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O14529

- CUX2_HUMAN

UniProt

O14529 - CUX2_HUMAN

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Protein

Homeobox protein cut-like 2

Gene
CUX2, CUTL2, KIAA0293
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi544 – 63188CUT 1Add
BLAST
DNA bindingi887 – 97488CUT 2Add
BLAST
DNA bindingi1038 – 112588CUT 3Add
BLAST
DNA bindingi1168 – 122760HomeoboxAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProt
  2. sequence-specific DNA binding Source: UniProt
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cellular response to organic substance Source: Ensembl
  2. cognition Source: UniProt
  3. negative regulation of transcription from RNA polymerase II promoter Source: UniProt
  4. positive regulation of dendrite morphogenesis Source: UniProt
  5. positive regulation of dendritic spine morphogenesis Source: UniProt
  6. positive regulation of excitatory postsynaptic membrane potential Source: UniProt
  7. positive regulation of gene expression Source: UniProt
  8. positive regulation of synapse assembly Source: UniProt
  9. short-term memory Source: UniProt
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein cux-2
Gene namesi
Name:CUX2
Synonyms:CUTL2, KIAA0293
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:19347. CUX2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382977.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14861486Homeobox protein cut-like 2PRO_0000202396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei143 – 1431Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14529.
PaxDbiO14529.
PRIDEiO14529.

PTM databases

PhosphoSiteiO14529.

Expressioni

Gene expression databases

ArrayExpressiO14529.
BgeeiO14529.
CleanExiHS_CUX2.
GenevestigatoriO14529.

Organism-specific databases

HPAiHPA044772.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261726.

Structurei

Secondary structure

1
1486
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi555 – 56814
Helixi573 – 5797
Helixi585 – 5939
Helixi598 – 6003
Helixi603 – 61614
Helixi620 – 63011
Helixi889 – 8935
Helixi898 – 91013
Turni911 – 9133
Helixi916 – 9227
Helixi928 – 9369
Turni941 – 9433
Helixi946 – 96116
Helixi1037 – 10437
Helixi1049 – 106214
Helixi1067 – 10737
Helixi1079 – 10879
Turni1092 – 10943
Helixi1097 – 111115
Helixi1115 – 11239

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WH6NMR-A887-974[»]
1WH8NMR-A1028-1125[»]
1X2LNMR-A544-631[»]
ProteinModelPortaliO14529.
SMRiO14529. Positions 549-631, 887-976, 1032-1220.

Miscellaneous databases

EvolutionaryTraceiO14529.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili195 – 374180 Reviewed predictionAdd
BLAST
Coiled coili690 – 71728 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi440 – 53596Pro-richAdd
BLAST
Compositional biasi802 – 81312Poly-SerAdd
BLAST
Compositional biasi1327 – 1437111Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CUT homeobox family.

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiNOG325167.
HOGENOMiHOG000143386.
HOVERGENiHBG051268.
InParanoidiO14529.
KOiK09313.
OMAiLVFPPAF.
OrthoDBiEOG7VTDMF.
PhylomeDBiO14529.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. Hmoeo_CUT.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14529-1 [UniParc]FASTAAdd to Basket

« Hide

MAANVGSMFQ YWKRFDLRRL QKELNSVASE LSARQEESEH SHKHLIELRR     50
EFKKNVPEEI REMVAPVLKS FQAEVVALSK RSQEAEAAFL SVYKQLIEAP 100
DPVPVFEAAR SLDDRLQPPS FDPSGQPRRD LHTSWKRNPE LLSPKEQREG 150
TSPAGPTLTE GSRLPGIPGK ALLTETLLQR NEAEKQKGLQ EVQITLAARL 200
GEAEEKIKVL HSALKATQAE LLELRRKYDE EAASKADEVG LIMTNLEKAN 250
QRAEAAQREV ESLREQLASV NSSIRLACCS PQGPSGDKVN FTLCSGPRLE 300
AALASKDREI LRLLKDVQHL QSSLQELEEA SANQIADLER QLTAKSEAIE 350
KLEEKLQAQS DYEEIKTELS ILKAMKLASS TCSLPQGMAK PEDSLLIAKE 400
AFFPTQKFLL EKPSLLASPE EDPSEDDSIK DSLGTEQSYP SPQQLPPPPG 450
PEDPLSPSPG QPLLGPSLGP DGTRTFSLSP FPSLASGERL MMPPAAFKGE 500
AGGLLVFPPA FYGAKPPTAP ATPAPGPEPL GGPEPADGGG GGAAGPGAEE 550
EQLDTAEIAF QVKEQLLKHN IGQRVFGHYV LGLSQGSVSE ILARPKPWRK 600
LTVKGKEPFI KMKQFLSDEQ NVLALRTIQV RQRGSITPRI RTPETGSDDA 650
IKSILEQAKK EIESQKGGEP KTSVAPLSIA NGTTPASTSE DAIKSILEQA 700
RREMQAQQQA LLEMEVAPRG RSVPPSPPER PSLATASQNG APALVKQEEG 750
SGGPAQAPLP VLSPAAFVQS IIRKVKSEIG DAGYFDHHWA SDRGLLSRPY 800
ASVSPSLSSS SSSGYSGQPN GRAWPRGDEA PVPPEDEAAA GAEDEPPRTG 850
ELKAEGATAE AGARLPYYPA YVPRTLKPTV PPLTPEQYEL YMYREVDTLE 900
LTRQVKEKLA KNGICQRIFG EKVLGLSQGS VSDMLSRPKP WSKLTQKGRE 950
PFIRMQLWLS DQLGQAVGQQ PGASQASPTE PRSSPSPPPS PTEPEKSSQE 1000
PLSLSLESSK ENQQPEGRSS SSLSGKMYSG SQAPGGIQEI VAMSPELDTY 1050
SITKRVKEVL TDNNLGQRLF GESILGLTQG SVSDLLSRPK PWHKLSLKGR 1100
EPFVRMQLWL NDPHNVEKLR DMKKLEKKAY LKRRYGLIST GSDSESPATR 1150
SECPSPCLQP QDLSLLQIKK PRVVLAPEEK EALRKAYQLE PYPSQQTIEL 1200
LSFQLNLKTN TVINWFHNYR SRMRREMLVE GTQDEPDLDP SGGPGILPPG 1250
HSHPDPTPQS PDSETEDQKP TVKELELQEG PEENSTPLTT QDKAQVRIKQ 1300
EQMEEDAEEE AGSQPQDSGE LDKGQGPPKE EHPDPPGNDG LPKVAPGPLL 1350
PGGSTPDCPS LHPQQESEAG ERLHPDPLSF KSASESSRCS LEVSLNSPSA 1400
ASSPGLMMSV SPVPSSSAPI SPSPPGAPPA KVPSASPTAD MAGALHPSAK 1450
VNPNLQRRHE KMANLNNIIY RVERAANREE ALEWEF 1486
Length:1,486
Mass (Da):161,677
Last modified:November 30, 2010 - v4
Checksum:i71782EF5214D0262
GO

Sequence cautioni

The sequence BAA22962.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1472 – 14721V → L.2 Publications
Corresponds to variant rs6490073 [ dbSNP | Ensembl ].
VAR_065096

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006631 mRNA. Translation: BAA22962.2. Different initiation.
AC005805 Genomic DNA. No translation available.
AC002979 Genomic DNA. No translation available.
AC002352 Genomic DNA. No translation available.
AC002978 Genomic DNA. No translation available.
BC151245 mRNA. Translation: AAI51246.1.
CCDSiCCDS41837.1.
RefSeqiNP_056082.2. NM_015267.3.
UniGeneiHs.124953.

Genome annotation databases

EnsembliENST00000261726; ENSP00000261726; ENSG00000111249.
GeneIDi23316.
KEGGihsa:23316.
UCSCiuc001tsa.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB006631 mRNA. Translation: BAA22962.2 . Different initiation.
AC005805 Genomic DNA. No translation available.
AC002979 Genomic DNA. No translation available.
AC002352 Genomic DNA. No translation available.
AC002978 Genomic DNA. No translation available.
BC151245 mRNA. Translation: AAI51246.1 .
CCDSi CCDS41837.1.
RefSeqi NP_056082.2. NM_015267.3.
UniGenei Hs.124953.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WH6 NMR - A 887-974 [» ]
1WH8 NMR - A 1028-1125 [» ]
1X2L NMR - A 544-631 [» ]
ProteinModelPortali O14529.
SMRi O14529. Positions 549-631, 887-976, 1032-1220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000261726.

PTM databases

PhosphoSitei O14529.

Proteomic databases

MaxQBi O14529.
PaxDbi O14529.
PRIDEi O14529.

Protocols and materials databases

DNASUi 23316.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261726 ; ENSP00000261726 ; ENSG00000111249 .
GeneIDi 23316.
KEGGi hsa:23316.
UCSCi uc001tsa.2. human.

Organism-specific databases

CTDi 23316.
GeneCardsi GC12P111471.
HGNCi HGNC:19347. CUX2.
HPAi HPA044772.
MIMi 610648. gene.
neXtProti NX_O14529.
PharmGKBi PA162382977.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325167.
HOGENOMi HOG000143386.
HOVERGENi HBG051268.
InParanoidi O14529.
KOi K09313.
OMAi LVFPPAF.
OrthoDBi EOG7VTDMF.
PhylomeDBi O14529.
TreeFami TF318206.

Miscellaneous databases

EvolutionaryTracei O14529.
GenomeRNAii 23316.
NextBioi 45200.
PROi O14529.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14529.
Bgeei O14529.
CleanExi HS_CUX2.
Genevestigatori O14529.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProi IPR003350. Hmoeo_CUT.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view ]
Pfami PF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEi PS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."
    Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Nomura N.
    DNA Res. 4:53-59(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-1472.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-1472.
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Solution structure of the first, second and third CUT domains of human homeobox protein CUX-2 (CUT-like 2)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 544-631 AND 887-1125.

Entry informationi

Entry nameiCUX2_HUMAN
AccessioniPrimary (citable) accession number: O14529
Secondary accession number(s): A7E2Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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