Reviewed, UniProtKB/Swiss-Prot O14522 (PTPRT_HUMAN)

Names and origin

Protein names

Recommended name:
    Receptor-type tyrosine-protein phosphatase T
      Short name=R-PTP-T
      Short name=RPTP-rho
    EC=3.1.3.48

Gene names

Name:	PTPRT
Synonyms:	KIAA0283

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in both signal transduction and cellular adhesion in the CNS.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes. Ref.6
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Contains 4 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 MAM domain. Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Molecular function	Hydrolase Protein phosphatase Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	homophilic cell adhesion Inferred from direct assay. Source: UniProtKB protein amino acid dephosphorylation Inferred from direct assay. Source: UniProtKB transmembrane receptor protein tyrosine kinase signaling pathway Inferred from mutant phenotype. Source: UniProtKB
Cellular component	cell surface Inferred from direct assay. Source: UniProtKB integral to membrane Ref.1 Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from direct assay. Source: UniProtKB
Molecular function	alpha-catenin binding Inferred from direct assay. Source: UniProtKB beta-catenin binding Inferred from physical interaction. Source: UniProtKB cadherin binding Inferred from physical interaction. Source: UniProtKB delta-catenin binding Inferred from physical interaction. Source: UniProtKB gamma-catenin binding Inferred from direct assay. Source: UniProtKB protein tyrosine phosphatase activity Inferred from mutant phenotype. Source: UniProtKB receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PTPRN	Q16849	3	EBI-728180,EBI-728153

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14522-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14522-2)

The sequence of this isoform differs from the canonical sequence as follows:
     726-744: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 25

25

Potential

Chain

26 – 1463

1438

Receptor-type tyrosine-protein phosphatase T

PRO_0000025463

Regions

Topological domain

26 – 766

741

Extracellular Potential

Transmembrane

767 – 787

21

Potential

Topological domain

788 – 1463

676

Cytoplasmic Potential

Domain

30 – 191

162

MAM

Domain

193 – 284

92

Ig-like C2-type

Domain

288 – 379

92

Fibronectin type-III 1

Domain

386 – 480

95

Fibronectin type-III 2

Domain

481 – 584

104

Fibronectin type-III 3

Domain

589 – 726

138

Fibronectin type-III 4

Domain

911 – 1165

255

Tyrosine-protein phosphatase 1

Domain

1197 – 1459

263

Tyrosine-protein phosphatase 2

Sites

Active site

1106

1

Phosphocysteine intermediate By similarity

Active site

1400

1

Phosphocysteine intermediate By similarity

Amino acid modifications

Glycosylation

78

1

N-linked (GlcNAc...) Potential

Glycosylation

98

1

N-linked (GlcNAc...) Potential

Glycosylation

137

1

N-linked (GlcNAc...) Potential

Glycosylation

208

1

N-linked (GlcNAc...) Potential

Glycosylation

421

1

N-linked (GlcNAc...) Potential

Glycosylation

510

1

N-linked (GlcNAc...) Potential

Glycosylation

547

1

N-linked (GlcNAc...) Potential

Glycosylation

601

1

N-linked (GlcNAc...) Potential

Glycosylation

654

1

N-linked (GlcNAc...) Potential

Glycosylation

684

1

N-linked (GlcNAc...) Potential

Disulfide bond

213 ↔ 267

Potential

Natural variations

Alternative sequence

726 – 744

19

Missing in isoform 2.

VSP_007802

Natural variant

29

1

A → P: dbSNP rs2867655. Ref.1 Ref.2

VAR_028795

Natural variant

74

1

F → S in a colorectal cancer. Ref.6

VAR_020746

Natural variant

76

1

M → V: dbSNP rs17811401.

VAR_028796

Natural variant

209

1

A → T in some colorectal cancers. Ref.6

VAR_020747

Natural variant

218

1

K → T in a gastric cancer. Ref.6

VAR_020748

Natural variant

248

1

F → S in a colorectal cancer. Ref.6

VAR_020749

Natural variant

280

1

Y → H in a colorectal cancer. Ref.6

VAR_020750

Natural variant

395

1

I → V in a colorectal cancer. Ref.6

VAR_020751

Natural variant

412

1

Y → F in a colorectal cancer. Ref.6

VAR_020752

Natural variant

453

1

R → C in a gastric cancer. Ref.6

VAR_020753

Natural variant

510

1

N → K in a colorectal cancer. Ref.6

VAR_020754

Natural variant

605

1

T → M in a colorectal cancer. Ref.6

VAR_020755

Natural variant

648

1

V → G in a colorectal cancer. Ref.6

VAR_020756

Natural variant

707

1

A → T in a colorectal cancer. Ref.6

VAR_020757

Natural variant

707

1

A → V in a colorectal cancer. Ref.6

VAR_020758

Natural variant

708

1

L → P in a colorectal cancer. Ref.6

VAR_020759

Natural variant

790

1

R → I in a lung cancer. Ref.6

VAR_020760

Natural variant

927

1

D → G in a colorectal cancer. Ref.6

VAR_020761

Natural variant

987

1

Q → K in a colorectal cancer; reduced phosphatase activity. Ref.6

VAR_020762

Natural variant

1118

1

A → P in a colorectal cancer. Ref.6

VAR_020763

Natural variant

1128

1

N → I in a colorectal cancer; reduced phosphatase activity. Ref.6

VAR_020764

Natural variant

1212

1

R → W in a colorectal cancer; reduced phosphatase activity. Ref.6

VAR_020765

Natural variant

1235

1

P → L in an acute myeloid leukemia sample; somatic mutation. Ref.7

VAR_054144

Natural variant

1259

1

M → L in a colorectal cancer. Ref.6

VAR_020766

Natural variant

1269

1

V → M in a colorectal cancer. Ref.6

VAR_020767

Natural variant

1346

1

R → L in a lung cancer; reduced phosphatase activity. Ref.6

VAR_020768

Natural variant

1351

1

Y → F in a colorectal cancer. Ref.6

VAR_020769

Natural variant

1368

1

T → M in some colorectal cancers; reduced phosphatase activity. Ref.6

VAR_020770

Experimental info

Sequence conflict

60

1

W → T in BAA22952. Ref.2

Sequence conflict

375

1

P → A in BAA22952. Ref.2

Sequence conflict

801 – 803

3

Missing in AAD09421. Ref.1

Sequence conflict

889

1

P → L in BAA22952. Ref.2

Secondary structure

1

.

.

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.

.

.

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.

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.

.

.

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.

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1463

Helix Strand Turn

Details...

Helix

893 – 895

3

Helix

896 – 904

9

Helix

912 – 917

6

Turn

927 – 930

4

Helix

932 – 937

6

Helix

947 – 949

3

Helix

960 – 963

4

Beta strand

966 – 970

5

Beta strand

979 – 982

4

Turn

987 – 989

3

Helix

990 – 1000

11

Beta strand

1004 – 1007

4

Beta strand

1025 – 1029

5

Beta strand

1033 – 1055

23

Beta strand

1062 – 1069

8

Helix

1088 – 1094

7

Beta strand

1102 – 1105

4

Helix

1116 – 1128

13

Helix

1134 – 1144

11

Helix

1152 – 1167

16

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 31, 2006. Version 5. Checksum: 531E33DF9040F4B5	FASTA	1,463	164,346
	10 20 30 40 50 60 MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN GFTWEQINTW 70 80 90 100 110 120 EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT HCIDFHYYFS SRDRSSPGAL 130 140 150 160 170 180 NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE LAISTFWPHF YQVIFESVSL KGHPGYIAVD 190 200 210 220 230 240 EVRVLAHPCR KAPHFLRLQN VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT 250 260 270 280 290 300 RVVNHRRFSA TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV 310 320 330 340 350 360 GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL DPDVEYEIRV 370 380 390 400 410 420 LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA RQLTLQWEPF GYAVTRCHSY 430 440 450 460 470 480 NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR GLRPFMTIRL RLLLSNPEGR MESEELVVQT 490 500 510 520 530 540 EEDVPGAVPL ESIQGGPFEE KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG 550 560 570 580 590 600 KVFKLRNETH HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL 610 620 630 640 650 660 NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV SYRNASSLDS 670 680 690 700 710 720 LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS YSIYFQALSK ANGETKINCV 730 740 750 760 770 780 RLATKAPMGS AQVTPGTPLC LLTTGASTQN SNTVEPEKQV DNTVKMAGVI AGLLMFIIIL 790 800 810 820 830 840 LGVMLTIKRR RNAYSYSYYL SQRKLAKKQK ETQSGAQREM GPVASADKPT TKLSASRNDE 850 860 870 880 890 900 GFSSSSQDVN GFTDGSRGEL SQPTLTIQTH PYRTCDPVEM SYPRDQFQPA IRVADLLQHI 910 920 930 940 950 960 TQMKRGQGYG FKEEYEALPE GQTASWDTAK EDENRNKNRY GNIISYDHSR VRLLVLDGDP 970 980 990 1000 1010 1020 HSDYINANYI DGYHRPRHYI ATQGPMQETV KDFWRMIWQE NSASIVMVTN LVEVGRVKCV 1030 1040 1050 1060 1070 1080 RYWPDDTEVY GDIKVTLIET EPLAEYVIRT FTVQKKGYHE IRELRLFHFT SWPDHGVPCY 1090 1100 1110 1120 1130 1140 ATGLLGFVRQ VKFLNPPEAG PIVVHCSAGA GRTGCFIAID TMLDMAENEG VVDIFNCVRE 1150 1160 1170 1180 1190 1200 LRAQRVNLVQ TEEQYVFVHD AILEACLCGN TAIPVCEFRS LYYNISRLDP QTNSSQIKDE 1210 1220 1230 1240 1250 1260 FQTLNIVTPR VRPEDCSIGL LPRNHDKNRS MDVLPLDRCL PFLISVDGES SNYINAALMD 1270 1280 1290 1300 1310 1320 SHKQPAAFVV TQHPLPNTVA DFWRLVFDYN CSSVVMLNEM DTAQFCMQYW PEKTSGCYGP 1330 1340 1350 1360 1370 1380 IQVEFVSADI DEDIIHRIFR ICNMARPQDG YRIVQHLQYI GWPAYRDTPP SKRSLLKVVR 1390 1400 1410 1420 1430 1440 RLEKWQEQYD GREGRTVVHC LNGGGRSGTF CAICSVCEMI QQQNIIDVFH IVKTLRNNKS 1450 1460 NMVETLEQYK FVYEVALEYL SSF
	Isoform 2. Checksum: AF8D5E200D0B2B13	FASTA	1,444	162,505
	10 20 30 40 50 60 MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN GFTWEQINTW 70 80 90 100 110 120 EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT HCIDFHYYFS SRDRSSPGAL 130 140 150 160 170 180 NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE LAISTFWPHF YQVIFESVSL KGHPGYIAVD 190 200 210 220 230 240 EVRVLAHPCR KAPHFLRLQN VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT 250 260 270 280 290 300 RVVNHRRFSA TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV 310 320 330 340 350 360 GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL DPDVEYEIRV 370 380 390 400 410 420 LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA RQLTLQWEPF GYAVTRCHSY 430 440 450 460 470 480 NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR GLRPFMTIRL RLLLSNPEGR MESEELVVQT 490 500 510 520 530 540 EEDVPGAVPL ESIQGGPFEE KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG 550 560 570 580 590 600 KVFKLRNETH HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL 610 620 630 640 650 660 NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV SYRNASSLDS 670 680 690 700 710 720 LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS YSIYFQALSK ANGETKINCV 730 740 750 760 770 780 RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV IAGLLMFIII LLGVMLTIKR RRNAYSYSYY 790 800 810 820 830 840 LSQRKLAKKQ KETQSGAQRE MGPVASADKP TTKLSASRND EGFSSSSQDV NGFTDGSRGE 850 860 870 880 890 900 LSQPTLTIQT HPYRTCDPVE MSYPRDQFQP AIRVADLLQH ITQMKRGQGY GFKEEYEALP 910 920 930 940 950 960 EGQTASWDTA KEDENRNKNR YGNIISYDHS RVRLLVLDGD PHSDYINANY IDGYHRPRHY 970 980 990 1000 1010 1020 IATQGPMQET VKDFWRMIWQ ENSASIVMVT NLVEVGRVKC VRYWPDDTEV YGDIKVTLIE 1030 1040 1050 1060 1070 1080 TEPLAEYVIR TFTVQKKGYH EIRELRLFHF TSWPDHGVPC YATGLLGFVR QVKFLNPPEA 1090 1100 1110 1120 1130 1140 GPIVVHCSAG AGRTGCFIAI DTMLDMAENE GVVDIFNCVR ELRAQRVNLV QTEEQYVFVH 1150 1160 1170 1180 1190 1200 DAILEACLCG NTAIPVCEFR SLYYNISRLD PQTNSSQIKD EFQTLNIVTP RVRPEDCSIG 1210 1220 1230 1240 1250 1260 LLPRNHDKNR SMDVLPLDRC LPFLISVDGE SSNYINAALM DSHKQPAAFV VTQHPLPNTV 1270 1280 1290 1300 1310 1320 ADFWRLVFDY NCSSVVMLNE MDTAQFCMQY WPEKTSGCYG PIQVEFVSAD IDEDIIHRIF 1330 1340 1350 1360 1370 1380 RICNMARPQD GYRIVQHLQY IGWPAYRDTP PSKRSLLKVV RRLEKWQEQY DGREGRTVVH 1390 1400 1410 1420 1430 1440 CLNGGGRSGT FCAICSVCEM IQQQNIIDVF HIVKTLRNNK SNMVETLEQY KFVYEVALEY LSSF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system." McAndrew P.E., Frostholm A., White R.A., Rotter A., Burghes A.H.M. Brain Res. Mol. Brain Res. 56:9-21(1998) [PubMed: 9602027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT PRO-29.
[2]	"Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins." Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Nomura N. DNA Res. 4:53-59(1997) [PubMed: 9179496] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-29. Tissue: Brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Genomic organization and alternative splicing of the human and mouse RPTPrho genes." Besco J.A., Frostholm A., Popesco M.C., Burghes A.H.M., Rotter A. BMC Genomics 2:1-1(2001) [PubMed: 11423001] [Abstract] Cited for: ALTERNATIVE SPLICING.
[5]	Erratum Besco J.A., Frostholm A., Popesco M.C., Burghes A.H.M., Rotter A. BMC Genomics 2:5-5(2001) [PubMed: 11814386] [Abstract]
[6]	"Mutational analysis of the tyrosine phosphatome in colorectal cancers." Wang Z., Shen D., Parsons D.W., Bardelli A., Sager J., Szabo S., Ptak J., Silliman N., Peters B.A., van der Heijden M.S., Parmigiani G., Yan H., Wang T.-L., Riggins G., Powell S.M., Willson J.K.V., Markowitz S., Kinzler K.W., Vogelstein B., Velculescu V.E. Science 304:1164-1166(2004) [PubMed: 15155950] [Abstract] Cited for: VARIANTS SER-74; THR-209; THR-218; SER-248; HIS-280; VAL-395; PHE-412; CYS-453; LYS-510; MET-605; GLY-648; THR-707; VAL-707; PRO-708; ILE-790; GLY-927; LYS-987; PRO-1118; ILE-1128; TRP-1212; LEU-1259; MET-1269; LEU-1346; PHE-1351 AND MET-1368, TISSUE SPECIFICITY.
[7]	"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K. Nature 456:66-72(2008) [PubMed: 18987736] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-1235.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF043644 mRNA. Translation: AAD09421.2.
AB006621 mRNA. Translation: BAA22952.2. Different initiation.
AL021395 , AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19981.1.
AL021395 , AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19983.1.
AL022239 , AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20437.1.
AL022239 , AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20439.1.
AL024473 , AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22489.1.
AL024473 , AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22491.1.
AL031656 , AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19877.1.
AL031656 , AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19879.1.
AL035459 , AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22909.1.
AL035459 , AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22911.1.
AL049812 , AL021395, AL022239, AL024473, AL031656, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19251.1.
AL049812 , AL022239, AL031656, AL021395, AL024473, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19253.1.
AL121763 , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23310.1.
AL121763 , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23312.1.
AL136461 , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72553.1.
AL136461 , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72555.1.
Z93942 , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19865.1.
Z93942 , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19867.1.

IPI

IPI00013096.
IPI00337350.

RefSeq

NP_008981.4.
NP_573400.3.

UniGene

Hs.526879

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OOQ	X-ray	1.80	A/B	890-1173	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

O14522. 1 interaction.

STRING

O14522.

PTM databases

PhosphoSite

O14522.

Proteomic databases

PRIDE

O14522.

Genome annotation databases

Ensembl

ENST00000373198; ENSP00000362294; ENSG00000196090; Homo sapiens. [Genome view]

GeneID

11122.

KEGG

hsa:11122.

UCSC

uc010ggj.1. human.

Organism-specific databases

CTD

11122.

GeneCards

GC20M040134.

H-InvDB

HIX0015825.

HGNC

HGNC:9682. PTPRT.

HPA

HPA017336.

MIM

608712. gene.

PharmGKB

PA34027.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

O14522.

OMA

NRNDEGF

Enzyme and pathway databases

BRENDA

3.1.3.48. 247.

Gene expression databases

ArrayExpress

O14522.

Bgee

O14522.

Genevestigator

O14522.

GermOnline

ENSG00000196090. Homo sapiens.

Family and domain databases

InterPro

IPR000387. Dual-sp/Tyr_phosphatase.
IPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR007110. Ig-like.
IPR003599. Ig_sub.
IPR000998. MAM.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Gene3D

G3DSA:2.60.40.30. FN_III-like. 2 hits.

Pfam

PF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]

PRINTS

PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.

SMART

SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]

PROSITE

PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

42270.

SOURCE

Search...

Entry information

Entry name

PTPRT_HUMAN

Accession

Primary (citable) accession number: O14522
Secondary accession number(s): O43655 , O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	October 31, 2006
Last modified:	November 24, 2009
This is version 88 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.