O14490 (DLGP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disks large-associated protein 1
Short name=DAP-1

Alternative name(s):
Guanylate kinase-associated protein
Short name=hGKAP
PSD-95/SAP90-binding protein 1
SAP90/PSD-95-associated protein 1
Short name=SAPAP1

Gene names

Name:	DLGAP1
Synonyms:	DAP1, GKAP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	977 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the postsynaptic scaffold in neuronal cells.
Subunit structure	Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1 By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density By similarity. Cell junction › synapse By similarity. Note: Found in postsynaptic density of neuronal cells By similarity.
Tissue specificity	Expressed in brain.
Sequence similarities	Belongs to the SAPAP family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synaptic transmission Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic density Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GRB2	P62993	3	EBI-1753207,EBI-401755
NCK1	P16333	4	EBI-1753207,EBI-389883

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O14490-1)

Also known as: DAP1-alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O14490-2)

Also known as: DAP1-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-302: Missing.
     303-319: MVKSESCQQERSCQYLQ → MNLIFHKDILFGIPANK

Isoform 3 (identifier: O14490-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-302: Missing.
     303-319: MVKSESCQQERSCQYLQ → MNLIFHKDILFGIPANK
     909-929: ERRAPPPVPKKPAKGPAPLIR → VEQCRFCMVHLKTCTNTGQSK
     930-977: Missing.

Isoform 4 (identifier: O14490-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MKGLSGSRSHHHGVTCDSACDSLS → MIDLFKAEWVSSVCVQVSRNGRTD
     25-318: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: O14490-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: MKGLSGSRSHHHGVTCDSACDSLSHHSDRKP → MDLKTLKLFNSQLRCGWLLYIWNKAFMAHLR
     32-319: Missing.
     530-557: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: O14490-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MKGLSGSRSHHHGVTCD → MNLIFHKDILFGIPANK
     18-31: Missing.
     32-319: Missing.
     530-530: T → TGVIKLSSAVE

Note: No experimental confirmation available.

Isoform 7 (identifier: O14490-7)

The sequence of this isoform differs from the canonical sequence as follows:
     909-929: ERRAPPPVPKKPAKGPAPLIR → VEQCRFCMVHLKTCTNTGQSK
     930-977: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 977	977	Disks large-associated protein 1		PRO_0000174288
Regions
	Region	650 – 661	12	Interaction with DYL2 By similarity
	Region	672 – 683	12	Interaction with DYL2 By similarity
	Motif	975 – 977	3	PDZ-binding By similarity
	Compositional bias	622 – 630	9	Poly-Thr
Amino acid modifications
	Modified residue	123	1	Phosphotyrosine By similarity
	Modified residue	134	1	Phosphoserine By similarity
	Modified residue	346	1	Phosphoserine By similarity
	Modified residue	356	1	Phosphoserine By similarity
	Modified residue	383	1	Phosphoserine By similarity
	Modified residue	406	1	Phosphoserine By similarity
	Modified residue	415	1	Phosphoserine By similarity
	Modified residue	430	1	Phosphothreonine By similarity
	Modified residue	431	1	Phosphoserine By similarity
	Modified residue	440	1	Phosphoserine By similarity
	Modified residue	493	1	Phosphoserine By similarity
	Modified residue	503	1	Phosphoserine By similarity
	Modified residue	510	1	Phosphoserine By similarity
	Modified residue	932	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 302	302	Missing in isoform 2 and isoform 3.		VSP_006003
	Alternative sequence	1 – 31	31	MKGLS…SDRKP → MDLKTLKLFNSQLRCGWLLY IWNKAFMAHLR in isoform 5.		VSP_043718
	Alternative sequence	1 – 24	24	MKGLS…CDSLS → MIDLFKAEWVSSVCVQVSRN GRTD in isoform 4.		VSP_043222
	Alternative sequence	1 – 17	17	MKGLS…GVTCD → MNLIFHKDILFGIPANK in isoform 6.		VSP_043719
	Alternative sequence	18 – 31	14	Missing in isoform 6.		VSP_043720
	Alternative sequence	25 – 318	294	Missing in isoform 4.		VSP_043223
	Alternative sequence	32 – 319	288	Missing in isoform 5 and isoform 6.		VSP_043721
	Alternative sequence	303 – 319	17	MVKSE…CQYLQ → MNLIFHKDILFGIPANK in isoform 2 and isoform 3.		VSP_006004
	Alternative sequence	530 – 557	28	Missing in isoform 5.		VSP_043722
	Alternative sequence	530	1	T → TGVIKLSSAVE in isoform 6.		VSP_043723
	Alternative sequence	909 – 929	21	ERRAP…APLIR → VEQCRFCMVHLKTCTNTGQS K in isoform 3 and isoform 7.		VSP_006005
	Alternative sequence	930 – 977	48	Missing in isoform 3 and isoform 7.		VSP_006006
	Natural variant	816	1	R → Q. Corresponds to variant rs35822832 [ dbSNP | Ensembl ].		VAR_053648
Experimental info
	Sequence conflict	734	1	A → P in AAC51119. Ref.2
	Sequence conflict	740	1	S → T in AAC51119. Ref.2
	Sequence conflict	752 – 753	2	AA → SP in AAC51119. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (DAP1-alpha) [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 670F72B17D9BE667	FASTA	977	108,873
	10 20 30 40 50 60 MKGLSGSRSH HHGVTCDSAC DSLSHHSDRK PYLLSPVEHH PADHPYYTQR NSFQAECVGP 70 80 90 100 110 120 FSDPLASSTF PRRHYTSQQE LKDECALVPR TLATKANRIP ANLLDQFERQ LPLSRDGYHT 130 140 150 160 170 180 LQYKRTAVEH RSDSPGRIRH LVHSVQKLFT KSHSLEGPSK GSVNGGKASP DEAQAARYGK 190 200 210 220 230 240 RSKSKERRAE PKARPSTSPG WWSSDDNLDG DMCIYHAPSG VMTMGRCPDR SASQYFLEAY 250 260 270 280 290 300 NTISEQAVKA SRSNNDVKCS TCANLPVSLD TPLLKKSAWS STLTVSRARE VYQKASVNMD 310 320 330 340 350 360 QAMVKSESCQ QERSCQYLQV PQDEWTGYTP RGKDDEIPCR RMRSGSYIKA MGDEDSGDSD 370 380 390 400 410 420 TSPKPSPKVA ARRESYLKAT QPSLTELTTL KISNEHSPKL QIRSHSYLRA VSEVSINRSL 430 440 450 460 470 480 DSLDPAGLLT SPKFRSRNES YMRAMSTISQ VSEMEVNGQF ESVCESVFSE LESQAVEALD 490 500 510 520 530 540 LPMPGCFRMR SHSYVRAIEK GCSQDDECVS LRSSSPPRTT TTVRTIQSST VSSCITTYKK 550 560 570 580 590 600 TPPPVPPRTT TKPFISITAQ SSTESAQDAY MDGQGQRGDI ISQSGLSNST ESLDSMKALT 610 620 630 640 650 660 AAIEAANAQI HGPASQHMGN NTATVTTTTT IATVTTEDRK KDHFKKNRCL SIGIQVDDAE 670 680 690 700 710 720 EPDKTGENKA PSKFQSVGVQ VEEEKCFRRF TRSNSVTTAV QADLDFHDNL ENSLESIEDN 730 740 750 760 770 780 SCPGPMARQF SRDASTSTVS IQGSGNHYHA CAADDDFDTD FDPSILPPPD PWIDSITEDP 790 800 810 820 830 840 LEAVQRSVCH RDGHWFLKLL QAERDRMEGW CQQMEREERE NNLPEDILGK IRTAVGSAQL 850 860 870 880 890 900 LMAQKFYQFR ELCEENLNPN AHPRPTSQDL AGFWDMLQLS IENISMKFDE LHQLKANNWK 910 920 930 940 950 960 QMDPLDKKER RAPPPVPKKP AKGPAPLIRE RSLESSQRQE ARKRLMAAKR AASVRQNSAT 970 ESAESIEIYI PEAQTRL
	Isoform 2 (DAP1-beta) [UniParc]. Checksum: A88274F7F3D9F5ED	FASTA	675	75,261
	10 20 30 40 50 60 MNLIFHKDIL FGIPANKVPQ DEWTGYTPRG KDDEIPCRRM RSGSYIKAMG DEDSGDSDTS 70 80 90 100 110 120 PKPSPKVAAR RESYLKATQP SLTELTTLKI SNEHSPKLQI RSHSYLRAVS EVSINRSLDS 130 140 150 160 170 180 LDPAGLLTSP KFRSRNESYM RAMSTISQVS EMEVNGQFES VCESVFSELE SQAVEALDLP 190 200 210 220 230 240 MPGCFRMRSH SYVRAIEKGC SQDDECVSLR SSSPPRTTTT VRTIQSSTVS SCITTYKKTP 250 260 270 280 290 300 PPVPPRTTTK PFISITAQSS TESAQDAYMD GQGQRGDIIS QSGLSNSTES LDSMKALTAA 310 320 330 340 350 360 IEAANAQIHG PASQHMGNNT ATVTTTTTIA TVTTEDRKKD HFKKNRCLSI GIQVDDAEEP 370 380 390 400 410 420 DKTGENKAPS KFQSVGVQVE EEKCFRRFTR SNSVTTAVQA DLDFHDNLEN SLESIEDNSC 430 440 450 460 470 480 PGPMARQFSR DASTSTVSIQ GSGNHYHACA ADDDFDTDFD PSILPPPDPW IDSITEDPLE 490 500 510 520 530 540 AVQRSVCHRD GHWFLKLLQA ERDRMEGWCQ QMEREERENN LPEDILGKIR TAVGSAQLLM 550 560 570 580 590 600 AQKFYQFREL CEENLNPNAH PRPTSQDLAG FWDMLQLSIE NISMKFDELH QLKANNWKQM 610 620 630 640 650 660 DPLDKKERRA PPPVPKKPAK GPAPLIRERS LESSQRQEAR KRLMAAKRAA SVRQNSATES 670 AESIEIYIPE AQTRL
	Isoform 3 [UniParc]. Checksum: 2326123341316726	FASTA	627	69,969
	10 20 30 40 50 60 MNLIFHKDIL FGIPANKVPQ DEWTGYTPRG KDDEIPCRRM RSGSYIKAMG DEDSGDSDTS 70 80 90 100 110 120 PKPSPKVAAR RESYLKATQP SLTELTTLKI SNEHSPKLQI RSHSYLRAVS EVSINRSLDS 130 140 150 160 170 180 LDPAGLLTSP KFRSRNESYM RAMSTISQVS EMEVNGQFES VCESVFSELE SQAVEALDLP 190 200 210 220 230 240 MPGCFRMRSH SYVRAIEKGC SQDDECVSLR SSSPPRTTTT VRTIQSSTVS SCITTYKKTP 250 260 270 280 290 300 PPVPPRTTTK PFISITAQSS TESAQDAYMD GQGQRGDIIS QSGLSNSTES LDSMKALTAA 310 320 330 340 350 360 IEAANAQIHG PASQHMGNNT ATVTTTTTIA TVTTEDRKKD HFKKNRCLSI GIQVDDAEEP 370 380 390 400 410 420 DKTGENKAPS KFQSVGVQVE EEKCFRRFTR SNSVTTAVQA DLDFHDNLEN SLESIEDNSC 430 440 450 460 470 480 PGPMARQFSR DASTSTVSIQ GSGNHYHACA ADDDFDTDFD PSILPPPDPW IDSITEDPLE 490 500 510 520 530 540 AVQRSVCHRD GHWFLKLLQA ERDRMEGWCQ QMEREERENN LPEDILGKIR TAVGSAQLLM 550 560 570 580 590 600 AQKFYQFREL CEENLNPNAH PRPTSQDLAG FWDMLQLSIE NISMKFDELH QLKANNWKQM 610 620 DPLDKKVEQC RFCMVHLKTC TNTGQSK
	Isoform 4 [UniParc]. Checksum: 8F23FC02956683BE	FASTA	683	76,159
	10 20 30 40 50 60 MIDLFKAEWV SSVCVQVSRN GRTDQVPQDE WTGYTPRGKD DEIPCRRMRS GSYIKAMGDE 70 80 90 100 110 120 DSGDSDTSPK PSPKVAARRE SYLKATQPSL TELTTLKISN EHSPKLQIRS HSYLRAVSEV 130 140 150 160 170 180 SINRSLDSLD PAGLLTSPKF RSRNESYMRA MSTISQVSEM EVNGQFESVC ESVFSELESQ 190 200 210 220 230 240 AVEALDLPMP GCFRMRSHSY VRAIEKGCSQ DDECVSLRSS SPPRTTTTVR TIQSSTVSSC 250 260 270 280 290 300 ITTYKKTPPP VPPRTTTKPF ISITAQSSTE SAQDAYMDGQ GQRGDIISQS GLSNSTESLD 310 320 330 340 350 360 SMKALTAAIE AANAQIHGPA SQHMGNNTAT VTTTTTIATV TTEDRKKDHF KKNRCLSIGI 370 380 390 400 410 420 QVDDAEEPDK TGENKAPSKF QSVGVQVEEE KCFRRFTRSN SVTTAVQADL DFHDNLENSL 430 440 450 460 470 480 ESIEDNSCPG PMARQFSRDA STSTVSIQGS GNHYHACAAD DDFDTDFDPS ILPPPDPWID 490 500 510 520 530 540 SITEDPLEAV QRSVCHRDGH WFLKLLQAER DRMEGWCQQM EREERENNLP EDILGKIRTA 550 560 570 580 590 600 VGSAQLLMAQ KFYQFRELCE ENLNPNAHPR PTSQDLAGFW DMLQLSIENI SMKFDELHQL 610 620 630 640 650 660 KANNWKQMDP LDKKERRAPP PVPKKPAKGP APLIRERSLE SSQRQEARKR LMAAKRAASV 670 680 RQNSATESAE SIEIYIPEAQ TRL
	Isoform 5 [UniParc]. Checksum: 5A96B64BA7D70469	FASTA	661	74,058
	10 20 30 40 50 60 MDLKTLKLFN SQLRCGWLLY IWNKAFMAHL RVPQDEWTGY TPRGKDDEIP CRRMRSGSYI 70 80 90 100 110 120 KAMGDEDSGD SDTSPKPSPK VAARRESYLK ATQPSLTELT TLKISNEHSP KLQIRSHSYL 130 140 150 160 170 180 RAVSEVSINR SLDSLDPAGL LTSPKFRSRN ESYMRAMSTI SQVSEMEVNG QFESVCESVF 190 200 210 220 230 240 SELESQAVEA LDLPMPGCFR MRSHSYVRAI EKGCSQDDEC VSLRSSSPPR TTTTVRTIQS 250 260 270 280 290 300 STAQSSTESA QDAYMDGQGQ RGDIISQSGL SNSTESLDSM KALTAAIEAA NAQIHGPASQ 310 320 330 340 350 360 HMGNNTATVT TTTTIATVTT EDRKKDHFKK NRCLSIGIQV DDAEEPDKTG ENKAPSKFQS 370 380 390 400 410 420 VGVQVEEEKC FRRFTRSNSV TTAVQADLDF HDNLENSLES IEDNSCPGPM ARQFSRDAST 430 440 450 460 470 480 STVSIQGSGN HYHACAADDD FDTDFDPSIL PPPDPWIDSI TEDPLEAVQR SVCHRDGHWF 490 500 510 520 530 540 LKLLQAERDR MEGWCQQMER EERENNLPED ILGKIRTAVG SAQLLMAQKF YQFRELCEEN 550 560 570 580 590 600 LNPNAHPRPT SQDLAGFWDM LQLSIENISM KFDELHQLKA NNWKQMDPLD KKERRAPPPV 610 620 630 640 650 660 PKKPAKGPAP LIRERSLESS QRQEARKRLM AAKRAASVRQ NSATESAESI EIYIPEAQTR L
	Isoform 6 [UniParc]. Checksum: ACBD1D7BB4CC8756	FASTA	685	76,245
	10 20 30 40 50 60 MNLIFHKDIL FGIPANKVPQ DEWTGYTPRG KDDEIPCRRM RSGSYIKAMG DEDSGDSDTS 70 80 90 100 110 120 PKPSPKVAAR RESYLKATQP SLTELTTLKI SNEHSPKLQI RSHSYLRAVS EVSINRSLDS 130 140 150 160 170 180 LDPAGLLTSP KFRSRNESYM RAMSTISQVS EMEVNGQFES VCESVFSELE SQAVEALDLP 190 200 210 220 230 240 MPGCFRMRSH SYVRAIEKGC SQDDECVSLR SSSPPRTTTT VRTIQSSTGV IKLSSAVEVS 250 260 270 280 290 300 SCITTYKKTP PPVPPRTTTK PFISITAQSS TESAQDAYMD GQGQRGDIIS QSGLSNSTES 310 320 330 340 350 360 LDSMKALTAA IEAANAQIHG PASQHMGNNT ATVTTTTTIA TVTTEDRKKD HFKKNRCLSI 370 380 390 400 410 420 GIQVDDAEEP DKTGENKAPS KFQSVGVQVE EEKCFRRFTR SNSVTTAVQA DLDFHDNLEN 430 440 450 460 470 480 SLESIEDNSC PGPMARQFSR DASTSTVSIQ GSGNHYHACA ADDDFDTDFD PSILPPPDPW 490 500 510 520 530 540 IDSITEDPLE AVQRSVCHRD GHWFLKLLQA ERDRMEGWCQ QMEREERENN LPEDILGKIR 550 560 570 580 590 600 TAVGSAQLLM AQKFYQFREL CEENLNPNAH PRPTSQDLAG FWDMLQLSIE NISMKFDELH 610 620 630 640 650 660 QLKANNWKQM DPLDKKERRA PPPVPKKPAK GPAPLIRERS LESSQRQEAR KRLMAAKRAA 670 680 SVRQNSATES AESIEIYIPE AQTRL
	Isoform 7 [UniParc]. Checksum: 00E65FE3F36B7D6B	FASTA	929	103,581
	10 20 30 40 50 60 MKGLSGSRSH HHGVTCDSAC DSLSHHSDRK PYLLSPVEHH PADHPYYTQR NSFQAECVGP 70 80 90 100 110 120 FSDPLASSTF PRRHYTSQQE LKDECALVPR TLATKANRIP ANLLDQFERQ LPLSRDGYHT 130 140 150 160 170 180 LQYKRTAVEH RSDSPGRIRH LVHSVQKLFT KSHSLEGPSK GSVNGGKASP DEAQAARYGK 190 200 210 220 230 240 RSKSKERRAE PKARPSTSPG WWSSDDNLDG DMCIYHAPSG VMTMGRCPDR SASQYFLEAY 250 260 270 280 290 300 NTISEQAVKA SRSNNDVKCS TCANLPVSLD TPLLKKSAWS STLTVSRARE VYQKASVNMD 310 320 330 340 350 360 QAMVKSESCQ QERSCQYLQV PQDEWTGYTP RGKDDEIPCR RMRSGSYIKA MGDEDSGDSD 370 380 390 400 410 420 TSPKPSPKVA ARRESYLKAT QPSLTELTTL KISNEHSPKL QIRSHSYLRA VSEVSINRSL 430 440 450 460 470 480 DSLDPAGLLT SPKFRSRNES YMRAMSTISQ VSEMEVNGQF ESVCESVFSE LESQAVEALD 490 500 510 520 530 540 LPMPGCFRMR SHSYVRAIEK GCSQDDECVS LRSSSPPRTT TTVRTIQSST VSSCITTYKK 550 560 570 580 590 600 TPPPVPPRTT TKPFISITAQ SSTESAQDAY MDGQGQRGDI ISQSGLSNST ESLDSMKALT 610 620 630 640 650 660 AAIEAANAQI HGPASQHMGN NTATVTTTTT IATVTTEDRK KDHFKKNRCL SIGIQVDDAE 670 680 690 700 710 720 EPDKTGENKA PSKFQSVGVQ VEEEKCFRRF TRSNSVTTAV QADLDFHDNL ENSLESIEDN 730 740 750 760 770 780 SCPGPMARQF SRDASTSTVS IQGSGNHYHA CAADDDFDTD FDPSILPPPD PWIDSITEDP 790 800 810 820 830 840 LEAVQRSVCH RDGHWFLKLL QAERDRMEGW CQQMEREERE NNLPEDILGK IRTAVGSAQL 850 860 870 880 890 900 LMAQKFYQFR ELCEENLNPN AHPRPTSQDL AGFWDMLQLS IENISMKFDE LHQLKANNWK 910 920 QMDPLDKKVE QCRFCMVHLK TCTNTGQSK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95." Satoh K., Yanai H., Senda T., Kohu K., Nakamura T., Okumura N., Matsumine A., Kobayashi S., Toyoshima K., Akiyama T. Genes Cells 2:415-424(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[2]	"GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules." Kim E., Naisbitt S., Hsueh Y.-P., Rao A., Rothschild A., Craig A.M., Sheng M. J. Cell Biol. 136:669-678(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5; 6 AND 7). Tissue: Brain and Thalamus.
[4]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB000277 mRNA. Translation: BAA23258.1. AB000276 mRNA. Translation: BAA23257.1. U67988 mRNA. Translation: AAC51119.1. AK294717 mRNA. Translation: BAH11858.1. AK294747 mRNA. Translation: BAH11868.1. AK299880 mRNA. Translation: BAH13160.1. AK316099 mRNA. Translation: BAH14470.1. AP002472 Genomic DNA. No translation available. AP002478 Genomic DNA. No translation available. AP005130 Genomic DNA. No translation available. AP005204 Genomic DNA. No translation available. AP005241 Genomic DNA. No translation available. CH471113 Genomic DNA. Translation: EAX01654.1. CH471113 Genomic DNA. Translation: EAX01658.1. CH471113 Genomic DNA. Translation: EAX01659.1. BC136453 mRNA. Translation: AAI36454.1. BC136454 mRNA. Translation: AAI36455.1.
IPI	IPI00021941. IPI00216228. IPI00216229. IPI00788990. IPI00789415. IPI00790084.
PIR	T00014.
RefSeq	NP_001003809.1. NM_001003809.2. NP_001229690.1. NM_001242761.1. NP_001229691.1. NM_001242762.1. NP_001229692.1. NM_001242763.1. NP_001229693.1. NM_001242764.1. NP_001229694.1. NM_001242765.1. NP_001229695.1. NM_001242766.1. NP_004737.2. NM_004746.3.
UniGene	Hs.594640. Hs.654793.
3D structure databases
ProteinModelPortal	O14490.
ModBase	Search...
Protein-protein interaction databases
IntAct	O14490. 8 interactions.
MINT	MINT-2795054.
STRING	9606.ENSP00000316377.
PTM databases
PhosphoSite	O14490.
Proteomic databases
PaxDb	O14490.
PRIDE	O14490.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315677; ENSP00000316377; ENSG00000170579. ENST00000400145; ENSP00000383010; ENSG00000170579. ENST00000400147; ENSP00000383011; ENSG00000170579. ENST00000400155; ENSP00000383019; ENSG00000170579. ENST00000515196; ENSP00000445973; ENSG00000170579. ENST00000534970; ENSP00000437817; ENSG00000170579. ENST00000539435; ENSP00000446312; ENSG00000170579. ENST00000581527; ENSP00000463864; ENSG00000170579. ENST00000581699; ENSP00000462848; ENSG00000170579. ENST00000584874; ENSP00000462882; ENSG00000170579.
GeneID	9229.
KEGG	hsa:9229.
UCSC	uc002kme.2. human. uc002kmf.3. human. uc002kmg.3. human.
Organism-specific databases
CTD	9229.
GeneCards	GC18M003488.
HGNC	HGNC:2905. DLGAP1.
HPA	HPA040963.
MIM	605445. gene.
neXtProt	NX_O14490.
PharmGKB	PA27361.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG277836.
HOGENOM	HOG000015346.
HOVERGEN	HBG018957.
InParanoid	O14490.
KO	K15008.
OMA	PDETQTV.
OrthoDB	EOG4TB49Q.
PhylomeDB	O14490.
Gene expression databases
ArrayExpress	O14490.
Bgee	O14490.
CleanEx	HS_DLGAP1.
Genevestigator	O14490.
GermOnline	ENSG00000170579. Homo sapiens.
Family and domain databases
InterPro	IPR005026. GKAP. [Graphical view]
Pfam	PF03359. GKAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DLGAP1. human.
GenomeRNAi	9229.
NextBio	34591.
SOURCE	Search...

Entry information

Entry name

DLGP1_HUMAN

Accession

Primary (citable) accession number: O14490
Secondary accession number(s): A8MWN8 , B2RMU8, B7WPA1, B7Z2H2, B7Z2I2, B7Z9Y4, O14489, P78335

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.