ID   NCKP5_HUMAN             Reviewed;        1909 AA.
AC   O14513; B8ZZL0; Q29SS9; Q29ST0; Q2NL90; Q6ZVE2; Q8NAS3;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   24-JAN-2024, entry version 145.
DE   RecName: Full=Nck-associated protein 5;
DE            Short=NAP-5;
DE   AltName: Full=Peripheral clock protein;
GN   Name=NCKAP5; Synonyms=ERIH, NAP5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 1586-1909 (ISOFORM 1).
RC   TISSUE=Amygdala, and Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1909 (ISOFORM 4).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 69-1909 (ISOFORMS 1 AND 2).
RA   Hisa T.;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 661-1077 (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=9344857; DOI=10.1006/bbrc.1997.7492;
RA   Matuoka K., Miki H., Takahashi K., Takenawa T.;
RT   "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2
RT   domain and nuclear signaling motifs.";
RL   Biochem. Biophys. Res. Commun. 239:488-492(1997).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- SUBUNIT: Interacts with the SH3-containing region of the adapter
CC       protein NCK.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1; Synonyms=Peripheral clock protein 2, ERIH2;
CC         IsoId=O14513-1; Sequence=Displayed;
CC       Name=2; Synonyms=Peripheral clock protein 1, ERIH1;
CC         IsoId=O14513-2; Sequence=VSP_021606;
CC       Name=3;
CC         IsoId=O14513-3; Sequence=VSP_021601, VSP_021604, VSP_021605;
CC       Name=4;
CC         IsoId=O14513-4; Sequence=VSP_021602, VSP_021603;
CC   -!- TISSUE SPECIFICITY: Expressed in fetal and adult brain, leukocytes and
CC       fetal fibroblasts.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-26 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA22433.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAC85920.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK057980; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK092189; BAC03824.1; -; mRNA.
DR   EMBL; AK124659; BAC85920.1; ALT_INIT; mRNA.
DR   EMBL; AC010890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC012489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC110831; AAI10832.1; -; mRNA.
DR   EMBL; AY946007; AAY23346.1; -; mRNA.
DR   EMBL; AY946008; AAY23347.1; -; mRNA.
DR   EMBL; AB005217; BAA22433.1; ALT_FRAME; mRNA.
DR   CCDS; CCDS46417.1; -. [O14513-2]
DR   CCDS; CCDS46418.1; -. [O14513-1]
DR   RefSeq; NP_997246.2; NM_207363.2. [O14513-1]
DR   RefSeq; NP_997364.3; NM_207481.3. [O14513-2]
DR   RefSeq; XP_016859469.1; XM_017003980.1.
DR   AlphaFoldDB; O14513; -.
DR   SMR; O14513; -.
DR   BioGRID; 131288; 30.
DR   IntAct; O14513; 11.
DR   MINT; O14513; -.
DR   STRING; 9606.ENSP00000387128; -.
DR   GlyConnect; 758; 1 N-Linked glycan (1 site).
DR   GlyCosmos; O14513; 2 sites, 4 glycans.
DR   GlyGen; O14513; 3 sites, 2 N-linked glycans (1 site), 2 O-linked glycans (2 sites).
DR   iPTMnet; O14513; -.
DR   PhosphoSitePlus; O14513; -.
DR   BioMuta; NCKAP5; -.
DR   jPOST; O14513; -.
DR   MassIVE; O14513; -.
DR   MaxQB; O14513; -.
DR   PaxDb; 9606-ENSP00000387128; -.
DR   PeptideAtlas; O14513; -.
DR   ProteomicsDB; 48057; -. [O14513-1]
DR   ProteomicsDB; 48058; -. [O14513-2]
DR   ProteomicsDB; 48059; -. [O14513-3]
DR   Antibodypedia; 50647; 60 antibodies from 12 providers.
DR   DNASU; 344148; -.
DR   Ensembl; ENST00000409213.5; ENSP00000386952.1; ENSG00000176771.18. [O14513-2]
DR   Ensembl; ENST00000409261.6; ENSP00000387128.1; ENSG00000176771.18. [O14513-1]
DR   GeneID; 344148; -.
DR   KEGG; hsa:344148; -.
DR   MANE-Select; ENST00000409261.6; ENSP00000387128.1; NM_207363.3; NP_997246.2.
DR   UCSC; uc002ttp.3; human. [O14513-1]
DR   AGR; HGNC:29847; -.
DR   CTD; 344148; -.
DR   DisGeNET; 344148; -.
DR   GeneCards; NCKAP5; -.
DR   HGNC; HGNC:29847; NCKAP5.
DR   HPA; ENSG00000176771; Tissue enhanced (lung).
DR   MIM; 608789; gene.
DR   neXtProt; NX_O14513; -.
DR   OpenTargets; ENSG00000176771; -.
DR   PharmGKB; PA165696957; -.
DR   VEuPathDB; HostDB:ENSG00000176771; -.
DR   eggNOG; ENOG502QWN7; Eukaryota.
DR   GeneTree; ENSGT00530000063607; -.
DR   HOGENOM; CLU_002885_0_0_1; -.
DR   InParanoid; O14513; -.
DR   OMA; RRDWAQC; -.
DR   OrthoDB; 5400585at2759; -.
DR   PhylomeDB; O14513; -.
DR   TreeFam; TF331208; -.
DR   PathwayCommons; O14513; -.
DR   SignaLink; O14513; -.
DR   BioGRID-ORCS; 344148; 10 hits in 1146 CRISPR screens.
DR   ChiTaRS; NCKAP5; human.
DR   GenomeRNAi; 344148; -.
DR   Pharos; O14513; Tbio.
DR   PRO; PR:O14513; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; O14513; Protein.
DR   Bgee; ENSG00000176771; Expressed in corpus callosum and 100 other cell types or tissues.
DR   ExpressionAtlas; O14513; baseline and differential.
DR   GO; GO:0035371; C:microtubule plus-end; IBA:GO_Central.
DR   GO; GO:0001578; P:microtubule bundle formation; IBA:GO_Central.
DR   GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR   InterPro; IPR032769; NCKAP5_C.
DR   InterPro; IPR026163; Nckap5l.
DR   PANTHER; PTHR21740; NCK-ASSOCIATED PROTEIN 5; 1.
DR   PANTHER; PTHR21740:SF0; NCK-ASSOCIATED PROTEIN 5; 1.
DR   Pfam; PF15246; NCKAP5; 1.
DR   Genevisible; O14513; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..1909
FT                   /note="Nck-associated protein 5"
FT                   /id="PRO_0000096711"
FT   REGION          351..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          736..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          855..997
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1026..1469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1486..1509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1541..1592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1725..1750
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1763..1885
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          71..253
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        749..808
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        885..904
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        947..965
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1046..1134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1178..1192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1273..1328
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1347..1366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1424..1466
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1541..1574
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1577..1592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1763..1792
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1811..1830
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1863..1882
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..25
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_021601"
FT   VAR_SEQ         115..118
FT                   /note="MEET -> RRKM (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_021602"
FT   VAR_SEQ         119..1909
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_021603"
FT   VAR_SEQ         194..203
FT                   /note="AENSALALEN -> KHGWNWRPLS (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_021604"
FT   VAR_SEQ         204..1909
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_021605"
FT   VAR_SEQ         365..1683
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.4"
FT                   /id="VSP_021606"
FT   VARIANT         250
FT                   /note="R -> Q (in dbSNP:rs58963837)"
FT                   /id="VAR_061686"
FT   VARIANT         600
FT                   /note="S -> T (in dbSNP:rs17325719)"
FT                   /id="VAR_051220"
FT   VARIANT         937
FT                   /note="V -> I (in dbSNP:rs12611515)"
FT                   /id="VAR_051221"
FT   VARIANT         977
FT                   /note="I -> T (in dbSNP:rs12691830)"
FT                   /id="VAR_051222"
FT   VARIANT         1093
FT                   /note="N -> Y (in dbSNP:rs16841277)"
FT                   /id="VAR_051223"
FT   VARIANT         1260
FT                   /note="P -> Q (in dbSNP:rs13016342)"
FT                   /id="VAR_051224"
FT   VARIANT         1403
FT                   /note="V -> A (in dbSNP:rs2278752)"
FT                   /id="VAR_051225"
FT   CONFLICT        931..932
FT                   /note="PP -> QS (in Ref. 5; BAA22433)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        948
FT                   /note="S -> P (in Ref. 5; BAA22433)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1018
FT                   /note="T -> S (in Ref. 5; BAA22433)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1909 AA;  208537 MW;  74CE34DF3ED05A29 CRC64;
     MEGKRQLEKR DFGKRLSLDS SLVEYMDSNK YIEHLLTQLE EQHRSLWREK LAVARLQREV
     AQRTSEGAMH EKLIHELEEE RHLRLQSEKR LQEVTLESER NRIQMRSLQQ QFSRMEETVR
     NLLQSQGSPE QKKEETVNIM VYQEKLSEEE RKHKEALEDL HMVVDEDSRS ESSSTDEGKE
     KTKLLLERLK ALEAENSALA LENENQREQY ERCLDEVANQ VVQALLTQKD LREECVKLKT
     RVFDLEQQNR TLSILFQQRV RPTSDLLLQK LHSRLLDLSS GDLLSEVERN RSLTQSRTDA
     EVHEHQLNTK SALKCPGLGA VIPGHLCPRN SYSSSSELSL SSTCSEYSSG SSYTWHDGKN
     LRKRQSSQNW DKRLSIDSSL PSGFASPTNE LPPTRIKESH ILEGLRKLQK RKVLLEPPSV
     ITKWGYKDCM NSNEGIYSPG IKSSSLKEYP PCKTADLGSP CKEPHKTFVY DLDSHVDADD
     DPSTLALLQA VPNQSCRPHG SKLTHSVSDS LFGWETNRKH FLEGTSSVYP KERPEKLTSC
     ASSCPLEMKL CPSVQTPQVQ RERGPQGQGH GRMALNLQLS DTDDNETFDE LHIESSDEKS
     PSDVSLAADT DKSVENLDVL VGFGKSLCGS PEEEEKQVPI PSETRPKTFS FIKQQRVVKR
     TSSEECVTVI FDAEDGEPIE FSSHQTGVVT VTRNEISINS TPAGPKAEHT ELLPQGIACL
     QPRAAARDYT FFKRSEEDTE KNIPKDNVDN VPRVSTESFS SRTVTQNPQQ QKLVKPTHNI
     SCQSNSRSSA PMGIYQKQNL TKIPPRGKSS PQKSKLMEPE ATTLLPSSGL VTLEKSPALA
     PGKLSRFMKT ESSGPLFELR SDPHIPKHSA QLPHSSRMPS RRDWVQCPKS QTPGSRSRPA
     IESSDSGEPP TRDEHCGSGP EAGVKSPSPP PPPGRSVSLL ARPSYDYSPA PSSTKSETRV
     PSETARTPFK SPLLKGISAP VISSNPATTE VQRKKPSVAF KKPIFTHPMP SPEAVIQTRC
     PAHAPSSSFT VMALGPPKVS PKRGVPKTSP RQTLGTPQRD IGLQTPRISP STHEPLEMTS
     SKSVSPGRKG QLNDSASTPP KPSFLGVNES PSSQVSSSSS SSSPAKSHNS PHGCQSAHEK
     GLKTRLPVGL KVLMKSPQLL RKSSTVPGKH EKDSLNEASK SSVAVNKSKP EDSKNPASME
     ITAGERNVTL PDSQAQGSLA DGLPLETALQ EPLESSIPGS DGRDGVDNRS MRRSLSSSKP
     HLKPALGMNG AKARSHSFST HSGDKPSTPP IEGSGKVRTQ IITNTAERGN SLTRQNSSTE
     SSPNKAPSAP MLESLPSVGR PSGHPSSGKG SLGSSGSFSS QHGSPSKLPL RIPPKSEGLL
     IPPGKEDQQA FTQGECPSAN VAVLGEPGSD RRSCPPTPTD CPEALQSPGR TQHPSTFETS
     STSKLETSGR HPDASATATD AVSSEAPLSP TIEEKVMLCI QENVEKGQVQ TKPTSVEAKQ
     KPGPSFASWF GFRKSRLPAL SSRKMDISKT KVEKKDAKVL GFGNRQLKSE RKKEKKKPEL
     QCETENELIK DTKSADNPDG GLQSKNNRRT PQDIYNQLKI EPRNRHSPVA CSTKDTFMTE
     LLNRVDKKAA PQTESGSSNA SCRNVLKGSS QGSCLIGSSI STQGNHKKNM KIKADMEVPK
     DSLVKEANEN LQEDEDDAVA DSVFQSHIIE SNCQMRTLDS GIGTFPLPDS GNRSTGRYLC
     QPDSPEDAEP LLPLQSALSA VSSMRAQTLE REVPSSTDGQ RPADSAIVHS TSDPIMTARG
     MRPLQSRLPK PASSGKVSSQ KQNEAEPRPQ TCSSFGYAED PMASQPLPDW GSEVAATGTQ
     DKAPRMCTYS ASGGSNSDSD LDYGDNGFGA GRGQLVKALK SAAPEIETT
//