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Protein

Disks large-associated protein 1

Gene

DLGAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the postsynaptic scaffold in neuronal cells.

GO - Biological processi

  • synaptic transmission Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 1
Short name:
DAP-1
Alternative name(s):
Guanylate kinase-associated protein
Short name:
hGKAP
PSD-95/SAP90-binding protein 1
SAP90/PSD-95-associated protein 1
Short name:
SAPAP1
Gene namesi
Name:DLGAP1
Synonyms:DAP1, GKAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:2905. DLGAP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27361.

Polymorphism and mutation databases

BioMutaiDLGAP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 977977Disks large-associated protein 1PRO_0000174288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei356 – 3561PhosphoserineBy similarity
Modified residuei503 – 5031PhosphoserineBy similarity
Modified residuei510 – 5101PhosphoserineBy similarity
Modified residuei932 – 9321PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO14490.
PRIDEiO14490.

PTM databases

PhosphoSiteiO14490.

Expressioni

Tissue specificityi

Expressed in brain.

Gene expression databases

BgeeiO14490.
CleanExiHS_DLGAP1.
ExpressionAtlasiO14490. baseline and differential.
GenevisibleiO14490. HS.

Organism-specific databases

HPAiHPA040963.

Interactioni

Subunit structurei

Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg1Q626962EBI-1753207,EBI-389325From a different organism.
DLG4P783525EBI-1753207,EBI-80389
GRB2P629933EBI-1753207,EBI-401755
NCK1P163334EBI-1753207,EBI-389883

Protein-protein interaction databases

BioGridi114660. 18 interactions.
IntActiO14490. 12 interactions.
MINTiMINT-2795054.

Structurei

3D structure databases

ProteinModelPortaliO14490.
SMRiO14490. Positions 792-901.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni650 – 66112Interaction with DYL2By similarityAdd
BLAST
Regioni672 – 68312Interaction with DYL2By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi975 – 9773PDZ-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi622 – 6309Poly-Thr

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiNOG277836.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiO14490.
KOiK15008.
OMAiAVEVSSC.
OrthoDBiEOG75QR37.
PhylomeDBiO14490.
TreeFamiTF321382.

Family and domain databases

InterProiIPR030524. DLGAP1.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF7. PTHR12353:SF7. 1 hit.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O14490-1) [UniParc]FASTAAdd to basket

Also known as: DAP1-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGLSGSRSH HHGVTCDSAC DSLSHHSDRK PYLLSPVEHH PADHPYYTQR
60 70 80 90 100
NSFQAECVGP FSDPLASSTF PRRHYTSQQE LKDECALVPR TLATKANRIP
110 120 130 140 150
ANLLDQFERQ LPLSRDGYHT LQYKRTAVEH RSDSPGRIRH LVHSVQKLFT
160 170 180 190 200
KSHSLEGPSK GSVNGGKASP DEAQAARYGK RSKSKERRAE PKARPSTSPG
210 220 230 240 250
WWSSDDNLDG DMCIYHAPSG VMTMGRCPDR SASQYFLEAY NTISEQAVKA
260 270 280 290 300
SRSNNDVKCS TCANLPVSLD TPLLKKSAWS STLTVSRARE VYQKASVNMD
310 320 330 340 350
QAMVKSESCQ QERSCQYLQV PQDEWTGYTP RGKDDEIPCR RMRSGSYIKA
360 370 380 390 400
MGDEDSGDSD TSPKPSPKVA ARRESYLKAT QPSLTELTTL KISNEHSPKL
410 420 430 440 450
QIRSHSYLRA VSEVSINRSL DSLDPAGLLT SPKFRSRNES YMRAMSTISQ
460 470 480 490 500
VSEMEVNGQF ESVCESVFSE LESQAVEALD LPMPGCFRMR SHSYVRAIEK
510 520 530 540 550
GCSQDDECVS LRSSSPPRTT TTVRTIQSST VSSCITTYKK TPPPVPPRTT
560 570 580 590 600
TKPFISITAQ SSTESAQDAY MDGQGQRGDI ISQSGLSNST ESLDSMKALT
610 620 630 640 650
AAIEAANAQI HGPASQHMGN NTATVTTTTT IATVTTEDRK KDHFKKNRCL
660 670 680 690 700
SIGIQVDDAE EPDKTGENKA PSKFQSVGVQ VEEEKCFRRF TRSNSVTTAV
710 720 730 740 750
QADLDFHDNL ENSLESIEDN SCPGPMARQF SRDASTSTVS IQGSGNHYHA
760 770 780 790 800
CAADDDFDTD FDPSILPPPD PWIDSITEDP LEAVQRSVCH RDGHWFLKLL
810 820 830 840 850
QAERDRMEGW CQQMEREERE NNLPEDILGK IRTAVGSAQL LMAQKFYQFR
860 870 880 890 900
ELCEENLNPN AHPRPTSQDL AGFWDMLQLS IENISMKFDE LHQLKANNWK
910 920 930 940 950
QMDPLDKKER RAPPPVPKKP AKGPAPLIRE RSLESSQRQE ARKRLMAAKR
960 970
AASVRQNSAT ESAESIEIYI PEAQTRL
Length:977
Mass (Da):108,873
Last modified:January 1, 1998 - v1
Checksum:i670F72B17D9BE667
GO
Isoform 2 (identifier: O14490-2) [UniParc]FASTAAdd to basket

Also known as: DAP1-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-302: Missing.
     303-319: MVKSESCQQERSCQYLQ → MNLIFHKDILFGIPANK

Show »
Length:675
Mass (Da):75,261
Checksum:iA88274F7F3D9F5ED
GO
Isoform 3 (identifier: O14490-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-302: Missing.
     303-319: MVKSESCQQERSCQYLQ → MNLIFHKDILFGIPANK
     909-929: ERRAPPPVPKKPAKGPAPLIR → VEQCRFCMVHLKTCTNTGQSK
     930-977: Missing.

Show »
Length:627
Mass (Da):69,969
Checksum:i2326123341316726
GO
Isoform 4 (identifier: O14490-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MKGLSGSRSHHHGVTCDSACDSLS → MIDLFKAEWVSSVCVQVSRNGRTD
     25-318: Missing.

Note: No experimental confirmation available.
Show »
Length:683
Mass (Da):76,159
Checksum:i8F23FC02956683BE
GO
Isoform 5 (identifier: O14490-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: MKGLSGSRSHHHGVTCDSACDSLSHHSDRKP → MDLKTLKLFNSQLRCGWLLYIWNKAFMAHLR
     32-319: Missing.
     530-557: Missing.

Note: No experimental confirmation available.
Show »
Length:661
Mass (Da):74,058
Checksum:i5A96B64BA7D70469
GO
Isoform 6 (identifier: O14490-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MKGLSGSRSHHHGVTCD → MNLIFHKDILFGIPANK
     18-31: Missing.
     32-319: Missing.
     530-530: T → TGVIKLSSAVE

Note: No experimental confirmation available.
Show »
Length:685
Mass (Da):76,245
Checksum:iACBD1D7BB4CC8756
GO
Isoform 7 (identifier: O14490-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     909-929: ERRAPPPVPKKPAKGPAPLIR → VEQCRFCMVHLKTCTNTGQSK
     930-977: Missing.

Note: No experimental confirmation available.
Show »
Length:929
Mass (Da):103,581
Checksum:i00E65FE3F36B7D6B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti734 – 7341A → P in AAC51119 (PubMed:9024696).Curated
Sequence conflicti740 – 7401S → T in AAC51119 (PubMed:9024696).Curated
Sequence conflicti752 – 7532AA → SP in AAC51119 (PubMed:9024696).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti816 – 8161R → Q.
Corresponds to variant rs35822832 [ dbSNP | Ensembl ].
VAR_053648

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 302302Missing in isoform 2 and isoform 3. 2 PublicationsVSP_006003Add
BLAST
Alternative sequencei1 – 3131MKGLS…SDRKP → MDLKTLKLFNSQLRCGWLLY IWNKAFMAHLR in isoform 5. 1 PublicationVSP_043718Add
BLAST
Alternative sequencei1 – 2424MKGLS…CDSLS → MIDLFKAEWVSSVCVQVSRN GRTD in isoform 4. 1 PublicationVSP_043222Add
BLAST
Alternative sequencei1 – 1717MKGLS…GVTCD → MNLIFHKDILFGIPANK in isoform 6. 1 PublicationVSP_043719Add
BLAST
Alternative sequencei18 – 3114Missing in isoform 6. 1 PublicationVSP_043720Add
BLAST
Alternative sequencei25 – 318294Missing in isoform 4. 1 PublicationVSP_043223Add
BLAST
Alternative sequencei32 – 319288Missing in isoform 5 and isoform 6. 1 PublicationVSP_043721Add
BLAST
Alternative sequencei303 – 31917MVKSE…CQYLQ → MNLIFHKDILFGIPANK in isoform 2 and isoform 3. 2 PublicationsVSP_006004Add
BLAST
Alternative sequencei530 – 55728Missing in isoform 5. 1 PublicationVSP_043722Add
BLAST
Alternative sequencei530 – 5301T → TGVIKLSSAVE in isoform 6. 1 PublicationVSP_043723
Alternative sequencei909 – 92921ERRAP…APLIR → VEQCRFCMVHLKTCTNTGQS K in isoform 3 and isoform 7. 2 PublicationsVSP_006005Add
BLAST
Alternative sequencei930 – 97748Missing in isoform 3 and isoform 7. 2 PublicationsVSP_006006Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000277 mRNA. Translation: BAA23258.1.
AB000276 mRNA. Translation: BAA23257.1.
U67988 mRNA. Translation: AAC51119.1.
AK294717 mRNA. Translation: BAH11858.1.
AK294747 mRNA. Translation: BAH11868.1.
AK299880 mRNA. Translation: BAH13160.1.
AK316099 mRNA. Translation: BAH14470.1.
AP002472 Genomic DNA. No translation available.
AP002478 Genomic DNA. No translation available.
AP005130 Genomic DNA. No translation available.
AP005204 Genomic DNA. No translation available.
AP005241 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01654.1.
CH471113 Genomic DNA. Translation: EAX01658.1.
CH471113 Genomic DNA. Translation: EAX01659.1.
BC136453 mRNA. Translation: AAI36454.1.
BC136454 mRNA. Translation: AAI36455.1.
CCDSiCCDS11836.1. [O14490-1]
CCDS42406.1. [O14490-2]
CCDS56049.1. [O14490-3]
CCDS56050.1. [O14490-6]
CCDS56051.1. [O14490-4]
CCDS56052.1. [O14490-5]
CCDS56053.1. [O14490-7]
PIRiT00014.
RefSeqiNP_001003809.1. NM_001003809.2. [O14490-2]
NP_001229690.1. NM_001242761.1. [O14490-7]
NP_001229691.1. NM_001242762.1. [O14490-5]
NP_001229692.1. NM_001242763.1.
NP_001229693.1. NM_001242764.1. [O14490-4]
NP_001229694.1. NM_001242765.1. [O14490-3]
NP_001229695.1. NM_001242766.1. [O14490-6]
NP_004737.2. NM_004746.3. [O14490-1]
UniGeneiHs.594640.
Hs.654793.

Genome annotation databases

EnsembliENST00000315677; ENSP00000316377; ENSG00000170579. [O14490-1]
ENST00000400145; ENSP00000383010; ENSG00000170579. [O14490-3]
ENST00000400147; ENSP00000383011; ENSG00000170579. [O14490-2]
ENST00000400155; ENSP00000383019; ENSG00000170579. [O14490-4]
ENST00000534970; ENSP00000437817; ENSG00000170579. [O14490-5]
ENST00000539435; ENSP00000446312; ENSG00000170579. [O14490-6]
ENST00000581527; ENSP00000463864; ENSG00000170579. [O14490-7]
ENST00000581699; ENSP00000462848; ENSG00000170579. [O14490-4]
ENST00000584874; ENSP00000462882; ENSG00000170579. [O14490-1]
GeneIDi9229.
KEGGihsa:9229.
UCSCiuc002kme.2. human. [O14490-2]
uc002kmf.3. human. [O14490-1]
uc002kmg.3. human. [O14490-3]
uc010dkn.3. human. [O14490-6]
uc010wyw.2. human. [O14490-4]
uc010wyy.2. human. [O14490-5]
uc010wyz.2. human. [O14490-7]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000277 mRNA. Translation: BAA23258.1.
AB000276 mRNA. Translation: BAA23257.1.
U67988 mRNA. Translation: AAC51119.1.
AK294717 mRNA. Translation: BAH11858.1.
AK294747 mRNA. Translation: BAH11868.1.
AK299880 mRNA. Translation: BAH13160.1.
AK316099 mRNA. Translation: BAH14470.1.
AP002472 Genomic DNA. No translation available.
AP002478 Genomic DNA. No translation available.
AP005130 Genomic DNA. No translation available.
AP005204 Genomic DNA. No translation available.
AP005241 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01654.1.
CH471113 Genomic DNA. Translation: EAX01658.1.
CH471113 Genomic DNA. Translation: EAX01659.1.
BC136453 mRNA. Translation: AAI36454.1.
BC136454 mRNA. Translation: AAI36455.1.
CCDSiCCDS11836.1. [O14490-1]
CCDS42406.1. [O14490-2]
CCDS56049.1. [O14490-3]
CCDS56050.1. [O14490-6]
CCDS56051.1. [O14490-4]
CCDS56052.1. [O14490-5]
CCDS56053.1. [O14490-7]
PIRiT00014.
RefSeqiNP_001003809.1. NM_001003809.2. [O14490-2]
NP_001229690.1. NM_001242761.1. [O14490-7]
NP_001229691.1. NM_001242762.1. [O14490-5]
NP_001229692.1. NM_001242763.1.
NP_001229693.1. NM_001242764.1. [O14490-4]
NP_001229694.1. NM_001242765.1. [O14490-3]
NP_001229695.1. NM_001242766.1. [O14490-6]
NP_004737.2. NM_004746.3. [O14490-1]
UniGeneiHs.594640.
Hs.654793.

3D structure databases

ProteinModelPortaliO14490.
SMRiO14490. Positions 792-901.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114660. 18 interactions.
IntActiO14490. 12 interactions.
MINTiMINT-2795054.

PTM databases

PhosphoSiteiO14490.

Polymorphism and mutation databases

BioMutaiDLGAP1.

Proteomic databases

PaxDbiO14490.
PRIDEiO14490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315677; ENSP00000316377; ENSG00000170579. [O14490-1]
ENST00000400145; ENSP00000383010; ENSG00000170579. [O14490-3]
ENST00000400147; ENSP00000383011; ENSG00000170579. [O14490-2]
ENST00000400155; ENSP00000383019; ENSG00000170579. [O14490-4]
ENST00000534970; ENSP00000437817; ENSG00000170579. [O14490-5]
ENST00000539435; ENSP00000446312; ENSG00000170579. [O14490-6]
ENST00000581527; ENSP00000463864; ENSG00000170579. [O14490-7]
ENST00000581699; ENSP00000462848; ENSG00000170579. [O14490-4]
ENST00000584874; ENSP00000462882; ENSG00000170579. [O14490-1]
GeneIDi9229.
KEGGihsa:9229.
UCSCiuc002kme.2. human. [O14490-2]
uc002kmf.3. human. [O14490-1]
uc002kmg.3. human. [O14490-3]
uc010dkn.3. human. [O14490-6]
uc010wyw.2. human. [O14490-4]
uc010wyy.2. human. [O14490-5]
uc010wyz.2. human. [O14490-7]

Organism-specific databases

CTDi9229.
GeneCardsiGC18M003488.
HGNCiHGNC:2905. DLGAP1.
HPAiHPA040963.
MIMi605445. gene.
neXtProtiNX_O14490.
PharmGKBiPA27361.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG277836.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiO14490.
KOiK15008.
OMAiAVEVSSC.
OrthoDBiEOG75QR37.
PhylomeDBiO14490.
TreeFamiTF321382.

Miscellaneous databases

ChiTaRSiDLGAP1. human.
GeneWikiiDLGAP1.
GenomeRNAii9229.
NextBioi34591.
PROiO14490.
SOURCEiSearch...

Gene expression databases

BgeeiO14490.
CleanExiHS_DLGAP1.
ExpressionAtlasiO14490. baseline and differential.
GenevisibleiO14490. HS.

Family and domain databases

InterProiIPR030524. DLGAP1.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF7. PTHR12353:SF7. 1 hit.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95."
    Satoh K., Yanai H., Senda T., Kohu K., Nakamura T., Okumura N., Matsumine A., Kobayashi S., Toyoshima K., Akiyama T.
    Genes Cells 2:415-424(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules."
    Kim E., Naisbitt S., Hsueh Y.-P., Rao A., Rothschild A., Craig A.M., Sheng M.
    J. Cell Biol. 136:669-678(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5; 6 AND 7).
    Tissue: Brain and Thalamus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.

Entry informationi

Entry nameiDLGP1_HUMAN
AccessioniPrimary (citable) accession number: O14490
Secondary accession number(s): A8MWN8
, B2RMU8, B7WPA1, B7Z2H2, B7Z2I2, B7Z9Y4, O14489, P78335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: June 24, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.