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Protein

Endochitinase 1

Gene

chit1

Organism
Metarhizium anisopliae (Entomophthora anisopliae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Participates in the infection process and directly acts in the penetration process of the host cuticle.2 Publications

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei172Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation, Virulence
LigandChitin-binding

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.
mycoCLAPiCHI18A_METAN.

Names & Taxonomyi

Protein namesi
Recommended name:
Endochitinase 1 (EC:3.2.1.14)
Alternative name(s):
Chitinase 1
Gene namesi
Name:chit1
Synonyms:chit42
OrganismiMetarhizium anisopliae (Entomophthora anisopliae)
Taxonomic identifieri5530 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaeMetarhizium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Biotechnological usei

When expressed in tobacco plants, chit1 confers resistance against Rhizoctonia solani.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000042986423 – 423Endochitinase 1Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO14456.
SMRiO14456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00704. Glyco_hydro_18. 1 hit.
SMARTiView protein in SMART
SM00636. Glyco_18. 1 hit.
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
PROSITEiView protein in PROSITE
PS01095. CHITINASE_18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLFAQSLA IIATLQATLG LATPVSAPDT VIGKHAGGYV NAVYFTNWGI
60 70 80 90 100
YGRNYQPADL PASQISHVLY SFLNLSNNGT VYSGDSWADI DKHYPNDSWN
110 120 130 140 150
DVGTNVYGCV KQLYLLKKAN RNMKTMLSIG GWTWSTNFPA AASTAATRSN
160 170 180 190 200
FAKSAVTIMK DWGFDGIDVD WEYPADDVQA TNMVLLLQAI REELDAYAAK
210 220 230 240 250
FAQGYHFQLS IAAPAGPANY NKLHLGDLGK VLDYINLMAY DFSGSWSNSS
260 270 280 290 300
AHNANLYAIR ANLNAPFNTD HAVNDYIKGG VPASKIVLAL PIYGNSFQKT
310 320 330 340 350
NGIGKPFSGA GDGSWENGIW DYKVHSKAGA DGIYDDGDKG YYSYDPSVKE
360 370 380 390 400
LISIDTPDIT KDKVTYLKSK GLGGSMFWEA SSDRSGSQSL IGTSSNKLGG
410 420
PDSTENLLNY PDSKYDNMRK QMA
Length:423
Mass (Da):45,945
Last modified:January 1, 1998 - v1
Checksum:i3123E41808F783AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027497 mRNA. Translation: AAB81998.1.
AF027498 Genomic DNA. Translation: AAB81999.1.

Similar proteinsi

Entry informationi

Entry nameiCHI1_METAN
AccessioniPrimary (citable) accession number: O14456
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: January 1, 1998
Last modified: May 10, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families