene expression databases

BgeeiENSG00000115944.
CleanExiHS_COX7A2L.
ExpressionAtlasiO14548. baseline and differential.
GenevisibleiO14548. HS.

Organism-specific databases

HPAiCAB073545.
HPA059124.

Interactioni

Subunit structurei

Interacts with the mitochondrial respiratory supercomplex.By similarity

Protein-protein interaction databases

BioGridi114608. 18 interactors.
IntActiO14548. 6 interactors.
MINTiMINT-1484437.
STRINGi9606.ENSP00000234301.

Structurei

3D structure databases

ProteinModelPortaliO14548.
SMRiO14548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IYMH. Eukaryota.
ENOG41120Z9. LUCA.
GeneTreeiENSGT00400000022054.
HOGENOMiHOG000264231.
HOVERGENiHBG051095.
InParanoidiO14548.
KOiK02270.
OMAiKRGYPDR.
OrthoDBiEOG091G12UD.
PhylomeDBiO14548.
TreeFamiTF105067.

Family and domain databases

CDDicd00928. Cyt_c_Oxidase_VIIa. 1 hit.
InterProiView protein in InterPro
IPR003177. Cyt_c_oxidase_su7a.
IPR017267. Cyt_c_oxidase_su7a-rel_mt.
PANTHERiPTHR10510. PTHR10510. 1 hit.
PTHR10510:SF15. PTHR10510:SF15. 1 hit.
PIRSFiPIRSF037710. COX7A-rel_mt. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYKFSGFTQ KLAGAWASEA YSPQGLKPVV STEAPPIIFA TPTKLTSDST
60 70 80 90 100
VYDYAGKNKV PELQKFFQKA DGVPVYLKRG LPDQMLYRTT MALTVGGTIY
110
CLIALYMASQ PKNK
Length:114
Mass (Da):12,615
Last modified:April 3, 2002 - v2
Checksum:i67BCABEEAE0F552B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107M → N in BAA22571 (PubMed:9418891).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007618 mRNA. Translation: BAA22571.1.
AF127788 mRNA. Translation: AAF72746.1.
AY007643 Genomic DNA. Translation: AAG32129.1.
BT007371 mRNA. Translation: AAP36035.1.
BC005251 mRNA. Translation: AAH05251.1.
BC007095 mRNA. Translation: AAH07095.1.
CCDSiCCDS1808.1.
RefSeqiNP_001305965.1. NM_001319036.1.
NP_001305969.1. NM_001319040.1.
NP_004709.2. NM_004718.3.
UniGeneiHs.339639.
Hs.744101.

Genome annotation databases

EnsembliENST00000234301; ENSP00000234301; ENSG00000115944.
ENST00000378669; ENSP00000367938; ENSG00000115944.
GeneIDi9167.
KEGGihsa:9167.

Similar proteinsi

Entry informationi

Entry nameiCOX7R_HUMAN
AccessioniPrimary (citable) accession number: O14548
Secondary accession number(s): Q9P118
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 3, 2002
Last modified: August 30, 2017
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families