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O14514

- BAI1_HUMAN

UniProt

O14514 - BAI1_HUMAN

Protein

Brain-specific angiogenesis inhibitor 1

Gene

BAI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (31 Oct 2012)
      Previous versions | rss
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    Functioni

    Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. axonogenesis Source: ProtInc
    2. cell adhesion Source: ProtInc
    3. G-protein coupled receptor signaling pathway Source: GDB
    4. negative regulation of angiogenesis Source: InterPro
    5. negative regulation of cell proliferation Source: ProtInc
    6. neuropeptide signaling pathway Source: InterPro
    7. peripheral nervous system development Source: ProtInc
    8. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    SignaLinkiO14514.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-specific angiogenesis inhibitor 1
    Gene namesi
    Name:BAI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:943. BAI1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Likely to be concentrated at cell-cell adhesion sites.

    GO - Cellular componenti

    1. cell-cell junction Source: ProtInc
    2. integral component of membrane Source: GDB
    3. integral component of plasma membrane Source: ProtInc
    4. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25247.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 15841554Brain-specific angiogenesis inhibitor 1PRO_0000012863Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi273 ↔ 309PROSITE-ProRule annotation
    Disulfide bondi277 ↔ 314PROSITE-ProRule annotation
    Disulfide bondi288 ↔ 299PROSITE-ProRule annotation
    Disulfide bondi366 ↔ 400PROSITE-ProRule annotation
    Disulfide bondi370 ↔ 406PROSITE-ProRule annotation
    Disulfide bondi381 ↔ 390PROSITE-ProRule annotation
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi421 ↔ 456PROSITE-ProRule annotation
    Disulfide bondi425 ↔ 461PROSITE-ProRule annotation
    Disulfide bondi436 ↔ 446PROSITE-ProRule annotation
    Disulfide bondi479 ↔ 514PROSITE-ProRule annotation
    Disulfide bondi483 ↔ 519PROSITE-ProRule annotation
    Disulfide bondi494 ↔ 504PROSITE-ProRule annotation
    Disulfide bondi534 ↔ 569PROSITE-ProRule annotation
    Disulfide bondi538 ↔ 574PROSITE-ProRule annotation
    Disulfide bondi549 ↔ 559PROSITE-ProRule annotation
    Disulfide bondi581 ↔ 616PROSITE-ProRule annotation
    Disulfide bondi604 ↔ 634PROSITE-ProRule annotation
    Glycosylationi607 – 6071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi692 – 6921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi844 – 8441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi877 – 8771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi881 – 8811N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi884 ↔ 921PROSITE-ProRule annotation
    Disulfide bondi909 ↔ 923PROSITE-ProRule annotation

    Post-translational modificationi

    The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO14514.
    PRIDEiO14514.

    PTM databases

    PhosphoSiteiO14514.

    Expressioni

    Tissue specificityi

    Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes.3 Publications

    Inductioni

    By p53/TP53.

    Gene expression databases

    ArrayExpressiO14514.
    BgeeiO14514.
    CleanExiHS_BAI1.
    GenevestigatoriO14514.

    Organism-specific databases

    HPAiHPA038785.

    Interactioni

    Subunit structurei

    Interacts with ELMO1 and DOCK1. When bound to ELMO1 and DOCK1, it may act as a module to promote the engulfment By similarity. Interacts with MAGI1, MAGI3, BAIAP2 and PHYHIP.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi107051. 18 interactions.
    DIPiDIP-40884N.
    IntActiO14514. 3 interactions.
    MINTiMINT-93782.
    STRINGi9606.ENSP00000313046.

    Structurei

    3D structure databases

    ProteinModelPortaliO14514.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 948918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini970 – 98011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1002 – 10087ExtracellularSequence Analysis
    Topological domaini1030 – 105223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1074 – 109320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1115 – 113622CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1158 – 11669ExtracellularSequence Analysis
    Topological domaini1188 – 1584397CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei949 – 96921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei981 – 100121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei1009 – 102921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei1053 – 107321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei1094 – 111421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1137 – 115721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1167 – 118721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini261 – 31555TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini354 – 40754TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini409 – 46254TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini467 – 52054TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini522 – 57554TSP type-1 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini881 – 93858GPSPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1365 – 1584220Necessary for interaction with MAGI1Add
    BLAST
    Regioni1581 – 15844Indispensable for interaction with MAGI1

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi231 – 2333Cell attachment siteSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1411 – 142212Poly-ProAdd
    BLAST
    Compositional biasi1425 – 14306Poly-Pro

    Domaini

    The TSP1 repeats inhibit in vivo angiogenesis in rat cornea induced by BFGF.

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 5 TSP type-1 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285547.
    HOGENOMiHOG000230916.
    HOVERGENiHBG004813.
    InParanoidiO14514.
    KOiK04596.
    OMAiDSKPEKQ.
    OrthoDBiEOG7KDF90.
    PhylomeDBiO14514.
    TreeFamiTF331634.

    Family and domain databases

    InterProiIPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR008077. GPCR_2_brain-spec_angio_inhib.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF00090. TSP_1. 5 hits.
    [Graphical view]
    PRINTSiPR01694. BAIPRECURSOR.
    PR00249. GPCRSECRETIN.
    SMARTiSM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00209. TSP1. 5 hits.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 5 hits.
    PROSITEiPS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50092. TSP1. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14514-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGQAAAPGP VWILAPLLLL LLLLGRRARA AAGADAGPGP EPCATLVQGK     50
    FFGYFSAAAV FPANASRCSW TLRNPDPRRY TLYMKVAKAP VPCSGPGRVR 100
    TYQFDSFLES TRTYLGVESF DEVLRLCDPS APLAFLQASK QFLQMRRQQP 150
    PQHDGLRPRA GPPGPTDDFS VEYLVVGNRN PSRAACQMLC RWLDACLAGS 200
    RSSHPCGIMQ TPCACLGGEA GGPAAGPLAP RGDVCLRDAV AGGPENCLTS 250
    LTQDRGGHGA TGGWKLWSLW GECTRDCGGG LQTRTRTCLP APGVEGGGCE 300
    GVLEEGRQCN REACGPAGRT SSRSQSLRST DARRREELGD ELQQFGFPAP 350
    QTGDPAAEEW SPWSVCSSTC GEGWQTRTRF CVSSSYSTQC SGPLREQRLC 400
    NNSAVCPVHG AWDEWSPWSL CSSTCGRGFR DRTRTCRPPQ FGGNPCEGPE 450
    KQTKFCNIAL CPGRAVDGNW NEWSSWSACS ASCSQGRQQR TRECNGPSYG 500
    GAECQGHWVE TRDCFLQQCP VDGKWQAWAS WGSCSVTCGA GSQRRERVCS 550
    GPFFGGAACQ GPQDEYRQCG TQRCPEPHEI CDEDNFGAVI WKETPAGEVA 600
    AVRCPRNATG LILRRCELDE EGIAYWEPPT YIRCVSIDYR NIQMMTREHL 650
    AKAQRGLPGE GVSEVIQTLV EISQDGTSYS GDLLSTIDVL RNMTEIFRRA 700
    YYSPTPGDVQ NFVQILSNLL AEENRDKWEE AQLAGPNAKE LFRLVEDFVD 750
    VIGFRMKDLR DAYQVTDNLV LSIHKLPASG ATDISFPMKG WRATGDWAKV 800
    PEDRVTVSKS VFSTGLTEAD EASVFVVGTV LYRNLGSFLA LQRNTTVLNS 850
    KVISVTVKPP PRSLRTPLEI EFAHMYNGTT NQTCILWDET DVPSSSAPPQ 900
    LGPWSWRGCR TVPLDALRTR CLCDRLSTFA ILAQLSADAN MEKATLPSVT 950
    LIVGCGVSSL TLLMLVIIYV SVWRYIRSER SVILINFCLS IISSNALILI 1000
    GQTQTRNKVV CTLVAAFLHF FFLSSFCWVL TEAWQSYMAV TGHLRNRLIR 1050
    KRFLCLGWGL PALVVAISVG FTKAKGYSTM NYCWLSLEGG LLYAFVGPAA 1100
    AVVLVNMVIG ILVFNKLVSK DGITDKKLKE RAGASLWSSC VVLPLLALTW 1150
    MSAVLAVTDR RSALFQILFA VFDSLEGFVI VMVHCILRRE VQDAVKCRVV 1200
    DRQEEGNGDS GGSFQNGHAQ LMTDFEKDVD LACRSVLNKD IAACRTATIT 1250
    GTLKRPSLPE EEKLKLAHAK GPPTNFNSLP ANVSKLHLHG SPRYPGGPLP 1300
    DFPNHSLTLK RDKAPKSSFV GDGDIFKKLD SELSRAQEKA LDTSYVILPT 1350
    ATATLRPKPK EEPKYSIHID QMPQTRLIHL STAPEASLPA RSPPSRQPPS 1400
    GGPPEAPPAQ PPPPPPPPPP PPQQPLPPPP NLEPAPPSLG DPGEPAAHPG 1450
    PSTGPSTKNE NVATLSVSSL ERRKSRYAEL DFEKIMHTRK RHQDMFQDLN 1500
    RKLQHAAEKD KEVLGPDSKP EKQQTPNKRP WESLRKAHGT PTWVKKELEP 1550
    LQPSPLELRS VEWERSGATI PLVGQDIIDL QTEV 1584
    Length:1,584
    Mass (Da):173,501
    Last modified:October 31, 2012 - v2
    Checksum:iA604E634DDD741F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1010 – 10101V → M in BAA23647. (PubMed:9393972)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005297 mRNA. Translation: BAA23647.1.
    AC139676 Genomic DNA. No translation available.
    CCDSiCCDS64985.1.
    PIRiT00026.
    RefSeqiNP_001693.2. NM_001702.2.
    UniGeneiHs.194654.

    Genome annotation databases

    EnsembliENST00000323289; ENSP00000313046; ENSG00000181790.
    ENST00000517894; ENSP00000430945; ENSG00000181790.
    GeneIDi575.
    KEGGihsa:575.
    UCSCiuc003ywm.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005297 mRNA. Translation: BAA23647.1 .
    AC139676 Genomic DNA. No translation available.
    CCDSi CCDS64985.1.
    PIRi T00026.
    RefSeqi NP_001693.2. NM_001702.2.
    UniGenei Hs.194654.

    3D structure databases

    ProteinModelPortali O14514.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107051. 18 interactions.
    DIPi DIP-40884N.
    IntActi O14514. 3 interactions.
    MINTi MINT-93782.
    STRINGi 9606.ENSP00000313046.

    Chemistry

    GuidetoPHARMACOLOGYi 174.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O14514.

    Proteomic databases

    PaxDbi O14514.
    PRIDEi O14514.

    Protocols and materials databases

    DNASUi 575.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323289 ; ENSP00000313046 ; ENSG00000181790 .
    ENST00000517894 ; ENSP00000430945 ; ENSG00000181790 .
    GeneIDi 575.
    KEGGi hsa:575.
    UCSCi uc003ywm.3. human.

    Organism-specific databases

    CTDi 575.
    GeneCardsi GC08P143542.
    H-InvDB HIX0025534.
    HGNCi HGNC:943. BAI1.
    HPAi HPA038785.
    MIMi 602682. gene.
    neXtProti NX_O14514.
    PharmGKBi PA25247.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285547.
    HOGENOMi HOG000230916.
    HOVERGENi HBG004813.
    InParanoidi O14514.
    KOi K04596.
    OMAi DSKPEKQ.
    OrthoDBi EOG7KDF90.
    PhylomeDBi O14514.
    TreeFami TF331634.

    Enzyme and pathway databases

    SignaLinki O14514.

    Miscellaneous databases

    GeneWikii Brain-specific_angiogenesis_inhibitor_1.
    GenomeRNAii 575.
    NextBioi 2345.
    PROi O14514.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14514.
    Bgeei O14514.
    CleanExi HS_BAI1.
    Genevestigatori O14514.

    Family and domain databases

    InterProi IPR022624. DUF3497.
    IPR017981. GPCR_2-like.
    IPR008077. GPCR_2_brain-spec_angio_inhib.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF12003. DUF3497. 1 hit.
    PF01825. GPS. 1 hit.
    PF02793. HRM. 1 hit.
    PF00090. TSP_1. 5 hits.
    [Graphical view ]
    PRINTSi PR01694. BAIPRECURSOR.
    PR00249. GPCRSECRETIN.
    SMARTi SM00303. GPS. 1 hit.
    SM00008. HormR. 1 hit.
    SM00209. TSP1. 5 hits.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 5 hits.
    PROSITEi PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    PS50092. TSP1. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis."
      Nishimori H., Shiratsuchi T., Urano T., Kimura Y., Kiyono K., Tatsumi K., Yoshida S., Ono M., Kuwano M., Nakamura Y., Tokino T.
      Oncogene 15:2145-2150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1."
      Shiratsuchi T., Futamura M., Oda K., Nishimori H., Nakamura Y., Tokino T.
      Biochem. Biophys. Res. Commun. 247:597-604(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAGI1.
    4. "Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1."
      Oda K., Shiratsuchi T., Nishimori H., Inazawa J., Yoshikawa H., Taketani Y., Nakamura Y., Tokino T.
      Cytogenet. Cell Genet. 84:75-82(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BAIAP2.
    5. "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase."
      Wu Y., Dowbenko D., Spencer S., Laura R., Lee J., Gu Q., Lasky L.A.
      J. Biol. Chem. 275:21477-21485(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAGI3.
    6. "Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis."
      Duda D.G., Sunamura M., Lozonschi L., Yokoyama T., Yatsuoka T., Motoi F., Horii A., Tani K., Asano S., Nakamura Y., Matsuno S.
      Br. J. Cancer 86:490-496(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    7. "Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells."
      Mori K., Kanemura Y., Fujikawa H., Nakano A., Ikemoto H., Ozaki I., Matsumoto T., Tamura K., Yokota M., Arita N.
      Neurosci. Res. 43:69-74(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    8. "Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression."
      Kaur B., Brat D.J., Calkins C.C., Van Meir E.G.
      Am. J. Pathol. 162:19-27(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis."
      Arac D., Boucard A.A., Bolliger M.F., Nguyen J., Soltis S.M., Sudhof T.C., Brunger A.T.
      EMBO J. 31:1364-1378(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING.

    Entry informationi

    Entry nameiBAI1_HUMAN
    AccessioniPrimary (citable) accession number: O14514
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: October 31, 2012
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3