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Protein

Suppressor of cytokine signaling 7

Gene

SOCS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • protein kinase inhibitor activity Source: GO_Central
  • SH3 domain binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processGrowth regulation, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiO14512
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 7
Short name:
SOCS-7
Alternative name(s):
Nck, Ash and phospholipase C gamma-binding protein
Nck-associated protein 4
Short name:
NAP-4
Gene namesi
Name:SOCS7
Synonyms:NAP4, SOCS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000274211.4
HGNCiHGNC:29846 SOCS7
MIMi608788 gene
neXtProtiNX_O14512

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi425 – 427RDS → KDC: Loss of IRS1 ubiquitination and degradation. 1 Publication3

Organism-specific databases

DisGeNETi30837
OpenTargetsiENSG00000274211
PharmGKBiPA164742488

Polymorphism and mutation databases

BioMutaiSOCS7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001812531 – 581Suppressor of cytokine signaling 7Add BLAST581

Proteomic databases

PaxDbiO14512
PeptideAtlasiO14512
PRIDEiO14512

PTM databases

iPTMnetiO14512
PhosphoSitePlusiO14512

Expressioni

Tissue specificityi

Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.1 Publication

Inductioni

By IL6/interleukin-6, prolactin and growth hormone.1 Publication

Gene expression databases

BgeeiENSG00000274211
CleanExiHS_SOCS6
HS_SOCS7
ExpressionAtlasiO14512 baseline and differential
GenevisibleiO14512 HS

Organism-specific databases

HPAiHPA004475

Interactioni

Subunit structurei

Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts, via the third proline-rich region, with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2, INSR, IRS1, PLCG1, SORBS3/vinexin, and phosphorylated STAT3 and STAT5. Interacts with SEPT6.By similarity5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • SH3 domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119053, 8 interactors
IntActiO14512, 16 interactors
MINTiO14512
STRINGi9606.ENSP00000464034

Structurei

3D structure databases

ProteinModelPortaliO14512
SMRiO14512
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini400 – 509SH2PROSITE-ProRule annotationAdd BLAST110
Domaini504 – 554SOCS boxPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 494Mediates interaction with SORBS31 PublicationAdd BLAST371

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 97Poly-ProAdd BLAST16
Compositional biasi141 – 148Poly-Gly8
Compositional biasi180 – 187Poly-Gln8
Compositional biasi188 – 197Poly-Pro10
Compositional biasi303 – 312Poly-Pro10
Compositional biasi343 – 350Poly-Pro8

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566 Eukaryota
ENOG4111V4J LUCA
GeneTreeiENSGT00760000119136
HOGENOMiHOG000035093
HOVERGENiHBG079201
InParanoidiO14512
KOiK04699
OMAiFPMQDLV
OrthoDBiEOG091G0EP6
PhylomeDBiO14512
TreeFamiTF321368

Family and domain databases

CDDicd10388 SH2_SOCS7, 1 hit
cd03741 SOCS_SOCS7, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028423 SOCS7
IPR035866 SOCS7_SH2
IPR037346 SOCS7_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR45052 PTHR45052, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50225 SOCS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14512-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFRNVGRPP EEEDVEAAPE PGPSELLCPR HRCALDPKAL PPGLALERTW
60 70 80 90 100
GPAAGLEAQL AALGLGQPAG PGVKTVGGGC CPCPCPPQPP PPQPQPPAAA
110 120 130 140 150
PQAGEDPTET SDALLVLEGL ESEAESLETN SCSEEELSSP GRGGGGGGRL
160 170 180 190 200
LLQPPGPELP PVPFPLQDLV PLGRLSRGEQ QQQQQQQPPP PPPPPGPLRP
210 220 230 240 250
LAGPSRKGSF KIRLSRLFRT KSCNGGSGGG DGTGKRPSGE LAASAASLTD
260 270 280 290 300
MGGSAGRELD AGRKPKLTRT QSAFSPVSFS PLFTGETVSL VDVDISQRGL
310 320 330 340 350
TSPHPPTPPP PPRRSLSLLD DISGTLPTSV LVAPMGSSLQ SFPLPPPPPP
360 370 380 390 400
HAPDAFPRIA PIRAAESLHS QPPQHLQCPL YRPDSSSFAA SLRELEKCGW
410 420 430 440 450
YWGPMNWEDA EMKLKGKPDG SFLVRDSSDP RYILSLSFRS QGITHHTRME
460 470 480 490 500
HYRGTFSLWC HPKFEDRCQS VVEFIKRAIM HSKNGKFLYF LRSRVPGLPP
510 520 530 540 550
TPVQLLYPVS RFSNVKSLQH LCRFRIRQLV RIDHIPDLPL PKPLISYIRK
560 570 580
FYYYDPQEEV YLSLKEAQLI SKQKQEVEPS T
Length:581
Mass (Da):62,969
Last modified:November 28, 2006 - v2
Checksum:i3F326532262AF6AA
GO
Isoform 2 (identifier: O14512-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-250: Missing.

Show »
Length:331
Mass (Da):37,461
Checksum:iC0D465C715B14D11
GO

Sequence cautioni

The sequence AAI28608 differs from that shown. Contaminating sequence. The N-terminus may be contaminated with vector sequence.Curated
The sequence BAA22432 differs from that shown. Reason: Erroneous termination at position 582. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti357P → S in AAI28608 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0216451 – 250Missing in isoform 2. 1 PublicationAdd BLAST250

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005216 mRNA Translation: BAA22432.1 Sequence problems.
AC115992 Genomic DNA No translation available.
AC124789 Genomic DNA No translation available.
BC128607 mRNA Translation: AAI28608.1 Sequence problems.
CCDSiCCDS32637.1 [O14512-1]
PIRiPC4427
RefSeqiNP_055413.1, NM_014598.3 [O14512-1]
UniGeneiHs.514132

Genome annotation databases

EnsembliENST00000612932; ENSP00000482229; ENSG00000274211 [O14512-1]
ENST00000615473; ENSP00000480736; ENSG00000274229 [O14512-1]
GeneIDi30837
KEGGihsa:30837
UCSCiuc002hqa.4 human [O14512-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSOCS7_HUMAN
AccessioniPrimary (citable) accession number: O14512
Secondary accession number(s): A2VCU2, Q0IJ63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 28, 2006
Last modified: March 28, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health