Reviewed,
UniProtKB/Swiss-Prot O14508 (SOCS2_HUMAN)
Last modified
June 16, 2009.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (7) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Suppressor of cytokine signaling 2 Short name=SOCS-2 Alternative name(s): Cytokine-inducible SH2 protein 2 Short name=CIS-2 STAT-induced STAT inhibitor 2 Short name=SSI-2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 198 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Pathway | |
| Subunit structure | Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. |
| Tissue specificity | High expression in heart, placenta, lung, kidney and prostate. |
| Induction | By a subset of cytokines, including erythropoietin and granulocyte-macrophage colony stimulating factor (GM-CSF). |
| Domain | The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. |
| Sequence similarities | Contains 1 SH2 domain. Contains 1 SOCS box domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 198 | 198 | Suppressor of cytokine signaling 2 | PRO_0000181238 | |||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||
| Domain | 48 – 156 | 109 | SH2 | ||||||||||||||||||||||||||||||
| Domain | 151 – 197 | 47 | SOCS box | ||||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||
| Natural variant | 52 | 1 | S → N: dbSNP rs3741676. | VAR_052032 | |||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||
| Sequence conflict | 2 | 1 | T → N in AAC98896. Ref.3 | ||||||||||||||||||||||||||||||
| Sequence conflict | 5 | 1 | C → R in BAA22536. Ref.2 | ||||||||||||||||||||||||||||||
| Sequence conflict | 31 – 39 | 9 | PQAARLAKA → RRRRVWRR in AAC98896. Ref.3 | ||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||
| Helix | 33 – 45 | 13 | |||||||||||||||||||||||||||||||
| Helix | 55 – 62 | 8 | |||||||||||||||||||||||||||||||
| Beta strand | 70 – 74 | 5 | |||||||||||||||||||||||||||||||
| Beta strand | 81 – 88 | 8 | |||||||||||||||||||||||||||||||
| Beta strand | 91 – 100 | 10 | |||||||||||||||||||||||||||||||
| Beta strand | 103 – 106 | 4 | |||||||||||||||||||||||||||||||
| Turn | 108 – 112 | 5 | |||||||||||||||||||||||||||||||
| Helix | 113 – 115 | 3 | |||||||||||||||||||||||||||||||
| Helix | 122 – 132 | 11 | |||||||||||||||||||||||||||||||
| Helix | 163 – 174 | 12 | |||||||||||||||||||||||||||||||
| Helix | 178 – 180 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 181 – 183 | 3 | |||||||||||||||||||||||||||||||
| Helix | 185 – 192 | 8 | |||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." Minamoto S., Ikegame K., Ueno K., Narazaki M., Naka T., Yamamoto H., Matsumoto T., Saito H., Hosoe S., Kishimoto T. Biochem. Biophys. Res. Commun. 237:79-83(1997) [PubMed: 9266833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell lymphoma. |
| [2] | "Cloning and characterization of novel CIS family genes." Masuhara M., Sakamoto H., Matsumoto A., Suzuki R., Yasukawa H., Mitsui K., Wakioka T., Tanimura S., Sasaki A., Misawa H., Yokouchi M., Ohtsubo M., Yoshimura A. Biochem. Biophys. Res. Commun. 239:439-446(1997) [PubMed: 9344848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Cloning of a novel human gene coding human suppressor of cytokine signaling-2 (HsSOCS-2)." Tu Q., Yu L., Zhang Q. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor." Dey B.R., Spence S.L., Nissley P., Furlanetto R.W. J. Biol. Chem. 273:24095-24101(1998) [PubMed: 9727029] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [6] | "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively." Yandava C.N., Pillari A., Drazen J.M. Genomics 61:108-111(1999) [PubMed: 10512686] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-198. |
| [7] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [8] | "Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase." Bullock A.N., Debreczeni J.E., Edwards A.M., Sundstrom M., Knapp S. Proc. Natl. Acad. Sci. U.S.A. 103:7637-7642(2006) [PubMed: 16675548] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH THE ELONGIN BC COMPLEX. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AB004903 mRNA. Translation: BAA22429.1. AB006966 mRNA. Translation: BAA22536.1. AF020590 mRNA. Translation: AAC98896.1. AF037989 mRNA. Translation: AAC34745.1. BC010399 mRNA. Translation: AAH10399.1. AF132441 Genomic DNA. Translation: AAD27710.1. | |||||||||||||
| IPI | IPI00033944. | ||||||||||||
| PIR | JC5626. JC5760. | ||||||||||||
| RefSeq | NP_003868.1. | ||||||||||||
| UniGene | Hs.485572 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | O14508. 1 interaction. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | O14508. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000120833. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 8835. | ||||||||||||
| KEGG | hsa:8835. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC12P092466. | ||||||||||||
| H-InvDB | HIX0010881. | ||||||||||||
| HGNC | HGNC:19382. SOCS2. | ||||||||||||
| HPA | CAB010356. | ||||||||||||
| MIM | 605117. gene. | ||||||||||||
| PharmGKB | PA128394542. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | O14508. | ||||||||||||
| HOVERGEN | O14508. | ||||||||||||
| OMA | O14508. EGTRSQW. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Pathway_Interaction_DB | il2_1pathway. IL2-mediated signaling events. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | O14508. | ||||||||||||
| Bgee | O14508. | ||||||||||||
| CleanEx | HS_SOCS2. | ||||||||||||
| GermOnline | ENSG00000120833. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR000980. SH2. IPR001496. SOCS_C. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.30.505.10. SH2. 1 hit. | ||||||||||||
| Pfam | PF00017. SH2. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00401. SH2DOMAIN. | ||||||||||||
| ProDom | PD000093. SH2. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||
| SMART | SM00252. SH2. 1 hit. SM00253. SOCS. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS50001. SH2. 1 hit. PS50225. SOCS. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 33160. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | SOCS2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O14508 Secondary accession number(s): O14542, O95102, Q9UKS5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


