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O14522

- PTPRT_HUMAN

UniProt

O14522 - PTPRT_HUMAN

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Protein

Receptor-type tyrosine-protein phosphatase T

Gene
PTPRT, KIAA0283
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in both signal transduction and cellular adhesion in the CNS.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1052 – 10521Substrate By similarity
Active sitei1084 – 10841Phosphocysteine intermediate By similarity
Binding sitei1128 – 11281Substrate By similarity
Active sitei1378 – 13781Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. alpha-catenin binding Source: UniProtKB
  2. beta-catenin binding Source: UniProtKB
  3. cadherin binding Source: UniProtKB
  4. delta-catenin binding Source: UniProtKB
  5. gamma-catenin binding Source: UniProtKB
  6. protein binding Source: IntAct
  7. protein tyrosine phosphatase activity Source: UniProtKB
  8. thiolester hydrolase activity Source: Ensembl

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. homophilic cell adhesion Source: UniProtKB
  3. peptidyl-tyrosine dephosphorylation Source: GOC
  4. protein dephosphorylation Source: UniProtKB
  5. signal transduction Source: UniProtKB
  6. transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

SignaLinkiO14522.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase T (EC:3.1.3.48)
Short name:
R-PTP-T
Alternative name(s):
Receptor-type tyrosine-protein phosphatase rho
Short name:
RPTP-rho
Gene namesi
Name:PTPRT
Synonyms:KIAA0283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:9682. PTPRT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 747722Extracellular Reviewed predictionAdd
BLAST
Transmembranei748 – 76821Helical; Reviewed predictionAdd
BLAST
Topological domaini769 – 1441673Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of membrane Source: UniProtKB
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 14411416Receptor-type tyrosine-protein phosphatase TPRO_0000025463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi208 – 2081N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi213 ↔ 267 By similarity
Glycosylationi421 – 4211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi510 – 5101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi547 – 5471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi601 – 6011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi654 – 6541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi684 – 6841N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14522.
PRIDEiO14522.

PTM databases

PhosphoSiteiO14522.

Expressioni

Tissue specificityi

Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.1 Publication

Gene expression databases

ArrayExpressiO14522.
BgeeiO14522.
GenevestigatoriO14522.

Organism-specific databases

HPAiHPA017336.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629932EBI-728180,EBI-401755
Nlgn1Q99K102EBI-728180,EBI-775037From a different organism.
Nlgn2Q69ZK92EBI-728180,EBI-775065From a different organism.
Nrxn1Q9CS842EBI-728180,EBI-399696From a different organism.
Nrxn3Q6P9K92EBI-728180,EBI-7281557From a different organism.
PTPRNQ168493EBI-728180,EBI-728153

Protein-protein interaction databases

BioGridi116296. 1 interaction.
DIPiDIP-33967N.
IntActiO14522. 12 interactions.
MINTiMINT-1350261.

Structurei

Secondary structure

1
1441
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi871 – 8733
Helixi874 – 8829
Helixi889 – 8957
Turni905 – 9084
Helixi910 – 9156
Helixi925 – 9273
Helixi938 – 9414
Beta strandi944 – 9485
Beta strandi951 – 9533
Beta strandi957 – 9604
Turni965 – 9673
Helixi968 – 97811
Beta strandi982 – 9854
Beta strandi989 – 9913
Beta strandi1003 – 10097
Beta strandi1011 – 102010
Beta strandi1022 – 103312
Beta strandi1040 – 10478
Helixi1060 – 107213
Beta strandi1080 – 10834
Beta strandi1085 – 10884
Helixi1089 – 110719
Beta strandi1108 – 11103
Helixi1112 – 112211
Helixi1130 – 114516

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OOQX-ray1.80A/B868-1151[»]
ProteinModelPortaliO14522.
SMRiO14522. Positions 29-591, 866-1441.

Miscellaneous databases

EvolutionaryTraceiO14522.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 191162MAMAdd
BLAST
Domaini193 – 28492Ig-like C2-typeAdd
BLAST
Domaini291 – 38494Fibronectin type-III 1Add
BLAST
Domaini389 – 48395Fibronectin type-III 2Add
BLAST
Domaini484 – 590107Fibronectin type-III 3Add
BLAST
Domaini591 – 726136Fibronectin type-III 4Add
BLAST
Domaini889 – 1143255Tyrosine-protein phosphatase 1Add
BLAST
Domaini1175 – 1437263Tyrosine-protein phosphatase 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1084 – 10907Substrate binding By similarity

Sequence similaritiesi

Contains 1 MAM domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOVERGENiHBG062785.
InParanoidiO14522.
KOiK13297.
OMAiTHPYRTC.
OrthoDBiEOG70KGNP.
PhylomeDBiO14522.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: O14522-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN     50
GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT 100
HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE 150
LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN 200
VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA 250
TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV 300
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL 350
DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA 400
RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR 450
GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE 500
KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH 550
HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL 600
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV 650
SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS 700
YSIYFQALSK ANGETKINCV RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV 750
IAGLLMFIII LLGVMLTIKR RRNAYSYSYY LKLAKKQKET QSGAQREMGP 800
VASADKPTTK LSASRNDEGF SSSSQDVNGF TDGSRGELSQ PTLTIQTHPY 850
RTCDPVEMSY PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ 900
TASWDTAKED ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG 950
YHRPRHYIAT QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY 1000
WPDDTEVYGD IKVTLIETEP LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW 1050
PDHGVPCYAT GLLGFVRQVK FLNPPEAGPI VVHCSAGAGR TGCFIAIDTM 1100
LDMAENEGVV DIFNCVRELR AQRVNLVQTE EQYVFVHDAI LEACLCGNTA 1150
IPVCEFRSLY YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP 1200
RNHDKNRSMD VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ 1250
HPLPNTVADF WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ 1300
VEFVSADIDE DIIHRIFRIC NMARPQDGYR IVQHLQYIGW PAYRDTPPSK 1350
RSLLKVVRRL EKWQEQYDGR EGRTVVHCLN GGGRSGTFCA ICSVCEMIQQ 1400
QNIIDVFHIV KTLRNNKSNM VETLEQYKFV YEVALEYLSS F 1441
Length:1,441
Mass (Da):162,134
Last modified:January 11, 2011 - v6
Checksum:iBE60F3DB2CE13539
GO
Isoform 1 (identifier: O14522-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     725-725: K → KAPMGSAQVTPGTPLCLLTT
     781-781: L → LSQR

Show »
Length:1,463
Mass (Da):164,346
Checksum:i531E33DF9040F4B5
GO

Sequence cautioni

The sequence BAA22952.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAH72555.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI19251.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI19867.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI19879.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI19983.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI20439.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI22491.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI22911.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI23312.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291A → P.3 Publications
Corresponds to variant rs2867655 [ dbSNP | Ensembl ].
VAR_028795
Natural varianti74 – 741F → S in a colorectal cancer. 1 Publication
VAR_020746
Natural varianti76 – 761M → V.
Corresponds to variant rs17811401 [ dbSNP | Ensembl ].
VAR_028796
Natural varianti209 – 2091A → T in some colorectal cancers. 1 Publication
VAR_020747
Natural varianti218 – 2181K → T in a gastric cancer. 1 Publication
VAR_020748
Natural varianti248 – 2481F → S in a colorectal cancer. 1 Publication
VAR_020749
Natural varianti280 – 2801Y → H in a colorectal cancer. 1 Publication
VAR_020750
Natural varianti395 – 3951I → V in a colorectal cancer. 1 Publication
VAR_020751
Natural varianti412 – 4121Y → F in a colorectal cancer. 1 Publication
VAR_020752
Natural varianti453 – 4531R → C in a gastric cancer. 1 Publication
VAR_020753
Natural varianti510 – 5101N → K in a colorectal cancer. 1 Publication
VAR_020754
Natural varianti605 – 6051T → M in a colorectal cancer. 1 Publication
VAR_020755
Natural varianti648 – 6481V → G in a colorectal cancer. 1 Publication
VAR_020756
Natural varianti707 – 7071A → T in a colorectal cancer. 1 Publication
VAR_020757
Natural varianti707 – 7071A → V in a colorectal cancer. 1 Publication
VAR_020758
Natural varianti708 – 7081L → P in a colorectal cancer. 1 Publication
VAR_020759
Natural varianti771 – 7711R → I in a lung cancer. 1 Publication
VAR_020760
Natural varianti905 – 9051D → G in a colorectal cancer. 1 Publication
VAR_020761
Natural varianti965 – 9651Q → K in a colorectal cancer; reduced phosphatase activity. 1 Publication
VAR_020762
Natural varianti1096 – 10961A → P in a colorectal cancer. 1 Publication
VAR_020763
Natural varianti1106 – 11061N → I in a colorectal cancer; reduced phosphatase activity. 1 Publication
VAR_020764
Natural varianti1190 – 11901R → W in a colorectal cancer; reduced phosphatase activity. 1 Publication
VAR_020765
Natural varianti1213 – 12131P → L in an acute myeloid leukemia sample; somatic mutation. 1 Publication
VAR_054144
Natural varianti1237 – 12371M → L in a colorectal cancer. 1 Publication
VAR_020766
Natural varianti1247 – 12471V → M in a colorectal cancer. 1 Publication
VAR_020767
Natural varianti1324 – 13241R → L in a lung cancer; reduced phosphatase activity. 1 Publication
VAR_020768
Natural varianti1329 – 13291Y → F in a colorectal cancer. 1 Publication
VAR_020769
Natural varianti1346 – 13461T → M Found in a patient with severe intellectual disability, behavioral problems, microcephaly, congenital cardiac defect and herniation of the abdominal diaphragm; also observed in some colorectal cancers; reduced phosphatase activity; unknown pathological significance. 2 Publications
VAR_020770

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei725 – 7251K → KAPMGSAQVTPGTPLCLLTT in isoform 1. VSP_040385
Alternative sequencei781 – 7811L → LSQR in isoform 1. VSP_040386

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601W → T in AAD09421. 1 Publication
Sequence conflicti375 – 3751P → A in AAD09421. 1 Publication
Sequence conflicti867 – 8671P → L in AAD09421. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF043644 mRNA. Translation: AAD09421.2.
AB006621 mRNA. Translation: BAA22952.2. Different initiation.
AL021395
, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19981.1.
AL021395
, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19983.1. Sequence problems.
AL022239
, AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20437.1.
AL022239
, AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20439.1. Sequence problems.
AL024473
, AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22489.1.
AL024473
, AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22491.1. Sequence problems.
AL031656
, AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19877.1.
AL031656
, AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19879.1. Sequence problems.
AL035459
, AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22909.1.
AL035459
, AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22911.1. Sequence problems.
AL049812
, AL021395, AL022239, AL024473, AL031656, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19251.1. Sequence problems.
AL049812
, AL022239, AL031656, AL021395, AL024473, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19253.1.
AL121763
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23310.1.
AL121763
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23312.1. Sequence problems.
AL136461
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72553.1.
AL136461
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72555.1. Sequence problems.
Z93942
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19865.1.
Z93942
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19867.1. Sequence problems.
AL031676 Genomic DNA. No translation available.
AL035666 Genomic DNA. No translation available.
AL109826 Genomic DNA. No translation available.
AL117374 Genomic DNA. No translation available.
AL359695 Genomic DNA. No translation available.
BC153300 mRNA. Translation: AAI53301.1.
CCDSiCCDS42874.1. [O14522-3]
RefSeqiNP_008981.4. NM_007050.5. [O14522-3]
NP_573400.3. NM_133170.3.
UniGeneiHs.526879.

Genome annotation databases

EnsembliENST00000373187; ENSP00000362283; ENSG00000196090. [O14522-3]
GeneIDi11122.
KEGGihsa:11122.
UCSCiuc002xkg.3. human. [O14522-3]
uc010ggj.3. human. [O14522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF043644 mRNA. Translation: AAD09421.2 .
AB006621 mRNA. Translation: BAA22952.2 . Different initiation.
AL021395
, AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19981.1 .
AL021395
, AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19983.1 . Sequence problems.
AL022239
, AL021395 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI20437.1 .
AL022239
, AL021395 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI20439.1 . Sequence problems.
AL024473
, AL021395 , AL022239 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22489.1 .
AL024473
, AL021395 , AL022239 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22491.1 . Sequence problems.
AL031656
, AL021395 , AL022239 , AL024473 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19877.1 .
AL031656
, AL021395 , AL022239 , AL024473 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19879.1 . Sequence problems.
AL035459
, AL021395 , AL022239 , AL024473 , AL031656 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22909.1 .
AL035459
, AL021395 , AL022239 , AL024473 , AL031656 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22911.1 . Sequence problems.
AL049812
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19251.1 . Sequence problems.
AL049812
, AL022239 , AL031656 , AL021395 , AL024473 , AL035459 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19253.1 .
AL121763
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL136461 , Z93942 Genomic DNA. Translation: CAI23310.1 .
AL121763
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL136461 , Z93942 Genomic DNA. Translation: CAI23312.1 . Sequence problems.
AL136461
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , Z93942 Genomic DNA. Translation: CAH72553.1 .
AL136461
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , Z93942 Genomic DNA. Translation: CAH72555.1 . Sequence problems.
Z93942
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 Genomic DNA. Translation: CAI19865.1 .
Z93942
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 Genomic DNA. Translation: CAI19867.1 . Sequence problems.
AL031676 Genomic DNA. No translation available.
AL035666 Genomic DNA. No translation available.
AL109826 Genomic DNA. No translation available.
AL117374 Genomic DNA. No translation available.
AL359695 Genomic DNA. No translation available.
BC153300 mRNA. Translation: AAI53301.1 .
CCDSi CCDS42874.1. [O14522-3 ]
RefSeqi NP_008981.4. NM_007050.5. [O14522-3 ]
NP_573400.3. NM_133170.3.
UniGenei Hs.526879.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2OOQ X-ray 1.80 A/B 868-1151 [» ]
ProteinModelPortali O14522.
SMRi O14522. Positions 29-591, 866-1441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116296. 1 interaction.
DIPi DIP-33967N.
IntActi O14522. 12 interactions.
MINTi MINT-1350261.

PTM databases

PhosphoSitei O14522.

Proteomic databases

PaxDbi O14522.
PRIDEi O14522.

Protocols and materials databases

DNASUi 11122.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373187 ; ENSP00000362283 ; ENSG00000196090 . [O14522-3 ]
GeneIDi 11122.
KEGGi hsa:11122.
UCSCi uc002xkg.3. human. [O14522-3 ]
uc010ggj.3. human. [O14522-1 ]

Organism-specific databases

CTDi 11122.
GeneCardsi GC20M040701.
HGNCi HGNC:9682. PTPRT.
HPAi HPA017336.
MIMi 608712. gene.
neXtProti NX_O14522.
PharmGKBi PA34027.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
HOVERGENi HBG062785.
InParanoidi O14522.
KOi K13297.
OMAi THPYRTC.
OrthoDBi EOG70KGNP.
PhylomeDBi O14522.
TreeFami TF312900.

Enzyme and pathway databases

SignaLinki O14522.

Miscellaneous databases

EvolutionaryTracei O14522.
GeneWikii PTPRT.
GenomeRNAii 11122.
NextBioi 42270.
PROi O14522.
SOURCEi Search...

Gene expression databases

ArrayExpressi O14522.
Bgeei O14522.
Genevestigatori O14522.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system."
    McAndrew P.E., Frostholm A., White R.A., Rotter A., Burghes A.H.M.
    Brain Res. Mol. Brain Res. 56:9-21(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT PRO-29.
  2. "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."
    Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Nomura N.
    DNA Res. 4:53-59(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-29.
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-29.
  5. "Genomic organization and alternative splicing of the human and mouse RPTPrho genes."
    Besco J.A., Frostholm A., Popesco M.C., Burghes A.H.M., Rotter A.
    BMC Genomics 2:1-1(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  6. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
    Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
    Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 868-1151.
  7. Cited for: VARIANTS SER-74; THR-209; THR-218; SER-248; HIS-280; VAL-395; PHE-412; CYS-453; LYS-510; MET-605; GLY-648; THR-707; VAL-707; PRO-708; ILE-771; GLY-905; LYS-965; PRO-1096; ILE-1106; TRP-1190; LEU-1237; MET-1247; LEU-1324; PHE-1329 AND MET-1346, TISSUE SPECIFICITY.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-1213.
  9. Cited for: VARIANT MET-1346.

Entry informationi

Entry nameiPTPRT_HUMAN
AccessioniPrimary (citable) accession number: O14522
Secondary accession number(s): A8E4R6
, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 133 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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