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Protein

Immunoglobulin superfamily containing leucine-rich repeat protein

Gene

ISLR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • platelet degranulation Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129009-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin superfamily containing leucine-rich repeat protein
Gene namesi
Name:ISLR
ORF Names:UNQ189/PRO215
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:6133. ISLR.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • platelet alpha granule lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129009.
PharmGKBiPA29933.

Polymorphism and mutation databases

BioMutaiISLR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000031220819 – 428Immunoglobulin superfamily containing leucine-rich repeat proteinAdd BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi257 ↔ 327PROSITE-ProRule annotation
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14498.
PeptideAtlasiO14498.
PRIDEiO14498.

Expressioni

Tissue specificityi

Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach and spinal cord.2 Publications

Developmental stagei

Expressed in fetal lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000129009.
CleanExiHS_ISLR.
ExpressionAtlasiO14498. baseline and differential.
GenevisibleiO14498. HS.

Organism-specific databases

HPAiHPA050811.

Interactioni

Protein-protein interaction databases

BioGridi109878. 58 interactors.
STRINGi9606.ENSP00000249842.

Structurei

3D structure databases

ProteinModelPortaliO14498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 50LRRNTAdd BLAST32
Repeati51 – 72LRR 1Add BLAST22
Repeati75 – 96LRR 2Add BLAST22
Repeati99 – 122LRR 3Add BLAST24
Repeati123 – 144LRR 4Add BLAST22
Repeati147 – 168LRR 5Add BLAST22
Domaini180 – 231LRRCTAdd BLAST52
Domaini232 – 343Ig-likeAdd BLAST112

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00850000132257.
HOGENOMiHOG000113109.
HOVERGENiHBG100853.
InParanoidiO14498.
OMAiPEPCDCG.
OrthoDBiEOG091G03ZU.
PhylomeDBiO14498.
TreeFamiTF351112.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LESVPPGFPA
60 70 80 90 100
NVTTLSLSAN RLPGLPEGAF REVPLLQSLW LAHNEIRTVA AGALASLSHL
110 120 130 140 150
KSLDLSHNLI SDFAWSDLHN LSALQLLKMD SNELTFIPRD AFRSLRALRS
160 170 180 190 200
LQLNHNRLHT LAEGTFTPLT ALSHLQINEN PFDCTCGIVW LKTWALTTAV
210 220 230 240 250
SIPEQDNIAC TSPHVLKGTP LSRLPPLPCS APSVQLSYQP SQDGAELRPG
260 270 280 290 300
FVLALHCDVD GQPAPQLHWH IQIPSGIVEI TSPNVGTDGR ALPGTPVASS
310 320 330 340 350
QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV DVALATPGEG
360 370 380 390 400
GEDTLGRRFH GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGNPEAAV
410 420
AEGVPGQLPP GLLLLGQSLL LFFFLTSF
Length:428
Mass (Da):45,997
Last modified:January 1, 1998 - v1
Checksum:i3163F89D59F6F3A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037454183D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs376998994dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003184 mRNA. Translation: BAA22848.1.
AB024536 mRNA. Translation: BAA85970.1.
AB024537 Genomic DNA. Translation: BAA85971.1.
AY358871 mRNA. Translation: AAQ89230.1.
CCDSiCCDS10260.1.
RefSeqiNP_005536.1. NM_005545.3.
NP_958934.1. NM_201526.1.
UniGeneiHs.699822.
Hs.745166.

Genome annotation databases

EnsembliENST00000249842; ENSP00000249842; ENSG00000129009.
ENST00000395118; ENSP00000378550; ENSG00000129009.
GeneIDi3671.
KEGGihsa:3671.
UCSCiuc002axg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003184 mRNA. Translation: BAA22848.1.
AB024536 mRNA. Translation: BAA85970.1.
AB024537 Genomic DNA. Translation: BAA85971.1.
AY358871 mRNA. Translation: AAQ89230.1.
CCDSiCCDS10260.1.
RefSeqiNP_005536.1. NM_005545.3.
NP_958934.1. NM_201526.1.
UniGeneiHs.699822.
Hs.745166.

3D structure databases

ProteinModelPortaliO14498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109878. 58 interactors.
STRINGi9606.ENSP00000249842.

Polymorphism and mutation databases

BioMutaiISLR.

Proteomic databases

PaxDbiO14498.
PeptideAtlasiO14498.
PRIDEiO14498.

Protocols and materials databases

DNASUi3671.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249842; ENSP00000249842; ENSG00000129009.
ENST00000395118; ENSP00000378550; ENSG00000129009.
GeneIDi3671.
KEGGihsa:3671.
UCSCiuc002axg.2. human.

Organism-specific databases

CTDi3671.
GeneCardsiISLR.
HGNCiHGNC:6133. ISLR.
HPAiHPA050811.
MIMi602059. gene.
neXtProtiNX_O14498.
OpenTargetsiENSG00000129009.
PharmGKBiPA29933.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00850000132257.
HOGENOMiHOG000113109.
HOVERGENiHBG100853.
InParanoidiO14498.
OMAiPEPCDCG.
OrthoDBiEOG091G03ZU.
PhylomeDBiO14498.
TreeFamiTF351112.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129009-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiISLR. human.
GenomeRNAii3671.
PROiO14498.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129009.
CleanExiHS_ISLR.
ExpressionAtlasiO14498. baseline and differential.
GenevisibleiO14498. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISLR_HUMAN
AccessioniPrimary (citable) accession number: O14498
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.