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Protein

SWI/SNF and RSC complexes subunit ssr2

Gene

ssr2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 231ZZ-typeAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF and RSC complexes subunit ssr2
Gene namesi
Name:ssr2
ORF Names:SPAC23H3.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23H3.10
PomBaseiSPAC23H3.10 ssr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001970841 – 503SWI/SNF and RSC complexes subunit ssr2Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175Phosphoserine1 Publication1
Modified residuei306Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14470
PaxDbiO14470
PRIDEiO14470

PTM databases

iPTMnetiO14470

Interactioni

Subunit structurei

Component of the RSC complex composed of at least arp9, arp42, rsc1, rsc4, rsc7, rsc9, rsc58, sfh1, snf21, ssr1, ssr2, ssr3 and ssr4. The complex interacts with histone and histone variant components of centromeric chromatin (By similarity). Component of the SWI/SNF global transcription activator complex composed of at least arp9, arp42, snf5, snf22, snf30, sbf59, sol1, ssr1, ssr2, ssr3, ssr4 and tfg3.By similarity1 Publication

Protein-protein interaction databases

BioGridi278342, 11 interactors
DIPiDIP-48383N
IntActiO14470, 10 interactors
STRINGi4896.SPAC23H3.10.1

Structurei

3D structure databases

ProteinModelPortaliO14470
SMRiO14470
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 115SWIRMPROSITE-ProRule annotationAdd BLAST98
Domaini245 – 296SANTPROSITE-ProRule annotationAdd BLAST52

Sequence similaritiesi

Belongs to the SMARCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 231ZZ-typeAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiO14470
KOiK11649
OMAiSKTPAVY
OrthoDBiEOG092C5VLW
PhylomeDBiO14470

Family and domain databases

CDDicd00167 SANT, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR032451 SMARCC_C
IPR007526 SWIRM
IPR036388 WH-like_DNA-bd_sf
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF04433 SWIRM, 1 hit
PF16495 SWIRM-assoc_1, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293 SANT, 1 hit
PS50934 SWIRM, 1 hit

Sequencei

Sequence statusi: Complete.

O14470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDQVRIPF LVEQTYPIIV PSYAGWFDMS KIHDIERRSN PEFFNGKSPL
60 70 80 90 100
KTPSIYKDYR DFMINSYRLE PNEYLTVTAC RRNLVGDVCA IIRVHAFLEQ
110 120 130 140 150
WGLINYQIDP ETRPAFRLPP ISGHVQAISN TPIVTQEMLA QHPPPSTVGG
160 170 180 190 200
SSSQEFVKLE EKHYSPSLNA MEQTSPKEED EKSDKVPRVD KVCFTCGVNC
210 220 230 240 250
SQTWYHNLKN KKYDICPNCY KQGRFSSSFN SSDFLCMDAI DFNHDEEKPW
260 270 280 290 300
SNQETLLLLE AIETYGDDWN QIALHVGSRT KEQCLIHFLQ IPIEDPYRQK
310 320 330 340 350
LQGDFSPFKK GFLPFDENEN PVLSTLTYLA SIVQQGMKER KQNESVKQGE
360 370 380 390 400
TSFGNSEFKN PLERVAYYAL KSAAQKAKLI AAFENRQLRR LVFSLIQAQL
410 420 430 440 450
EKLQLKMKVL EQLEKMCSLE LSELDLRGKN LLLSRLSTKK MLLAFNKKLE
460 470 480 490 500
EAVNLGGEDG LKIIDDLMST EHAEALLTFE MPTATTVSPL SKQYPDKFRT

IAL
Length:503
Mass (Da):57,685
Last modified:February 1, 2005 - v3
Checksum:i41FA0BEE2E372114
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti465D → A in BAA13888 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16236.1
D89227 mRNA Translation: BAA13888.1
PIRiT38303
T43061
RefSeqiNP_593800.1, NM_001019229.2

Genome annotation databases

EnsemblFungiiSPAC23H3.10.1; SPAC23H3.10.1:pep; SPAC23H3.10
GeneIDi2541851
KEGGispo:SPAC23H3.10

Similar proteinsi

Entry informationi

Entry nameiSSR2_SCHPO
AccessioniPrimary (citable) accession number: O14470
Secondary accession number(s): P78877
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: April 25, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health