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O14544 (SOCS6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Suppressor of cytokine signaling 6

Short name=SOCS-6
Alternative name(s):
Cytokine-inducible SH2 protein 4
Short name=CIS-4
Suppressor of cytokine signaling 4
Short name=SOCS-4
Gene names
Name:SOCS6
Synonyms:CIS4, SOCS4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. Ref.5

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with RBCK1. Interacts with phosphorylated IRS4 By similarity. Interacts with PIM3 By similarity. Interacts with KIT (phosphorylated).

Domain

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.

Sequence similarities

Contains 1 SH2 domain.

Contains 1 SOCS box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 535535Suppressor of cytokine signaling 6
PRO_0000181251

Regions

Domain384 – 491108SH2
Domain486 – 53550SOCS box
Compositional bias105 – 1084Poly-Ser

Experimental info

Sequence conflict741M → I in BAA22538. Ref.1
Sequence conflict1611S → T in BAA22538. Ref.1

Secondary structure

................... 535
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O14544 [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: AE513312A999B763

FASTA53559,528
        10         20         30         40         50         60 
MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD MASCDINGED 

        70         80         90        100        110        120 
EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD EDTFSSSSAP IVFKDVRAQR 

       130        140        150        160        170        180 
PIRSTSLRSH HYSPAPWPLR PTNSEETCIK MEVRVKALVH SSSPSPALNG VRKDFHDLQS 

       190        200        210        220        230        240 
ETTCQEQANS LKSSASHNGD LHLHLDEHVP VVIGLMPQDY IQYTVPLDEG MYPLEGSRSY 

       250        260        270        280        290        300 
CLDSSSPMEV SAVPPQVGGR AFPEDESQVD QDLVVAPEIF VDQSVNGLLI GTTGVMLQSP 

       310        320        330        340        350        360 
RAGHDDVPPL SPLLPPMQNN QIQRNFSGLT GTEAHVAESM RCHLNFDPNS APGVARVYDS 

       370        380        390        400        410        420 
VQSSGPMVVT SLTEELKKLA KQGWYWGPIT RWEAEGKLAN VPDGSFLVRD SSDDRYLLSL 

       430        440        450        460        470        480 
SFRSHGKTLH TRIEHSNGRF SFYEQPDVEG HTSIVDLIEH SIRDSENGAF CYSRSRLPGS 

       490        500        510        520        530 
ATYPVRLTNP VSRFMQVRSL QYLCRFVIRQ YTRIDLIQKL PLPNKMKDYL QEKHY 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of novel CIS family genes."
Masuhara M., Sakamoto H., Matsumoto A., Suzuki R., Yasukawa H., Mitsui K., Wakioka T., Tanimura S., Sasaki A., Misawa H., Yokouchi M., Ohtsubo M., Yoshimura A.
Biochem. Biophys. Res. Commun. 239:439-446(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[4]"Signal transduction via the stem cell factor receptor/c-Kit."
Ronnstrand L.
Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW ON ROLE IN KIT SIGNALING AND KIT DEGRADATION.
[5]"Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase."
Zadjali F., Pike A.C., Vesterlund M., Sun J., Wu C., Li S.S., Ronnstrand L., Knapp S., Bullock A.N., Flores-Morales A.
J. Biol. Chem. 286:480-490(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 361-499 IN COMPLEX WITH KIT, FUNCTION AS E3 UBIQUITIN-PROTEIN LIGASE FOR KIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006968 mRNA. Translation: BAA22538.1.
CH471117 Genomic DNA. Translation: EAW66522.1.
BC020082 mRNA. Translation: AAH20082.1.
PIRJC5762.
RefSeqNP_004223.2. NM_004232.3.
XP_005266840.1. XM_005266783.1.
UniGeneHs.44439.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VIFX-ray1.45A361-499[»]
ProteinModelPortalO14544.
SMRO14544. Positions 367-535.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114719. 22 interactions.
IntActO14544. 8 interactions.
MINTMINT-4821450.
STRING9606.ENSP00000306939.

PTM databases

PhosphoSiteO14544.

Proteomic databases

PaxDbO14544.
PRIDEO14544.

Protocols and materials databases

DNASU9306.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397942; ENSP00000381034; ENSG00000170677.
ENST00000582322; ENSP00000463395; ENSG00000170677.
GeneID9306.
KEGGhsa:9306.
UCSCuc002lkr.1. human.

Organism-specific databases

CTD9306.
GeneCardsGC18P067956.
HGNCHGNC:16833. SOCS6.
HPACAB010189.
HPA035477.
MIM605118. gene.
neXtProtNX_O14544.
PharmGKBPA134917653.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG318341.
HOGENOMHOG000027792.
HOVERGENHBG057479.
InParanoidO14544.
KOK10322.
OMATRWEAEG.
OrthoDBEOG7SXW3G.
PhylomeDBO14544.
TreeFamTF321368.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkO14544.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressO14544.
BgeeO14544.
CleanExHS_SOCS4.
HS_SOCS6.
GenevestigatorO14544.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR000980. SH2.
IPR028413. SOCS.
IPR028421. SOCS6.
IPR001496. SOCS_C.
[Graphical view]
PANTHERPTHR10385. PTHR10385. 1 hit.
PTHR10385:SF17. PTHR10385:SF17. 1 hit.
PfamPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
PROSITEPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO14544.
GeneWikiSOCS6.
GenomeRNAi9306.
NextBio34859.
PROO14544.
SOURCESearch...

Entry information

Entry nameSOCS6_HUMAN
AccessionPrimary (citable) accession number: O14544
Secondary accession number(s): Q8WUM3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM