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Protein

SWI/SNF and RSC complexes subunit ssr2

Gene

ssr2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri190 – 23142ZZ-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF and RSC complexes subunit ssr2
Gene namesi
Name:ssr2
ORF Names:SPAC23H3.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H3.10.
PomBaseiSPAC23H3.10. ssr2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • nuclear chromatin Source: PomBase
  • RSC complex Source: PomBase
  • SWI/SNF complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503SWI/SNF and RSC complexes subunit ssr2PRO_0000197084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751Phosphoserine1 Publication
Modified residuei306 – 3061Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14470.

PTM databases

iPTMnetiO14470.

Interactioni

Subunit structurei

Component of the RSC complex composed of at least arp9, arp42, rsc1, rsc4, rsc7, rsc9, rsc58, sfh1, snf21, ssr1, ssr2, ssr3 and ssr4. The complex interacts with histone and histone variant components of centromeric chromatin (By similarity). Component of the SWI/SNF global transcription activator complex composed of at least arp9, arp42, snf5, snf22, snf30, sbf59, sol1, ssr1, ssr2, ssr3, ssr4 and tfg3.By similarity1 Publication

Protein-protein interaction databases

BioGridi278342. 11 interactions.
DIPiDIP-48383N.
MINTiMINT-4672890.

Structurei

3D structure databases

ProteinModelPortaliO14470.
SMRiO14470. Positions 265-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 11598SWIRMPROSITE-ProRule annotationAdd
BLAST
Domaini245 – 29652SANTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SMARCC family.Curated
Contains 1 SANT domain.PROSITE-ProRule annotation
Contains 1 SWIRM domain.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri190 – 23142ZZ-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiO14470.
KOiK11649.
OMAiNSIHDIE.
OrthoDBiEOG092C5VLW.
PhylomeDBiO14470.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR032451. SMARCC_C.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
PF16495. SWIRM-assoc_1. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDQVRIPF LVEQTYPIIV PSYAGWFDMS KIHDIERRSN PEFFNGKSPL
60 70 80 90 100
KTPSIYKDYR DFMINSYRLE PNEYLTVTAC RRNLVGDVCA IIRVHAFLEQ
110 120 130 140 150
WGLINYQIDP ETRPAFRLPP ISGHVQAISN TPIVTQEMLA QHPPPSTVGG
160 170 180 190 200
SSSQEFVKLE EKHYSPSLNA MEQTSPKEED EKSDKVPRVD KVCFTCGVNC
210 220 230 240 250
SQTWYHNLKN KKYDICPNCY KQGRFSSSFN SSDFLCMDAI DFNHDEEKPW
260 270 280 290 300
SNQETLLLLE AIETYGDDWN QIALHVGSRT KEQCLIHFLQ IPIEDPYRQK
310 320 330 340 350
LQGDFSPFKK GFLPFDENEN PVLSTLTYLA SIVQQGMKER KQNESVKQGE
360 370 380 390 400
TSFGNSEFKN PLERVAYYAL KSAAQKAKLI AAFENRQLRR LVFSLIQAQL
410 420 430 440 450
EKLQLKMKVL EQLEKMCSLE LSELDLRGKN LLLSRLSTKK MLLAFNKKLE
460 470 480 490 500
EAVNLGGEDG LKIIDDLMST EHAEALLTFE MPTATTVSPL SKQYPDKFRT

IAL
Length:503
Mass (Da):57,685
Last modified:February 1, 2005 - v3
Checksum:i41FA0BEE2E372114
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti465 – 4651D → A in BAA13888 (PubMed:9501991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16236.1.
D89227 mRNA. Translation: BAA13888.1.
PIRiT38303.
T43061.
RefSeqiNP_593800.1. NM_001019229.2.

Genome annotation databases

EnsemblFungiiSPAC23H3.10.1; SPAC23H3.10.1:pep; SPAC23H3.10.
GeneIDi2541851.
KEGGispo:SPAC23H3.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16236.1.
D89227 mRNA. Translation: BAA13888.1.
PIRiT38303.
T43061.
RefSeqiNP_593800.1. NM_001019229.2.

3D structure databases

ProteinModelPortaliO14470.
SMRiO14470. Positions 265-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278342. 11 interactions.
DIPiDIP-48383N.
MINTiMINT-4672890.

PTM databases

iPTMnetiO14470.

Proteomic databases

MaxQBiO14470.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23H3.10.1; SPAC23H3.10.1:pep; SPAC23H3.10.
GeneIDi2541851.
KEGGispo:SPAC23H3.10.

Organism-specific databases

EuPathDBiFungiDB:SPAC23H3.10.
PomBaseiSPAC23H3.10. ssr2.

Phylogenomic databases

InParanoidiO14470.
KOiK11649.
OMAiNSIHDIE.
OrthoDBiEOG092C5VLW.
PhylomeDBiO14470.

Miscellaneous databases

PROiO14470.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR032451. SMARCC_C.
IPR007526. SWIRM.
IPR011991. WHTH_DNA-bd_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
PF16495. SWIRM-assoc_1. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSR2_SCHPO
AccessioniPrimary (citable) accession number: O14470
Secondary accession number(s): P78877
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.