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O14530

- TXND9_HUMAN

UniProt

O14530 - TXND9_HUMAN

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Protein

Thioredoxin domain-containing protein 9

Gene
TXNDC9, APACD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 9
Alternative name(s):
ATP-binding protein associated with cell differentiation
Protein 1-4
Gene namesi
Name:TXNDC9
Synonyms:APACD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:24110. TXNDC9.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. midbody Source: Ensembl
  4. nucleus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134957934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Thioredoxin domain-containing protein 9PRO_0000120166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei188 – 1881Phosphoserine3 Publications
Modified residuei221 – 2211Phosphoserine1 Publication
Modified residuei223 – 2231Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14530.
PaxDbiO14530.
PeptideAtlasiO14530.
PRIDEiO14530.

PTM databases

PhosphoSiteiO14530.

Expressioni

Gene expression databases

ArrayExpressiO14530.
BgeeiO14530.
CleanExiHS_TXNDC9.
GenevestigatoriO14530.

Organism-specific databases

HPAiHPA031844.
HPA031845.
HPA031846.

Interactioni

Subunit structurei

Forms ternary complexes with the chaperonin TCP1 complex, spanning the cylindrical chaperonin cavity and contacting at least 2 subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
FEZ1Q996892EBI-707554,EBI-396435

Protein-protein interaction databases

BioGridi115487. 22 interactions.
IntActiO14530. 9 interactions.
MINTiMINT-1374838.
STRINGi9606.ENSP00000264255.

Structurei

3D structure databases

ProteinModelPortaliO14530.
SMRiO14530. Positions 71-189.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 180107ThioredoxinAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.

Phylogenomic databases

eggNOGiCOG0526.
HOVERGENiHBG054120.
InParanoidiO14530.
OMAiMHLKILA.
PhylomeDBiO14530.
TreeFamiTF313442.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

O14530-1 [UniParc]FASTAAdd to Basket

« Hide

MEADASVDMF SKVLEHQLLQ TTKLVEEHLD SEIQKLDQMD EDELERLKEK    50
RLQALRKAQQ QKQEWLSKGH GEYREIPSER DFFQEVKESE NVVCHFYRDS 100
TFRCKILDRH LAILSKKHLE TKFLKLNVEK APFLCERLHI KVIPTLALLK 150
DGKTQDYVVG FTDLGNTDDF TTETLEWRLG SSDILNYSGN LMEPPFQNQK 200
KFGTNFTKLE KKTIRGKKYD SDSDDD 226
Length:226
Mass (Da):26,534
Last modified:September 19, 2002 - v2
Checksum:i2735A2562D1143C3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21E → G.
Corresponds to variant rs11542366 [ dbSNP | Ensembl ].
VAR_058327
Natural varianti14 – 141L → Q.
Corresponds to variant rs11542369 [ dbSNP | Ensembl ].
VAR_058328
Natural varianti38 – 381Q → R.
Corresponds to variant rs11542371 [ dbSNP | Ensembl ].
VAR_058329

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221K → N in BAA21881. 1 Publication
Sequence conflicti190 – 1901N → D in BAD96336. 1 Publication
Sequence conflicti214 – 2141I → M in BAA21881. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006679 mRNA. Translation: BAA21881.1.
AK313777 mRNA. Translation: BAG36515.1.
CR456935 mRNA. Translation: CAG33216.1.
AK222616 mRNA. Translation: BAD96336.1.
AB451403 mRNA. Translation: BAG70217.1.
AC079447 Genomic DNA. Translation: AAX93257.1.
CH471127 Genomic DNA. Translation: EAX01869.1.
CH471127 Genomic DNA. Translation: EAX01870.1.
BC005968 mRNA. Translation: AAH05968.1.
BC022864 mRNA. Translation: AAH22864.1.
BC070183 mRNA. Translation: AAH70183.2.
CCDSiCCDS2044.1.
RefSeqiNP_005774.2. NM_005783.3.
UniGeneiHs.536122.

Genome annotation databases

EnsembliENST00000264255; ENSP00000264255; ENSG00000115514.
GeneIDi10190.
KEGGihsa:10190.
UCSCiuc002szz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006679 mRNA. Translation: BAA21881.1 .
AK313777 mRNA. Translation: BAG36515.1 .
CR456935 mRNA. Translation: CAG33216.1 .
AK222616 mRNA. Translation: BAD96336.1 .
AB451403 mRNA. Translation: BAG70217.1 .
AC079447 Genomic DNA. Translation: AAX93257.1 .
CH471127 Genomic DNA. Translation: EAX01869.1 .
CH471127 Genomic DNA. Translation: EAX01870.1 .
BC005968 mRNA. Translation: AAH05968.1 .
BC022864 mRNA. Translation: AAH22864.1 .
BC070183 mRNA. Translation: AAH70183.2 .
CCDSi CCDS2044.1.
RefSeqi NP_005774.2. NM_005783.3.
UniGenei Hs.536122.

3D structure databases

ProteinModelPortali O14530.
SMRi O14530. Positions 71-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115487. 22 interactions.
IntActi O14530. 9 interactions.
MINTi MINT-1374838.
STRINGi 9606.ENSP00000264255.

PTM databases

PhosphoSitei O14530.

Proteomic databases

MaxQBi O14530.
PaxDbi O14530.
PeptideAtlasi O14530.
PRIDEi O14530.

Protocols and materials databases

DNASUi 10190.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264255 ; ENSP00000264255 ; ENSG00000115514 .
GeneIDi 10190.
KEGGi hsa:10190.
UCSCi uc002szz.3. human.

Organism-specific databases

CTDi 10190.
GeneCardsi GC02M099921.
HGNCi HGNC:24110. TXNDC9.
HPAi HPA031844.
HPA031845.
HPA031846.
MIMi 612564. gene.
neXtProti NX_O14530.
PharmGKBi PA134957934.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0526.
HOVERGENi HBG054120.
InParanoidi O14530.
OMAi MHLKILA.
PhylomeDBi O14530.
TreeFami TF313442.

Miscellaneous databases

GeneWikii TXNDC9.
GenomeRNAii 10190.
NextBioi 38568.
PROi O14530.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14530.
Bgeei O14530.
CleanExi HS_TXNDC9.
Genevestigatori O14530.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of 1-4 gene in functionally distinct ME-1 subclones."
    Shiosaka T.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leukemia.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
    Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
    , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
    Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow, Brain and Kidney.
  9. "PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates."
    Stirling P.C., Cuellar J., Alfaro G.A., El Khadali F., Beh C.T., Valpuesta J.M., Melki R., Leroux M.R.
    J. Biol. Chem. 281:7012-7021(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TCP1 COMPLEX.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221 AND SER-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTXND9_HUMAN
AccessioniPrimary (citable) accession number: O14530
Secondary accession number(s): B2R9G8
, D3DVI4, Q53HG4, Q53RV8, Q6NSF5, Q9BRU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: September 19, 2002
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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