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Protein

Receptor-type tyrosine-protein phosphatase T

Gene

PTPRT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in both signal transduction and cellular adhesion in the CNS.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1052SubstrateBy similarity1
Active sitei1084Phosphocysteine intermediateBy similarity1
Binding sitei1128SubstrateBy similarity1
Active sitei1378Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • alpha-catenin binding Source: UniProtKB
  • beta-catenin binding Source: UniProtKB
  • cadherin binding Source: UniProtKB
  • delta-catenin binding Source: UniProtKB
  • gamma-catenin binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
  • protein dephosphorylation Source: UniProtKB
  • signal transduction Source: UniProtKB
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BioCyciZFISH:HS00002-MONOMER.
BRENDAi3.1.3.48. 2681.
SignaLinkiO14522.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase T (EC:3.1.3.48)
Short name:
R-PTP-T
Alternative name(s):
Receptor-type tyrosine-protein phosphatase rho
Short name:
RPTP-rho
Gene namesi
Name:PTPRT
Synonyms:KIAA0283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9682. PTPRT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 747ExtracellularSequence analysisAdd BLAST722
Transmembranei748 – 768HelicalSequence analysisAdd BLAST21
Topological domaini769 – 1441CytoplasmicSequence analysisAdd BLAST673

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11122.
OpenTargetsiENSG00000196090.
PharmGKBiPA34027.

Polymorphism and mutation databases

BioMutaiPTPRT.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002546326 – 1441Receptor-type tyrosine-protein phosphatase TAdd BLAST1416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Glycosylationi137N-linked (GlcNAc...)Sequence analysis1
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi213 ↔ 267PROSITE-ProRule annotation
Glycosylationi421N-linked (GlcNAc...)Sequence analysis1
Glycosylationi510N-linked (GlcNAc...)Sequence analysis1
Glycosylationi547N-linked (GlcNAc...)Sequence analysis1
Glycosylationi601N-linked (GlcNAc...)Sequence analysis1
Glycosylationi654N-linked (GlcNAc...)Sequence analysis1
Glycosylationi684N-linked (GlcNAc...)Sequence analysis1
Modified residuei1208PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO14522.
PaxDbiO14522.
PeptideAtlasiO14522.
PRIDEiO14522.

PTM databases

DEPODiO14522.
iPTMnetiO14522.
PhosphoSitePlusiO14522.

Expressioni

Tissue specificityi

Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000196090.
ExpressionAtlasiO14522. baseline and differential.
GenevisibleiO14522. HS.

Organism-specific databases

HPAiCAB069423.
HPA017336.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629932EBI-728180,EBI-401755
Nlgn1Q99K102EBI-728180,EBI-775037From a different organism.
Nlgn2Q69ZK92EBI-728180,EBI-775065From a different organism.
Nrxn1Q9CS842EBI-728180,EBI-399696From a different organism.
Nrxn3Q6P9K92EBI-728180,EBI-7281557From a different organism.
PTPRNQ168493EBI-728180,EBI-728153

GO - Molecular functioni

  • alpha-catenin binding Source: UniProtKB
  • beta-catenin binding Source: UniProtKB
  • cadherin binding Source: UniProtKB
  • delta-catenin binding Source: UniProtKB
  • gamma-catenin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116296. 1 interactor.
DIPiDIP-33967N.
IntActiO14522. 12 interactors.
MINTiMINT-1350261.
STRINGi9606.ENSP00000362283.

Structurei

Secondary structure

11441
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi871 – 873Combined sources3
Helixi874 – 882Combined sources9
Helixi889 – 895Combined sources7
Turni905 – 908Combined sources4
Helixi910 – 915Combined sources6
Helixi925 – 927Combined sources3
Helixi938 – 941Combined sources4
Beta strandi944 – 948Combined sources5
Beta strandi951 – 953Combined sources3
Beta strandi957 – 960Combined sources4
Turni965 – 967Combined sources3
Helixi968 – 978Combined sources11
Beta strandi982 – 985Combined sources4
Beta strandi989 – 991Combined sources3
Beta strandi1003 – 1009Combined sources7
Beta strandi1011 – 1020Combined sources10
Beta strandi1022 – 1033Combined sources12
Beta strandi1040 – 1047Combined sources8
Helixi1060 – 1072Combined sources13
Beta strandi1080 – 1083Combined sources4
Beta strandi1085 – 1088Combined sources4
Helixi1089 – 1107Combined sources19
Beta strandi1108 – 1110Combined sources3
Helixi1112 – 1122Combined sources11
Helixi1130 – 1145Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OOQX-ray1.80A/B868-1151[»]
ProteinModelPortaliO14522.
SMRiO14522.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14522.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 191MAMPROSITE-ProRule annotationAdd BLAST162
Domaini193 – 284Ig-like C2-typeAdd BLAST92
Domaini291 – 384Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini389 – 483Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini484 – 590Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST107
Domaini591 – 726Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST136
Domaini889 – 1143Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST255
Domaini1175 – 1437Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST263

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1084 – 1090Substrate bindingBy similarity7

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOVERGENiHBG062785.
InParanoidiO14522.
KOiK13297.
OMAiGPPITTR.
OrthoDBiEOG091G00CK.
PhylomeDBiO14522.
TreeFamiTF312900.

Family and domain databases

CDDicd00063. FN3. 3 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: O14522-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN
60 70 80 90 100
GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT
110 120 130 140 150
HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE
160 170 180 190 200
LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN
210 220 230 240 250
VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA
260 270 280 290 300
TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV
310 320 330 340 350
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL
360 370 380 390 400
DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA
410 420 430 440 450
RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR
460 470 480 490 500
GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE
510 520 530 540 550
KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH
560 570 580 590 600
HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL
610 620 630 640 650
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV
660 670 680 690 700
SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS
710 720 730 740 750
YSIYFQALSK ANGETKINCV RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV
760 770 780 790 800
IAGLLMFIII LLGVMLTIKR RRNAYSYSYY LKLAKKQKET QSGAQREMGP
810 820 830 840 850
VASADKPTTK LSASRNDEGF SSSSQDVNGF TDGSRGELSQ PTLTIQTHPY
860 870 880 890 900
RTCDPVEMSY PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ
910 920 930 940 950
TASWDTAKED ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG
960 970 980 990 1000
YHRPRHYIAT QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY
1010 1020 1030 1040 1050
WPDDTEVYGD IKVTLIETEP LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW
1060 1070 1080 1090 1100
PDHGVPCYAT GLLGFVRQVK FLNPPEAGPI VVHCSAGAGR TGCFIAIDTM
1110 1120 1130 1140 1150
LDMAENEGVV DIFNCVRELR AQRVNLVQTE EQYVFVHDAI LEACLCGNTA
1160 1170 1180 1190 1200
IPVCEFRSLY YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP
1210 1220 1230 1240 1250
RNHDKNRSMD VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ
1260 1270 1280 1290 1300
HPLPNTVADF WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ
1310 1320 1330 1340 1350
VEFVSADIDE DIIHRIFRIC NMARPQDGYR IVQHLQYIGW PAYRDTPPSK
1360 1370 1380 1390 1400
RSLLKVVRRL EKWQEQYDGR EGRTVVHCLN GGGRSGTFCA ICSVCEMIQQ
1410 1420 1430 1440
QNIIDVFHIV KTLRNNKSNM VETLEQYKFV YEVALEYLSS F
Length:1,441
Mass (Da):162,134
Last modified:January 11, 2011 - v6
Checksum:iBE60F3DB2CE13539
GO
Isoform 1 (identifier: O14522-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     725-725: K → KAPMGSAQVTPGTPLCLLTT
     781-781: L → LSQR

Show »
Length:1,463
Mass (Da):164,346
Checksum:i531E33DF9040F4B5
GO

Sequence cautioni

The sequence BAA22952 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH72555 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI19251 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI19867 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI19879 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI19983 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20439 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI22491 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI22911 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI23312 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60W → T in AAD09421 (PubMed:9602027).Curated1
Sequence conflicti375P → A in AAD09421 (PubMed:9602027).Curated1
Sequence conflicti867P → L in AAD09421 (PubMed:9602027).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02879529A → P.3 PublicationsCorresponds to variant rs2867655dbSNPEnsembl.1
Natural variantiVAR_02074674F → S in a colorectal cancer. 1 Publication1
Natural variantiVAR_02879676M → V.Corresponds to variant rs17811401dbSNPEnsembl.1
Natural variantiVAR_020747209A → T in some colorectal cancers. 1 Publication1
Natural variantiVAR_020748218K → T in a gastric cancer. 1 Publication1
Natural variantiVAR_020749248F → S in a colorectal cancer. 1 Publication1
Natural variantiVAR_020750280Y → H in a colorectal cancer. 1 Publication1
Natural variantiVAR_020751395I → V in a colorectal cancer. 1 Publication1
Natural variantiVAR_020752412Y → F in a colorectal cancer. 1 Publication1
Natural variantiVAR_020753453R → C in a gastric cancer. 1 Publication1
Natural variantiVAR_020754510N → K in a colorectal cancer. 1 PublicationCorresponds to variant rs749647294dbSNPEnsembl.1
Natural variantiVAR_020755605T → M in a colorectal cancer. 1 Publication1
Natural variantiVAR_020756648V → G in a colorectal cancer. 1 Publication1
Natural variantiVAR_020757707A → T in a colorectal cancer. 1 Publication1
Natural variantiVAR_020758707A → V in a colorectal cancer. 1 Publication1
Natural variantiVAR_020759708L → P in a colorectal cancer. 1 Publication1
Natural variantiVAR_020760771R → I in a lung cancer. 1 Publication1
Natural variantiVAR_020761905D → G in a colorectal cancer. 1 Publication1
Natural variantiVAR_020762965Q → K in a colorectal cancer; reduced phosphatase activity. 1 Publication1
Natural variantiVAR_0207631096A → P in a colorectal cancer. 1 Publication1
Natural variantiVAR_0207641106N → I in a colorectal cancer; reduced phosphatase activity. 1 Publication1
Natural variantiVAR_0207651190R → W in a colorectal cancer; reduced phosphatase activity. 1 PublicationCorresponds to variant rs370873414dbSNPEnsembl.1
Natural variantiVAR_0541441213P → L in an acute myeloid leukemia sample; somatic mutation. 1 Publication1
Natural variantiVAR_0207661237M → L in a colorectal cancer. 1 Publication1
Natural variantiVAR_0207671247V → M in a colorectal cancer. 1 PublicationCorresponds to variant rs761148007dbSNPEnsembl.1
Natural variantiVAR_0207681324R → L in a lung cancer; reduced phosphatase activity. 1 Publication1
Natural variantiVAR_0207691329Y → F in a colorectal cancer. 1 Publication1
Natural variantiVAR_0207701346T → M Found in a patient with severe intellectual disability, behavioral problems, microcephaly, congenital cardiac defect and herniation of the abdominal diaphragm; also observed in some colorectal cancers; reduced phosphatase activity; unknown pathological significance. 2 PublicationsCorresponds to variant rs199947379dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040385725K → KAPMGSAQVTPGTPLCLLTT in isoform 1. 1 Publication1
Alternative sequenceiVSP_040386781L → LSQR in isoform 1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043644 mRNA. Translation: AAD09421.2.
AB006621 mRNA. Translation: BAA22952.2. Different initiation.
AL021395
, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19981.1.
AL021395
, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19983.1. Sequence problems.
AL022239
, AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20437.1.
AL022239
, AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20439.1. Sequence problems.
AL024473
, AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22489.1.
AL024473
, AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22491.1. Sequence problems.
AL031656
, AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19877.1.
AL031656
, AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19879.1. Sequence problems.
AL035459
, AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22909.1.
AL035459
, AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22911.1. Sequence problems.
AL049812
, AL021395, AL022239, AL024473, AL031656, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19251.1. Sequence problems.
AL049812
, AL022239, AL031656, AL021395, AL024473, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19253.1.
AL121763
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23310.1.
AL121763
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23312.1. Sequence problems.
AL136461
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72553.1.
AL136461
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72555.1. Sequence problems.
Z93942
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19865.1.
Z93942
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19867.1. Sequence problems.
AL031676 Genomic DNA. No translation available.
AL035666 Genomic DNA. No translation available.
AL109826 Genomic DNA. No translation available.
AL117374 Genomic DNA. No translation available.
AL359695 Genomic DNA. No translation available.
BC153300 mRNA. Translation: AAI53301.1.
CCDSiCCDS42874.1. [O14522-3]
RefSeqiNP_008981.4. NM_007050.5. [O14522-3]
NP_573400.3. NM_133170.3.
UniGeneiHs.526879.

Genome annotation databases

EnsembliENST00000373187; ENSP00000362283; ENSG00000196090. [O14522-3]
ENST00000373193; ENSP00000362289; ENSG00000196090. [O14522-1]
GeneIDi11122.
KEGGihsa:11122.
UCSCiuc002xkg.4. human. [O14522-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043644 mRNA. Translation: AAD09421.2.
AB006621 mRNA. Translation: BAA22952.2. Different initiation.
AL021395
, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19981.1.
AL021395
, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19983.1. Sequence problems.
AL022239
, AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20437.1.
AL022239
, AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20439.1. Sequence problems.
AL024473
, AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22489.1.
AL024473
, AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22491.1. Sequence problems.
AL031656
, AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19877.1.
AL031656
, AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19879.1. Sequence problems.
AL035459
, AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22909.1.
AL035459
, AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22911.1. Sequence problems.
AL049812
, AL021395, AL022239, AL024473, AL031656, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19251.1. Sequence problems.
AL049812
, AL022239, AL031656, AL021395, AL024473, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19253.1.
AL121763
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23310.1.
AL121763
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23312.1. Sequence problems.
AL136461
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72553.1.
AL136461
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72555.1. Sequence problems.
Z93942
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19865.1.
Z93942
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19867.1. Sequence problems.
AL031676 Genomic DNA. No translation available.
AL035666 Genomic DNA. No translation available.
AL109826 Genomic DNA. No translation available.
AL117374 Genomic DNA. No translation available.
AL359695 Genomic DNA. No translation available.
BC153300 mRNA. Translation: AAI53301.1.
CCDSiCCDS42874.1. [O14522-3]
RefSeqiNP_008981.4. NM_007050.5. [O14522-3]
NP_573400.3. NM_133170.3.
UniGeneiHs.526879.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OOQX-ray1.80A/B868-1151[»]
ProteinModelPortaliO14522.
SMRiO14522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116296. 1 interactor.
DIPiDIP-33967N.
IntActiO14522. 12 interactors.
MINTiMINT-1350261.
STRINGi9606.ENSP00000362283.

PTM databases

DEPODiO14522.
iPTMnetiO14522.
PhosphoSitePlusiO14522.

Polymorphism and mutation databases

BioMutaiPTPRT.

Proteomic databases

MaxQBiO14522.
PaxDbiO14522.
PeptideAtlasiO14522.
PRIDEiO14522.

Protocols and materials databases

DNASUi11122.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373187; ENSP00000362283; ENSG00000196090. [O14522-3]
ENST00000373193; ENSP00000362289; ENSG00000196090. [O14522-1]
GeneIDi11122.
KEGGihsa:11122.
UCSCiuc002xkg.4. human. [O14522-3]

Organism-specific databases

CTDi11122.
DisGeNETi11122.
GeneCardsiPTPRT.
HGNCiHGNC:9682. PTPRT.
HPAiCAB069423.
HPA017336.
MIMi608712. gene.
neXtProtiNX_O14522.
OpenTargetsiENSG00000196090.
PharmGKBiPA34027.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOVERGENiHBG062785.
InParanoidiO14522.
KOiK13297.
OMAiGPPITTR.
OrthoDBiEOG091G00CK.
PhylomeDBiO14522.
TreeFamiTF312900.

Enzyme and pathway databases

BioCyciZFISH:HS00002-MONOMER.
BRENDAi3.1.3.48. 2681.
SignaLinkiO14522.

Miscellaneous databases

ChiTaRSiPTPRT. human.
EvolutionaryTraceiO14522.
GeneWikiiPTPRT.
GenomeRNAii11122.
PROiO14522.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196090.
ExpressionAtlasiO14522. baseline and differential.
GenevisibleiO14522. HS.

Family and domain databases

CDDicd00063. FN3. 3 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRT_HUMAN
AccessioniPrimary (citable) accession number: O14522
Secondary accession number(s): A8E4R6
, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 153 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.