Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O14498 (ISLR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin superfamily containing leucine-rich repeat protein
Gene names
Name:ISLR
ORF Names:UNQ189/PRO215
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Potential.

Tissue specificity

Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach and spinal cord. Ref.1 Ref.2

Developmental stage

Expressed in fetal lung and kidney. Ref.1

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Contains 5 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Leucine-rich repeat
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 428410Immunoglobulin superfamily containing leucine-rich repeat protein
PRO_0000312208

Regions

Domain19 – 5032LRRNT
Repeat51 – 7222LRR 1
Repeat75 – 9622LRR 2
Repeat99 – 12224LRR 3
Repeat123 – 14422LRR 4
Repeat147 – 16822LRR 5
Domain180 – 23152LRRCT
Domain232 – 343112Ig-like

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation3091N-linked (GlcNAc...) Potential
Disulfide bond257 ↔ 327 By similarity

Natural variations

Natural variant1831D → N in a colorectal cancer sample; somatic mutation. Ref.4
VAR_037454

Sequences

Sequence LengthMass (Da)Tools
O14498 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 3163F89D59F6F3A4

FASTA42845,997
        10         20         30         40         50         60 
MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LESVPPGFPA NVTTLSLSAN 

        70         80         90        100        110        120 
RLPGLPEGAF REVPLLQSLW LAHNEIRTVA AGALASLSHL KSLDLSHNLI SDFAWSDLHN 

       130        140        150        160        170        180 
LSALQLLKMD SNELTFIPRD AFRSLRALRS LQLNHNRLHT LAEGTFTPLT ALSHLQINEN 

       190        200        210        220        230        240 
PFDCTCGIVW LKTWALTTAV SIPEQDNIAC TSPHVLKGTP LSRLPPLPCS APSVQLSYQP 

       250        260        270        280        290        300 
SQDGAELRPG FVLALHCDVD GQPAPQLHWH IQIPSGIVEI TSPNVGTDGR ALPGTPVASS 

       310        320        330        340        350        360 
QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV DVALATPGEG GEDTLGRRFH 

       370        380        390        400        410        420 
GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGNPEAAV AEGVPGQLPP GLLLLGQSLL 


LFFFLTSF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR)."
Nagasawa A., Kubota R., Imamura Y., Nagamine K., Wang Y., Asakawa S., Kudoh J., Minoshima S., Mashima Y., Oguchi Y., Shimizu N.
Genomics 44:273-279(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Retina.
[2]"Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression."
Nagasawa A., Kudoh J., Noda S., Mashima Y., Wright A., Oguchi Y., Shimizu N.
Genomics 61:37-43(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
Tissue: Retina.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-183.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB003184 mRNA. Translation: BAA22848.1.
AB024536 mRNA. Translation: BAA85970.1.
AB024537 Genomic DNA. Translation: BAA85971.1.
AY358871 mRNA. Translation: AAQ89230.1.
RefSeqNP_005536.1. NM_005545.3.
NP_958934.1. NM_201526.1.
UniGeneHs.699822.
Hs.745166.

3D structure databases

ProteinModelPortalO14498.
SMRO14498. Positions 18-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000249842.

Proteomic databases

PaxDbO14498.
PeptideAtlasO14498.
PRIDEO14498.

Protocols and materials databases

DNASU3671.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000249842; ENSP00000249842; ENSG00000129009.
ENST00000395118; ENSP00000378550; ENSG00000129009.
GeneID3671.
KEGGhsa:3671.
UCSCuc002axg.1. human.

Organism-specific databases

CTD3671.
GeneCardsGC15P074466.
HGNCHGNC:6133. ISLR.
HPAHPA050811.
MIM602059. gene.
neXtProtNX_O14498.
PharmGKBPA29933.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240332.
HOGENOMHOG000113109.
HOVERGENHBG100853.
InParanoidO14498.
OMAPEPCDCG.
OrthoDBEOG7MH0Z3.
PhylomeDBO14498.
TreeFamTF351112.

Gene expression databases

ArrayExpressO14498.
BgeeO14498.
CleanExHS_ISLR.
GenevestigatorO14498.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF07679. I-set. 1 hit.
[Graphical view]
SMARTSM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSISLR. human.
GenomeRNAi3671.
NextBio14367.
PROO14498.
SOURCESearch...

Entry information

Entry nameISLR_HUMAN
AccessionPrimary (citable) accession number: O14498
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: March 19, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM