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O14498

- ISLR_HUMAN

UniProt

O14498 - ISLR_HUMAN

Protein

Immunoglobulin superfamily containing leucine-rich repeat protein

Gene

ISLR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cell adhesion Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin superfamily containing leucine-rich repeat protein
    Gene namesi
    Name:ISLR
    ORF Names:UNQ189/PRO215
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:6133. ISLR.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29933.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 428410Immunoglobulin superfamily containing leucine-rich repeat proteinPRO_0000312208Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi257 ↔ 327PROSITE-ProRule annotation
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO14498.
    PeptideAtlasiO14498.
    PRIDEiO14498.

    Expressioni

    Tissue specificityi

    Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach and spinal cord.2 Publications

    Developmental stagei

    Expressed in fetal lung and kidney.1 Publication

    Gene expression databases

    ArrayExpressiO14498.
    BgeeiO14498.
    CleanExiHS_ISLR.
    GenevestigatoriO14498.

    Organism-specific databases

    HPAiHPA050811.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000249842.

    Structurei

    3D structure databases

    ProteinModelPortaliO14498.
    SMRiO14498. Positions 17-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 5032LRRNTAdd
    BLAST
    Repeati51 – 7222LRR 1Add
    BLAST
    Repeati75 – 9622LRR 2Add
    BLAST
    Repeati99 – 12224LRR 3Add
    BLAST
    Repeati123 – 14422LRR 4Add
    BLAST
    Repeati147 – 16822LRR 5Add
    BLAST
    Domaini180 – 23152LRRCTAdd
    BLAST
    Domaini232 – 343112Ig-likeAdd
    BLAST

    Sequence similaritiesi

    Contains 5 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG240332.
    HOGENOMiHOG000113109.
    HOVERGENiHBG100853.
    InParanoidiO14498.
    OMAiPEPCDCG.
    OrthoDBiEOG7MH0Z3.
    PhylomeDBiO14498.
    TreeFamiTF351112.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF07679. I-set. 1 hit.
    PF13855. LRR_8. 2 hits.
    [Graphical view]
    SMARTiSM00408. IGc2. 1 hit.
    SM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51450. LRR. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14498-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LESVPPGFPA    50
    NVTTLSLSAN RLPGLPEGAF REVPLLQSLW LAHNEIRTVA AGALASLSHL 100
    KSLDLSHNLI SDFAWSDLHN LSALQLLKMD SNELTFIPRD AFRSLRALRS 150
    LQLNHNRLHT LAEGTFTPLT ALSHLQINEN PFDCTCGIVW LKTWALTTAV 200
    SIPEQDNIAC TSPHVLKGTP LSRLPPLPCS APSVQLSYQP SQDGAELRPG 250
    FVLALHCDVD GQPAPQLHWH IQIPSGIVEI TSPNVGTDGR ALPGTPVASS 300
    QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV DVALATPGEG 350
    GEDTLGRRFH GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGNPEAAV 400
    AEGVPGQLPP GLLLLGQSLL LFFFLTSF 428
    Length:428
    Mass (Da):45,997
    Last modified:January 1, 1998 - v1
    Checksum:i3163F89D59F6F3A4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti183 – 1831D → N in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_037454

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003184 mRNA. Translation: BAA22848.1.
    AB024536 mRNA. Translation: BAA85970.1.
    AB024537 Genomic DNA. Translation: BAA85971.1.
    AY358871 mRNA. Translation: AAQ89230.1.
    CCDSiCCDS10260.1.
    RefSeqiNP_005536.1. NM_005545.3.
    NP_958934.1. NM_201526.1.
    UniGeneiHs.699822.
    Hs.745166.

    Genome annotation databases

    EnsembliENST00000249842; ENSP00000249842; ENSG00000129009.
    ENST00000395118; ENSP00000378550; ENSG00000129009.
    GeneIDi3671.
    KEGGihsa:3671.
    UCSCiuc002axg.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003184 mRNA. Translation: BAA22848.1 .
    AB024536 mRNA. Translation: BAA85970.1 .
    AB024537 Genomic DNA. Translation: BAA85971.1 .
    AY358871 mRNA. Translation: AAQ89230.1 .
    CCDSi CCDS10260.1.
    RefSeqi NP_005536.1. NM_005545.3.
    NP_958934.1. NM_201526.1.
    UniGenei Hs.699822.
    Hs.745166.

    3D structure databases

    ProteinModelPortali O14498.
    SMRi O14498. Positions 17-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000249842.

    Proteomic databases

    PaxDbi O14498.
    PeptideAtlasi O14498.
    PRIDEi O14498.

    Protocols and materials databases

    DNASUi 3671.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249842 ; ENSP00000249842 ; ENSG00000129009 .
    ENST00000395118 ; ENSP00000378550 ; ENSG00000129009 .
    GeneIDi 3671.
    KEGGi hsa:3671.
    UCSCi uc002axg.1. human.

    Organism-specific databases

    CTDi 3671.
    GeneCardsi GC15P074466.
    HGNCi HGNC:6133. ISLR.
    HPAi HPA050811.
    MIMi 602059. gene.
    neXtProti NX_O14498.
    PharmGKBi PA29933.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240332.
    HOGENOMi HOG000113109.
    HOVERGENi HBG100853.
    InParanoidi O14498.
    OMAi PEPCDCG.
    OrthoDBi EOG7MH0Z3.
    PhylomeDBi O14498.
    TreeFami TF351112.

    Miscellaneous databases

    ChiTaRSi ISLR. human.
    GenomeRNAii 3671.
    NextBioi 14367.
    PROi O14498.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O14498.
    Bgeei O14498.
    CleanExi HS_ISLR.
    Genevestigatori O14498.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF07679. I-set. 1 hit.
    PF13855. LRR_8. 2 hits.
    [Graphical view ]
    SMARTi SM00408. IGc2. 1 hit.
    SM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51450. LRR. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR)."
      Nagasawa A., Kubota R., Imamura Y., Nagamine K., Wang Y., Asakawa S., Kudoh J., Minoshima S., Mashima Y., Oguchi Y., Shimizu N.
      Genomics 44:273-279(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Retina.
    2. "Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression."
      Nagasawa A., Kudoh J., Noda S., Mashima Y., Wright A., Oguchi Y., Shimizu N.
      Genomics 61:37-43(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
      Tissue: Retina.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-183.

    Entry informationi

    Entry nameiISLR_HUMAN
    AccessioniPrimary (citable) accession number: O14498
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3