Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Astrotactin-1

Gene

ASTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152092-MONOMER.

Protein family/group databases

TCDBi9.B.87.2.1. the selenoprotein p receptor (selp-receptor) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Astrotactin-1
Gene namesi
Name:ASTN1
Synonyms:ASTN, KIAA0289
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:773. ASTN1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity
  • Perikaryon By similarity
  • Endosome By similarity
  • Cytoplasmic vesicleclathrin-coated vesicle By similarity

  • Note: Detected close to the anterior pole and at the base of the leading process in migrating neurons. Is internalized from the membrane via clathrin-coated vesicles and endosomes, and recycled to the anterior pole of the migrating cell.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 153ExtracellularCuratedAdd BLAST132
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 383CytoplasmicCuratedAdd BLAST209
Transmembranei384 – 402HelicalSequence analysisAdd BLAST19
Topological domaini403 – 1302ExtracellularBy similarityAdd BLAST900

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi460.
OpenTargetsiENSG00000152092.
PharmGKBiPA162376961.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000748122 – 1302Astrotactin-1Add BLAST1281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Modified residuei227PhosphoserineBy similarity1
Modified residuei337Omega-N-methylarginineBy similarity1
Glycosylationi453N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi463 ↔ 475By similarity
Disulfide bondi471 ↔ 490By similarity
Disulfide bondi492 ↔ 506By similarity
Disulfide bondi612 ↔ 625By similarity
Disulfide bondi619 ↔ 636By similarity
Disulfide bondi638 ↔ 651By similarity
Disulfide bondi660 ↔ 672By similarity
Disulfide bondi668 ↔ 692By similarity
Disulfide bondi694 ↔ 707By similarity
Glycosylationi729N-linked (GlcNAc...)Sequence analysis1
Glycosylationi742N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi785 ↔ 951By similarity
Glycosylationi804N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi876 ↔ 941By similarity
Disulfide bondi947 ↔ 954By similarity
Glycosylationi984N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1000 ↔ 1011By similarity
Disulfide bondi1013 ↔ 1026By similarity
Disulfide bondi1101 ↔ 1121By similarity
Disulfide bondi1153 ↔ 1240By similarity
Disulfide bondi1261 ↔ 1284By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiO14525.
PeptideAtlasiO14525.
PRIDEiO14525.

PTM databases

iPTMnetiO14525.
PhosphoSitePlusiO14525.

Expressioni

Gene expression databases

BgeeiENSG00000152092.
CleanExiHS_ASTN1.
ExpressionAtlasiO14525. baseline and differential.
GenevisibleiO14525. HS.

Interactioni

Subunit structurei

Interacts with ASTN2; the interaction is not calcium-dependent.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000354536.

Structurei

3D structure databases

ProteinModelPortaliO14525.
SMRiO14525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini459 – 507EGF-like 1Add BLAST49
Domaini608 – 652EGF-like 2Add BLAST45
Domaini656 – 708EGF-like 3Add BLAST53
Domaini1030 – 1145Fibronectin type-IIIAdd BLAST116

Sequence similaritiesi

Belongs to the astrotactin family.Curated
Contains 3 EGF-like domains.Curated
Contains 1 fibronectin type-III domain.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHIU. Eukaryota.
ENOG4110VB2. LUCA.
GeneTreeiENSGT00390000003140.
HOGENOMiHOG000034112.
HOVERGENiHBG050597.
InParanoidiO14525.
OMAiTNQGPWP.
OrthoDBiEOG091G00IB.
PhylomeDBiO14525.
TreeFamiTF332034.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR026995. Astrotactin.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR020864. MACPF.
[Graphical view]
PANTHERiPTHR16592. PTHR16592. 1 hit.
SMARTiSM00181. EGF. 3 hits.
SM00457. MACPF. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: O14525-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALAGLCALL ACCWGPAAVL ATAAGDVDPS KELECKLKSI TVSALPFLRE
60 70 80 90 100
NDLSIMHSPS ASEPKLLFSV RNDFPGEMVV VDDLENTELP YFVLEISGNT
110 120 130 140 150
EDIPLVRWRQ QWLENGTLLF HIHHQDGAPS LPGQDPTEEP QHESAEEELR
160 170 180 190 200
ILHISVMGGM IALLLSILCL VMILYTRRRW CKRRRVPQPQ KSASAEAANE
210 220 230 240 250
IHYIPSVLIG GHGRESLRNA RVQGHNSSGT LSIRETPILD GYEYDITDLR
260 270 280 290 300
HHLQRECMNG GEDFASQVTR TLDSLQGCNE KSGMDLTPGS DNAKLSLMNK
310 320 330 340 350
YKDNIIATSP VDSNHQQATL LSHTSSSQRK RINNKARAGS AFLNPEGDSG
360 370 380 390 400
TEAENDPQLT FYTDPSRSRR RSRVGSPRSP VNKTTLTLIS ITSCVIGLVC
410 420 430 440 450
SSHVNCPLVV KITLHVPEHL IADGSRFILL EGSQLDASDW LNPAQVVLFS
460 470 480 490 500
QQNSSGPWAM DLCARRLLDP CEHQCDPETG RREHRAAGEC LCYEGYMKDP
510 520 530 540 550
VHKHLCIRNE WGTNQGPWPY TIFQRGFDLV LGEQPSDKIF RFTYTLGEGM
560 570 580 590 600
WLPLSKSFVI PPAELAINPS AKCKTDMTVM EDAVEVREEL MTSSSFDSLE
610 620 630 640 650
VLLDSFGPVR DCSKDNGGCS KNFRCISDRK LDSTGCVCPS GLSPMKDSSG
660 670 680 690 700
CYDRHIGVDC SDGFNGGCEQ LCLQQMAPFP DDPTLYNILM FCGCIEDYKL
710 720 730 740 750
GVDGRSCQLI TETCPEGSDC GESRELPMNQ TLFGEMFFGY NNHSKEVAAG
760 770 780 790 800
QVLKGTFRQN NFARGLDQQL PDGLVVATVP LENQCLEEIS EPTPDPDFLT
810 820 830 840 850
GMVNFSEVSG YPVLQHWKVR SVMYHIKLNQ VAISQALSNA LHSLDGATSR
860 870 880 890 900
ADFVALLDQF GNHYIQEAIY GFEESCSIWY PNKQVQRRLW LEYEDISKGN
910 920 930 940 950
SPSDESEERE RDPKVLTFPE YITSLSDSGT KHMAAGVRME CHSKGRCPSS
960 970 980 990 1000
CPLCHVTSSP DTPAEPVLLE VTKAAPIYEL VTNNQTQRLL QEATMSSLWC
1010 1020 1030 1040 1050
SGTGDVIEDW CRCDSTAFGA DGLPTCAPLP QPVLRLSTVH EPSSTLVVLE
1060 1070 1080 1090 1100
WEHSEPPIGV QIVDYLLRQE KVTDRMDHSK VETETVLSFV DDIISGAKSP
1110 1120 1130 1140 1150
CAMPSQVPDK QLTTISLIIR CLEPDTIYMF TLWGVDNTGR RSRPSDVIVK
1160 1170 1180 1190 1200
TPCPVVDDVK AQEIADKIYN LFNGYTSGKE QQTAYNTLLD LGSPTLHRVL
1210 1220 1230 1240 1250
YHYNQHYESF GEFTWRCEDE LGPRKAGLIL SQLGDLSSWC NGLLQEPKIS
1260 1270 1280 1290 1300
LRRSSLKYLG CRYSEIKPYG LDWAELSRDL RKTCEEQTLS IPYNDYGDSK

EI
Note: No experimental confirmation available.
Length:1,302
Mass (Da):144,913
Last modified:May 10, 2005 - v3
Checksum:iCA9EDDA6621C4F3B
GO
Isoform 1 (identifier: O14525-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-487: Missing.

Show »
Length:1,294
Mass (Da):143,979
Checksum:iC38F3B239708FC9A
GO
Isoform 3 (identifier: O14525-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-487: Missing.
     1225-1302: Missing.

Show »
Length:1,216
Mass (Da):135,083
Checksum:i91B51202F5EF4EC7
GO

Sequence cautioni

The sequence BAA22958 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti439D → E in BAG58151 (PubMed:14702039).Curated1
Sequence conflicti994T → I in BAG58151 (PubMed:14702039).Curated1
Isoform 3 (identifier: O14525-3)
Sequence conflicti1216R → RYQ in BAG58151 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069030932H → R.3 PublicationsCorresponds to variant rs2228956dbSNPEnsembl.1
Natural variantiVAR_069031942H → Q.3 PublicationsCorresponds to variant rs2281180dbSNPEnsembl.1
Natural variantiVAR_0367641270G → R.Corresponds to variant rs12118933dbSNPEnsembl.1
Natural variantiVAR_0557131278R → G.Corresponds to variant rs12118933dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001371480 – 487Missing in isoform 1 and isoform 3. 3 Publications8
Alternative sequenceiVSP_0450691225 – 1302Missing in isoform 3. 2 PublicationsAdd BLAST78

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006627 mRNA. Translation: BAA22958.1. Different initiation.
AK295126 mRNA. Translation: BAG58151.1.
AL136983
, AL021398, AL022145, AL031290 Genomic DNA. Translation: CAH71678.1.
AL136983
, AL021398, AL022145, AL031290 Genomic DNA. Translation: CAH71679.1.
AL021398
, AL022145, AL136983, AL031290 Genomic DNA. Translation: CAI23463.1.
AL021398
, AL022145, AL136983, AL031290 Genomic DNA. Translation: CAI23464.1.
AL022145
, AL136983, AL031290, AL021398 Genomic DNA. Translation: CAI20555.1.
AL022145
, AL136983, AL031290, AL021398 Genomic DNA. Translation: CAI20556.1.
AL031290
, AL022145, AL136983, AL021398 Genomic DNA. Translation: CAI22718.1.
AL031290
, AL022145, AL136983, AL021398 Genomic DNA. Translation: CAI22719.1.
CH471067 Genomic DNA. Translation: EAW91007.1.
BC142697 mRNA. Translation: AAI42698.1.
CCDSiCCDS1319.1. [O14525-2]
CCDS44280.1. [O14525-3]
PIRiT00038.
RefSeqiNP_996991.1. NM_207108.2. [O14525-3]
XP_016856829.1. XM_017001340.1. [O14525-1]
UniGeneiHs.495897.

Genome annotation databases

EnsembliENST00000361833; ENSP00000354536; ENSG00000152092. [O14525-2]
ENST00000424564; ENSP00000395041; ENSG00000152092. [O14525-3]
GeneIDi460.
KEGGihsa:460.
UCSCiuc001glc.5. human. [O14525-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006627 mRNA. Translation: BAA22958.1. Different initiation.
AK295126 mRNA. Translation: BAG58151.1.
AL136983
, AL021398, AL022145, AL031290 Genomic DNA. Translation: CAH71678.1.
AL136983
, AL021398, AL022145, AL031290 Genomic DNA. Translation: CAH71679.1.
AL021398
, AL022145, AL136983, AL031290 Genomic DNA. Translation: CAI23463.1.
AL021398
, AL022145, AL136983, AL031290 Genomic DNA. Translation: CAI23464.1.
AL022145
, AL136983, AL031290, AL021398 Genomic DNA. Translation: CAI20555.1.
AL022145
, AL136983, AL031290, AL021398 Genomic DNA. Translation: CAI20556.1.
AL031290
, AL022145, AL136983, AL021398 Genomic DNA. Translation: CAI22718.1.
AL031290
, AL022145, AL136983, AL021398 Genomic DNA. Translation: CAI22719.1.
CH471067 Genomic DNA. Translation: EAW91007.1.
BC142697 mRNA. Translation: AAI42698.1.
CCDSiCCDS1319.1. [O14525-2]
CCDS44280.1. [O14525-3]
PIRiT00038.
RefSeqiNP_996991.1. NM_207108.2. [O14525-3]
XP_016856829.1. XM_017001340.1. [O14525-1]
UniGeneiHs.495897.

3D structure databases

ProteinModelPortaliO14525.
SMRiO14525.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000354536.

Protein family/group databases

TCDBi9.B.87.2.1. the selenoprotein p receptor (selp-receptor) family.

PTM databases

iPTMnetiO14525.
PhosphoSitePlusiO14525.

Proteomic databases

PaxDbiO14525.
PeptideAtlasiO14525.
PRIDEiO14525.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361833; ENSP00000354536; ENSG00000152092. [O14525-2]
ENST00000424564; ENSP00000395041; ENSG00000152092. [O14525-3]
GeneIDi460.
KEGGihsa:460.
UCSCiuc001glc.5. human. [O14525-1]

Organism-specific databases

CTDi460.
DisGeNETi460.
GeneCardsiASTN1.
HGNCiHGNC:773. ASTN1.
MIMi600904. gene.
neXtProtiNX_O14525.
OpenTargetsiENSG00000152092.
PharmGKBiPA162376961.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHIU. Eukaryota.
ENOG4110VB2. LUCA.
GeneTreeiENSGT00390000003140.
HOGENOMiHOG000034112.
HOVERGENiHBG050597.
InParanoidiO14525.
OMAiTNQGPWP.
OrthoDBiEOG091G00IB.
PhylomeDBiO14525.
TreeFamiTF332034.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000152092-MONOMER.

Miscellaneous databases

ChiTaRSiASTN1. human.
GenomeRNAii460.
PROiO14525.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152092.
CleanExiHS_ASTN1.
ExpressionAtlasiO14525. baseline and differential.
GenevisibleiO14525. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR026995. Astrotactin.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR020864. MACPF.
[Graphical view]
PANTHERiPTHR16592. PTHR16592. 1 hit.
SMARTiSM00181. EGF. 3 hits.
SM00457. MACPF. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiASTN1_HUMAN
AccessioniPrimary (citable) accession number: O14525
Secondary accession number(s): A5PL12
, B4DHI9, E9PFR8, O60799, Q5W0V7, Q5W0V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.