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O14519

- CDKA1_HUMAN

UniProt

O14519 - CDKA1_HUMAN

Protein

Cyclin-dependent kinase 2-associated protein 1

Gene

CDK2AP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    specific inhibitor of the cell-cycle kinase CDK2.By similarity

    GO - Molecular functioni

    1. DNA binding Source: ProtInc

    GO - Biological processi

    1. DNA-dependent DNA replication Source: ProtInc
    2. mitotic S phase Source: ProtInc
    3. protein phosphorylation Source: ProtInc

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 2-associated protein 1
    Short name:
    CDK2-associated protein 1
    Alternative name(s):
    Deleted in oral cancer 1
    Short name:
    DOC-1
    Putative oral cancer suppressor
    Gene namesi
    Name:CDK2AP1
    Synonyms:CDKAP1, DOC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14002. CDK2AP1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. nucleus Source: ProtInc

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi105 – 1051C → A: Does not alter homodimerization. 1 Publication

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA26308.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 115115Cyclin-dependent kinase 2-associated protein 1PRO_0000089452Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei46 – 461Phosphoserine; by IKKE1 Publication
    Disulfide bondi105 – 105InterchainSequence Analysis

    Post-translational modificationi

    Phosphorylated in vitro by IKBKE at Ser-46.1 Publication

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiO14519.
    PaxDbiO14519.
    PRIDEiO14519.

    PTM databases

    PhosphoSiteiO14519.

    Expressioni

    Gene expression databases

    ArrayExpressiO14519.
    BgeeiO14519.
    CleanExiHS_CDK2AP1.
    GenevestigatoriO14519.

    Organism-specific databases

    HPAiCAB019377.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with monomeric unphosphorylated CDK2.1 Publication

    Protein-protein interaction databases

    BioGridi113770. 19 interactions.
    IntActiO14519. 5 interactions.
    MINTiMINT-88804.
    STRINGi9606.ENSP00000261692.

    Structurei

    Secondary structure

    1
    115
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi62 – 7312
    Turni74 – 763
    Helixi77 – 815
    Helixi85 – 10925
    Turni110 – 1145

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KW6NMR-A/B61-115[»]
    ProteinModelPortaliO14519.
    SMRiO14519. Positions 62-115.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14519.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 6060intrinsically disorderedAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CDK2AP family.Curated

    Phylogenomic databases

    eggNOGiNOG235568.
    HOGENOMiHOG000035115.
    HOVERGENiHBG002074.
    InParanoidiO14519.
    OMAiCAICTHY.
    OrthoDBiEOG71RXN6.
    PhylomeDBiO14519.
    TreeFamiTF101037.

    Family and domain databases

    InterProiIPR017266. CDK2-associated_2.
    IPR019187. Cyclin-dep_kinase2-assoc_pr.
    [Graphical view]
    PfamiPF09806. CDK2AP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O14519-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSYKPNLAAH MPAAALNAAG SVHSPSTSMA TSSQYRQLLS DYGPPSLGYT    50
    QGTGNSQVPQ SKYAELLAII EELGKEIRPT YAGSKSAMER LKRGIIHARG 100
    LVRECLAETE RNARS 115
    Length:115
    Mass (Da):12,365
    Last modified:January 1, 1998 - v1
    Checksum:iF3149F72467598C2
    GO
    Isoform 2 (identifier: O14519-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-28: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:87
    Mass (Da):9,601
    Checksum:i6B823B0C04D5D88A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2828Missing in isoform 2. 1 PublicationVSP_046436Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006077 mRNA. Translation: BAA22937.1.
    AF006484 mRNA. Translation: AAC77831.1.
    DB465022 mRNA. No translation available.
    AC068768 Genomic DNA. No translation available.
    BC034717 mRNA. Translation: AAH34717.1.
    CCDSiCCDS58289.1. [O14519-2]
    CCDS9245.1. [O14519-1]
    RefSeqiNP_001257362.1. NM_001270433.1. [O14519-2]
    NP_001257363.1. NM_001270434.1. [O14519-2]
    NP_004633.1. NM_004642.3. [O14519-1]
    UniGeneiHs.433201.

    Genome annotation databases

    EnsembliENST00000261692; ENSP00000261692; ENSG00000111328. [O14519-1]
    ENST00000535979; ENSP00000442565; ENSG00000111328. [O14519-2]
    ENST00000538446; ENSP00000442502; ENSG00000111328. [O14519-2]
    ENST00000542174; ENSP00000440729; ENSG00000111328. [O14519-2]
    ENST00000544658; ENSP00000438561; ENSG00000111328. [O14519-2]
    GeneIDi8099.
    KEGGihsa:8099.
    UCSCiuc001ueq.4. human. [O14519-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB006077 mRNA. Translation: BAA22937.1 .
    AF006484 mRNA. Translation: AAC77831.1 .
    DB465022 mRNA. No translation available.
    AC068768 Genomic DNA. No translation available.
    BC034717 mRNA. Translation: AAH34717.1 .
    CCDSi CCDS58289.1. [O14519-2 ]
    CCDS9245.1. [O14519-1 ]
    RefSeqi NP_001257362.1. NM_001270433.1. [O14519-2 ]
    NP_001257363.1. NM_001270434.1. [O14519-2 ]
    NP_004633.1. NM_004642.3. [O14519-1 ]
    UniGenei Hs.433201.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KW6 NMR - A/B 61-115 [» ]
    ProteinModelPortali O14519.
    SMRi O14519. Positions 62-115.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113770. 19 interactions.
    IntActi O14519. 5 interactions.
    MINTi MINT-88804.
    STRINGi 9606.ENSP00000261692.

    Chemistry

    BindingDBi O14519.
    ChEMBLi CHEMBL5578.

    PTM databases

    PhosphoSitei O14519.

    Proteomic databases

    MaxQBi O14519.
    PaxDbi O14519.
    PRIDEi O14519.

    Protocols and materials databases

    DNASUi 8099.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261692 ; ENSP00000261692 ; ENSG00000111328 . [O14519-1 ]
    ENST00000535979 ; ENSP00000442565 ; ENSG00000111328 . [O14519-2 ]
    ENST00000538446 ; ENSP00000442502 ; ENSG00000111328 . [O14519-2 ]
    ENST00000542174 ; ENSP00000440729 ; ENSG00000111328 . [O14519-2 ]
    ENST00000544658 ; ENSP00000438561 ; ENSG00000111328 . [O14519-2 ]
    GeneIDi 8099.
    KEGGi hsa:8099.
    UCSCi uc001ueq.4. human. [O14519-1 ]

    Organism-specific databases

    CTDi 8099.
    GeneCardsi GC12M123745.
    HGNCi HGNC:14002. CDK2AP1.
    HPAi CAB019377.
    MIMi 602198. gene.
    neXtProti NX_O14519.
    PharmGKBi PA26308.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235568.
    HOGENOMi HOG000035115.
    HOVERGENi HBG002074.
    InParanoidi O14519.
    OMAi CAICTHY.
    OrthoDBi EOG71RXN6.
    PhylomeDBi O14519.
    TreeFami TF101037.

    Miscellaneous databases

    EvolutionaryTracei O14519.
    GeneWikii CDK2AP1.
    GenomeRNAii 8099.
    NextBioi 30740.
    PROi O14519.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14519.
    Bgeei O14519.
    CleanExi HS_CDK2AP1.
    Genevestigatori O14519.

    Family and domain databases

    InterProi IPR017266. CDK2-associated_2.
    IPR019187. Cyclin-dep_kinase2-assoc_pr.
    [Graphical view ]
    Pfami PF09806. CDK2AP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037709. CDK2-associated_p2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer."
      Daigo Y., Suzuki K., Maruyama O., Miyoshi Y., Yasuda T., Kabuto T., Imaoka S., Fujiwara T., Takahashi E., Fujino M.A., Nakamura Y.
      Genes Chromosomes Cancer 20:204-207(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1."
      Tsuji T., Duh F.-M., Latif F., Popescu N.C., Zimonjic D.B., McBride J., Matsuo K., Ohyama H., Todd R., Nagata E., Terakado N., Sasaki A., Matsumura T., Lerman M.I., Wong D.T.
      J. Biol. Chem. 273:6704-6709(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    6. "Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region."
      Ertekin A., Aramini J.M., Rossi P., Leonard P.G., Janjua H., Xiao R., Maglaqui M., Lee H.W., Prestegard J.H., Montelione G.T.
      J. Biol. Chem. 287:16541-16549(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 61-115, SUBUNIT, PHOSPHORYLATION AT SER-46, DISULFIDE BOND, MUTAGENESIS OF CYS-105.

    Entry informationi

    Entry nameiCDKA1_HUMAN
    AccessioniPrimary (citable) accession number: O14519
    Secondary accession number(s): F5GYA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3