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O14529 (CUX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein cux-2
Gene names
Name:CUX2
Synonyms:CUTL2, KIAA0293
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1486 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the CUT homeobox family.

Contains 3 CUT DNA-binding domains.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence BAA22962.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Homeobox
Repeat
   LigandDNA-binding
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to organic substance

Inferred from electronic annotation. Source: Ensembl

cognition

Inferred from mutant phenotype PubMed 15389760. Source: UniProt

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15656993. Source: UniProt

positive regulation of dendrite morphogenesis

Inferred from sequence or structural similarity. Source: UniProt

positive regulation of dendritic spine morphogenesis

Inferred from sequence or structural similarity. Source: UniProt

positive regulation of excitatory postsynaptic membrane potential

Inferred from sequence or structural similarity. Source: UniProt

positive regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProt

positive regulation of synapse assembly

Inferred from sequence or structural similarity. Source: UniProt

short-term memory

Inferred from sequence or structural similarity. Source: UniProt

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

nucleus

Inferred from direct assay PubMed 15656993. Source: UniProt

   Molecular_functionRNA polymerase II regulatory region sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProt

sequence-specific DNA binding

Inferred from direct assay PubMed 15656993. Source: UniProt

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14861486Homeobox protein cut-like 2
PRO_0000202396

Regions

DNA binding544 – 63188CUT 1
DNA binding887 – 97488CUT 2
DNA binding1038 – 112588CUT 3
DNA binding1168 – 122760Homeobox
Coiled coil195 – 374180 Potential
Coiled coil690 – 71728 Potential
Compositional bias440 – 53596Pro-rich
Compositional bias802 – 81312Poly-Ser
Compositional bias1327 – 1437111Pro-rich

Amino acid modifications

Modified residue1431Phosphoserine Ref.5

Natural variations

Natural variant14721V → L. Ref.1 Ref.4
Corresponds to variant rs6490073 [ dbSNP | Ensembl ].
VAR_065096

Secondary structure

........................................ 1486
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O14529 [UniParc].

Last modified November 30, 2010. Version 4.
Checksum: 71782EF5214D0262

FASTA1,486161,677
        10         20         30         40         50         60 
MAANVGSMFQ YWKRFDLRRL QKELNSVASE LSARQEESEH SHKHLIELRR EFKKNVPEEI 

        70         80         90        100        110        120 
REMVAPVLKS FQAEVVALSK RSQEAEAAFL SVYKQLIEAP DPVPVFEAAR SLDDRLQPPS 

       130        140        150        160        170        180 
FDPSGQPRRD LHTSWKRNPE LLSPKEQREG TSPAGPTLTE GSRLPGIPGK ALLTETLLQR 

       190        200        210        220        230        240 
NEAEKQKGLQ EVQITLAARL GEAEEKIKVL HSALKATQAE LLELRRKYDE EAASKADEVG 

       250        260        270        280        290        300 
LIMTNLEKAN QRAEAAQREV ESLREQLASV NSSIRLACCS PQGPSGDKVN FTLCSGPRLE 

       310        320        330        340        350        360 
AALASKDREI LRLLKDVQHL QSSLQELEEA SANQIADLER QLTAKSEAIE KLEEKLQAQS 

       370        380        390        400        410        420 
DYEEIKTELS ILKAMKLASS TCSLPQGMAK PEDSLLIAKE AFFPTQKFLL EKPSLLASPE 

       430        440        450        460        470        480 
EDPSEDDSIK DSLGTEQSYP SPQQLPPPPG PEDPLSPSPG QPLLGPSLGP DGTRTFSLSP 

       490        500        510        520        530        540 
FPSLASGERL MMPPAAFKGE AGGLLVFPPA FYGAKPPTAP ATPAPGPEPL GGPEPADGGG 

       550        560        570        580        590        600 
GGAAGPGAEE EQLDTAEIAF QVKEQLLKHN IGQRVFGHYV LGLSQGSVSE ILARPKPWRK 

       610        620        630        640        650        660 
LTVKGKEPFI KMKQFLSDEQ NVLALRTIQV RQRGSITPRI RTPETGSDDA IKSILEQAKK 

       670        680        690        700        710        720 
EIESQKGGEP KTSVAPLSIA NGTTPASTSE DAIKSILEQA RREMQAQQQA LLEMEVAPRG 

       730        740        750        760        770        780 
RSVPPSPPER PSLATASQNG APALVKQEEG SGGPAQAPLP VLSPAAFVQS IIRKVKSEIG 

       790        800        810        820        830        840 
DAGYFDHHWA SDRGLLSRPY ASVSPSLSSS SSSGYSGQPN GRAWPRGDEA PVPPEDEAAA 

       850        860        870        880        890        900 
GAEDEPPRTG ELKAEGATAE AGARLPYYPA YVPRTLKPTV PPLTPEQYEL YMYREVDTLE 

       910        920        930        940        950        960 
LTRQVKEKLA KNGICQRIFG EKVLGLSQGS VSDMLSRPKP WSKLTQKGRE PFIRMQLWLS 

       970        980        990       1000       1010       1020 
DQLGQAVGQQ PGASQASPTE PRSSPSPPPS PTEPEKSSQE PLSLSLESSK ENQQPEGRSS 

      1030       1040       1050       1060       1070       1080 
SSLSGKMYSG SQAPGGIQEI VAMSPELDTY SITKRVKEVL TDNNLGQRLF GESILGLTQG 

      1090       1100       1110       1120       1130       1140 
SVSDLLSRPK PWHKLSLKGR EPFVRMQLWL NDPHNVEKLR DMKKLEKKAY LKRRYGLIST 

      1150       1160       1170       1180       1190       1200 
GSDSESPATR SECPSPCLQP QDLSLLQIKK PRVVLAPEEK EALRKAYQLE PYPSQQTIEL 

      1210       1220       1230       1240       1250       1260 
LSFQLNLKTN TVINWFHNYR SRMRREMLVE GTQDEPDLDP SGGPGILPPG HSHPDPTPQS 

      1270       1280       1290       1300       1310       1320 
PDSETEDQKP TVKELELQEG PEENSTPLTT QDKAQVRIKQ EQMEEDAEEE AGSQPQDSGE 

      1330       1340       1350       1360       1370       1380 
LDKGQGPPKE EHPDPPGNDG LPKVAPGPLL PGGSTPDCPS LHPQQESEAG ERLHPDPLSF 

      1390       1400       1410       1420       1430       1440 
KSASESSRCS LEVSLNSPSA ASSPGLMMSV SPVPSSSAPI SPSPPGAPPA KVPSASPTAD 

      1450       1460       1470       1480 
MAGALHPSAK VNPNLQRRHE KMANLNNIIY RVERAANREE ALEWEF 

« Hide

References

« Hide 'large scale' references
[1]"Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."
Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Nomura N.
DNA Res. 4:53-59(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-1472.
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-1472.
Tissue: Brain.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Solution structure of the first, second and third CUT domains of human homeobox protein CUX-2 (CUT-like 2)."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 544-631 AND 887-1125.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB006631 mRNA. Translation: BAA22962.2. Different initiation.
AC005805 Genomic DNA. No translation available.
AC002979 Genomic DNA. No translation available.
AC002352 Genomic DNA. No translation available.
AC002978 Genomic DNA. No translation available.
BC151245 mRNA. Translation: AAI51246.1.
CCDSCCDS41837.1.
RefSeqNP_056082.2. NM_015267.3.
UniGeneHs.124953.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WH6NMR-A887-974[»]
1WH8NMR-A1028-1125[»]
1X2LNMR-A544-631[»]
ProteinModelPortalO14529.
SMRO14529. Positions 549-631, 887-976, 1032-1220.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000261726.

PTM databases

PhosphoSiteO14529.

Proteomic databases

MaxQBO14529.
PaxDbO14529.
PRIDEO14529.

Protocols and materials databases

DNASU23316.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261726; ENSP00000261726; ENSG00000111249.
GeneID23316.
KEGGhsa:23316.
UCSCuc001tsa.2. human.

Organism-specific databases

CTD23316.
GeneCardsGC12P111471.
HGNCHGNC:19347. CUX2.
HPAHPA044772.
MIM610648. gene.
neXtProtNX_O14529.
PharmGKBPA162382977.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325167.
HOGENOMHOG000143386.
HOVERGENHBG051268.
InParanoidO14529.
KOK09313.
OMALVFPPAF.
OrthoDBEOG7VTDMF.
PhylomeDBO14529.
TreeFamTF318206.

Gene expression databases

ArrayExpressO14529.
BgeeO14529.
CleanExHS_CUX2.
GenevestigatorO14529.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProIPR003350. Hmoeo_CUT.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO14529.
GenomeRNAi23316.
NextBio45200.
PROO14529.
SOURCESearch...

Entry information

Entry nameCUX2_HUMAN
AccessionPrimary (citable) accession number: O14529
Secondary accession number(s): A7E2Y4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM