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Protein

Homeobox protein cut-like 2

Gene

CUX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi544 – 631CUT 1PROSITE-ProRule annotationAdd BLAST88
DNA bindingi887 – 974CUT 2PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1038 – 1125CUT 3PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1168 – 1227HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein cux-2
Gene namesi
Name:CUX2
Synonyms:CUTL2, KIAA0293
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111249.13
HGNCiHGNC:19347 CUX2
MIMi610648 gene
neXtProtiNX_O14529

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23316
OpenTargetsiENSG00000111249
PharmGKBiPA162382977

Polymorphism and mutation databases

BioMutaiCUX2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002023961 – 1486Homeobox protein cut-like 2Add BLAST1486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei143PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14529
MaxQBiO14529
PaxDbiO14529
PeptideAtlasiO14529
PRIDEiO14529

PTM databases

iPTMnetiO14529
PhosphoSitePlusiO14529

Expressioni

Gene expression databases

BgeeiENSG00000111249
CleanExiHS_CUX2
ExpressionAtlasiO14529 baseline and differential
GenevisibleiO14529 HS

Organism-specific databases

HPAiHPA044772

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261726

Structurei

Secondary structure

11486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi555 – 568Combined sources14
Helixi573 – 579Combined sources7
Helixi585 – 593Combined sources9
Helixi598 – 600Combined sources3
Helixi603 – 616Combined sources14
Helixi620 – 630Combined sources11
Helixi889 – 893Combined sources5
Helixi898 – 910Combined sources13
Turni911 – 913Combined sources3
Helixi916 – 922Combined sources7
Helixi928 – 936Combined sources9
Turni941 – 943Combined sources3
Helixi946 – 961Combined sources16
Helixi1037 – 1043Combined sources7
Helixi1049 – 1062Combined sources14
Helixi1067 – 1073Combined sources7
Helixi1079 – 1087Combined sources9
Turni1092 – 1094Combined sources3
Helixi1097 – 1111Combined sources15
Helixi1115 – 1123Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WH6NMR-A887-974[»]
1WH8NMR-A1028-1125[»]
1X2LNMR-A544-631[»]
ProteinModelPortaliO14529
SMRiO14529
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14529

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili195 – 374Sequence analysisAdd BLAST180
Coiled coili690 – 717Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi440 – 535Pro-richAdd BLAST96
Compositional biasi802 – 813Poly-SerAdd BLAST12
Compositional biasi1327 – 1437Pro-richAdd BLAST111

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0963 Eukaryota
KOG2252 Eukaryota
ENOG410XPKP LUCA
GeneTreeiENSGT00530000063019
HOGENOMiHOG000143386
HOVERGENiHBG051268
InParanoidiO14529
KOiK09313
OMAiACCSPQG
OrthoDBiEOG091G011E
PhylomeDBiO14529
TreeFamiTF318206

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376 CUT, 3 hits
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 3 hits
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 3 hits
PROSITEiView protein in PROSITE
PS51042 CUT, 3 hits
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O14529-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANVGSMFQ YWKRFDLRRL QKELNSVASE LSARQEESEH SHKHLIELRR
60 70 80 90 100
EFKKNVPEEI REMVAPVLKS FQAEVVALSK RSQEAEAAFL SVYKQLIEAP
110 120 130 140 150
DPVPVFEAAR SLDDRLQPPS FDPSGQPRRD LHTSWKRNPE LLSPKEQREG
160 170 180 190 200
TSPAGPTLTE GSRLPGIPGK ALLTETLLQR NEAEKQKGLQ EVQITLAARL
210 220 230 240 250
GEAEEKIKVL HSALKATQAE LLELRRKYDE EAASKADEVG LIMTNLEKAN
260 270 280 290 300
QRAEAAQREV ESLREQLASV NSSIRLACCS PQGPSGDKVN FTLCSGPRLE
310 320 330 340 350
AALASKDREI LRLLKDVQHL QSSLQELEEA SANQIADLER QLTAKSEAIE
360 370 380 390 400
KLEEKLQAQS DYEEIKTELS ILKAMKLASS TCSLPQGMAK PEDSLLIAKE
410 420 430 440 450
AFFPTQKFLL EKPSLLASPE EDPSEDDSIK DSLGTEQSYP SPQQLPPPPG
460 470 480 490 500
PEDPLSPSPG QPLLGPSLGP DGTRTFSLSP FPSLASGERL MMPPAAFKGE
510 520 530 540 550
AGGLLVFPPA FYGAKPPTAP ATPAPGPEPL GGPEPADGGG GGAAGPGAEE
560 570 580 590 600
EQLDTAEIAF QVKEQLLKHN IGQRVFGHYV LGLSQGSVSE ILARPKPWRK
610 620 630 640 650
LTVKGKEPFI KMKQFLSDEQ NVLALRTIQV RQRGSITPRI RTPETGSDDA
660 670 680 690 700
IKSILEQAKK EIESQKGGEP KTSVAPLSIA NGTTPASTSE DAIKSILEQA
710 720 730 740 750
RREMQAQQQA LLEMEVAPRG RSVPPSPPER PSLATASQNG APALVKQEEG
760 770 780 790 800
SGGPAQAPLP VLSPAAFVQS IIRKVKSEIG DAGYFDHHWA SDRGLLSRPY
810 820 830 840 850
ASVSPSLSSS SSSGYSGQPN GRAWPRGDEA PVPPEDEAAA GAEDEPPRTG
860 870 880 890 900
ELKAEGATAE AGARLPYYPA YVPRTLKPTV PPLTPEQYEL YMYREVDTLE
910 920 930 940 950
LTRQVKEKLA KNGICQRIFG EKVLGLSQGS VSDMLSRPKP WSKLTQKGRE
960 970 980 990 1000
PFIRMQLWLS DQLGQAVGQQ PGASQASPTE PRSSPSPPPS PTEPEKSSQE
1010 1020 1030 1040 1050
PLSLSLESSK ENQQPEGRSS SSLSGKMYSG SQAPGGIQEI VAMSPELDTY
1060 1070 1080 1090 1100
SITKRVKEVL TDNNLGQRLF GESILGLTQG SVSDLLSRPK PWHKLSLKGR
1110 1120 1130 1140 1150
EPFVRMQLWL NDPHNVEKLR DMKKLEKKAY LKRRYGLIST GSDSESPATR
1160 1170 1180 1190 1200
SECPSPCLQP QDLSLLQIKK PRVVLAPEEK EALRKAYQLE PYPSQQTIEL
1210 1220 1230 1240 1250
LSFQLNLKTN TVINWFHNYR SRMRREMLVE GTQDEPDLDP SGGPGILPPG
1260 1270 1280 1290 1300
HSHPDPTPQS PDSETEDQKP TVKELELQEG PEENSTPLTT QDKAQVRIKQ
1310 1320 1330 1340 1350
EQMEEDAEEE AGSQPQDSGE LDKGQGPPKE EHPDPPGNDG LPKVAPGPLL
1360 1370 1380 1390 1400
PGGSTPDCPS LHPQQESEAG ERLHPDPLSF KSASESSRCS LEVSLNSPSA
1410 1420 1430 1440 1450
ASSPGLMMSV SPVPSSSAPI SPSPPGAPPA KVPSASPTAD MAGALHPSAK
1460 1470 1480
VNPNLQRRHE KMANLNNIIY RVERAANREE ALEWEF
Length:1,486
Mass (Da):161,677
Last modified:November 30, 2010 - v4
Checksum:i71782EF5214D0262
GO

Sequence cautioni

The sequence BAA22962 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0650961472V → L2 PublicationsCorresponds to variant dbSNP:rs6490073Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006631 mRNA Translation: BAA22962.2 Different initiation.
AC005805 Genomic DNA No translation available.
AC002979 Genomic DNA No translation available.
AC002352 Genomic DNA No translation available.
AC002978 Genomic DNA No translation available.
BC151245 mRNA Translation: AAI51246.1
CCDSiCCDS41837.1
RefSeqiNP_056082.2, NM_015267.3
UniGeneiHs.124953

Genome annotation databases

EnsembliENST00000261726; ENSP00000261726; ENSG00000111249
GeneIDi23316
KEGGihsa:23316
UCSCiuc001tsa.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCUX2_HUMAN
AccessioniPrimary (citable) accession number: O14529
Secondary accession number(s): A7E2Y4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 165 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health