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O14529

- CUX2_HUMAN

UniProt

O14529 - CUX2_HUMAN

Protein

Homeobox protein cut-like 2

Gene

CUX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 4 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi544 – 63188CUT 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi887 – 97488CUT 2PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi1038 – 112588CUT 3PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi1168 – 122760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProt
    2. sequence-specific DNA binding Source: UniProt
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cellular response to organic substance Source: Ensembl
    2. cognition Source: UniProt
    3. negative regulation of transcription from RNA polymerase II promoter Source: UniProt
    4. positive regulation of dendrite morphogenesis Source: UniProt
    5. positive regulation of dendritic spine morphogenesis Source: UniProt
    6. positive regulation of excitatory postsynaptic membrane potential Source: UniProt
    7. positive regulation of gene expression Source: UniProt
    8. positive regulation of synapse assembly Source: UniProt
    9. short-term memory Source: UniProt
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein cut-like 2
    Alternative name(s):
    Homeobox protein cux-2
    Gene namesi
    Name:CUX2
    Synonyms:CUTL2, KIAA0293
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:19347. CUX2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. nucleus Source: UniProt

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162382977.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14861486Homeobox protein cut-like 2PRO_0000202396Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei143 – 1431Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO14529.
    PaxDbiO14529.
    PRIDEiO14529.

    PTM databases

    PhosphoSiteiO14529.

    Expressioni

    Gene expression databases

    ArrayExpressiO14529.
    BgeeiO14529.
    CleanExiHS_CUX2.
    GenevestigatoriO14529.

    Organism-specific databases

    HPAiHPA044772.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000261726.

    Structurei

    Secondary structure

    1
    1486
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi555 – 56814
    Helixi573 – 5797
    Helixi585 – 5939
    Helixi598 – 6003
    Helixi603 – 61614
    Helixi620 – 63011
    Helixi889 – 8935
    Helixi898 – 91013
    Turni911 – 9133
    Helixi916 – 9227
    Helixi928 – 9369
    Turni941 – 9433
    Helixi946 – 96116
    Helixi1037 – 10437
    Helixi1049 – 106214
    Helixi1067 – 10737
    Helixi1079 – 10879
    Turni1092 – 10943
    Helixi1097 – 111115
    Helixi1115 – 11239

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WH6NMR-A887-974[»]
    1WH8NMR-A1028-1125[»]
    1X2LNMR-A544-631[»]
    ProteinModelPortaliO14529.
    SMRiO14529. Positions 549-631, 887-976, 1032-1220.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14529.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili195 – 374180Sequence AnalysisAdd
    BLAST
    Coiled coili690 – 71728Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi440 – 53596Pro-richAdd
    BLAST
    Compositional biasi802 – 81312Poly-SerAdd
    BLAST
    Compositional biasi1327 – 1437111Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CUT homeobox family.Curated
    Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Homeobox, Repeat

    Phylogenomic databases

    eggNOGiNOG325167.
    HOGENOMiHOG000143386.
    HOVERGENiHBG051268.
    InParanoidiO14529.
    KOiK09313.
    OMAiLVFPPAF.
    OrthoDBiEOG7VTDMF.
    PhylomeDBiO14529.
    TreeFamiTF318206.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 3 hits.
    InterProiIPR003350. Hmoeo_CUT.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view]
    PfamiPF02376. CUT. 3 hits.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 3 hits.
    PROSITEiPS51042. CUT. 3 hits.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14529-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAANVGSMFQ YWKRFDLRRL QKELNSVASE LSARQEESEH SHKHLIELRR     50
    EFKKNVPEEI REMVAPVLKS FQAEVVALSK RSQEAEAAFL SVYKQLIEAP 100
    DPVPVFEAAR SLDDRLQPPS FDPSGQPRRD LHTSWKRNPE LLSPKEQREG 150
    TSPAGPTLTE GSRLPGIPGK ALLTETLLQR NEAEKQKGLQ EVQITLAARL 200
    GEAEEKIKVL HSALKATQAE LLELRRKYDE EAASKADEVG LIMTNLEKAN 250
    QRAEAAQREV ESLREQLASV NSSIRLACCS PQGPSGDKVN FTLCSGPRLE 300
    AALASKDREI LRLLKDVQHL QSSLQELEEA SANQIADLER QLTAKSEAIE 350
    KLEEKLQAQS DYEEIKTELS ILKAMKLASS TCSLPQGMAK PEDSLLIAKE 400
    AFFPTQKFLL EKPSLLASPE EDPSEDDSIK DSLGTEQSYP SPQQLPPPPG 450
    PEDPLSPSPG QPLLGPSLGP DGTRTFSLSP FPSLASGERL MMPPAAFKGE 500
    AGGLLVFPPA FYGAKPPTAP ATPAPGPEPL GGPEPADGGG GGAAGPGAEE 550
    EQLDTAEIAF QVKEQLLKHN IGQRVFGHYV LGLSQGSVSE ILARPKPWRK 600
    LTVKGKEPFI KMKQFLSDEQ NVLALRTIQV RQRGSITPRI RTPETGSDDA 650
    IKSILEQAKK EIESQKGGEP KTSVAPLSIA NGTTPASTSE DAIKSILEQA 700
    RREMQAQQQA LLEMEVAPRG RSVPPSPPER PSLATASQNG APALVKQEEG 750
    SGGPAQAPLP VLSPAAFVQS IIRKVKSEIG DAGYFDHHWA SDRGLLSRPY 800
    ASVSPSLSSS SSSGYSGQPN GRAWPRGDEA PVPPEDEAAA GAEDEPPRTG 850
    ELKAEGATAE AGARLPYYPA YVPRTLKPTV PPLTPEQYEL YMYREVDTLE 900
    LTRQVKEKLA KNGICQRIFG EKVLGLSQGS VSDMLSRPKP WSKLTQKGRE 950
    PFIRMQLWLS DQLGQAVGQQ PGASQASPTE PRSSPSPPPS PTEPEKSSQE 1000
    PLSLSLESSK ENQQPEGRSS SSLSGKMYSG SQAPGGIQEI VAMSPELDTY 1050
    SITKRVKEVL TDNNLGQRLF GESILGLTQG SVSDLLSRPK PWHKLSLKGR 1100
    EPFVRMQLWL NDPHNVEKLR DMKKLEKKAY LKRRYGLIST GSDSESPATR 1150
    SECPSPCLQP QDLSLLQIKK PRVVLAPEEK EALRKAYQLE PYPSQQTIEL 1200
    LSFQLNLKTN TVINWFHNYR SRMRREMLVE GTQDEPDLDP SGGPGILPPG 1250
    HSHPDPTPQS PDSETEDQKP TVKELELQEG PEENSTPLTT QDKAQVRIKQ 1300
    EQMEEDAEEE AGSQPQDSGE LDKGQGPPKE EHPDPPGNDG LPKVAPGPLL 1350
    PGGSTPDCPS LHPQQESEAG ERLHPDPLSF KSASESSRCS LEVSLNSPSA 1400
    ASSPGLMMSV SPVPSSSAPI SPSPPGAPPA KVPSASPTAD MAGALHPSAK 1450
    VNPNLQRRHE KMANLNNIIY RVERAANREE ALEWEF 1486
    Length:1,486
    Mass (Da):161,677
    Last modified:November 30, 2010 - v4
    Checksum:i71782EF5214D0262
    GO

    Sequence cautioni

    The sequence BAA22962.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1472 – 14721V → L.2 Publications
    Corresponds to variant rs6490073 [ dbSNP | Ensembl ].
    VAR_065096

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006631 mRNA. Translation: BAA22962.2. Different initiation.
    AC005805 Genomic DNA. No translation available.
    AC002979 Genomic DNA. No translation available.
    AC002352 Genomic DNA. No translation available.
    AC002978 Genomic DNA. No translation available.
    BC151245 mRNA. Translation: AAI51246.1.
    CCDSiCCDS41837.1.
    RefSeqiNP_056082.2. NM_015267.3.
    UniGeneiHs.124953.

    Genome annotation databases

    EnsembliENST00000261726; ENSP00000261726; ENSG00000111249.
    GeneIDi23316.
    KEGGihsa:23316.
    UCSCiuc001tsa.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006631 mRNA. Translation: BAA22962.2 . Different initiation.
    AC005805 Genomic DNA. No translation available.
    AC002979 Genomic DNA. No translation available.
    AC002352 Genomic DNA. No translation available.
    AC002978 Genomic DNA. No translation available.
    BC151245 mRNA. Translation: AAI51246.1 .
    CCDSi CCDS41837.1.
    RefSeqi NP_056082.2. NM_015267.3.
    UniGenei Hs.124953.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WH6 NMR - A 887-974 [» ]
    1WH8 NMR - A 1028-1125 [» ]
    1X2L NMR - A 544-631 [» ]
    ProteinModelPortali O14529.
    SMRi O14529. Positions 549-631, 887-976, 1032-1220.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000261726.

    PTM databases

    PhosphoSitei O14529.

    Proteomic databases

    MaxQBi O14529.
    PaxDbi O14529.
    PRIDEi O14529.

    Protocols and materials databases

    DNASUi 23316.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261726 ; ENSP00000261726 ; ENSG00000111249 .
    GeneIDi 23316.
    KEGGi hsa:23316.
    UCSCi uc001tsa.2. human.

    Organism-specific databases

    CTDi 23316.
    GeneCardsi GC12P111471.
    HGNCi HGNC:19347. CUX2.
    HPAi HPA044772.
    MIMi 610648. gene.
    neXtProti NX_O14529.
    PharmGKBi PA162382977.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325167.
    HOGENOMi HOG000143386.
    HOVERGENi HBG051268.
    InParanoidi O14529.
    KOi K09313.
    OMAi LVFPPAF.
    OrthoDBi EOG7VTDMF.
    PhylomeDBi O14529.
    TreeFami TF318206.

    Miscellaneous databases

    EvolutionaryTracei O14529.
    GenomeRNAii 23316.
    NextBioi 45200.
    PROi O14529.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14529.
    Bgeei O14529.
    CleanExi HS_CUX2.
    Genevestigatori O14529.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 3 hits.
    InterProi IPR003350. Hmoeo_CUT.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02376. CUT. 3 hits.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 3 hits.
    PROSITEi PS51042. CUT. 3 hits.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."
      Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Nomura N.
      DNA Res. 4:53-59(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-1472.
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-1472.
      Tissue: Brain.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Solution structure of the first, second and third CUT domains of human homeobox protein CUX-2 (CUT-like 2)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 544-631 AND 887-1125.

    Entry informationi

    Entry nameiCUX2_HUMAN
    AccessioniPrimary (citable) accession number: O14529
    Secondary accession number(s): A7E2Y4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 135 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3