Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thioredoxin-1

Gene

trx1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei24Deprotonates C-terminal active site CysBy similarity1
Active sitei30NucleophileBy similarity1
Sitei31Contributes to redox potential valueBy similarity1
Sitei32Contributes to redox potential valueBy similarity1
Active sitei33NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: PomBase
  • cellular detoxification of hydrogen peroxide Source: PomBase
  • cellular response to reactive oxygen species Source: PomBase
  • glycerol ether metabolic process Source: InterPro
  • hydrogen peroxide catabolic process Source: PomBase
  • L-methionine salvage from methionine sulphoxide Source: PomBase
  • positive regulation of cellular response to oxidative stress Source: PomBase
  • sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) Source: PomBase

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-3299685 Detoxification of Reactive Oxygen Species
R-SPO-499943 Interconversion of nucleotide di- and triphosphates
R-SPO-5628897 TP53 Regulates Metabolic Genes
R-SPO-5676934 Protein repair
R-SPO-844456 The NLRP3 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-1
Short name:
TR-1
Short name:
Trx-1
Gene namesi
Name:trx1
Synonyms:trx2
ORF Names:SPAC7D4.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC7D4.07c
PomBaseiSPAC7D4.07c trx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001200432 – 103Thioredoxin-1Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 33Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO14463
PaxDbiO14463
PRIDEiO14463

PTM databases

iPTMnetiO14463

Interactioni

Protein-protein interaction databases

BioGridi2785619 interactors.
STRINGi4896.SPAC7D4.07c.1

Structurei

3D structure databases

ProteinModelPortaliO14463
SMRiO14463
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 103ThioredoxinPROSITE-ProRule annotationAdd BLAST102

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000292977
InParanoidiO14463
KOiK03671
OMAiSKYAFQE
OrthoDBiEOG092C4AE3
PhylomeDBiO14463

Family and domain databases

InterProiView protein in InterPro
IPR005746 Thioredoxin
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PANTHERiPTHR10438 PTHR10438, 1 hit
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
PIRSFiPIRSF000077 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR01068 thioredoxin, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKQVSDSSE FKSIVCQDKL VVVDFFATWC GPCKAIAPKF EQFSNTYSDA
60 70 80 90 100
TFIKVDVDQL SEIAAEAGVH AMPSFFLYKN GEKIEEIVGA NPAKLEASIK

ANL
Length:103
Mass (Da):11,297
Last modified:January 23, 2007 - v3
Checksum:iB3A6C85F4F6A256C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97 – 102ASIKAN → VRLNRS in AAF05765 (PubMed:11267679).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251279 Genomic DNA Translation: AAF76881.1
AF192765 mRNA Translation: AAF05765.1
AJ003819 mRNA Translation: CAA06033.1
CU329670 Genomic DNA Translation: CAB16724.1
PIRiT39085
RefSeqiNP_593852.1, NM_001019281.2

Genome annotation databases

EnsemblFungiiSPAC7D4.07c.1; SPAC7D4.07c.1:pep; SPAC7D4.07c
GeneIDi2542084
KEGGispo:SPAC7D4.07c

Similar proteinsi

Entry informationi

Entry nameiTRX1_SCHPO
AccessioniPrimary (citable) accession number: O14463
Secondary accession number(s): P58265, Q9UTS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome