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Protein

Cyclin-dependent kinase 2-associated protein 1

Gene

CDK2AP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

specific inhibitor of the cell-cycle kinase CDK2.By similarity

GO - Molecular functioni

  • DNA polymerase binding Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • DNA-dependent DNA replication Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111328-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-associated protein 1
Short name:
CDK2-associated protein 1
Alternative name(s):
Deleted in oral cancer 1
Short name:
DOC-1
Putative oral cancer suppressor
Gene namesi
Name:CDK2AP1
Synonyms:CDKAP1, DOC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14002. CDK2AP1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi105C → A: Does not alter homodimerization. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi8099.
OpenTargetsiENSG00000111328.
PharmGKBiPA26308.

Chemistry databases

ChEMBLiCHEMBL5578.

Polymorphism and mutation databases

BioMutaiCDK2AP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894521 – 115Cyclin-dependent kinase 2-associated protein 1Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46Phosphoserine; by IKKE1 Publication1
Disulfide bondi105InterchainSequence analysis

Post-translational modificationi

Phosphorylated in vitro by IKBKE at Ser-46.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiO14519.
MaxQBiO14519.
PaxDbiO14519.
PeptideAtlasiO14519.
PRIDEiO14519.

PTM databases

iPTMnetiO14519.
PhosphoSitePlusiO14519.

Expressioni

Gene expression databases

BgeeiENSG00000111328.
CleanExiHS_CDK2AP1.
ExpressionAtlasiO14519. baseline and differential.
GenevisibleiO14519. HS.

Organism-specific databases

HPAiCAB019377.
HPA057648.

Interactioni

Subunit structurei

Homodimer. Interacts with monomeric unphosphorylated CDK2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC136Q96JN2-23EBI-1052532,EBI-10171416
MRFAP1L1Q96HT86EBI-1052532,EBI-748896

GO - Molecular functioni

  • DNA polymerase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113770. 59 interactors.
IntActiO14519. 44 interactors.
MINTiMINT-88804.
STRINGi9606.ENSP00000261692.

Chemistry databases

BindingDBiO14519.

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi62 – 73Combined sources12
Turni74 – 76Combined sources3
Helixi77 – 81Combined sources5
Helixi85 – 109Combined sources25
Turni110 – 114Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KW6NMR-A/B61-115[»]
ProteinModelPortaliO14519.
SMRiO14519.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14519.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 60intrinsically disorderedAdd BLAST60

Sequence similaritiesi

Belongs to the CDK2AP family.Curated

Phylogenomic databases

eggNOGiKOG4713. Eukaryota.
ENOG41126TJ. LUCA.
GeneTreeiENSGT00390000006964.
HOGENOMiHOG000035115.
HOVERGENiHBG002074.
InParanoidiO14519.
OMAiVHQHIPG.
OrthoDBiEOG091G1364.
PhylomeDBiO14519.
TreeFamiTF101037.

Family and domain databases

InterProiIPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]
PfamiPF09806. CDK2AP. 1 hit.
[Graphical view]
PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYKPNLAAH MPAAALNAAG SVHSPSTSMA TSSQYRQLLS DYGPPSLGYT
60 70 80 90 100
QGTGNSQVPQ SKYAELLAII EELGKEIRPT YAGSKSAMER LKRGIIHARG
110
LVRECLAETE RNARS
Length:115
Mass (Da):12,365
Last modified:January 1, 1998 - v1
Checksum:iF3149F72467598C2
GO
Isoform 2 (identifier: O14519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Note: No experimental confirmation available.
Show »
Length:87
Mass (Da):9,601
Checksum:i6B823B0C04D5D88A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0464361 – 28Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006077 mRNA. Translation: BAA22937.1.
AF006484 mRNA. Translation: AAC77831.1.
DB465022 mRNA. No translation available.
AC068768 Genomic DNA. No translation available.
BC034717 mRNA. Translation: AAH34717.1.
CCDSiCCDS58289.1. [O14519-2]
CCDS9245.1. [O14519-1]
RefSeqiNP_001257362.1. NM_001270433.1. [O14519-2]
NP_001257363.1. NM_001270434.1. [O14519-2]
NP_004633.1. NM_004642.3. [O14519-1]
UniGeneiHs.433201.

Genome annotation databases

EnsembliENST00000261692; ENSP00000261692; ENSG00000111328. [O14519-1]
ENST00000535979; ENSP00000442565; ENSG00000111328. [O14519-2]
ENST00000538446; ENSP00000442502; ENSG00000111328. [O14519-2]
ENST00000542174; ENSP00000440729; ENSG00000111328. [O14519-2]
ENST00000544658; ENSP00000438561; ENSG00000111328. [O14519-2]
ENST00000618072; ENSP00000479982; ENSG00000111328. [O14519-2]
GeneIDi8099.
KEGGihsa:8099.
UCSCiuc001ueq.5. human. [O14519-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006077 mRNA. Translation: BAA22937.1.
AF006484 mRNA. Translation: AAC77831.1.
DB465022 mRNA. No translation available.
AC068768 Genomic DNA. No translation available.
BC034717 mRNA. Translation: AAH34717.1.
CCDSiCCDS58289.1. [O14519-2]
CCDS9245.1. [O14519-1]
RefSeqiNP_001257362.1. NM_001270433.1. [O14519-2]
NP_001257363.1. NM_001270434.1. [O14519-2]
NP_004633.1. NM_004642.3. [O14519-1]
UniGeneiHs.433201.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KW6NMR-A/B61-115[»]
ProteinModelPortaliO14519.
SMRiO14519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113770. 59 interactors.
IntActiO14519. 44 interactors.
MINTiMINT-88804.
STRINGi9606.ENSP00000261692.

Chemistry databases

BindingDBiO14519.
ChEMBLiCHEMBL5578.

PTM databases

iPTMnetiO14519.
PhosphoSitePlusiO14519.

Polymorphism and mutation databases

BioMutaiCDK2AP1.

Proteomic databases

EPDiO14519.
MaxQBiO14519.
PaxDbiO14519.
PeptideAtlasiO14519.
PRIDEiO14519.

Protocols and materials databases

DNASUi8099.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261692; ENSP00000261692; ENSG00000111328. [O14519-1]
ENST00000535979; ENSP00000442565; ENSG00000111328. [O14519-2]
ENST00000538446; ENSP00000442502; ENSG00000111328. [O14519-2]
ENST00000542174; ENSP00000440729; ENSG00000111328. [O14519-2]
ENST00000544658; ENSP00000438561; ENSG00000111328. [O14519-2]
ENST00000618072; ENSP00000479982; ENSG00000111328. [O14519-2]
GeneIDi8099.
KEGGihsa:8099.
UCSCiuc001ueq.5. human. [O14519-1]

Organism-specific databases

CTDi8099.
DisGeNETi8099.
GeneCardsiCDK2AP1.
HGNCiHGNC:14002. CDK2AP1.
HPAiCAB019377.
HPA057648.
MIMi602198. gene.
neXtProtiNX_O14519.
OpenTargetsiENSG00000111328.
PharmGKBiPA26308.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4713. Eukaryota.
ENOG41126TJ. LUCA.
GeneTreeiENSGT00390000006964.
HOGENOMiHOG000035115.
HOVERGENiHBG002074.
InParanoidiO14519.
OMAiVHQHIPG.
OrthoDBiEOG091G1364.
PhylomeDBiO14519.
TreeFamiTF101037.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111328-MONOMER.

Miscellaneous databases

ChiTaRSiCDK2AP1. human.
EvolutionaryTraceiO14519.
GeneWikiiCDK2AP1.
GenomeRNAii8099.
PROiO14519.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111328.
CleanExiHS_CDK2AP1.
ExpressionAtlasiO14519. baseline and differential.
GenevisibleiO14519. HS.

Family and domain databases

InterProiIPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]
PfamiPF09806. CDK2AP. 1 hit.
[Graphical view]
PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDKA1_HUMAN
AccessioniPrimary (citable) accession number: O14519
Secondary accession number(s): F5GYA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.