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O14529

- CUX2_HUMAN

UniProt

O14529 - CUX2_HUMAN

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Protein

Homeobox protein cut-like 2

Gene

CUX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi544 – 63188CUT 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi887 – 97488CUT 2PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1038 – 112588CUT 3PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1168 – 122760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProt
  2. sequence-specific DNA binding Source: UniProt

GO - Biological processi

  1. cellular response to organic substance Source: Ensembl
  2. cognition Source: UniProt
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProt
  4. positive regulation of dendrite morphogenesis Source: UniProt
  5. positive regulation of dendritic spine morphogenesis Source: UniProt
  6. positive regulation of excitatory postsynaptic membrane potential Source: UniProt
  7. positive regulation of gene expression Source: UniProt
  8. positive regulation of synapse assembly Source: UniProt
  9. short-term memory Source: UniProt
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein cux-2
Gene namesi
Name:CUX2
Synonyms:CUTL2, KIAA0293
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:19347. CUX2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382977.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14861486Homeobox protein cut-like 2PRO_0000202396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei143 – 1431Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14529.
PaxDbiO14529.
PRIDEiO14529.

PTM databases

PhosphoSiteiO14529.

Expressioni

Gene expression databases

BgeeiO14529.
CleanExiHS_CUX2.
ExpressionAtlasiO14529. baseline and differential.
GenevestigatoriO14529.

Organism-specific databases

HPAiHPA044772.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261726.

Structurei

Secondary structure

1
1486
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi555 – 56814Combined sources
Helixi573 – 5797Combined sources
Helixi585 – 5939Combined sources
Helixi598 – 6003Combined sources
Helixi603 – 61614Combined sources
Helixi620 – 63011Combined sources
Helixi889 – 8935Combined sources
Helixi898 – 91013Combined sources
Turni911 – 9133Combined sources
Helixi916 – 9227Combined sources
Helixi928 – 9369Combined sources
Turni941 – 9433Combined sources
Helixi946 – 96116Combined sources
Helixi1037 – 10437Combined sources
Helixi1049 – 106214Combined sources
Helixi1067 – 10737Combined sources
Helixi1079 – 10879Combined sources
Turni1092 – 10943Combined sources
Helixi1097 – 111115Combined sources
Helixi1115 – 11239Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WH6NMR-A887-974[»]
1WH8NMR-A1028-1125[»]
1X2LNMR-A544-631[»]
ProteinModelPortaliO14529.
SMRiO14529. Positions 549-631, 887-976, 1032-1220.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14529.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili195 – 374180Sequence AnalysisAdd
BLAST
Coiled coili690 – 71728Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi440 – 53596Pro-richAdd
BLAST
Compositional biasi802 – 81312Poly-SerAdd
BLAST
Compositional biasi1327 – 1437111Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiNOG325167.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000143386.
HOVERGENiHBG051268.
InParanoidiO14529.
KOiK09313.
OMAiLVFPPAF.
OrthoDBiEOG7VTDMF.
PhylomeDBiO14529.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14529-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAANVGSMFQ YWKRFDLRRL QKELNSVASE LSARQEESEH SHKHLIELRR
60 70 80 90 100
EFKKNVPEEI REMVAPVLKS FQAEVVALSK RSQEAEAAFL SVYKQLIEAP
110 120 130 140 150
DPVPVFEAAR SLDDRLQPPS FDPSGQPRRD LHTSWKRNPE LLSPKEQREG
160 170 180 190 200
TSPAGPTLTE GSRLPGIPGK ALLTETLLQR NEAEKQKGLQ EVQITLAARL
210 220 230 240 250
GEAEEKIKVL HSALKATQAE LLELRRKYDE EAASKADEVG LIMTNLEKAN
260 270 280 290 300
QRAEAAQREV ESLREQLASV NSSIRLACCS PQGPSGDKVN FTLCSGPRLE
310 320 330 340 350
AALASKDREI LRLLKDVQHL QSSLQELEEA SANQIADLER QLTAKSEAIE
360 370 380 390 400
KLEEKLQAQS DYEEIKTELS ILKAMKLASS TCSLPQGMAK PEDSLLIAKE
410 420 430 440 450
AFFPTQKFLL EKPSLLASPE EDPSEDDSIK DSLGTEQSYP SPQQLPPPPG
460 470 480 490 500
PEDPLSPSPG QPLLGPSLGP DGTRTFSLSP FPSLASGERL MMPPAAFKGE
510 520 530 540 550
AGGLLVFPPA FYGAKPPTAP ATPAPGPEPL GGPEPADGGG GGAAGPGAEE
560 570 580 590 600
EQLDTAEIAF QVKEQLLKHN IGQRVFGHYV LGLSQGSVSE ILARPKPWRK
610 620 630 640 650
LTVKGKEPFI KMKQFLSDEQ NVLALRTIQV RQRGSITPRI RTPETGSDDA
660 670 680 690 700
IKSILEQAKK EIESQKGGEP KTSVAPLSIA NGTTPASTSE DAIKSILEQA
710 720 730 740 750
RREMQAQQQA LLEMEVAPRG RSVPPSPPER PSLATASQNG APALVKQEEG
760 770 780 790 800
SGGPAQAPLP VLSPAAFVQS IIRKVKSEIG DAGYFDHHWA SDRGLLSRPY
810 820 830 840 850
ASVSPSLSSS SSSGYSGQPN GRAWPRGDEA PVPPEDEAAA GAEDEPPRTG
860 870 880 890 900
ELKAEGATAE AGARLPYYPA YVPRTLKPTV PPLTPEQYEL YMYREVDTLE
910 920 930 940 950
LTRQVKEKLA KNGICQRIFG EKVLGLSQGS VSDMLSRPKP WSKLTQKGRE
960 970 980 990 1000
PFIRMQLWLS DQLGQAVGQQ PGASQASPTE PRSSPSPPPS PTEPEKSSQE
1010 1020 1030 1040 1050
PLSLSLESSK ENQQPEGRSS SSLSGKMYSG SQAPGGIQEI VAMSPELDTY
1060 1070 1080 1090 1100
SITKRVKEVL TDNNLGQRLF GESILGLTQG SVSDLLSRPK PWHKLSLKGR
1110 1120 1130 1140 1150
EPFVRMQLWL NDPHNVEKLR DMKKLEKKAY LKRRYGLIST GSDSESPATR
1160 1170 1180 1190 1200
SECPSPCLQP QDLSLLQIKK PRVVLAPEEK EALRKAYQLE PYPSQQTIEL
1210 1220 1230 1240 1250
LSFQLNLKTN TVINWFHNYR SRMRREMLVE GTQDEPDLDP SGGPGILPPG
1260 1270 1280 1290 1300
HSHPDPTPQS PDSETEDQKP TVKELELQEG PEENSTPLTT QDKAQVRIKQ
1310 1320 1330 1340 1350
EQMEEDAEEE AGSQPQDSGE LDKGQGPPKE EHPDPPGNDG LPKVAPGPLL
1360 1370 1380 1390 1400
PGGSTPDCPS LHPQQESEAG ERLHPDPLSF KSASESSRCS LEVSLNSPSA
1410 1420 1430 1440 1450
ASSPGLMMSV SPVPSSSAPI SPSPPGAPPA KVPSASPTAD MAGALHPSAK
1460 1470 1480
VNPNLQRRHE KMANLNNIIY RVERAANREE ALEWEF
Length:1,486
Mass (Da):161,677
Last modified:November 30, 2010 - v4
Checksum:i71782EF5214D0262
GO

Sequence cautioni

The sequence BAA22962.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1472 – 14721V → L.2 Publications
Corresponds to variant rs6490073 [ dbSNP | Ensembl ].
VAR_065096

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006631 mRNA. Translation: BAA22962.2. Different initiation.
AC005805 Genomic DNA. No translation available.
AC002979 Genomic DNA. No translation available.
AC002352 Genomic DNA. No translation available.
AC002978 Genomic DNA. No translation available.
BC151245 mRNA. Translation: AAI51246.1.
CCDSiCCDS41837.1.
RefSeqiNP_056082.2. NM_015267.3.
UniGeneiHs.124953.

Genome annotation databases

EnsembliENST00000261726; ENSP00000261726; ENSG00000111249.
GeneIDi23316.
KEGGihsa:23316.
UCSCiuc001tsa.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006631 mRNA. Translation: BAA22962.2 . Different initiation.
AC005805 Genomic DNA. No translation available.
AC002979 Genomic DNA. No translation available.
AC002352 Genomic DNA. No translation available.
AC002978 Genomic DNA. No translation available.
BC151245 mRNA. Translation: AAI51246.1 .
CCDSi CCDS41837.1.
RefSeqi NP_056082.2. NM_015267.3.
UniGenei Hs.124953.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WH6 NMR - A 887-974 [» ]
1WH8 NMR - A 1028-1125 [» ]
1X2L NMR - A 544-631 [» ]
ProteinModelPortali O14529.
SMRi O14529. Positions 549-631, 887-976, 1032-1220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000261726.

PTM databases

PhosphoSitei O14529.

Proteomic databases

MaxQBi O14529.
PaxDbi O14529.
PRIDEi O14529.

Protocols and materials databases

DNASUi 23316.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261726 ; ENSP00000261726 ; ENSG00000111249 .
GeneIDi 23316.
KEGGi hsa:23316.
UCSCi uc001tsa.2. human.

Organism-specific databases

CTDi 23316.
GeneCardsi GC12P111471.
HGNCi HGNC:19347. CUX2.
HPAi HPA044772.
MIMi 610648. gene.
neXtProti NX_O14529.
PharmGKBi PA162382977.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325167.
GeneTreei ENSGT00530000063019.
HOGENOMi HOG000143386.
HOVERGENi HBG051268.
InParanoidi O14529.
KOi K09313.
OMAi LVFPPAF.
OrthoDBi EOG7VTDMF.
PhylomeDBi O14529.
TreeFami TF318206.

Miscellaneous databases

EvolutionaryTracei O14529.
GenomeRNAii 23316.
NextBioi 45200.
PROi O14529.
SOURCEi Search...

Gene expression databases

Bgeei O14529.
CleanExi HS_CUX2.
ExpressionAtlasi O14529. baseline and differential.
Genevestigatori O14529.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProi IPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view ]
Pfami PF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEi PS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."
    Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Nomura N.
    DNA Res. 4:53-59(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-1472.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-1472.
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Solution structure of the first, second and third CUT domains of human homeobox protein CUX-2 (CUT-like 2)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 544-631 AND 887-1125.

Entry informationi

Entry nameiCUX2_HUMAN
AccessioniPrimary (citable) accession number: O14529
Secondary accession number(s): A7E2Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 136 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3