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Protein

Homeobox protein cut-like 2

Gene

CUX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi544 – 631CUT 1PROSITE-ProRule annotationAdd BLAST88
DNA bindingi887 – 974CUT 2PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1038 – 1125CUT 3PROSITE-ProRule annotationAdd BLAST88
DNA bindingi1168 – 1227HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111249-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein cux-2
Gene namesi
Name:CUX2
Synonyms:CUTL2, KIAA0293
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:19347. CUX2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • Golgi membrane Source: GO_Central
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23316.
OpenTargetsiENSG00000111249.
PharmGKBiPA162382977.

Polymorphism and mutation databases

BioMutaiCUX2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002023961 – 1486Homeobox protein cut-like 2Add BLAST1486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei143PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14529.
PaxDbiO14529.
PeptideAtlasiO14529.
PRIDEiO14529.

PTM databases

iPTMnetiO14529.
PhosphoSitePlusiO14529.

Expressioni

Gene expression databases

BgeeiENSG00000111249.
CleanExiHS_CUX2.
ExpressionAtlasiO14529. baseline and differential.
GenevisibleiO14529. HS.

Organism-specific databases

HPAiHPA044772.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261726.

Structurei

Secondary structure

11486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi555 – 568Combined sources14
Helixi573 – 579Combined sources7
Helixi585 – 593Combined sources9
Helixi598 – 600Combined sources3
Helixi603 – 616Combined sources14
Helixi620 – 630Combined sources11
Helixi889 – 893Combined sources5
Helixi898 – 910Combined sources13
Turni911 – 913Combined sources3
Helixi916 – 922Combined sources7
Helixi928 – 936Combined sources9
Turni941 – 943Combined sources3
Helixi946 – 961Combined sources16
Helixi1037 – 1043Combined sources7
Helixi1049 – 1062Combined sources14
Helixi1067 – 1073Combined sources7
Helixi1079 – 1087Combined sources9
Turni1092 – 1094Combined sources3
Helixi1097 – 1111Combined sources15
Helixi1115 – 1123Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WH6NMR-A887-974[»]
1WH8NMR-A1028-1125[»]
1X2LNMR-A544-631[»]
ProteinModelPortaliO14529.
SMRiO14529.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14529.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili195 – 374Sequence analysisAdd BLAST180
Coiled coili690 – 717Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi440 – 535Pro-richAdd BLAST96
Compositional biasi802 – 813Poly-SerAdd BLAST12
Compositional biasi1327 – 1437Pro-richAdd BLAST111

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0963. Eukaryota.
KOG2252. Eukaryota.
ENOG410XPKP. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000143386.
HOVERGENiHBG051268.
InParanoidiO14529.
KOiK09313.
OMAiPSGDKVN.
OrthoDBiEOG091G011E.
PhylomeDBiO14529.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 3 hits.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14529-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANVGSMFQ YWKRFDLRRL QKELNSVASE LSARQEESEH SHKHLIELRR
60 70 80 90 100
EFKKNVPEEI REMVAPVLKS FQAEVVALSK RSQEAEAAFL SVYKQLIEAP
110 120 130 140 150
DPVPVFEAAR SLDDRLQPPS FDPSGQPRRD LHTSWKRNPE LLSPKEQREG
160 170 180 190 200
TSPAGPTLTE GSRLPGIPGK ALLTETLLQR NEAEKQKGLQ EVQITLAARL
210 220 230 240 250
GEAEEKIKVL HSALKATQAE LLELRRKYDE EAASKADEVG LIMTNLEKAN
260 270 280 290 300
QRAEAAQREV ESLREQLASV NSSIRLACCS PQGPSGDKVN FTLCSGPRLE
310 320 330 340 350
AALASKDREI LRLLKDVQHL QSSLQELEEA SANQIADLER QLTAKSEAIE
360 370 380 390 400
KLEEKLQAQS DYEEIKTELS ILKAMKLASS TCSLPQGMAK PEDSLLIAKE
410 420 430 440 450
AFFPTQKFLL EKPSLLASPE EDPSEDDSIK DSLGTEQSYP SPQQLPPPPG
460 470 480 490 500
PEDPLSPSPG QPLLGPSLGP DGTRTFSLSP FPSLASGERL MMPPAAFKGE
510 520 530 540 550
AGGLLVFPPA FYGAKPPTAP ATPAPGPEPL GGPEPADGGG GGAAGPGAEE
560 570 580 590 600
EQLDTAEIAF QVKEQLLKHN IGQRVFGHYV LGLSQGSVSE ILARPKPWRK
610 620 630 640 650
LTVKGKEPFI KMKQFLSDEQ NVLALRTIQV RQRGSITPRI RTPETGSDDA
660 670 680 690 700
IKSILEQAKK EIESQKGGEP KTSVAPLSIA NGTTPASTSE DAIKSILEQA
710 720 730 740 750
RREMQAQQQA LLEMEVAPRG RSVPPSPPER PSLATASQNG APALVKQEEG
760 770 780 790 800
SGGPAQAPLP VLSPAAFVQS IIRKVKSEIG DAGYFDHHWA SDRGLLSRPY
810 820 830 840 850
ASVSPSLSSS SSSGYSGQPN GRAWPRGDEA PVPPEDEAAA GAEDEPPRTG
860 870 880 890 900
ELKAEGATAE AGARLPYYPA YVPRTLKPTV PPLTPEQYEL YMYREVDTLE
910 920 930 940 950
LTRQVKEKLA KNGICQRIFG EKVLGLSQGS VSDMLSRPKP WSKLTQKGRE
960 970 980 990 1000
PFIRMQLWLS DQLGQAVGQQ PGASQASPTE PRSSPSPPPS PTEPEKSSQE
1010 1020 1030 1040 1050
PLSLSLESSK ENQQPEGRSS SSLSGKMYSG SQAPGGIQEI VAMSPELDTY
1060 1070 1080 1090 1100
SITKRVKEVL TDNNLGQRLF GESILGLTQG SVSDLLSRPK PWHKLSLKGR
1110 1120 1130 1140 1150
EPFVRMQLWL NDPHNVEKLR DMKKLEKKAY LKRRYGLIST GSDSESPATR
1160 1170 1180 1190 1200
SECPSPCLQP QDLSLLQIKK PRVVLAPEEK EALRKAYQLE PYPSQQTIEL
1210 1220 1230 1240 1250
LSFQLNLKTN TVINWFHNYR SRMRREMLVE GTQDEPDLDP SGGPGILPPG
1260 1270 1280 1290 1300
HSHPDPTPQS PDSETEDQKP TVKELELQEG PEENSTPLTT QDKAQVRIKQ
1310 1320 1330 1340 1350
EQMEEDAEEE AGSQPQDSGE LDKGQGPPKE EHPDPPGNDG LPKVAPGPLL
1360 1370 1380 1390 1400
PGGSTPDCPS LHPQQESEAG ERLHPDPLSF KSASESSRCS LEVSLNSPSA
1410 1420 1430 1440 1450
ASSPGLMMSV SPVPSSSAPI SPSPPGAPPA KVPSASPTAD MAGALHPSAK
1460 1470 1480
VNPNLQRRHE KMANLNNIIY RVERAANREE ALEWEF
Length:1,486
Mass (Da):161,677
Last modified:November 30, 2010 - v4
Checksum:i71782EF5214D0262
GO

Sequence cautioni

The sequence BAA22962 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0650961472V → L.2 PublicationsCorresponds to variant rs6490073dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006631 mRNA. Translation: BAA22962.2. Different initiation.
AC005805 Genomic DNA. No translation available.
AC002979 Genomic DNA. No translation available.
AC002352 Genomic DNA. No translation available.
AC002978 Genomic DNA. No translation available.
BC151245 mRNA. Translation: AAI51246.1.
CCDSiCCDS41837.1.
RefSeqiNP_056082.2. NM_015267.3.
UniGeneiHs.124953.

Genome annotation databases

EnsembliENST00000261726; ENSP00000261726; ENSG00000111249.
GeneIDi23316.
KEGGihsa:23316.
UCSCiuc001tsa.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006631 mRNA. Translation: BAA22962.2. Different initiation.
AC005805 Genomic DNA. No translation available.
AC002979 Genomic DNA. No translation available.
AC002352 Genomic DNA. No translation available.
AC002978 Genomic DNA. No translation available.
BC151245 mRNA. Translation: AAI51246.1.
CCDSiCCDS41837.1.
RefSeqiNP_056082.2. NM_015267.3.
UniGeneiHs.124953.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WH6NMR-A887-974[»]
1WH8NMR-A1028-1125[»]
1X2LNMR-A544-631[»]
ProteinModelPortaliO14529.
SMRiO14529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000261726.

PTM databases

iPTMnetiO14529.
PhosphoSitePlusiO14529.

Polymorphism and mutation databases

BioMutaiCUX2.

Proteomic databases

MaxQBiO14529.
PaxDbiO14529.
PeptideAtlasiO14529.
PRIDEiO14529.

Protocols and materials databases

DNASUi23316.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261726; ENSP00000261726; ENSG00000111249.
GeneIDi23316.
KEGGihsa:23316.
UCSCiuc001tsa.4. human.

Organism-specific databases

CTDi23316.
DisGeNETi23316.
GeneCardsiCUX2.
HGNCiHGNC:19347. CUX2.
HPAiHPA044772.
MIMi610648. gene.
neXtProtiNX_O14529.
OpenTargetsiENSG00000111249.
PharmGKBiPA162382977.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0963. Eukaryota.
KOG2252. Eukaryota.
ENOG410XPKP. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000143386.
HOVERGENiHBG051268.
InParanoidiO14529.
KOiK09313.
OMAiPSGDKVN.
OrthoDBiEOG091G011E.
PhylomeDBiO14529.
TreeFamiTF318206.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111249-MONOMER.

Miscellaneous databases

ChiTaRSiCUX2. human.
EvolutionaryTraceiO14529.
GenomeRNAii23316.
PROiO14529.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111249.
CleanExiHS_CUX2.
ExpressionAtlasiO14529. baseline and differential.
GenevisibleiO14529. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 3 hits.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUX2_HUMAN
AccessioniPrimary (citable) accession number: O14529
Secondary accession number(s): A7E2Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 156 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.