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Protein

Thioredoxin-1

Gene

trx1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei24 – 241Deprotonates C-terminal active site CysBy similarity
Active sitei30 – 301NucleophileBy similarity
Sitei31 – 311Contributes to redox potential valueBy similarity
Sitei32 – 321Contributes to redox potential valueBy similarity
Active sitei33 – 331NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: PomBase
  • cellular response to reactive oxygen species Source: PomBase
  • glycerol ether metabolic process Source: InterPro
  • hydrogen peroxide catabolic process Source: PomBase
  • L-methionine biosynthetic process from methionine sulphoxide Source: PomBase
  • positive regulation of cellular response to oxidative stress Source: PomBase
  • protein folding Source: GO_Central
  • sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-3299685. Detoxification of Reactive Oxygen Species.
R-SPO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.
R-SPO-5628897. TP53 Regulates Metabolic Genes.
R-SPO-5676934. Protein repair.
R-SPO-844456. The NLRP3 inflammasome.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-1
Short name:
TR-1
Short name:
Trx-1
Gene namesi
Name:trx1
Synonyms:trx2
ORF Names:SPAC7D4.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC7D4.07c.
PomBaseiSPAC7D4.07c. trx1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 103102Thioredoxin-1PRO_0000120043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 33Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO14463.

Interactioni

Protein-protein interaction databases

BioGridi278561. 9 interactions.
MINTiMINT-4672859.

Structurei

3D structure databases

ProteinModelPortaliO14463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 103102ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the thioredoxin family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000292977.
InParanoidiO14463.
KOiK03671.
OMAiSMVDFWA.
OrthoDBiEOG092C4AE3.
PhylomeDBiO14463.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKQVSDSSE FKSIVCQDKL VVVDFFATWC GPCKAIAPKF EQFSNTYSDA
60 70 80 90 100
TFIKVDVDQL SEIAAEAGVH AMPSFFLYKN GEKIEEIVGA NPAKLEASIK

ANL
Length:103
Mass (Da):11,297
Last modified:January 23, 2007 - v3
Checksum:iB3A6C85F4F6A256C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 1026ASIKAN → VRLNRS in AAF05765 (PubMed:11267679).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251279 Genomic DNA. Translation: AAF76881.1.
AF192765 mRNA. Translation: AAF05765.1.
AJ003819 mRNA. Translation: CAA06033.1.
CU329670 Genomic DNA. Translation: CAB16724.1.
PIRiT39085.
RefSeqiNP_593852.1. NM_001019281.2.

Genome annotation databases

EnsemblFungiiSPAC7D4.07c.1; SPAC7D4.07c.1:pep; SPAC7D4.07c.
GeneIDi2542084.
KEGGispo:SPAC7D4.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251279 Genomic DNA. Translation: AAF76881.1.
AF192765 mRNA. Translation: AAF05765.1.
AJ003819 mRNA. Translation: CAA06033.1.
CU329670 Genomic DNA. Translation: CAB16724.1.
PIRiT39085.
RefSeqiNP_593852.1. NM_001019281.2.

3D structure databases

ProteinModelPortaliO14463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278561. 9 interactions.
MINTiMINT-4672859.

Proteomic databases

MaxQBiO14463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC7D4.07c.1; SPAC7D4.07c.1:pep; SPAC7D4.07c.
GeneIDi2542084.
KEGGispo:SPAC7D4.07c.

Organism-specific databases

EuPathDBiFungiDB:SPAC7D4.07c.
PomBaseiSPAC7D4.07c. trx1.

Phylogenomic databases

HOGENOMiHOG000292977.
InParanoidiO14463.
KOiK03671.
OMAiSMVDFWA.
OrthoDBiEOG092C4AE3.
PhylomeDBiO14463.

Enzyme and pathway databases

ReactomeiR-SPO-3299685. Detoxification of Reactive Oxygen Species.
R-SPO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.
R-SPO-5628897. TP53 Regulates Metabolic Genes.
R-SPO-5676934. Protein repair.
R-SPO-844456. The NLRP3 inflammasome.

Miscellaneous databases

PROiO14463.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRX1_SCHPO
AccessioniPrimary (citable) accession number: O14463
Secondary accession number(s): P58265, Q9UTS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.