Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Immunoglobulin superfamily containing leucine-rich repeat protein

Gene

ISLR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • platelet degranulation Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily containing leucine-rich repeat protein
Gene namesi
Name:ISLR
ORF Names:UNQ189/PRO215
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000129009.12
HGNCiHGNC:6133 ISLR
MIMi602059 gene
neXtProtiNX_O14498

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129009
PharmGKBiPA29933

Polymorphism and mutation databases

BioMutaiISLR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000031220819 – 428Immunoglobulin superfamily containing leucine-rich repeat proteinAdd BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi257 ↔ 327PROSITE-ProRule annotation
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14498
PeptideAtlasiO14498
PRIDEiO14498
ProteomicsDBi48044

Expressioni

Tissue specificityi

Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach and spinal cord.2 Publications

Developmental stagei

Expressed in fetal lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000129009
CleanExiHS_ISLR
ExpressionAtlasiO14498 baseline and differential
GenevisibleiO14498 HS

Organism-specific databases

HPAiHPA040326
HPA050811

Interactioni

Protein-protein interaction databases

BioGridi109878, 60 interactors
STRINGi9606.ENSP00000249842

Structurei

3D structure databases

ProteinModelPortaliO14498
SMRiO14498
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 50LRRNTAdd BLAST32
Repeati51 – 72LRR 1Add BLAST22
Repeati75 – 96LRR 2Add BLAST22
Repeati99 – 122LRR 3Add BLAST24
Repeati123 – 144LRR 4Add BLAST22
Repeati147 – 168LRR 5Add BLAST22
Domaini180 – 231LRRCTAdd BLAST52
Domaini232 – 343Ig-likeAdd BLAST112

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00920000149011
HOGENOMiHOG000113109
HOVERGENiHBG100853
InParanoidiO14498
OMAiPEPCDCG
OrthoDBiEOG091G03ZU
PhylomeDBiO14498
TreeFamiTF351112

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LESVPPGFPA
60 70 80 90 100
NVTTLSLSAN RLPGLPEGAF REVPLLQSLW LAHNEIRTVA AGALASLSHL
110 120 130 140 150
KSLDLSHNLI SDFAWSDLHN LSALQLLKMD SNELTFIPRD AFRSLRALRS
160 170 180 190 200
LQLNHNRLHT LAEGTFTPLT ALSHLQINEN PFDCTCGIVW LKTWALTTAV
210 220 230 240 250
SIPEQDNIAC TSPHVLKGTP LSRLPPLPCS APSVQLSYQP SQDGAELRPG
260 270 280 290 300
FVLALHCDVD GQPAPQLHWH IQIPSGIVEI TSPNVGTDGR ALPGTPVASS
310 320 330 340 350
QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV DVALATPGEG
360 370 380 390 400
GEDTLGRRFH GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGNPEAAV
410 420
AEGVPGQLPP GLLLLGQSLL LFFFLTSF
Length:428
Mass (Da):45,997
Last modified:January 1, 1998 - v1
Checksum:i3163F89D59F6F3A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037454183D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs376998994Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003184 mRNA Translation: BAA22848.1
AB024536 mRNA Translation: BAA85970.1
AB024537 Genomic DNA Translation: BAA85971.1
AY358871 mRNA Translation: AAQ89230.1
CCDSiCCDS10260.1
RefSeqiNP_005536.1, NM_005545.3
NP_958934.1, NM_201526.1
UniGeneiHs.699822
Hs.745166

Genome annotation databases

EnsembliENST00000249842; ENSP00000249842; ENSG00000129009
ENST00000395118; ENSP00000378550; ENSG00000129009
GeneIDi3671
KEGGihsa:3671
UCSCiuc002axg.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiISLR_HUMAN
AccessioniPrimary (citable) accession number: O14498
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health