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O14522

- PTPRT_HUMAN

UniProt

O14522 - PTPRT_HUMAN

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Protein

Receptor-type tyrosine-protein phosphatase T

Gene

PTPRT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in both signal transduction and cellular adhesion in the CNS.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1052 – 10521SubstrateBy similarity
Active sitei1084 – 10841Phosphocysteine intermediateBy similarity
Binding sitei1128 – 11281SubstrateBy similarity
Active sitei1378 – 13781Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. alpha-catenin binding Source: UniProtKB
  2. beta-catenin binding Source: UniProtKB
  3. cadherin binding Source: UniProtKB
  4. delta-catenin binding Source: UniProtKB
  5. gamma-catenin binding Source: UniProtKB
  6. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. homophilic cell adhesion Source: UniProtKB
  3. peptidyl-tyrosine dephosphorylation Source: GOC
  4. protein dephosphorylation Source: UniProtKB
  5. signal transduction Source: UniProtKB
  6. transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

SignaLinkiO14522.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase T (EC:3.1.3.48)
Short name:
R-PTP-T
Alternative name(s):
Receptor-type tyrosine-protein phosphatase rho
Short name:
RPTP-rho
Gene namesi
Name:PTPRT
Synonyms:KIAA0283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:9682. PTPRT.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. integral component of membrane Source: UniProtKB
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 14411416Receptor-type tyrosine-protein phosphatase TPRO_0000025463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi213 ↔ 267PROSITE-ProRule annotation
Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi601 – 6011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi654 – 6541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi684 – 6841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14522.
PRIDEiO14522.

PTM databases

PhosphoSiteiO14522.

Expressioni

Tissue specificityi

Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiO14522.
ExpressionAtlasiO14522. baseline and differential.
GenevestigatoriO14522.

Organism-specific databases

HPAiHPA017336.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GRB2P629932EBI-728180,EBI-401755
Nlgn1Q99K102EBI-728180,EBI-775037From a different organism.
Nlgn2Q69ZK92EBI-728180,EBI-775065From a different organism.
Nrxn1Q9CS842EBI-728180,EBI-399696From a different organism.
Nrxn3Q6P9K92EBI-728180,EBI-7281557From a different organism.
PTPRNQ168493EBI-728180,EBI-728153

Protein-protein interaction databases

BioGridi116296. 1 interaction.
DIPiDIP-33967N.
IntActiO14522. 12 interactions.
MINTiMINT-1350261.

Structurei

Secondary structure

1
1441
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi871 – 8733Combined sources
Helixi874 – 8829Combined sources
Helixi889 – 8957Combined sources
Turni905 – 9084Combined sources
Helixi910 – 9156Combined sources
Helixi925 – 9273Combined sources
Helixi938 – 9414Combined sources
Beta strandi944 – 9485Combined sources
Beta strandi951 – 9533Combined sources
Beta strandi957 – 9604Combined sources
Turni965 – 9673Combined sources
Helixi968 – 97811Combined sources
Beta strandi982 – 9854Combined sources
Beta strandi989 – 9913Combined sources
Beta strandi1003 – 10097Combined sources
Beta strandi1011 – 102010Combined sources
Beta strandi1022 – 103312Combined sources
Beta strandi1040 – 10478Combined sources
Helixi1060 – 107213Combined sources
Beta strandi1080 – 10834Combined sources
Beta strandi1085 – 10884Combined sources
Helixi1089 – 110719Combined sources
Beta strandi1108 – 11103Combined sources
Helixi1112 – 112211Combined sources
Helixi1130 – 114516Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OOQX-ray1.80A/B868-1151[»]
ProteinModelPortaliO14522.
SMRiO14522. Positions 29-591, 866-1441.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14522.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 747722ExtracellularSequence AnalysisAdd
BLAST
Topological domaini769 – 1441673CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei748 – 76821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 191162MAMPROSITE-ProRule annotationAdd
BLAST
Domaini193 – 28492Ig-like C2-typeAdd
BLAST
Domaini291 – 38494Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini389 – 48395Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini484 – 590107Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini591 – 726136Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini889 – 1143255Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1175 – 1437263Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1084 – 10907Substrate bindingBy similarity

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOVERGENiHBG062785.
InParanoidiO14522.
KOiK13297.
OMAiTHPYRTC.
OrthoDBiEOG70KGNP.
PhylomeDBiO14522.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: O14522-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN
60 70 80 90 100
GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT
110 120 130 140 150
HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE
160 170 180 190 200
LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN
210 220 230 240 250
VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA
260 270 280 290 300
TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV
310 320 330 340 350
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL
360 370 380 390 400
DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA
410 420 430 440 450
RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR
460 470 480 490 500
GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE
510 520 530 540 550
KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH
560 570 580 590 600
HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL
610 620 630 640 650
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV
660 670 680 690 700
SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS
710 720 730 740 750
YSIYFQALSK ANGETKINCV RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV
760 770 780 790 800
IAGLLMFIII LLGVMLTIKR RRNAYSYSYY LKLAKKQKET QSGAQREMGP
810 820 830 840 850
VASADKPTTK LSASRNDEGF SSSSQDVNGF TDGSRGELSQ PTLTIQTHPY
860 870 880 890 900
RTCDPVEMSY PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ
910 920 930 940 950
TASWDTAKED ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG
960 970 980 990 1000
YHRPRHYIAT QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY
1010 1020 1030 1040 1050
WPDDTEVYGD IKVTLIETEP LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW
1060 1070 1080 1090 1100
PDHGVPCYAT GLLGFVRQVK FLNPPEAGPI VVHCSAGAGR TGCFIAIDTM
1110 1120 1130 1140 1150
LDMAENEGVV DIFNCVRELR AQRVNLVQTE EQYVFVHDAI LEACLCGNTA
1160 1170 1180 1190 1200
IPVCEFRSLY YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP
1210 1220 1230 1240 1250
RNHDKNRSMD VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ
1260 1270 1280 1290 1300
HPLPNTVADF WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ
1310 1320 1330 1340 1350
VEFVSADIDE DIIHRIFRIC NMARPQDGYR IVQHLQYIGW PAYRDTPPSK
1360 1370 1380 1390 1400
RSLLKVVRRL EKWQEQYDGR EGRTVVHCLN GGGRSGTFCA ICSVCEMIQQ
1410 1420 1430 1440
QNIIDVFHIV KTLRNNKSNM VETLEQYKFV YEVALEYLSS F
Length:1,441
Mass (Da):162,134
Last modified:January 11, 2011 - v6
Checksum:iBE60F3DB2CE13539
GO
Isoform 1 (identifier: O14522-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     725-725: K → KAPMGSAQVTPGTPLCLLTT
     781-781: L → LSQR

Show »
Length:1,463
Mass (Da):164,346
Checksum:i531E33DF9040F4B5
GO

Sequence cautioni

The sequence BAA22952.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAH72555.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI19251.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI19867.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI19879.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI19983.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI20439.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI22491.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI22911.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI23312.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601W → T in AAD09421. (PubMed:9602027)Curated
Sequence conflicti375 – 3751P → A in AAD09421. (PubMed:9602027)Curated
Sequence conflicti867 – 8671P → L in AAD09421. (PubMed:9602027)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291A → P.3 Publications
Corresponds to variant rs2867655 [ dbSNP | Ensembl ].
VAR_028795
Natural varianti74 – 741F → S in a colorectal cancer. 1 Publication
VAR_020746
Natural varianti76 – 761M → V.
Corresponds to variant rs17811401 [ dbSNP | Ensembl ].
VAR_028796
Natural varianti209 – 2091A → T in some colorectal cancers. 1 Publication
VAR_020747
Natural varianti218 – 2181K → T in a gastric cancer. 1 Publication
VAR_020748
Natural varianti248 – 2481F → S in a colorectal cancer. 1 Publication
VAR_020749
Natural varianti280 – 2801Y → H in a colorectal cancer. 1 Publication
VAR_020750
Natural varianti395 – 3951I → V in a colorectal cancer. 1 Publication
VAR_020751
Natural varianti412 – 4121Y → F in a colorectal cancer. 1 Publication
VAR_020752
Natural varianti453 – 4531R → C in a gastric cancer. 1 Publication
VAR_020753
Natural varianti510 – 5101N → K in a colorectal cancer. 1 Publication
VAR_020754
Natural varianti605 – 6051T → M in a colorectal cancer. 1 Publication
VAR_020755
Natural varianti648 – 6481V → G in a colorectal cancer. 1 Publication
VAR_020756
Natural varianti707 – 7071A → T in a colorectal cancer. 1 Publication
VAR_020757
Natural varianti707 – 7071A → V in a colorectal cancer. 1 Publication
VAR_020758
Natural varianti708 – 7081L → P in a colorectal cancer. 1 Publication
VAR_020759
Natural varianti771 – 7711R → I in a lung cancer. 1 Publication
VAR_020760
Natural varianti905 – 9051D → G in a colorectal cancer. 1 Publication
VAR_020761
Natural varianti965 – 9651Q → K in a colorectal cancer; reduced phosphatase activity. 1 Publication
VAR_020762
Natural varianti1096 – 10961A → P in a colorectal cancer. 1 Publication
VAR_020763
Natural varianti1106 – 11061N → I in a colorectal cancer; reduced phosphatase activity. 1 Publication
VAR_020764
Natural varianti1190 – 11901R → W in a colorectal cancer; reduced phosphatase activity. 1 Publication
VAR_020765
Natural varianti1213 – 12131P → L in an acute myeloid leukemia sample; somatic mutation. 1 Publication
VAR_054144
Natural varianti1237 – 12371M → L in a colorectal cancer. 1 Publication
VAR_020766
Natural varianti1247 – 12471V → M in a colorectal cancer. 1 Publication
VAR_020767
Natural varianti1324 – 13241R → L in a lung cancer; reduced phosphatase activity. 1 Publication
VAR_020768
Natural varianti1329 – 13291Y → F in a colorectal cancer. 1 Publication
VAR_020769
Natural varianti1346 – 13461T → M Found in a patient with severe intellectual disability, behavioral problems, microcephaly, congenital cardiac defect and herniation of the abdominal diaphragm; also observed in some colorectal cancers; reduced phosphatase activity; unknown pathological significance. 2 Publications
VAR_020770

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei725 – 7251K → KAPMGSAQVTPGTPLCLLTT in isoform 1. 1 PublicationVSP_040385
Alternative sequencei781 – 7811L → LSQR in isoform 1. 1 PublicationVSP_040386

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF043644 mRNA. Translation: AAD09421.2.
AB006621 mRNA. Translation: BAA22952.2. Different initiation.
AL021395
, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19981.1.
AL021395
, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19983.1. Sequence problems.
AL022239
, AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20437.1.
AL022239
, AL021395, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI20439.1. Sequence problems.
AL024473
, AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22489.1.
AL024473
, AL021395, AL022239, AL031656, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22491.1. Sequence problems.
AL031656
, AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19877.1.
AL031656
, AL021395, AL022239, AL024473, AL035459, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19879.1. Sequence problems.
AL035459
, AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22909.1.
AL035459
, AL021395, AL022239, AL024473, AL031656, AL049812, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI22911.1. Sequence problems.
AL049812
, AL021395, AL022239, AL024473, AL031656, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19251.1. Sequence problems.
AL049812
, AL022239, AL031656, AL021395, AL024473, AL035459, AL121763, AL136461, Z93942 Genomic DNA. Translation: CAI19253.1.
AL121763
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23310.1.
AL121763
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL136461, Z93942 Genomic DNA. Translation: CAI23312.1. Sequence problems.
AL136461
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72553.1.
AL136461
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, Z93942 Genomic DNA. Translation: CAH72555.1. Sequence problems.
Z93942
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19865.1.
Z93942
, AL021395, AL022239, AL024473, AL031656, AL035459, AL049812, AL121763, AL136461 Genomic DNA. Translation: CAI19867.1. Sequence problems.
AL031676 Genomic DNA. No translation available.
AL035666 Genomic DNA. No translation available.
AL109826 Genomic DNA. No translation available.
AL117374 Genomic DNA. No translation available.
AL359695 Genomic DNA. No translation available.
BC153300 mRNA. Translation: AAI53301.1.
CCDSiCCDS42874.1. [O14522-3]
RefSeqiNP_008981.4. NM_007050.5. [O14522-3]
NP_573400.3. NM_133170.3.
UniGeneiHs.526879.

Genome annotation databases

EnsembliENST00000373187; ENSP00000362283; ENSG00000196090. [O14522-3]
ENST00000373193; ENSP00000362289; ENSG00000196090. [O14522-1]
GeneIDi11122.
KEGGihsa:11122.
UCSCiuc002xkg.3. human. [O14522-3]
uc010ggj.3. human. [O14522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF043644 mRNA. Translation: AAD09421.2 .
AB006621 mRNA. Translation: BAA22952.2 . Different initiation.
AL021395
, AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19981.1 .
AL021395
, AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19983.1 . Sequence problems.
AL022239
, AL021395 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI20437.1 .
AL022239
, AL021395 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI20439.1 . Sequence problems.
AL024473
, AL021395 , AL022239 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22489.1 .
AL024473
, AL021395 , AL022239 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22491.1 . Sequence problems.
AL031656
, AL021395 , AL022239 , AL024473 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19877.1 .
AL031656
, AL021395 , AL022239 , AL024473 , AL035459 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19879.1 . Sequence problems.
AL035459
, AL021395 , AL022239 , AL024473 , AL031656 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22909.1 .
AL035459
, AL021395 , AL022239 , AL024473 , AL031656 , AL049812 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI22911.1 . Sequence problems.
AL049812
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19251.1 . Sequence problems.
AL049812
, AL022239 , AL031656 , AL021395 , AL024473 , AL035459 , AL121763 , AL136461 , Z93942 Genomic DNA. Translation: CAI19253.1 .
AL121763
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL136461 , Z93942 Genomic DNA. Translation: CAI23310.1 .
AL121763
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL136461 , Z93942 Genomic DNA. Translation: CAI23312.1 . Sequence problems.
AL136461
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , Z93942 Genomic DNA. Translation: CAH72553.1 .
AL136461
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , Z93942 Genomic DNA. Translation: CAH72555.1 . Sequence problems.
Z93942
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 Genomic DNA. Translation: CAI19865.1 .
Z93942
, AL021395 , AL022239 , AL024473 , AL031656 , AL035459 , AL049812 , AL121763 , AL136461 Genomic DNA. Translation: CAI19867.1 . Sequence problems.
AL031676 Genomic DNA. No translation available.
AL035666 Genomic DNA. No translation available.
AL109826 Genomic DNA. No translation available.
AL117374 Genomic DNA. No translation available.
AL359695 Genomic DNA. No translation available.
BC153300 mRNA. Translation: AAI53301.1 .
CCDSi CCDS42874.1. [O14522-3 ]
RefSeqi NP_008981.4. NM_007050.5. [O14522-3 ]
NP_573400.3. NM_133170.3.
UniGenei Hs.526879.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2OOQ X-ray 1.80 A/B 868-1151 [» ]
ProteinModelPortali O14522.
SMRi O14522. Positions 29-591, 866-1441.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116296. 1 interaction.
DIPi DIP-33967N.
IntActi O14522. 12 interactions.
MINTi MINT-1350261.

PTM databases

PhosphoSitei O14522.

Proteomic databases

PaxDbi O14522.
PRIDEi O14522.

Protocols and materials databases

DNASUi 11122.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373187 ; ENSP00000362283 ; ENSG00000196090 . [O14522-3 ]
ENST00000373193 ; ENSP00000362289 ; ENSG00000196090 . [O14522-1 ]
GeneIDi 11122.
KEGGi hsa:11122.
UCSCi uc002xkg.3. human. [O14522-3 ]
uc010ggj.3. human. [O14522-1 ]

Organism-specific databases

CTDi 11122.
GeneCardsi GC20M040701.
HGNCi HGNC:9682. PTPRT.
HPAi HPA017336.
MIMi 608712. gene.
neXtProti NX_O14522.
PharmGKBi PA34027.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118900.
HOVERGENi HBG062785.
InParanoidi O14522.
KOi K13297.
OMAi THPYRTC.
OrthoDBi EOG70KGNP.
PhylomeDBi O14522.
TreeFami TF312900.

Enzyme and pathway databases

SignaLinki O14522.

Miscellaneous databases

EvolutionaryTracei O14522.
GeneWikii PTPRT.
GenomeRNAii 11122.
NextBioi 42270.
PROi O14522.
SOURCEi Search...

Gene expression databases

Bgeei O14522.
ExpressionAtlasi O14522. baseline and differential.
Genevestigatori O14522.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system."
    McAndrew P.E., Frostholm A., White R.A., Rotter A., Burghes A.H.M.
    Brain Res. Mol. Brain Res. 56:9-21(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, VARIANT PRO-29.
  2. "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."
    Ohara O., Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Nomura N.
    DNA Res. 4:53-59(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-29.
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT PRO-29.
  5. "Genomic organization and alternative splicing of the human and mouse RPTPrho genes."
    Besco J.A., Frostholm A., Popesco M.C., Burghes A.H.M., Rotter A.
    BMC Genomics 2:1-1(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  6. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
    Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
    Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 868-1151.
  7. Cited for: VARIANTS SER-74; THR-209; THR-218; SER-248; HIS-280; VAL-395; PHE-412; CYS-453; LYS-510; MET-605; GLY-648; THR-707; VAL-707; PRO-708; ILE-771; GLY-905; LYS-965; PRO-1096; ILE-1106; TRP-1190; LEU-1237; MET-1247; LEU-1324; PHE-1329 AND MET-1346, TISSUE SPECIFICITY.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-1213.
  9. Cited for: VARIANT MET-1346.

Entry informationi

Entry nameiPTPRT_HUMAN
AccessioniPrimary (citable) accession number: O14522
Secondary accession number(s): A8E4R6
, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 135 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3