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O14498

- ISLR_HUMAN

UniProt

O14498 - ISLR_HUMAN

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Protein

Immunoglobulin superfamily containing leucine-rich repeat protein

Gene

ISLR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cell adhesion Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily containing leucine-rich repeat protein
Gene namesi
Name:ISLR
ORF Names:UNQ189/PRO215
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:6133. ISLR.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 428410Immunoglobulin superfamily containing leucine-rich repeat proteinPRO_0000312208Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi257 ↔ 327PROSITE-ProRule annotation
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14498.
PeptideAtlasiO14498.
PRIDEiO14498.

Expressioni

Tissue specificityi

Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach and spinal cord.2 Publications

Developmental stagei

Expressed in fetal lung and kidney.1 Publication

Gene expression databases

BgeeiO14498.
CleanExiHS_ISLR.
ExpressionAtlasiO14498. baseline and differential.
GenevestigatoriO14498.

Organism-specific databases

HPAiHPA050811.

Interactioni

Protein-protein interaction databases

BioGridi109878. 53 interactions.
STRINGi9606.ENSP00000249842.

Structurei

3D structure databases

ProteinModelPortaliO14498.
SMRiO14498. Positions 17-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 5032LRRNTAdd
BLAST
Repeati51 – 7222LRR 1Add
BLAST
Repeati75 – 9622LRR 2Add
BLAST
Repeati99 – 12224LRR 3Add
BLAST
Repeati123 – 14422LRR 4Add
BLAST
Repeati147 – 16822LRR 5Add
BLAST
Domaini180 – 23152LRRCTAdd
BLAST
Domaini232 – 343112Ig-likeAdd
BLAST

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG240332.
GeneTreeiENSGT00770000120471.
HOGENOMiHOG000113109.
HOVERGENiHBG100853.
InParanoidiO14498.
OMAiPEPCDCG.
OrthoDBiEOG7MH0Z3.
PhylomeDBiO14498.
TreeFamiTF351112.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14498-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LESVPPGFPA
60 70 80 90 100
NVTTLSLSAN RLPGLPEGAF REVPLLQSLW LAHNEIRTVA AGALASLSHL
110 120 130 140 150
KSLDLSHNLI SDFAWSDLHN LSALQLLKMD SNELTFIPRD AFRSLRALRS
160 170 180 190 200
LQLNHNRLHT LAEGTFTPLT ALSHLQINEN PFDCTCGIVW LKTWALTTAV
210 220 230 240 250
SIPEQDNIAC TSPHVLKGTP LSRLPPLPCS APSVQLSYQP SQDGAELRPG
260 270 280 290 300
FVLALHCDVD GQPAPQLHWH IQIPSGIVEI TSPNVGTDGR ALPGTPVASS
310 320 330 340 350
QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV DVALATPGEG
360 370 380 390 400
GEDTLGRRFH GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGNPEAAV
410 420
AEGVPGQLPP GLLLLGQSLL LFFFLTSF
Length:428
Mass (Da):45,997
Last modified:January 1, 1998 - v1
Checksum:i3163F89D59F6F3A4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831D → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_037454

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003184 mRNA. Translation: BAA22848.1.
AB024536 mRNA. Translation: BAA85970.1.
AB024537 Genomic DNA. Translation: BAA85971.1.
AY358871 mRNA. Translation: AAQ89230.1.
CCDSiCCDS10260.1.
RefSeqiNP_005536.1. NM_005545.3.
NP_958934.1. NM_201526.1.
UniGeneiHs.699822.
Hs.745166.

Genome annotation databases

EnsembliENST00000249842; ENSP00000249842; ENSG00000129009.
ENST00000395118; ENSP00000378550; ENSG00000129009.
GeneIDi3671.
KEGGihsa:3671.
UCSCiuc002axg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003184 mRNA. Translation: BAA22848.1 .
AB024536 mRNA. Translation: BAA85970.1 .
AB024537 Genomic DNA. Translation: BAA85971.1 .
AY358871 mRNA. Translation: AAQ89230.1 .
CCDSi CCDS10260.1.
RefSeqi NP_005536.1. NM_005545.3.
NP_958934.1. NM_201526.1.
UniGenei Hs.699822.
Hs.745166.

3D structure databases

ProteinModelPortali O14498.
SMRi O14498. Positions 17-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109878. 53 interactions.
STRINGi 9606.ENSP00000249842.

Proteomic databases

PaxDbi O14498.
PeptideAtlasi O14498.
PRIDEi O14498.

Protocols and materials databases

DNASUi 3671.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249842 ; ENSP00000249842 ; ENSG00000129009 .
ENST00000395118 ; ENSP00000378550 ; ENSG00000129009 .
GeneIDi 3671.
KEGGi hsa:3671.
UCSCi uc002axg.1. human.

Organism-specific databases

CTDi 3671.
GeneCardsi GC15P074466.
HGNCi HGNC:6133. ISLR.
HPAi HPA050811.
MIMi 602059. gene.
neXtProti NX_O14498.
PharmGKBi PA29933.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240332.
GeneTreei ENSGT00770000120471.
HOGENOMi HOG000113109.
HOVERGENi HBG100853.
InParanoidi O14498.
OMAi PEPCDCG.
OrthoDBi EOG7MH0Z3.
PhylomeDBi O14498.
TreeFami TF351112.

Miscellaneous databases

ChiTaRSi ISLR. human.
GenomeRNAii 3671.
NextBioi 14367.
PROi O14498.
SOURCEi Search...

Gene expression databases

Bgeei O14498.
CleanExi HS_ISLR.
ExpressionAtlasi O14498. baseline and differential.
Genevestigatori O14498.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF07679. I-set. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR)."
    Nagasawa A., Kubota R., Imamura Y., Nagamine K., Wang Y., Asakawa S., Kudoh J., Minoshima S., Mashima Y., Oguchi Y., Shimizu N.
    Genomics 44:273-279(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Retina.
  2. "Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression."
    Nagasawa A., Kudoh J., Noda S., Mashima Y., Wright A., Oguchi Y., Shimizu N.
    Genomics 61:37-43(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Tissue: Retina.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-183.

Entry informationi

Entry nameiISLR_HUMAN
AccessioniPrimary (citable) accession number: O14498
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3