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Protein

Dihydropyrimidinase-related protein 4

Gene

DPYSL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).By similarity

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

GO - Molecular functioni

GO - Biological processi

  • nervous system development Source: ProtInc
  • neuron death Source: InterPro
  • neuron projection guidance Source: InterPro

Enzyme and pathway databases

ReactomeiR-HSA-399956 CRMPs in Sema3A signaling

Protein family/group databases

MEROPSiM38.977

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 4
Short name:
DRP-4
Alternative name(s):
Collapsin response mediator protein 3
Short name:
CRMP-3
UNC33-like phosphoprotein 4
Short name:
ULIP-4
Gene namesi
Name:DPYSL4
Synonyms:CRMP3, ULIP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151640.12
HGNCiHGNC:3016 DPYSL4
MIMi608407 gene
neXtProtiNX_O14531

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10570
OpenTargetsiENSG00000151640
PharmGKBiPA27474

Polymorphism and mutation databases

BioMutaiDPYSL4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659211 – 572Dihydropyrimidinase-related protein 4Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei537PhosphoserineBy similarity1
Modified residuei544PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14531
MaxQBiO14531
PaxDbiO14531
PeptideAtlasiO14531
PRIDEiO14531
TopDownProteomicsiO14531

PTM databases

iPTMnetiO14531
PhosphoSitePlusiO14531

Expressioni

Gene expression databases

BgeeiENSG00000151640
CleanExiHS_DPYSL4
ExpressionAtlasiO14531 baseline and differential
GenevisibleiO14531 HS

Organism-specific databases

HPAiHPA049066

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • filamin binding Source: WormBase

Protein-protein interaction databases

BioGridi115821, 37 interactors
IntActiO14531, 8 interactors
MINTiO14531
STRINGi9606.ENSP00000339850

Structurei

Secondary structure

1572
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 21Combined sources5
Beta strandi23 – 25Combined sources3
Beta strandi30 – 32Combined sources3
Beta strandi34 – 38Combined sources5
Beta strandi41 – 48Combined sources8
Beta strandi57 – 59Combined sources3
Beta strandi63 – 67Combined sources5
Beta strandi69 – 74Combined sources6
Helixi89 – 98Combined sources10
Beta strandi101 – 108Combined sources8
Helixi116 – 130Combined sources15
Beta strandi132 – 141Combined sources10
Helixi148 – 158Combined sources11
Beta strandi163 – 168Combined sources6
Turni171 – 174Combined sources4
Helixi178 – 190Combined sources13
Beta strandi194 – 198Combined sources5
Helixi202 – 214Combined sources13
Helixi220 – 225Combined sources6
Helixi229 – 246Combined sources18
Beta strandi250 – 255Combined sources6
Helixi258 – 269Combined sources12
Beta strandi274 – 279Combined sources6
Helixi280 – 284Combined sources5
Helixi287 – 291Combined sources5
Helixi295 – 300Combined sources6
Helixi313 – 322Combined sources10
Helixi338 – 341Combined sources4
Helixi342 – 344Combined sources3
Helixi348 – 350Combined sources3
Turni358 – 360Combined sources3
Helixi361 – 369Combined sources9
Turni370 – 373Combined sources4
Helixi377 – 384Combined sources8
Helixi386 – 392Combined sources7
Turni395 – 397Combined sources3
Beta strandi409 – 419Combined sources11
Turni422 – 424Combined sources3
Beta strandi426 – 430Combined sources5
Turni433 – 436Combined sources4
Beta strandi438 – 448Combined sources11
Beta strandi451 – 455Combined sources5
Helixi476 – 491Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NKSX-ray1.80A1-572[»]
ProteinModelPortaliO14531
SMRiO14531
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiO14531
OMAiSVVWEKC
OrthoDBiEOG091G05F3
PhylomeDBiO14531
TreeFamiTF314706

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030612 DRP4
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF55 PTHR11647:SF55, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit

Sequencei

Sequence statusi: Complete.

O14531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFQGKKSIP RITSDRLLIR GGRIVNDDQS FYADVHVEDG LIKQIGENLI
60 70 80 90 100
VPGGIKTIDA HGLMVLPGGV DVHTRLQMPV LGMTPADDFC QGTKAALAGG
110 120 130 140 150
TTMILDHVFP DTGVSLLAAY EQWRERADSA ACCDYSLHVD ITRWHESIKE
160 170 180 190 200
ELEALVKEKG VNSFLVFMAY KDRCQCSDSQ MYEIFSIIRD LGALAQVHAE
210 220 230 240 250
NGDIVEEEQK RLLELGITGP EGHVLSHPEE VEAEAVYRAV TIAKQANCPL
260 270 280 290 300
YVTKVMSKGA ADAIAQAKRR GVVVFGEPIT ASLGTDGSHY WSKNWAKAAA
310 320 330 340 350
FVTSPPVNPD PTTADHLTCL LSSGDLQVTG SAHCTFTTAQ KAVGKDNFAL
360 370 380 390 400
IPEGTNGIEE RMSMVWEKCV ASGKMDENEF VAVTSTNAAK IFNFYPRKGR
410 420 430 440 450
VAVGSDADLV IWNPKATKII SAKTHNLNVE YNIFEGVECR GAPAVVISQG
460 470 480 490 500
RVALEDGKMF VTPGAGRFVP RKTFPDFVYK RIKARNRLAE IHGVPRGLYD
510 520 530 540 550
GPVHEVMVPA KPGSGAPARA SCPGKISVPP VRNLHQSGFS LSGSQADDHI
560 570
ARRTAQKIMA PPGGRSNITS LS
Length:572
Mass (Da):61,878
Last modified:June 21, 2005 - v2
Checksum:iFCFF3212B4AEA5B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122Q → R in BAA21886 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006713 mRNA Translation: BAA21886.1
AL512622 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49132.1
CH471066 Genomic DNA Translation: EAW49134.1
CH471066 Genomic DNA Translation: EAW49135.1
BC136329 mRNA Translation: AAI36330.1
BC136330 mRNA Translation: AAI36331.1
Y10976 mRNA Translation: CAA71872.1
CCDSiCCDS7665.1
RefSeqiNP_006417.2, NM_006426.2
UniGeneiHs.100058

Genome annotation databases

EnsembliENST00000338492; ENSP00000339850; ENSG00000151640
GeneIDi10570
KEGGihsa:10570
UCSCiuc009ybb.4 human

Similar proteinsi

Entry informationi

Entry nameiDPYL4_HUMAN
AccessioniPrimary (citable) accession number: O14531
Secondary accession number(s): B2RMQ1
, D3DRG5, O00240, Q5T0Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 21, 2005
Last modified: May 23, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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