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Protein

Thioredoxin-1

Gene

trx1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei24 – 241Deprotonates C-terminal active site CysBy similarity
Active sitei30 – 301NucleophileBy similarity
Sitei31 – 311Contributes to redox potential valueBy similarity
Sitei32 – 321Contributes to redox potential valueBy similarity
Active sitei33 – 331NucleophileBy similarity

GO - Molecular functioni

  • antioxidant activity Source: PomBase
  • protein disulfide oxidoreductase activity Source: PomBase

GO - Biological processi

  • cell redox homeostasis Source: PomBase
  • cellular oxidant detoxification Source: GOC
  • cellular response to reactive oxygen species Source: PomBase
  • glycerol ether metabolic process Source: InterPro
  • hydrogen peroxide catabolic process Source: PomBase
  • L-methionine biosynthetic process from methionine sulphoxide Source: PomBase
  • positive regulation of cellular response to oxidative stress Source: PomBase
  • sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-3299685. Detoxification of Reactive Oxygen Species.
R-SPO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.
R-SPO-5628897. TP53 Regulates Metabolic Genes.
R-SPO-5676934. Protein repair.
R-SPO-844456. The NLRP3 inflammasome.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-1
Short name:
TR-1
Short name:
Trx-1
Gene namesi
Name:trx1
Synonyms:trx2
ORF Names:SPAC7D4.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC7D4.07c.
PomBaseiSPAC7D4.07c. trx1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 103102Thioredoxin-1PRO_0000120043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 33Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO14463.

Interactioni

Protein-protein interaction databases

BioGridi278561. 9 interactions.
MINTiMINT-4672859.

Structurei

3D structure databases

ProteinModelPortaliO14463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 103102ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thioredoxin family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000292977.
InParanoidiO14463.
KOiK03671.
OMAiEDIAMDY.
OrthoDBiEOG71CFZN.
PhylomeDBiO14463.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKQVSDSSE FKSIVCQDKL VVVDFFATWC GPCKAIAPKF EQFSNTYSDA
60 70 80 90 100
TFIKVDVDQL SEIAAEAGVH AMPSFFLYKN GEKIEEIVGA NPAKLEASIK

ANL
Length:103
Mass (Da):11,297
Last modified:January 23, 2007 - v3
Checksum:iB3A6C85F4F6A256C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 1026ASIKAN → VRLNRS in AAF05765 (PubMed:11267679).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251279 Genomic DNA. Translation: AAF76881.1.
AF192765 mRNA. Translation: AAF05765.1.
AJ003819 mRNA. Translation: CAA06033.1.
CU329670 Genomic DNA. Translation: CAB16724.1.
PIRiT39085.
RefSeqiNP_593852.1. NM_001019281.2.

Genome annotation databases

EnsemblFungiiSPAC7D4.07c.1; SPAC7D4.07c.1:pep; SPAC7D4.07c.
GeneIDi2542084.
KEGGispo:SPAC7D4.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251279 Genomic DNA. Translation: AAF76881.1.
AF192765 mRNA. Translation: AAF05765.1.
AJ003819 mRNA. Translation: CAA06033.1.
CU329670 Genomic DNA. Translation: CAB16724.1.
PIRiT39085.
RefSeqiNP_593852.1. NM_001019281.2.

3D structure databases

ProteinModelPortaliO14463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278561. 9 interactions.
MINTiMINT-4672859.

Proteomic databases

MaxQBiO14463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC7D4.07c.1; SPAC7D4.07c.1:pep; SPAC7D4.07c.
GeneIDi2542084.
KEGGispo:SPAC7D4.07c.

Organism-specific databases

EuPathDBiFungiDB:SPAC7D4.07c.
PomBaseiSPAC7D4.07c. trx1.

Phylogenomic databases

HOGENOMiHOG000292977.
InParanoidiO14463.
KOiK03671.
OMAiEDIAMDY.
OrthoDBiEOG71CFZN.
PhylomeDBiO14463.

Enzyme and pathway databases

ReactomeiR-SPO-3299685. Detoxification of Reactive Oxygen Species.
R-SPO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.
R-SPO-5628897. TP53 Regulates Metabolic Genes.
R-SPO-5676934. Protein repair.
R-SPO-844456. The NLRP3 inflammasome.

Miscellaneous databases

NextBioi20803157.
PROiO14463.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and regulation of Schizosaccharomyces pombe gene encoding thioredoxin."
    Cho Y.-W., Shin Y.H., Kim Y.-T., Kim H.-G., Lee Y.-J., Park E.-H., Fuchs J.A., Lim C.-J.
    Biochim. Biophys. Acta 1518:194-199(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "TRX2, a fission yeast stress protein."
    Lenaers G., Perret E., Bonin O., Picard A., Caput D.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 972 / ATCC 24843.
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiTRX1_SCHPO
AccessioniPrimary (citable) accession number: O14463
Secondary accession number(s): P58265, Q9UTS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.