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O14522

- PTPRT_HUMAN

UniProt

O14522 - PTPRT_HUMAN

Protein

Receptor-type tyrosine-protein phosphatase T

Gene

PTPRT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 6 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    May be involved in both signal transduction and cellular adhesion in the CNS.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1052 – 10521SubstrateBy similarity
    Active sitei1084 – 10841Phosphocysteine intermediateBy similarity
    Binding sitei1128 – 11281SubstrateBy similarity
    Active sitei1378 – 13781Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. alpha-catenin binding Source: UniProtKB
    2. beta-catenin binding Source: UniProtKB
    3. cadherin binding Source: UniProtKB
    4. delta-catenin binding Source: UniProtKB
    5. gamma-catenin binding Source: UniProtKB
    6. protein binding Source: IntAct
    7. protein tyrosine phosphatase activity Source: UniProtKB
    8. thiolester hydrolase activity Source: Ensembl

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. homophilic cell adhesion Source: UniProtKB
    3. peptidyl-tyrosine dephosphorylation Source: GOC
    4. protein dephosphorylation Source: UniProtKB
    5. signal transduction Source: UniProtKB
    6. transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Enzyme and pathway databases

    SignaLinkiO14522.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase T (EC:3.1.3.48)
    Short name:
    R-PTP-T
    Alternative name(s):
    Receptor-type tyrosine-protein phosphatase rho
    Short name:
    RPTP-rho
    Gene namesi
    Name:PTPRT
    Synonyms:KIAA0283
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:9682. PTPRT.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. integral component of membrane Source: UniProtKB
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34027.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 14411416Receptor-type tyrosine-protein phosphatase TPRO_0000025463Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi213 ↔ 267PROSITE-ProRule annotation
    Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi601 – 6011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi654 – 6541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi684 – 6841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO14522.
    PRIDEiO14522.

    PTM databases

    PhosphoSiteiO14522.

    Expressioni

    Tissue specificityi

    Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.1 Publication

    Gene expression databases

    ArrayExpressiO14522.
    BgeeiO14522.
    GenevestigatoriO14522.

    Organism-specific databases

    HPAiHPA017336.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GRB2P629932EBI-728180,EBI-401755
    Nlgn1Q99K102EBI-728180,EBI-775037From a different organism.
    Nlgn2Q69ZK92EBI-728180,EBI-775065From a different organism.
    Nrxn1Q9CS842EBI-728180,EBI-399696From a different organism.
    Nrxn3Q6P9K92EBI-728180,EBI-7281557From a different organism.
    PTPRNQ168493EBI-728180,EBI-728153

    Protein-protein interaction databases

    BioGridi116296. 1 interaction.
    DIPiDIP-33967N.
    IntActiO14522. 12 interactions.
    MINTiMINT-1350261.

    Structurei

    Secondary structure

    1
    1441
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi871 – 8733
    Helixi874 – 8829
    Helixi889 – 8957
    Turni905 – 9084
    Helixi910 – 9156
    Helixi925 – 9273
    Helixi938 – 9414
    Beta strandi944 – 9485
    Beta strandi951 – 9533
    Beta strandi957 – 9604
    Turni965 – 9673
    Helixi968 – 97811
    Beta strandi982 – 9854
    Beta strandi989 – 9913
    Beta strandi1003 – 10097
    Beta strandi1011 – 102010
    Beta strandi1022 – 103312
    Beta strandi1040 – 10478
    Helixi1060 – 107213
    Beta strandi1080 – 10834
    Beta strandi1085 – 10884
    Helixi1089 – 110719
    Beta strandi1108 – 11103
    Helixi1112 – 112211
    Helixi1130 – 114516

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2OOQX-ray1.80A/B868-1151[»]
    ProteinModelPortaliO14522.
    SMRiO14522. Positions 29-591, 866-1441.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14522.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 747722ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini769 – 1441673CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei748 – 76821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 191162MAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini193 – 28492Ig-like C2-typeAdd
    BLAST
    Domaini291 – 38494Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini389 – 48395Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 590107Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini591 – 726136Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini889 – 1143255Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1175 – 1437263Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1084 – 10907Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 MAM domain.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOVERGENiHBG062785.
    InParanoidiO14522.
    KOiK13297.
    OMAiTHPYRTC.
    OrthoDBiEOG70KGNP.
    PhylomeDBiO14522.
    TreeFamiTF312900.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR000998. MAM_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF00629. MAM. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00020. MAMDOMAIN.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00137. MAM. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 3 (identifier: O14522-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN     50
    GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT 100
    HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE 150
    LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN 200
    VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA 250
    TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV 300
    GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL 350
    DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA 400
    RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR 450
    GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE 500
    KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH 550
    HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL 600
    NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV 650
    SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS 700
    YSIYFQALSK ANGETKINCV RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV 750
    IAGLLMFIII LLGVMLTIKR RRNAYSYSYY LKLAKKQKET QSGAQREMGP 800
    VASADKPTTK LSASRNDEGF SSSSQDVNGF TDGSRGELSQ PTLTIQTHPY 850
    RTCDPVEMSY PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ 900
    TASWDTAKED ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG 950
    YHRPRHYIAT QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY 1000
    WPDDTEVYGD IKVTLIETEP LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW 1050
    PDHGVPCYAT GLLGFVRQVK FLNPPEAGPI VVHCSAGAGR TGCFIAIDTM 1100
    LDMAENEGVV DIFNCVRELR AQRVNLVQTE EQYVFVHDAI LEACLCGNTA 1150
    IPVCEFRSLY YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP 1200
    RNHDKNRSMD VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ 1250
    HPLPNTVADF WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ 1300
    VEFVSADIDE DIIHRIFRIC NMARPQDGYR IVQHLQYIGW PAYRDTPPSK 1350
    RSLLKVVRRL EKWQEQYDGR EGRTVVHCLN GGGRSGTFCA ICSVCEMIQQ 1400
    QNIIDVFHIV KTLRNNKSNM VETLEQYKFV YEVALEYLSS F 1441
    Length:1,441
    Mass (Da):162,134
    Last modified:January 11, 2011 - v6
    Checksum:iBE60F3DB2CE13539
    GO
    Isoform 1 (identifier: O14522-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         725-725: K → KAPMGSAQVTPGTPLCLLTT
         781-781: L → LSQR

    Show »
    Length:1,463
    Mass (Da):164,346
    Checksum:i531E33DF9040F4B5
    GO

    Sequence cautioni

    The sequence BAA22952.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAH72555.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI19251.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI19867.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI19879.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI19983.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI20439.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI22491.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI22911.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI23312.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601W → T in AAD09421. (PubMed:9602027)Curated
    Sequence conflicti375 – 3751P → A in AAD09421. (PubMed:9602027)Curated
    Sequence conflicti867 – 8671P → L in AAD09421. (PubMed:9602027)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291A → P.3 Publications
    Corresponds to variant rs2867655 [ dbSNP | Ensembl ].
    VAR_028795
    Natural varianti74 – 741F → S in a colorectal cancer. 1 Publication
    VAR_020746
    Natural varianti76 – 761M → V.
    Corresponds to variant rs17811401 [ dbSNP | Ensembl ].
    VAR_028796
    Natural varianti209 – 2091A → T in some colorectal cancers. 1 Publication
    VAR_020747
    Natural varianti218 – 2181K → T in a gastric cancer. 1 Publication
    VAR_020748
    Natural varianti248 – 2481F → S in a colorectal cancer. 1 Publication
    VAR_020749
    Natural varianti280 – 2801Y → H in a colorectal cancer. 1 Publication
    VAR_020750
    Natural varianti395 – 3951I → V in a colorectal cancer. 1 Publication
    VAR_020751
    Natural varianti412 – 4121Y → F in a colorectal cancer. 1 Publication
    VAR_020752
    Natural varianti453 – 4531R → C in a gastric cancer. 1 Publication
    VAR_020753
    Natural varianti510 – 5101N → K in a colorectal cancer. 1 Publication
    VAR_020754
    Natural varianti605 – 6051T → M in a colorectal cancer. 1 Publication
    VAR_020755
    Natural varianti648 – 6481V → G in a colorectal cancer. 1 Publication
    VAR_020756
    Natural varianti707 – 7071A → T in a colorectal cancer. 1 Publication
    VAR_020757
    Natural varianti707 – 7071A → V in a colorectal cancer. 1 Publication
    VAR_020758
    Natural varianti708 – 7081L → P in a colorectal cancer. 1 Publication
    VAR_020759
    Natural varianti771 – 7711R → I in a lung cancer. 1 Publication
    VAR_020760
    Natural varianti905 – 9051D → G in a colorectal cancer. 1 Publication
    VAR_020761
    Natural varianti965 – 9651Q → K in a colorectal cancer; reduced phosphatase activity. 1 Publication
    VAR_020762
    Natural varianti1096 – 10961A → P in a colorectal cancer. 1 Publication
    VAR_020763
    Natural varianti1106 – 11061N → I in a colorectal cancer; reduced phosphatase activity. 1 Publication
    VAR_020764
    Natural varianti1190 – 11901R → W in a colorectal cancer; reduced phosphatase activity. 1 Publication
    VAR_020765
    Natural varianti1213 – 12131P → L in an acute myeloid leukemia sample; somatic mutation. 1 Publication
    VAR_054144
    Natural varianti1237 – 12371M → L in a colorectal cancer. 1 Publication
    VAR_020766
    Natural varianti1247 – 12471V → M in a colorectal cancer. 1 Publication
    VAR_020767
    Natural varianti1324 – 13241R → L in a lung cancer; reduced phosphatase activity. 1 Publication
    VAR_020768
    Natural varianti1329 – 13291Y → F in a colorectal cancer. 1 Publication
    VAR_020769
    Natural varianti1346 – 13461T → M Found in a patient with severe intellectual disability, behavioral problems, microcephaly, congenital cardiac defect and herniation of the abdominal diaphragm; also observed in some colorectal cancers; reduced phosphatase activity; unknown pathological significance. 2 Publications
    VAR_020770

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei725 – 7251K → KAPMGSAQVTPGTPLCLLTT in isoform 1. 1 PublicationVSP_040385
    Alternative sequencei781 – 7811L → LSQR in isoform 1. 1 PublicationVSP_040386

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043644 mRNA. Translation: AAD09421.2.
    AB006621 mRNA. Translation: BAA22952.2. Different initiation.
    AL021395
    , AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19981.1.
    AL021395
    , AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19983.1. Sequence problems.
    AL022239
    , AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20437.1.
    AL022239
    , AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20439.1. Sequence problems.
    AL024473
    , AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22489.1.
    AL024473
    , AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22491.1. Sequence problems.
    AL031656
    , AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19877.1.
    AL031656
    , AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19879.1. Sequence problems.
    AL035459
    , AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22909.1.
    AL035459
    , AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22911.1. Sequence problems.
    AL049812
    , AL021395, AL022239, AL024473, AL031656, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19251.1. Sequence problems.
    AL049812
    , AL022239, AL031656, AL021395, AL024473, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19253.1.
    AL121763
    , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23310.1.
    AL121763
    , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23312.1. Sequence problems.
    AL136461
    , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72553.1.
    AL136461
    , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72555.1. Sequence problems.
    Z93942
    , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19865.1.
    Z93942
    , AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19867.1. Sequence problems.
    AL031676 Genomic DNA. No translation available.
    AL035666 Genomic DNA. No translation available.
    AL109826 Genomic DNA. No translation available.
    AL117374 Genomic DNA. No translation available.
    AL359695 Genomic DNA. No translation available.
    BC153300 mRNA. Translation: AAI53301.1.
    CCDSiCCDS42874.1. [O14522-3]
    RefSeqiNP_008981.4. NM_007050.5. [O14522-3]
    NP_573400.3. NM_133170.3.
    UniGeneiHs.526879.

    Genome annotation databases

    EnsembliENST00000373187; ENSP00000362283; ENSG00000196090. [O14522-3]
    GeneIDi11122.
    KEGGihsa:11122.
    UCSCiuc002xkg.3. human. [O14522-3]
    uc010ggj.3. human. [O14522-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043644 mRNA. Translation: AAD09421.2 .
    AB006621 mRNA. Translation: BAA22952.2 . Different initiation.
    AL021395
    , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19981.1 .
    AL021395
    , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19983.1 . Sequence problems.
    AL022239
    , AL021395 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI20437.1 .
    AL022239
    , AL021395 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI20439.1 . Sequence problems.
    AL024473
    , AL021395 , AL022239 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22489.1 .
    AL024473
    , AL021395 , AL022239 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22491.1 . Sequence problems.
    AL031656
    , AL021395 , AL022239 , AL024473 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19877.1 .
    AL031656
    , AL021395 , AL022239 , AL024473 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19879.1 . Sequence problems.
    AL035459
    , AL021395 , AL022239 , AL024473 , AL031656 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22909.1 .
    AL035459
    , AL021395 , AL022239 , AL024473 , AL031656 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22911.1 . Sequence problems.
    AL049812
    , AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19251.1 . Sequence problems.
    AL049812
    , AL022239 , AL031656 , AL021395 , AL024473 , AL035459 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19253.1 .
    AL121763
    , AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL136461 , Z93942 Genomic DNA. Translation: CAI23310.1 .
    AL121763
    , AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL136461 , Z93942 Genomic DNA. Translation: CAI23312.1 . Sequence problems.
    AL136461
    , AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , Z93942 Genomic DNA. Translation: CAH72553.1 .
    AL136461
    , AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , Z93942 Genomic DNA. Translation: CAH72555.1 . Sequence problems.
    Z93942
    , AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 Genomic DNA. Translation: CAI19865.1 .
    Z93942
    , AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 Genomic DNA. Translation: CAI19867.1 . Sequence problems.
    AL031676 Genomic DNA. No translation available.
    AL035666 Genomic DNA. No translation available.
    AL109826 Genomic DNA. No translation available.
    AL117374 Genomic DNA. No translation available.
    AL359695 Genomic DNA. No translation available.
    BC153300 mRNA. Translation: AAI53301.1 .
    CCDSi CCDS42874.1. [O14522-3 ]
    RefSeqi NP_008981.4. NM_007050.5. [O14522-3 ]
    NP_573400.3. NM_133170.3.
    UniGenei Hs.526879.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2OOQ X-ray 1.80 A/B 868-1151 [» ]
    ProteinModelPortali O14522.
    SMRi O14522. Positions 29-591, 866-1441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116296. 1 interaction.
    DIPi DIP-33967N.
    IntActi O14522. 12 interactions.
    MINTi MINT-1350261.

    PTM databases

    PhosphoSitei O14522.

    Proteomic databases

    PaxDbi O14522.
    PRIDEi O14522.

    Protocols and materials databases

    DNASUi 11122.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373187 ; ENSP00000362283 ; ENSG00000196090 . [O14522-3 ]
    GeneIDi 11122.
    KEGGi hsa:11122.
    UCSCi uc002xkg.3. human. [O14522-3 ]
    uc010ggj.3. human. [O14522-1 ]

    Organism-specific databases

    CTDi 11122.
    GeneCardsi GC20M040701.
    HGNCi HGNC:9682. PTPRT.
    HPAi HPA017336.
    MIMi 608712. gene.
    neXtProti NX_O14522.
    PharmGKBi PA34027.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOVERGENi HBG062785.
    InParanoidi O14522.
    KOi K13297.
    OMAi THPYRTC.
    OrthoDBi EOG70KGNP.
    PhylomeDBi O14522.
    TreeFami TF312900.

    Enzyme and pathway databases

    SignaLinki O14522.

    Miscellaneous databases

    EvolutionaryTracei O14522.
    GeneWikii PTPRT.
    GenomeRNAii 11122.
    NextBioi 42270.
    PROi O14522.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14522.
    Bgeei O14522.
    Genevestigatori O14522.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR000998. MAM_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF00629. MAM. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00020. MAMDOMAIN.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00137. MAM. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system."
      McAndrew P.E., Frostholm A., White R.A., Rotter A., Burghes A.H.M.
      Brain Res. Mol. Brain Res. 56:9-21(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT PRO-29.
    2. "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."
      Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Nomura N.
      DNA Res. 4:53-59(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-29.
      Tissue: Brain.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-29.
    5. "Genomic organization and alternative splicing of the human and mouse RPTPrho genes."
      Besco J.A., Frostholm A., Popesco M.C., Burghes A.H.M., Rotter A.
      BMC Genomics 2:1-1(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    6. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
      Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
      Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 868-1151.
    7. Cited for: VARIANTS SER-74; THR-209; THR-218; SER-248; HIS-280; VAL-395; PHE-412; CYS-453; LYS-510; MET-605; GLY-648; THR-707; VAL-707; PRO-708; ILE-771; GLY-905; LYS-965; PRO-1096; ILE-1106; TRP-1190; LEU-1237; MET-1247; LEU-1324; PHE-1329 AND MET-1346, TISSUE SPECIFICITY.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-1213.
    9. Cited for: VARIANT MET-1346.

    Entry informationi

    Entry nameiPTPRT_HUMAN
    AccessioniPrimary (citable) accession number: O14522
    Secondary accession number(s): A8E4R6
    , O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 134 of the entry and version 6 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3