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Protein

Nck-associated protein 5

Gene

NCKAP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176771-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nck-associated protein 5
Short name:
NAP-5
Alternative name(s):
Peripheral clock protein
Gene namesi
Name:NCKAP5
Synonyms:ERIH, NAP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29847. NCKAP5.

Pathology & Biotechi

Organism-specific databases

DisGeNETi344148.
OpenTargetsiENSG00000176771.
PharmGKBiPA165696957.

Polymorphism and mutation databases

BioMutaiNCKAP5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000967111 – 1909Nck-associated protein 5Add BLAST1909

Proteomic databases

MaxQBiO14513.
PaxDbiO14513.
PeptideAtlasiO14513.
PRIDEiO14513.

PTM databases

iPTMnetiO14513.
PhosphoSitePlusiO14513.
UniCarbKBiO14513.

Expressioni

Tissue specificityi

Expressed in fetal and adult brain, leukocytes and fetal fibroblasts.

Gene expression databases

BgeeiENSG00000176771.
ExpressionAtlasiO14513. baseline and differential.
GenevisibleiO14513. HS.

Organism-specific databases

HPAiHPA034639.
HPA044859.

Interactioni

Subunit structurei

Interacts with the SH3-containing region of the adapter protein NCK.

Protein-protein interaction databases

BioGridi131288. 4 interactors.
IntActiO14513. 7 interactors.
MINTiMINT-7241081.
STRINGi9606.ENSP00000380603.

Structurei

3D structure databases

ProteinModelPortaliO14513.
SMRiO14513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili71 – 253Sequence analysisAdd BLAST183

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi331 – 386Ser-richAdd BLAST56
Compositional biasi927 – 933Poly-Pro7
Compositional biasi1080 – 1130Ser-richAdd BLAST51

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IK14. Eukaryota.
ENOG410ZI7V. LUCA.
GeneTreeiENSGT00530000063607.
HOVERGENiHBG062295.
InParanoidiO14513.
OMAiDSLFGWE.
PhylomeDBiO14513.
TreeFamiTF331208.

Family and domain databases

InterProiIPR032769. NCKAP5_C.
IPR026163. Nckap5l.
[Graphical view]
PANTHERiPTHR21740. PTHR21740. 2 hits.
PfamiPF15246. NCKAP5. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14513-1) [UniParc]FASTAAdd to basket
Also known as: Peripheral clock protein 2, ERIH2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGKRQLEKR DFGKRLSLDS SLVEYMDSNK YIEHLLTQLE EQHRSLWREK
60 70 80 90 100
LAVARLQREV AQRTSEGAMH EKLIHELEEE RHLRLQSEKR LQEVTLESER
110 120 130 140 150
NRIQMRSLQQ QFSRMEETVR NLLQSQGSPE QKKEETVNIM VYQEKLSEEE
160 170 180 190 200
RKHKEALEDL HMVVDEDSRS ESSSTDEGKE KTKLLLERLK ALEAENSALA
210 220 230 240 250
LENENQREQY ERCLDEVANQ VVQALLTQKD LREECVKLKT RVFDLEQQNR
260 270 280 290 300
TLSILFQQRV RPTSDLLLQK LHSRLLDLSS GDLLSEVERN RSLTQSRTDA
310 320 330 340 350
EVHEHQLNTK SALKCPGLGA VIPGHLCPRN SYSSSSELSL SSTCSEYSSG
360 370 380 390 400
SSYTWHDGKN LRKRQSSQNW DKRLSIDSSL PSGFASPTNE LPPTRIKESH
410 420 430 440 450
ILEGLRKLQK RKVLLEPPSV ITKWGYKDCM NSNEGIYSPG IKSSSLKEYP
460 470 480 490 500
PCKTADLGSP CKEPHKTFVY DLDSHVDADD DPSTLALLQA VPNQSCRPHG
510 520 530 540 550
SKLTHSVSDS LFGWETNRKH FLEGTSSVYP KERPEKLTSC ASSCPLEMKL
560 570 580 590 600
CPSVQTPQVQ RERGPQGQGH GRMALNLQLS DTDDNETFDE LHIESSDEKS
610 620 630 640 650
PSDVSLAADT DKSVENLDVL VGFGKSLCGS PEEEEKQVPI PSETRPKTFS
660 670 680 690 700
FIKQQRVVKR TSSEECVTVI FDAEDGEPIE FSSHQTGVVT VTRNEISINS
710 720 730 740 750
TPAGPKAEHT ELLPQGIACL QPRAAARDYT FFKRSEEDTE KNIPKDNVDN
760 770 780 790 800
VPRVSTESFS SRTVTQNPQQ QKLVKPTHNI SCQSNSRSSA PMGIYQKQNL
810 820 830 840 850
TKIPPRGKSS PQKSKLMEPE ATTLLPSSGL VTLEKSPALA PGKLSRFMKT
860 870 880 890 900
ESSGPLFELR SDPHIPKHSA QLPHSSRMPS RRDWVQCPKS QTPGSRSRPA
910 920 930 940 950
IESSDSGEPP TRDEHCGSGP EAGVKSPSPP PPPGRSVSLL ARPSYDYSPA
960 970 980 990 1000
PSSTKSETRV PSETARTPFK SPLLKGISAP VISSNPATTE VQRKKPSVAF
1010 1020 1030 1040 1050
KKPIFTHPMP SPEAVIQTRC PAHAPSSSFT VMALGPPKVS PKRGVPKTSP
1060 1070 1080 1090 1100
RQTLGTPQRD IGLQTPRISP STHEPLEMTS SKSVSPGRKG QLNDSASTPP
1110 1120 1130 1140 1150
KPSFLGVNES PSSQVSSSSS SSSPAKSHNS PHGCQSAHEK GLKTRLPVGL
1160 1170 1180 1190 1200
KVLMKSPQLL RKSSTVPGKH EKDSLNEASK SSVAVNKSKP EDSKNPASME
1210 1220 1230 1240 1250
ITAGERNVTL PDSQAQGSLA DGLPLETALQ EPLESSIPGS DGRDGVDNRS
1260 1270 1280 1290 1300
MRRSLSSSKP HLKPALGMNG AKARSHSFST HSGDKPSTPP IEGSGKVRTQ
1310 1320 1330 1340 1350
IITNTAERGN SLTRQNSSTE SSPNKAPSAP MLESLPSVGR PSGHPSSGKG
1360 1370 1380 1390 1400
SLGSSGSFSS QHGSPSKLPL RIPPKSEGLL IPPGKEDQQA FTQGECPSAN
1410 1420 1430 1440 1450
VAVLGEPGSD RRSCPPTPTD CPEALQSPGR TQHPSTFETS STSKLETSGR
1460 1470 1480 1490 1500
HPDASATATD AVSSEAPLSP TIEEKVMLCI QENVEKGQVQ TKPTSVEAKQ
1510 1520 1530 1540 1550
KPGPSFASWF GFRKSRLPAL SSRKMDISKT KVEKKDAKVL GFGNRQLKSE
1560 1570 1580 1590 1600
RKKEKKKPEL QCETENELIK DTKSADNPDG GLQSKNNRRT PQDIYNQLKI
1610 1620 1630 1640 1650
EPRNRHSPVA CSTKDTFMTE LLNRVDKKAA PQTESGSSNA SCRNVLKGSS
1660 1670 1680 1690 1700
QGSCLIGSSI STQGNHKKNM KIKADMEVPK DSLVKEANEN LQEDEDDAVA
1710 1720 1730 1740 1750
DSVFQSHIIE SNCQMRTLDS GIGTFPLPDS GNRSTGRYLC QPDSPEDAEP
1760 1770 1780 1790 1800
LLPLQSALSA VSSMRAQTLE REVPSSTDGQ RPADSAIVHS TSDPIMTARG
1810 1820 1830 1840 1850
MRPLQSRLPK PASSGKVSSQ KQNEAEPRPQ TCSSFGYAED PMASQPLPDW
1860 1870 1880 1890 1900
GSEVAATGTQ DKAPRMCTYS ASGGSNSDSD LDYGDNGFGA GRGQLVKALK

SAAPEIETT
Length:1,909
Mass (Da):208,537
Last modified:November 28, 2006 - v2
Checksum:i74CE34DF3ED05A29
GO
Isoform 2 (identifier: O14513-2) [UniParc]FASTAAdd to basket
Also known as: Peripheral clock protein 1, ERIH1

The sequence of this isoform differs from the canonical sequence as follows:
     365-1683: Missing.

Show »
Length:590
Mass (Da):66,362
Checksum:i672897BBC6BF2B1B
GO
Isoform 3 (identifier: O14513-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     194-203: AENSALALEN → KHGWNWRPLS
     204-1909: Missing.

Show »
Length:178
Mass (Da):21,367
Checksum:i1E1B278017DEE1C4
GO
Isoform 4 (identifier: O14513-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-118: MEET → RRKM
     119-1909: Missing.

Show »
Length:118
Mass (Da):14,443
Checksum:i7BBEAADEDE21F27A
GO

Sequence cautioni

The sequence BAA22433 differs from that shown. Reason: Frameshift at positions 856, 877, 920, 926, 957 and 967.Curated
The sequence BAC85920 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti931 – 932PP → QS in BAA22433 (PubMed:9344857).Curated2
Sequence conflicti948S → P in BAA22433 (PubMed:9344857).Curated1
Sequence conflicti1018T → S in BAA22433 (PubMed:9344857).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061686250R → Q.Corresponds to variant rs58963837dbSNPEnsembl.1
Natural variantiVAR_051220600S → T.Corresponds to variant rs17325719dbSNPEnsembl.1
Natural variantiVAR_051221937V → I.Corresponds to variant rs12611515dbSNPEnsembl.1
Natural variantiVAR_051222977I → T.Corresponds to variant rs12691830dbSNPEnsembl.1
Natural variantiVAR_0512231093N → Y.Corresponds to variant rs16841277dbSNPEnsembl.1
Natural variantiVAR_0512241260P → Q.Corresponds to variant rs13016342dbSNPEnsembl.1
Natural variantiVAR_0512251403V → A.Corresponds to variant rs2278752dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0216011 – 25Missing in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_021602115 – 118MEET → RRKM in isoform 4. 1 Publication4
Alternative sequenceiVSP_021603119 – 1909Missing in isoform 4. 1 PublicationAdd BLAST1791
Alternative sequenceiVSP_021604194 – 203AENSALALEN → KHGWNWRPLS in isoform 3. 1 Publication10
Alternative sequenceiVSP_021605204 – 1909Missing in isoform 3. 1 PublicationAdd BLAST1706
Alternative sequenceiVSP_021606365 – 1683Missing in isoform 2. 1 PublicationAdd BLAST1319

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057980 mRNA. No translation available.
AK092189 mRNA. Translation: BAC03824.1.
AK124659 mRNA. Translation: BAC85920.1. Different initiation.
AC010890 Genomic DNA. No translation available.
AC010974 Genomic DNA. No translation available.
AC011243 Genomic DNA. No translation available.
AC011755 Genomic DNA. No translation available.
AC011996 Genomic DNA. No translation available.
AC012489 Genomic DNA. No translation available.
AC016909 Genomic DNA. No translation available.
BC110831 mRNA. Translation: AAI10832.1.
AY946007 mRNA. Translation: AAY23346.1.
AY946008 mRNA. Translation: AAY23347.1.
AB005217 mRNA. Translation: BAA22433.1. Frameshift.
CCDSiCCDS46417.1. [O14513-2]
CCDS46418.1. [O14513-1]
RefSeqiNP_997246.2. NM_207363.2. [O14513-1]
NP_997364.3. NM_207481.3. [O14513-2]
XP_016859469.1. XM_017003980.1.
UniGeneiHs.537329.

Genome annotation databases

EnsembliENST00000409213; ENSP00000386952; ENSG00000176771. [O14513-2]
ENST00000409261; ENSP00000387128; ENSG00000176771. [O14513-1]
GeneIDi344148.
KEGGihsa:344148.
UCSCiuc002ttp.3. human. [O14513-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057980 mRNA. No translation available.
AK092189 mRNA. Translation: BAC03824.1.
AK124659 mRNA. Translation: BAC85920.1. Different initiation.
AC010890 Genomic DNA. No translation available.
AC010974 Genomic DNA. No translation available.
AC011243 Genomic DNA. No translation available.
AC011755 Genomic DNA. No translation available.
AC011996 Genomic DNA. No translation available.
AC012489 Genomic DNA. No translation available.
AC016909 Genomic DNA. No translation available.
BC110831 mRNA. Translation: AAI10832.1.
AY946007 mRNA. Translation: AAY23346.1.
AY946008 mRNA. Translation: AAY23347.1.
AB005217 mRNA. Translation: BAA22433.1. Frameshift.
CCDSiCCDS46417.1. [O14513-2]
CCDS46418.1. [O14513-1]
RefSeqiNP_997246.2. NM_207363.2. [O14513-1]
NP_997364.3. NM_207481.3. [O14513-2]
XP_016859469.1. XM_017003980.1.
UniGeneiHs.537329.

3D structure databases

ProteinModelPortaliO14513.
SMRiO14513.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131288. 4 interactors.
IntActiO14513. 7 interactors.
MINTiMINT-7241081.
STRINGi9606.ENSP00000380603.

PTM databases

iPTMnetiO14513.
PhosphoSitePlusiO14513.
UniCarbKBiO14513.

Polymorphism and mutation databases

BioMutaiNCKAP5.

Proteomic databases

MaxQBiO14513.
PaxDbiO14513.
PeptideAtlasiO14513.
PRIDEiO14513.

Protocols and materials databases

DNASUi344148.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409213; ENSP00000386952; ENSG00000176771. [O14513-2]
ENST00000409261; ENSP00000387128; ENSG00000176771. [O14513-1]
GeneIDi344148.
KEGGihsa:344148.
UCSCiuc002ttp.3. human. [O14513-1]

Organism-specific databases

CTDi344148.
DisGeNETi344148.
GeneCardsiNCKAP5.
H-InvDBHIX0021656.
HGNCiHGNC:29847. NCKAP5.
HPAiHPA034639.
HPA044859.
MIMi608789. gene.
neXtProtiNX_O14513.
OpenTargetsiENSG00000176771.
PharmGKBiPA165696957.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK14. Eukaryota.
ENOG410ZI7V. LUCA.
GeneTreeiENSGT00530000063607.
HOVERGENiHBG062295.
InParanoidiO14513.
OMAiDSLFGWE.
PhylomeDBiO14513.
TreeFamiTF331208.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176771-MONOMER.

Miscellaneous databases

ChiTaRSiNCKAP5. human.
GenomeRNAii344148.
PROiO14513.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176771.
ExpressionAtlasiO14513. baseline and differential.
GenevisibleiO14513. HS.

Family and domain databases

InterProiIPR032769. NCKAP5_C.
IPR026163. Nckap5l.
[Graphical view]
PANTHERiPTHR21740. PTHR21740. 2 hits.
PfamiPF15246. NCKAP5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNCKP5_HUMAN
AccessioniPrimary (citable) accession number: O14513
Secondary accession number(s): B8ZZL0
, Q29SS9, Q29ST0, Q2NL90, Q6ZVE2, Q8NAS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 28, 2006
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.