O14511 (NRG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pro-neuregulin-2, membrane-bound isoform
Short name=Pro-NRG2

Cleaved into the following chain:

1. Neuregulin-2
   Short name=NRG-2
   Alternative name(s):
   Divergent of neuregulin-1
   Short name=DON-1
   Neural- and thymus-derived activator for ERBB kinases
   Short name=NTAK

Gene names

Name:	NRG2
Synonyms:	NTAK

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	850 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Subunit structure	Interacts with ERBB3 and ERBB4. Ref.4
Subcellular location	Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein By similarity. Note: Does not seem to be active By similarity. Neuregulin-2: Secreted By similarity.
Tissue specificity	Restricted to the cerebellum in the adult.
Domain	The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization By similarity. ERBB receptor binding is elicited entirely by the EGF-like domain By similarity.
Post-translational modification	Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form By similarity. Extensive glycosylation precedes the proteolytic cleavage By similarity.
Sequence similarities	Belongs to the neuregulin family. Contains 1 EGF-like domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Immunoglobulin domain Transmembrane Transmembrane helix
Molecular function	Growth factor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	embryo development Inferred from electronic annotation. Source: InterPro signal transduction Traceable author statement PubMed 9168114PubMed 9168115. Source: ProtInc
Cellular_component	extracellular region Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	receptor binding Traceable author statement PubMed 9168114. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14511-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14511-2)

The sequence of this isoform differs from the canonical sequence as follows:
     374-396: NGFFGQRCLEKLPLRLYMPDPKQ → VGYTGDRCQQFAMVNFS

Note: No experimental confirmation available.

Isoform 3 (identifier: O14511-3)

The sequence of this isoform differs from the canonical sequence as follows:
     397-397: K → KHLGFELKE

Note: No experimental confirmation available.

Isoform 4 (identifier: O14511-4)

The sequence of this isoform differs from the canonical sequence as follows:
     374-397: NGFFGQRCLEKLPLRLYMPDPKQK → VGYTGDRCQQFAMVNFSKHLGFELKE

Note: No experimental confirmation available.

Isoform 5 (identifier: O14511-5)

The sequence of this isoform differs from the canonical sequence as follows:
     397-426: KAEELYQKRVLTITGICVALLVVGIVCVVA → SVLWDTPGTGVSSSQWSTSPKPRSCTRRGS
     427-850: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: O14511-6)

The sequence of this isoform differs from the canonical sequence as follows:
     397-422: KAEELYQKRVLTITGICVALLVVGIV → SVLWDTPGTGVSSSQWSTSPSTLDLN
     423-850: Missing.

Note: No experimental confirmation available.

Isoform DON-1B (identifier: O14511-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-241: Missing.
     397-397: K → KHLGFELKE

Isoform DON-1R (identifier: O14511-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: MRQVCCSALP...EVGKILCTDC → MSESRRRGRGRGKKHPEGRKREREPDPGEK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 111	111	By similarity		PRO_0000019472
	Chain	112 – 850	739	Pro-neuregulin-2, membrane-bound isoform		PRO_0000019473
	Chain	112 – 404	293	Neuregulin-2		PRO_0000019474
Regions
	Topological domain	112 – 405	294	Extracellular Potential
	Transmembrane	406 – 426	21	Helical; Note=Internal signal sequence; Potential
	Topological domain	427 – 850	424	Cytoplasmic Potential
	Domain	237 – 332	96	Ig-like C2-type
	Domain	341 – 382	42	EGF-like
	Compositional bias	10 – 13	4	Poly-Pro
	Compositional bias	20 – 30	11	Poly-Ser
	Compositional bias	33 – 47	15	Poly-Ser
	Compositional bias	87 – 90	4	Poly-Ala
	Compositional bias	330 – 340	11	Ser/Thr-rich
	Compositional bias	721 – 727	7	Poly-Pro
Amino acid modifications
	Modified residue	809	1	Phosphoserine By similarity
	Glycosylation	52	1	N-linked (GlcNAc...) Potential
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Glycosylation	147	1	N-linked (GlcNAc...) Potential
	Glycosylation	278	1	N-linked (GlcNAc...) Potential
	Glycosylation	346	1	N-linked (GlcNAc...) Potential
	Disulfide bond	257 ↔ 311		By similarity
	Disulfide bond	345 ↔ 359		By similarity
	Disulfide bond	353 ↔ 370		By similarity
	Disulfide bond	372 ↔ 381		By similarity
Natural variations
	Alternative sequence	1 – 241	241	Missing in isoform DON-1B.		VSP_003452
	Alternative sequence	1 – 233	233	MRQVC…LCTDC → MSESRRRGRGRGKKHPEGRK REREPDPGEK in isoform DON-1R.		VSP_003451
	Alternative sequence	374 – 397	24	NGFFG…DPKQK → VGYTGDRCQQFAMVNFSKHL GFELKE in isoform 4.		VSP_003454
	Alternative sequence	374 – 396	23	NGFFG…PDPKQ → VGYTGDRCQQFAMVNFS in isoform 2.		VSP_003453
	Alternative sequence	397 – 426	30	KAEEL…VCVVA → SVLWDTPGTGVSSSQWSTSP KPRSCTRRGS in isoform 5.		VSP_003458
	Alternative sequence	397 – 422	26	KAEEL…VVGIV → SVLWDTPGTGVSSSQWSTSP STLDLN in isoform 6.		VSP_003456
	Alternative sequence	397	1	K → KHLGFELKE in isoform 3 and isoform DON-1B.		VSP_003455
	Alternative sequence	423 – 850	428	Missing in isoform 6.		VSP_003457
	Alternative sequence	427 – 850	424	Missing in isoform 5.		VSP_003459

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 7124C089435FD2F4	FASTA	850	91,679
	10 20 30 40 50 60 MRQVCCSALP PPPLEKGRCS SYSDSSSSSS ERSSSSSSSS SESGSSSRSS SNNSSISRPA 70 80 90 100 110 120 APPEPRPQQQ PQPRSPAARR AAARSRAAAA GGMRRDPAPG FSMLLFGVSL ACYSPSLKSV 130 140 150 160 170 180 QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI 190 200 210 220 230 240 SVGSCVPLER NQRYIFFLEP TEQPLVFKTA FAPLDTNGKN LKKEVGKILC TDCATRPKLK 250 260 270 280 290 300 KMKSQTGQVG EKQSLKCEAA AGNPQPSYRW FKDGKELNRS RDIRIKYGNG RKNSRLQFNK 310 320 330 340 350 360 VKVEDAGEYV CEAENILGKD TVRGRLYVNS VSTTLSSWSG HARKCNETAK SYCVNGGVCY 370 380 390 400 410 420 YIEGINQLSC KCPNGFFGQR CLEKLPLRLY MPDPKQKAEE LYQKRVLTIT GICVALLVVG 430 440 450 460 470 480 IVCVVAYCKT KKQRKQMHNH LRQNMCPAHQ NRSLANGPSH PRLDPEEIQM ADYISKNVPA 490 500 510 520 530 540 TDHVIRRETE TTFSGSHSCS PSHHCSTATP TSSHRHESHT WSLERSESLT SDSQSGIMLS 550 560 570 580 590 600 SVGTSKCNSP ACVEARARRA AAYNLEERRR ATAPPYHDSV DSLRDSPHSE RYVSALTTPA 610 620 630 640 650 660 RLSPVDFHYS LATQVPTFEI TSPNSAHAVS LPPAAPISYR LAEQQPLLRH PAPPGPGPGP 670 680 690 700 710 720 GPGPGPGADM QRSYDSYYYP AAGPGPRRGT CALGGSLGSL PASPFRIPED DEYETTQECA 730 740 750 760 770 780 PPPPPRPRAR GASRRTSAGP RRWRRSRLNG LAAQRARAAR DSLSLSSGSG GGSASASDDD 790 800 810 820 830 840 ADDADGALAA ESTPFLGLRG AHDALRSDSP PLCPAADSRT YYSLDSHSTR ASSRHSRGPP 850 PRAKQDSAPL
	Isoform 2 [UniParc]. Checksum: A68F2D2C96C3C1C1	FASTA	844	90,851
	10 20 30 40 50 60 MRQVCCSALP PPPLEKGRCS SYSDSSSSSS ERSSSSSSSS SESGSSSRSS SNNSSISRPA 70 80 90 100 110 120 APPEPRPQQQ PQPRSPAARR AAARSRAAAA GGMRRDPAPG FSMLLFGVSL ACYSPSLKSV 130 140 150 160 170 180 QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI 190 200 210 220 230 240 SVGSCVPLER NQRYIFFLEP TEQPLVFKTA FAPLDTNGKN LKKEVGKILC TDCATRPKLK 250 260 270 280 290 300 KMKSQTGQVG EKQSLKCEAA AGNPQPSYRW FKDGKELNRS RDIRIKYGNG RKNSRLQFNK 310 320 330 340 350 360 VKVEDAGEYV CEAENILGKD TVRGRLYVNS VSTTLSSWSG HARKCNETAK SYCVNGGVCY 370 380 390 400 410 420 YIEGINQLSC KCPVGYTGDR CQQFAMVNFS KAEELYQKRV LTITGICVAL LVVGIVCVVA 430 440 450 460 470 480 YCKTKKQRKQ MHNHLRQNMC PAHQNRSLAN GPSHPRLDPE EIQMADYISK NVPATDHVIR 490 500 510 520 530 540 RETETTFSGS HSCSPSHHCS TATPTSSHRH ESHTWSLERS ESLTSDSQSG IMLSSVGTSK 550 560 570 580 590 600 CNSPACVEAR ARRAAAYNLE ERRRATAPPY HDSVDSLRDS PHSERYVSAL TTPARLSPVD 610 620 630 640 650 660 FHYSLATQVP TFEITSPNSA HAVSLPPAAP ISYRLAEQQP LLRHPAPPGP GPGPGPGPGP 670 680 690 700 710 720 GADMQRSYDS YYYPAAGPGP RRGTCALGGS LGSLPASPFR IPEDDEYETT QECAPPPPPR 730 740 750 760 770 780 PRARGASRRT SAGPRRWRRS RLNGLAAQRA RAARDSLSLS SGSGGGSASA SDDDADDADG 790 800 810 820 830 840 ALAAESTPFL GLRGAHDALR SDSPPLCPAA DSRTYYSLDS HSTRASSRHS RGPPPRAKQD SAPL
	Isoform 3 [UniParc]. Checksum: 171976A9397EA0B1	FASTA	858	92,633
	10 20 30 40 50 60 MRQVCCSALP PPPLEKGRCS SYSDSSSSSS ERSSSSSSSS SESGSSSRSS SNNSSISRPA 70 80 90 100 110 120 APPEPRPQQQ PQPRSPAARR AAARSRAAAA GGMRRDPAPG FSMLLFGVSL ACYSPSLKSV 130 140 150 160 170 180 QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI 190 200 210 220 230 240 SVGSCVPLER NQRYIFFLEP TEQPLVFKTA FAPLDTNGKN LKKEVGKILC TDCATRPKLK 250 260 270 280 290 300 KMKSQTGQVG EKQSLKCEAA AGNPQPSYRW FKDGKELNRS RDIRIKYGNG RKNSRLQFNK 310 320 330 340 350 360 VKVEDAGEYV CEAENILGKD TVRGRLYVNS VSTTLSSWSG HARKCNETAK SYCVNGGVCY 370 380 390 400 410 420 YIEGINQLSC KCPNGFFGQR CLEKLPLRLY MPDPKQKHLG FELKEAEELY QKRVLTITGI 430 440 450 460 470 480 CVALLVVGIV CVVAYCKTKK QRKQMHNHLR QNMCPAHQNR SLANGPSHPR LDPEEIQMAD 490 500 510 520 530 540 YISKNVPATD HVIRRETETT FSGSHSCSPS HHCSTATPTS SHRHESHTWS LERSESLTSD 550 560 570 580 590 600 SQSGIMLSSV GTSKCNSPAC VEARARRAAA YNLEERRRAT APPYHDSVDS LRDSPHSERY 610 620 630 640 650 660 VSALTTPARL SPVDFHYSLA TQVPTFEITS PNSAHAVSLP PAAPISYRLA EQQPLLRHPA 670 680 690 700 710 720 PPGPGPGPGP GPGPGADMQR SYDSYYYPAA GPGPRRGTCA LGGSLGSLPA SPFRIPEDDE 730 740 750 760 770 780 YETTQECAPP PPPRPRARGA SRRTSAGPRR WRRSRLNGLA AQRARAARDS LSLSSGSGGG 790 800 810 820 830 840 SASASDDDAD DADGALAAES TPFLGLRGAH DALRSDSPPL CPAADSRTYY SLDSHSTRAS 850 SRHSRGPPPR AKQDSAPL
	Isoform 4 [UniParc]. Checksum: FDE8AEB0E1C6F94B	FASTA	852	91,805
	10 20 30 40 50 60 MRQVCCSALP PPPLEKGRCS SYSDSSSSSS ERSSSSSSSS SESGSSSRSS SNNSSISRPA 70 80 90 100 110 120 APPEPRPQQQ PQPRSPAARR AAARSRAAAA GGMRRDPAPG FSMLLFGVSL ACYSPSLKSV 130 140 150 160 170 180 QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI 190 200 210 220 230 240 SVGSCVPLER NQRYIFFLEP TEQPLVFKTA FAPLDTNGKN LKKEVGKILC TDCATRPKLK 250 260 270 280 290 300 KMKSQTGQVG EKQSLKCEAA AGNPQPSYRW FKDGKELNRS RDIRIKYGNG RKNSRLQFNK 310 320 330 340 350 360 VKVEDAGEYV CEAENILGKD TVRGRLYVNS VSTTLSSWSG HARKCNETAK SYCVNGGVCY 370 380 390 400 410 420 YIEGINQLSC KCPVGYTGDR CQQFAMVNFS KHLGFELKEA EELYQKRVLT ITGICVALLV 430 440 450 460 470 480 VGIVCVVAYC KTKKQRKQMH NHLRQNMCPA HQNRSLANGP SHPRLDPEEI QMADYISKNV 490 500 510 520 530 540 PATDHVIRRE TETTFSGSHS CSPSHHCSTA TPTSSHRHES HTWSLERSES LTSDSQSGIM 550 560 570 580 590 600 LSSVGTSKCN SPACVEARAR RAAAYNLEER RRATAPPYHD SVDSLRDSPH SERYVSALTT 610 620 630 640 650 660 PARLSPVDFH YSLATQVPTF EITSPNSAHA VSLPPAAPIS YRLAEQQPLL RHPAPPGPGP 670 680 690 700 710 720 GPGPGPGPGA DMQRSYDSYY YPAAGPGPRR GTCALGGSLG SLPASPFRIP EDDEYETTQE 730 740 750 760 770 780 CAPPPPPRPR ARGASRRTSA GPRRWRRSRL NGLAAQRARA ARDSLSLSSG SGGGSASASD 790 800 810 820 830 840 DDADDADGAL AAESTPFLGL RGAHDALRSD SPPLCPAADS RTYYSLDSHS TRASSRHSRG 850 PPPRAKQDSA PL
	Isoform 5 [UniParc]. Checksum: ADC950AED919D5F4	FASTA	426	46,183
	10 20 30 40 50 60 MRQVCCSALP PPPLEKGRCS SYSDSSSSSS ERSSSSSSSS SESGSSSRSS SNNSSISRPA 70 80 90 100 110 120 APPEPRPQQQ PQPRSPAARR AAARSRAAAA GGMRRDPAPG FSMLLFGVSL ACYSPSLKSV 130 140 150 160 170 180 QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI 190 200 210 220 230 240 SVGSCVPLER NQRYIFFLEP TEQPLVFKTA FAPLDTNGKN LKKEVGKILC TDCATRPKLK 250 260 270 280 290 300 KMKSQTGQVG EKQSLKCEAA AGNPQPSYRW FKDGKELNRS RDIRIKYGNG RKNSRLQFNK 310 320 330 340 350 360 VKVEDAGEYV CEAENILGKD TVRGRLYVNS VSTTLSSWSG HARKCNETAK SYCVNGGVCY 370 380 390 400 410 420 YIEGINQLSC KCPNGFFGQR CLEKLPLRLY MPDPKQSVLW DTPGTGVSSS QWSTSPKPRS CTRRGS
	Isoform 6 [UniParc]. Checksum: 5CF05AF7A682310D	FASTA	422	45,698
	10 20 30 40 50 60 MRQVCCSALP PPPLEKGRCS SYSDSSSSSS ERSSSSSSSS SESGSSSRSS SNNSSISRPA 70 80 90 100 110 120 APPEPRPQQQ PQPRSPAARR AAARSRAAAA GGMRRDPAPG FSMLLFGVSL ACYSPSLKSV 130 140 150 160 170 180 QDQAYKAPVV VEGKVQGLVP AGGSSSNSTR EPPASGRVAL VKVLDKWPLR SGGLQREQVI 190 200 210 220 230 240 SVGSCVPLER NQRYIFFLEP TEQPLVFKTA FAPLDTNGKN LKKEVGKILC TDCATRPKLK 250 260 270 280 290 300 KMKSQTGQVG EKQSLKCEAA AGNPQPSYRW FKDGKELNRS RDIRIKYGNG RKNSRLQFNK 310 320 330 340 350 360 VKVEDAGEYV CEAENILGKD TVRGRLYVNS VSTTLSSWSG HARKCNETAK SYCVNGGVCY 370 380 390 400 410 420 YIEGINQLSC KCPNGFFGQR CLEKLPLRLY MPDPKQSVLW DTPGTGVSSS QWSTSPSTLD LN
	Isoform DON-1B [UniParc]. Checksum: 89A81CE27CE00B5C	FASTA	617	67,126
	10 20 30 40 50 60 MKSQTGQVGE KQSLKCEAAA GNPQPSYRWF KDGKELNRSR DIRIKYGNGR KNSRLQFNKV 70 80 90 100 110 120 KVEDAGEYVC EAENILGKDT VRGRLYVNSV STTLSSWSGH ARKCNETAKS YCVNGGVCYY 130 140 150 160 170 180 IEGINQLSCK CPNGFFGQRC LEKLPLRLYM PDPKQKHLGF ELKEAEELYQ KRVLTITGIC 190 200 210 220 230 240 VALLVVGIVC VVAYCKTKKQ RKQMHNHLRQ NMCPAHQNRS LANGPSHPRL DPEEIQMADY 250 260 270 280 290 300 ISKNVPATDH VIRRETETTF SGSHSCSPSH HCSTATPTSS HRHESHTWSL ERSESLTSDS 310 320 330 340 350 360 QSGIMLSSVG TSKCNSPACV EARARRAAAY NLEERRRATA PPYHDSVDSL RDSPHSERYV 370 380 390 400 410 420 SALTTPARLS PVDFHYSLAT QVPTFEITSP NSAHAVSLPP AAPISYRLAE QQPLLRHPAP 430 440 450 460 470 480 PGPGPGPGPG PGPGADMQRS YDSYYYPAAG PGPRRGTCAL GGSLGSLPAS PFRIPEDDEY 490 500 510 520 530 540 ETTQECAPPP PPRPRARGAS RRTSAGPRRW RRSRLNGLAA QRARAARDSL SLSSGSGGGS 550 560 570 580 590 600 ASASDDDADD ADGALAAEST PFLGLRGAHD ALRSDSPPLC PAADSRTYYS LDSHSTRASS 610 RHSRGPPPRA KQDSAPL
	Isoform DON-1R [UniParc]. Checksum: D1D5FDAF07CB3393	FASTA	647	70,637
	10 20 30 40 50 60 MSESRRRGRG RGKKHPEGRK REREPDPGEK ATRPKLKKMK SQTGQVGEKQ SLKCEAAAGN 70 80 90 100 110 120 PQPSYRWFKD GKELNRSRDI RIKYGNGRKN SRLQFNKVKV EDAGEYVCEA ENILGKDTVR 130 140 150 160 170 180 GRLYVNSVST TLSSWSGHAR KCNETAKSYC VNGGVCYYIE GINQLSCKCP NGFFGQRCLE 190 200 210 220 230 240 KLPLRLYMPD PKQKAEELYQ KRVLTITGIC VALLVVGIVC VVAYCKTKKQ RKQMHNHLRQ 250 260 270 280 290 300 NMCPAHQNRS LANGPSHPRL DPEEIQMADY ISKNVPATDH VIRRETETTF SGSHSCSPSH 310 320 330 340 350 360 HCSTATPTSS HRHESHTWSL ERSESLTSDS QSGIMLSSVG TSKCNSPACV EARARRAAAY 370 380 390 400 410 420 NLEERRRATA PPYHDSVDSL RDSPHSERYV SALTTPARLS PVDFHYSLAT QVPTFEITSP 430 440 450 460 470 480 NSAHAVSLPP AAPISYRLAE QQPLLRHPAP PGPGPGPGPG PGPGADMQRS YDSYYYPAAG 490 500 510 520 530 540 PGPRRGTCAL GGSLGSLPAS PFRIPEDDEY ETTQECAPPP PPRPRARGAS RRTSAGPRRW 550 560 570 580 590 600 RRSRLNGLAA QRARAARDSL SLSSGSGGGS ASASDDDADD ADGALAAEST PFLGLRGAHD 610 620 630 640 ALRSDSPPLC PAADSRTYYS LDSHSTRASS RHSRGPPPRA KQDSAPL

References

[1]	"A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4." Higashiyama S., Horikawa M., Yamada K., Ichino N., Nakano N., Nakagawa T., Miyagawa J., Matsushita N., Nagatsu T., Taniguchi N., Ishiguro H. J. Biochem. 122:675-680(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Neuroblastoma.
[2]	"Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus." Busfield S.J., Michnick D.A., Chickering T.W., Revett T.L., Ma J., Woolf E.A., Comrack C.A., Dussault B.J., Woolf J., Goodearl A.D.J., Gearing D.P. Mol. Cell. Biol. 17:4007-4014(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS DON-1B AND DON-1R). Tissue: Fetal brain.
[3]	"The human neuregulin 2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q." Ring H.Z., Chang H., Guilbot A., Brice A., LeGuern E., Francke U. Hum. Genet. 104:326-332(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4; 5 AND 6). Tissue: Fetal brain and Lung.
[4]	"Ligand discrimination in signaling through an ErbB4 receptor homodimer." Sweeney C., Lai C., Riese D.J. II, Diamonti A.J., Cantley L.C., Carraway K.L. III J. Biol. Chem. 275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ERBB4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB005060 mRNA. Translation: BAA23417.1. AF119162 , AF119151, AF119152, AF119153, AF119154, AF119155, AF119158, AF119159, AF119160, AF119161 Genomic DNA. Translation: AAF28848.1. AF119162 , AF119151, AF119152, AF119153, AF119154, AF119156, AF119158, AF119159, AF119160, AF119161 Genomic DNA. Translation: AAF28849.1. AF119162 , AF119151, AF119152, AF119153, AF119154, AF119155, AF119157, AF119158, AF119159, AF119160, AF119161 Genomic DNA. Translation: AAF28850.1. AF119162 , AF119151, AF119152, AF119153, AF119154, AF119156, AF119157, AF119158, AF119159, AF119160, AF119161 Genomic DNA. Translation: AAF28851.1. AF119158 , AF119151, AF119152, AF119153, AF119154, AF119155, AF119156 Genomic DNA. Translation: AAF28852.1. AF119157 , AF119151, AF119152, AF119153, AF119154, AF119155, AF119156 Genomic DNA. Translation: AAF28853.1.
IPI	IPI00003044. IPI00022325. IPI00217570. IPI00217571. IPI00217572. IPI00217573. IPI00217574. IPI00477848.
PIR	JC5700.
RefSeq	NP_001171864.1. NM_001184935.1. NP_004874.1. NM_004883.2. NP_053584.1. NM_013981.3. NP_053585.1. NM_013982.2. NP_053586.1. NM_013983.2.
UniGene	Hs.408515.
3D structure databases
ProteinModelPortal	O14511.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000289422.
PTM databases
PhosphoSite	O14511.
Proteomic databases
PaxDb	O14511.
PRIDE	O14511.
Protocols and materials databases
DNASU	9542.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000289409; ENSP00000289409; ENSG00000158458. ENST00000289422; ENSP00000289422; ENSG00000158458. ENST00000340391; ENSP00000342660; ENSG00000158458. ENST00000358522; ENSP00000351323; ENSG00000158458. ENST00000361474; ENSP00000354910; ENSG00000158458. ENST00000378238; ENSP00000367483; ENSG00000158458. ENST00000394770; ENSP00000378251; ENSG00000158458.
GeneID	9542.
KEGG	hsa:9542.
UCSC	uc003lev.2. human. uc003lew.2. human. uc003lex.2. human. uc003ley.2. human.
Organism-specific databases
CTD	9542.
GeneCards	GC05M139207.
HGNC	HGNC:7998. NRG2.
HPA	HPA038935.
MIM	603818. gene.
neXtProt	NX_O14511.
PharmGKB	PA31777.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47801.
HOGENOM	HOG000273863.
HOVERGEN	HBG006531.
KO	K05456.
OMA	KAGGMRL.
OrthoDB	EOG4J9MZF.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	O14511.
Bgee	O14511.
CleanEx	HS_NRG2.
Genevestigator	O14511.
GermOnline	ENSG00000158458. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR002154. Neuregulin_1_C. [Graphical view]
Pfam	PF07679. I-set. 1 hit. PF02158. Neuregulin. 1 hit. [Graphical view]
SMART	SM00181. EGF. 1 hit. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS00022. EGF_1. 1 hit. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 1 hit. PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9542.
NextBio	35779.
SOURCE	Search...

Entry information

Entry name

NRG2_HUMAN

Accession

Primary (citable) accession number: O14511

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.